The Oncosearch | Oncotarget

Identification of epipolythiodioxopiperazines HDN-1 and chaetocin as novel inhibitor of heat shock protein 90 Research Paper

Xiaoping Song, Zhimin Zhao, Xin Qi, Shuai Tang, Qiang Wang, Tianjiao Zhu, Qianqun Gu, Ming Liu, Jing Li

Published Jan 24, 2015 · Vol. 6, No. 7 · pp. 5263-5274

Cell-specific expression of artificial microRNAs targeting essential genes exhibit potent antitumor effect on hepatocellular carcinoma cells Research Paper

Chenyu Mao, Hao Liu, Ping Chen, Jingjia Ye, Lisong Teng, Zhenyu Jia, Jiang Cao

Published Jan 21, 2015 · Vol. 6, No. 8 · pp. 5707-5719

Inhibition of the Warburg effect with a natural compound reveals a novel measurement for determining the metastatic potential of breast cancers Research Paper

Ritu Arora, David Schmitt, Balasubramanyam Karanam, Ming Tan, Clayton Yates, Windy Dean-Colomb

Published Jan 7, 2015 · Vol. 6, No. 2 · pp. 662-678

Ferroxitosis: A cell death from modulation of oxidative phosphorylation and PKM2-dependent glycolysis in melanoma Research Paper

Alexander J. Lakhter, James Hamilton, Pierre C. Dagher, Suresh Mukkamala, Takashi Hato, X. Charlie Dong, Lindsey D. Mayo, Robert A. Harris, Anantha Shekhar, Mircea Ivan, Nickolay Brustovetsky, Samisubbu R. Naidu

Published Dec 26, 2014 · Vol. 5, No. 24 · pp. 12694-12703

Inhibition of HIF-1Î± by PX-478 enhances the anti-tumor effect of gemcitabine by inducing immunogenic cell death in pancreatic ductal adenocarcinoma Research Paper

Tiansuo Zhao, He Ren, Li Jia, Jing Chen, Wen Xin, Fan Yan, Jing Li, Xiuchao Wang, Song Gao, Dong Qian, Chongbiao Huang, Jihui Hao

Published Dec 10, 2014 · Vol. 6, No. 4 · pp. 2250-2262

A novel PI3K inhibitor PIK-C98 displays potent preclinical activity against multiple myeloma Research Paper

Jingyu Zhu, Man Wang, Yang Yu, Huixin Qi, Kunkun Han, Juan Tang, Zubin Zhang, Yuanying Zeng, Biyin Cao, Chunhua Qiao, Hongjian Zhang, Tingjun Hou, Xinliang Mao

Published Dec 2, 2014 · Vol. 6, No. 1 · pp. 185-195

Afatinib circumvents multidrug resistance via dually inhibiting ATP binding cassette subfamily G member 2 in vitro and in vivo Research Paper

Xiao-kun Wang, Kenneth Kin Wah To, Li-yan Huang, Jing-hong Xu, Ke Yang, Fang Wang, Zhen-cong Huang, Sheng Ye, Li-wu Fu

Published Nov 24, 2014 · Vol. 5, No. 23 · pp. 11971-11985

Glycolysis is the primary bioenergetic pathway for cell motility and cytoskeletal remodeling in human prostate and breast cancer cells Research Paper

Takumi Shiraishi, James E. Verdone, Jessie Huang, Ulf D. Kahlert, James R. Hernandez, Gonzalo Torga, Jelani C. Zarif, Tamir Epstein, Robert Gatenby, Annemarie McCartney, Jennifer H. Elisseeff, Steven M. Mooney, Steven S. An, Kenneth J. Pienta

Published Nov 16, 2014 · Vol. 6, No. 1 · pp. 130-143

Mitochondria as new therapeutic targets for eradicating cancer stem cells: Quantitative proteomics and functional validation via MCT1/2 inhibition Priority Research Paper

Rebecca Lamb, Hannah Harrison, James Hulit, Duncan L. Smith, Michael P. Lisanti, Federica Sotgia

Published Nov 15, 2014 · Vol. 5, No. 22 · pp. 11029-11037

VER-246608, a novel pan-isoform ATP competitive inhibitor of pyruvate dehydrogenase kinase, disrupts Warburg metabolism and induces context-dependent cytostasis in cancer cells Research Paper

Jonathan D. Moore, Anna Staniszewska, Terence Shaw, Jalanie Dâ€™Alessandro, Ben Davis, Alan Surgenor, Lisa Baker, Natalia Matassova, James Murray, Alba Macias, Paul Brough, Mike Wood, Patrick C. Mahon

Published Nov 2, 2014 · Vol. 5, No. 24 · pp. 12862-12876

Different effects of LDH-A inhibition by oxamate in non-small cell lung cancer cells Research Paper

Yang Yang, Dan Su, Lin Zhao, Dan Zhang, Jiaying Xu, Jianmei Wan, Saijun Fan, Ming Chen

Published Oct 22, 2014 · Vol. 5, No. 23 · pp. 11886-11896

Activity of the novel mTOR inhibitor Torin-2 in B-precursor acute lymphoblastic leukemia and its therapeutic potential to prevent Akt reactivation Research Paper

