The Oncosearch | Oncotarget

Structural basis of nSH2 regulation and lipid binding in PI3KÎ± Priority Research Paper

Michelle S. Miller, Oleg Schmidt-Kittler, David M. Bolduc, Evan T. Brower, Daniele Chaves-Moreira, Marc Allaire, Kenneth W. Kinzler, Ian G. Jennings, Philip E. Thompson, Philip A. Cole, L. Mario Amzel, Bert Vogelstein, Sandra B. Gabelli

Published Jul 25, 2014 · Vol. 5, No. 14 · pp. 5198-5208

Fructose-2,6-Bisphosphate synthesis by 6-Phosphofructo-2-Kinase/Fructose-2,6-Bisphosphatase 4 (PFKFB4) is required for the glycolytic response to hypoxia and tumor growth Research Paper

Jason Chesney, Jennifer Clark, Alden C. Klarer, Yoannis Imbert-Fernandez, Andrew N. Lane, Sucheta Telang

Published Jul 13, 2014 · Vol. 5, No. 16 · pp. 6670-6686

MicroRNA-25 regulates chemoresistance-associated autophagy in breast cancer cells, a process modulated by the natural autophagy inducer isoliquiritigenin Research Paper

Zhiyu Wang, Neng Wang, Pengxi Liu, Qianjun Chen, Honglin Situ, Ting Xie, Jianxing Zhang, Cheng Peng, Yi Lin, Jianping Chen

Published Jul 9, 2014 · Vol. 5, No. 16 · pp. 7013-7026

Guggulsterone inhibits prostate cancer growth via inactivation of Akt regulated by ATP citrate lyase signaling Advance Publication

Yajuan Gao, Yan Zeng, Jian Tian, Mohammad Shyful Islam, Guoqin Jiang, Dong Xiao

Published Jun 26, 2014 · Vol. 5

Discovery of novel non-ATP competitive FGFR1 inhibitors and evaluation of their anti-tumor activity in non-small cell lung cancer in vitro and in vivo Research Paper

Jianzhang Wu, Jiansong Ji, Bixia Weng, Peihong Qiu, Karvannan Kanchana, Tao Wei, Yi Wang, Yuepiao Cai, Xiaokun Li, Guang Liang

Published Jun 20, 2014 · Vol. 5, No. 12 · pp. 4543-4553

Inhibition of glucose turnover by 3-bromopyruvate counteracts pancreatic cancer stem cell features and sensitizes cells to gemcitabine Research Paper

Orkhan Isayev, Vanessa Rausch, Nathalie Bauer, Li Liu, Pei Fan, Yiyao Zhang, Jury Gladkich, Clifford C. Nwaeburu, JÃ¼rgen Mattern, Martin Mollenhauer, Felix RÃ¼ckert, Sebastian Zach, Uwe Haberkorn, Wolfgang Gross, Frank SchÃ¶nsiegel, Alexandr V. Bazhin, Ingrid Herr

Published Jun 15, 2014 · Vol. 5, No. 13 · pp. 5177-5189

Inhibition of Lon blocks cell proliferation, enhances chemosensitivity by promoting apoptosis and decreases cellular bioenergetics of bladder cancer: potential roles of Lon as a prognostic marker and therapeutic target in baldder cancer Research Paper

Yongzhang Liu, Linhua Lan, Kate Huang, Rongrong Wang, Cuicui Xu, Yang Shi, Xiaoyi Wu, Zhi Wu, Jiliang Zhang, Lin Chen, Lu Wang, Xiaomin Yu, Haibo Zhu, Bin Lu

Published May 28, 2014 · Vol. 5, No. 22 · pp. 11209-11224

Mitophagy switches cell death from apoptosis to necrosis in NSCLC cells treated with oncolytic measles virus Research Paper

Mao Xia, Gang Meng, Aiqin Jiang, Aiping Chen, Meike Dahlhaus, Patrick Gonzalez, Christian Beltinger, Jiwu Wei

Published May 28, 2014 · Vol. 5, No. 11 · pp. 3907-3918

Targeting Aerobic Glycolysis and HIF-1Î± Expression Enhance Imiquimod-induced Apoptosis in Cancer Cells Research Paper

Shi-Wei Huang, Jun-Kai Kao, Chun-Ying Wu, Sin-Ting Wang, Hsin-Chen Lee, Shu-Mei Liang, Yi-Ju Chen, Jeng-Jer Shieh

Published Mar 12, 2014 · Vol. 5, No. 5 · pp. 1363-1381

Keywords: imiquimod, aerobic glycolysis, HIF-1alpha, ï€¬ï€ apoptosis

Hypomethylation of the CTCFL/BORIS promoter and aberrant expression during endometrial cancer progression suggests a role as an Epi-driver gene Research Paper

Erling A. Hoivik, Kanthida Kusonmano, Mari K. Halle, Anna Berg, Elisabeth Wik, Henrica M. J. Werner, Kjell Petersen, Anne M. Oyan, Karl-Henning Kalland, Camilla Krakstad, Jone Trovik, Martin Widschwendter, Helga B. Salvesen

Published Jan 28, 2014 · Vol. 5, No. 4 · pp. 1052-1061

Keywords: CTCFL/BORIS, endometrial cancer, Epi-driver gene, recurrence, metastasis

Hypoxia inducible factor-1 alpha as a therapeutic target in multiple myeloma Research Paper

Enrica Borsi, Giulia Perrone, Carolina Terragna, Marina Martello, Angela F Dico, Giancarlo Solaini, Alessandra Baracca, Gianluca Sgarbi, Gianandrea Pasquinelli, Sabrina Valente, Elena Zamagni, Paola Tacchetti, Giovanni Martinelli, Michele Cavo

Published Jan 23, 2014 · Vol. 5, No. 7 · pp. 1779-1792

Keywords: HIF-1Î±, Multiple Myeloma, Cell cycle, Mitochondria, Warburg effect

Metformin sensitizes anticancer effect of dasatinib in head and neck squamous cell carcinoma cells through AMPK-dependent ER stress Research Paper

Yu-Chin Lin, Meng-Hsuan Wu, Tzu-Tang Wei, Yun-Chieh Lin, Wen-Chih Huang, Liang-Yu Huang, Yi-Ting Lin, Ching-Chow Chen

Published Jan 7, 2014 · Vol. 5, No. 1 · pp. 298-308

Keywords: AMPK, ER stress, EGFR, dasatinib, PDK4

Radiation-induced immunogenic modulation of tumor enhances antigen processing and calreticulin exposure, resulting in enhanced T-cell killing Research Paper

Sofia R. Gameiro, Momodou L. Jammeh, Max M. Wattenberg, Kwong Y. Tsang, Soldano Ferrone, James W. Hodge

Published Dec 31, 2013 · Vol. 5, No. 2 · pp. 403-416

Keywords: radiation, immunogenic modulation, antigen-processing machinery, calreticulin, CTL, ER stress, PERK

Resistance to Dasatinib in primary chronic lymphocytic leukemia lymphocytes involves