Carolina Simioni, Alice Cani, Alberto M. Martelli, Giorgio Zauli, Giovanna Tabellini, James McCubrey, Silvano Capitani, Luca M. Neri

Published Sep 16, 2014 · Vol. 5, No. 20 · pp. 10034-10047

Multidrug resistance protein 4/ ATP binding cassette transporter 4: a new potential therapeutic target for acute myeloid leukemia Research Paper

Sabrina Copsel, Ariana Bruzzone, Maria May, Julien Beyrath, Victoria Wargon, Jeannette Cany, Frans G.M. Russel, Carina Shayo, Carlos Davio

Published Sep 2, 2014 · Vol. 5, No. 19 · pp. 9308-9321

P2Y₂R activation by nucleotides released from the highly metastatic breast cancer cell contributes to pre-metastatic niche formation by mediating lysyl oxidase secretion, collagen crosslinking, and monocyte recruitment Research Paper

Young Nak Joo, Hana Jin, So Young Eun, Sang Won Park, Ki Churl Chang, Hye Jung Kim

Published Sep 2, 2014 · Vol. 5, No. 19 · pp. 9322-9334

Binding of a Smad4/Ets-1 complex to a novel intragenic regulatory element in exon12 of FPGS underlies decreased gene expression and antifolate resistance in leukemia Research Paper

Shachar Raz, Michal Stark, Yehuda G. Assaraf

Published Aug 27, 2014 · Vol. 5, No. 19 · pp. 9183-9198

Mutations in CIC and IDH1 cooperatively regulate 2-hydroxyglutarate levels and cell clonogenicity Research Paper

Suganthi Chittaranjan, Susanna Chan, Cindy Yang, Kevin C. Yang, Vincent Chen, Annie Moradian, Marlo Firme, Jungeun Song, Nancy E. Go, Michael D. Blough, Jennifer A. Chan, Gregory J. Cairncross, Sharon M. Gorski, Gregg B. Morin, Stephen Yip, Marco A. Marra

Published Aug 27, 2014 · Vol. 5, No. 17 · pp. 7960-7979

Multiple blocks in the engagement of oxidative phosphorylation in putative ovarian cancer stem cells: implication for maintenance therapy with glycolysis inhibitors Research Paper

Ayesha B. Alvero, Michele K. Montagna, Natalia J. Sumi, Won Duk Joo, Emma Graham, Gil Mor

Published Aug 19, 2014 · Vol. 5, No. 18 · pp. 8703-8715

Molecular rationale for the use of PI3K/AKT/mTOR pathway inhibitors in combination with crizotinib in ALK-mutated neuroblastoma Research Paper

Nathan F. Moore, Anna M. Azarova, Namrata Bhatnagar, Kenneth N. Ross, Lauren E. Drake, Stacey Frumm, Qinsong S. Liu, Amanda L. Christie, Takaomi Sanda, Louis Chesler, Andrew L. Kung, Nathanael S. Gray, Kimberly Stegmaier, Rani E. George

Published Aug 19, 2014 · Vol. 5, No. 18 · pp. 8737-8749

N-Myc-induced up-regulation of TRPM6/TRPM7 channels promotes neuroblastoma cell proliferation Research Paper

Zheng Zhang, Malika Faouzi, Junhao Huang, Dirk Geerts, Haijie Yu, Andrea Fleig, Reinhold Penner

Published Jul 31, 2014 · Vol. 5, No. 17 · pp. 7625-7634

Role of mesenchymal stem cells in osteosarcoma and metabolic reprogramming of tumor cells Research Paper

Gloria Bonuccelli, Sofia Avnet, Giulia Grisendi, Manuela Salerno, Donatella Granchi, Massimo Dominici, Katsuyuki Kusuzaki, Nicola Baldini

Published Jul 28, 2014 · Vol. 5, No. 17 · pp. 7575-7588

Publication Alerts

European Cancer and Oncology Congress

Post-Publication Promotion

Search Oncotarget

Identification of epipolythiodioxopiperazines HDN-1 and chaetocin as novel inhibitor of heat shock protein 90 Research Paper

Cell-specific expression of artificial microRNAs targeting essential genes exhibit potent antitumor effect on hepatocellular carcinoma cells Research Paper

Inhibition of the Warburg effect with a natural compound reveals a novel measurement for determining the metastatic potential of breast cancers Research Paper

Ferroxitosis: A cell death from modulation of oxidative phosphorylation and PKM2-dependent glycolysis in melanoma Research Paper

Inhibition of HIF-1Î± by PX-478 enhances the anti-tumor effect of gemcitabine by inducing immunogenic cell death in pancreatic ductal adenocarcinoma Research Paper

A novel PI3K inhibitor PIK-C98 displays potent preclinical activity against multiple myeloma Research Paper

Afatinib circumvents multidrug resistance via dually inhibiting ATP binding cassette subfamily G member 2 in vitro and in vivo Research Paper

Glycolysis is the primary bioenergetic pathway for cell motility and cytoskeletal remodeling in human prostate and breast cancer cells Research Paper

Mitochondria as new therapeutic targets for eradicating cancer stem cells: Quantitative proteomics and functional validation via MCT1/2 inhibition Priority Research Paper

VER-246608, a novel pan-isoform ATP competitive inhibitor of pyruvate dehydrogenase kinase, disrupts Warburg metabolism and induces context-dependent cytostasis in cancer cells Research Paper

Different effects of LDH-A inhibition by oxamate in non-small cell lung cancer cells Research Paper

Activity of the novel mTOR inhibitor Torin-2 in B-precursor acute lymphoblastic leukemia and its therapeutic potential to prevent Akt reactivation Research Paper

Multidrug resistance protein 4/ ATP binding cassette transporter 4: a new potential therapeutic target for acute myeloid leukemia Research Paper

P2Y₂R activation by nucleotides released from the highly metastatic breast cancer cell contributes to pre-metastatic niche formation by mediating lysyl oxidase secretion, collagen crosslinking, and monocyte recruitment Research Paper

Binding of a Smad4/Ets-1 complex to a novel intragenic regulatory element in exon12 of FPGS underlies decreased gene expression and antifolate resistance in leukemia Research Paper

Mutations in CIC and IDH1 cooperatively regulate 2-hydroxyglutarate levels and cell clonogenicity Research Paper

Multiple blocks in the engagement of oxidative phosphorylation in putative ovarian cancer stem cells: implication for maintenance therapy with glycolysis inhibitors Research Paper

Molecular rationale for the use of PI3K/AKT/mTOR pathway inhibitors in combination with crizotinib in ALK-mutated neuroblastoma Research Paper

N-Myc-induced up-regulation of TRPM6/TRPM7 channels promotes neuroblastoma cell proliferation Research Paper

Role of mesenchymal stem cells in osteosarcoma and metabolic reprogramming of tumor cells Research Paper

Publication Alerts

European Cancer and Oncology Congress

Oncoscience

Post-Publication Promotion

Search Oncotarget

Identification of epipolythiodioxopiperazines HDN-1 and chaetocin as novel inhibitor of heat shock protein 90 Research Paper

Cell-specific expression of artificial microRNAs targeting essential genes exhibit potent antitumor effect on hepatocellular carcinoma cells Research Paper

Inhibition of the Warburg effect with a natural compound reveals a novel measurement for determining the metastatic potential of breast cancers Research Paper

Ferroxitosis: A cell death from modulation of oxidative phosphorylation and PKM2-dependent glycolysis in melanoma Research Paper

Inhibition of HIF-1Î± by PX-478 enhances the anti-tumor effect of gemcitabine by inducing immunogenic cell death in pancreatic ductal adenocarcinoma Research Paper

A novel PI3K inhibitor PIK-C98 displays potent preclinical activity against multiple myeloma Research Paper

Afatinib circumvents multidrug resistance via dually inhibiting ATP binding cassette subfamily G member 2 in vitro and in vivo Research Paper

Glycolysis is the primary bioenergetic pathway for cell motility and cytoskeletal remodeling in human prostate and breast cancer cells Research Paper

Mitochondria as new therapeutic targets for eradicating cancer stem cells: Quantitative proteomics and functional validation via MCT1/2 inhibition Priority Research Paper

VER-246608, a novel pan-isoform ATP competitive inhibitor of pyruvate dehydrogenase kinase, disrupts Warburg metabolism and induces context-dependent cytostasis in cancer cells Research Paper

Different effects of LDH-A inhibition by oxamate in non-small cell lung cancer cells Research Paper

Activity of the novel mTOR inhibitor Torin-2 in B-precursor acute lymphoblastic leukemia and its therapeutic potential to prevent Akt reactivation Research Paper

Multidrug resistance protein 4/ ATP binding cassette transporter 4: a new potential therapeutic target for acute myeloid leukemia Research Paper

P2Y2R activation by nucleotides released from the highly metastatic breast cancer cell contributes to pre-metastatic niche formation by mediating lysyl oxidase secretion, collagen crosslinking, and monocyte recruitment Research Paper

Binding of a Smad4/Ets-1 complex to a novel intragenic regulatory element in exon12 of FPGS underlies decreased gene expression and antifolate resistance in leukemia Research Paper

Mutations in CIC and IDH1 cooperatively regulate 2-hydroxyglutarate levels and cell clonogenicity Research Paper

Multiple blocks in the engagement of oxidative phosphorylation in putative ovarian cancer stem cells: implication for maintenance therapy with glycolysis inhibitors Research Paper

Molecular rationale for the use of PI3K/AKT/mTOR pathway inhibitors in combination with crizotinib in ALK-mutated neuroblastoma Research Paper

N-Myc-induced up-regulation of TRPM6/TRPM7 channels promotes neuroblastoma cell proliferation Research Paper

Role of mesenchymal stem cells in osteosarcoma and metabolic reprogramming of tumor cells Research Paper

P2Y₂R activation by nucleotides released from the highly metastatic breast cancer cell contributes to pre-metastatic niche formation by mediating lysyl oxidase secretion, collagen crosslinking, and monocyte recruitment Research Paper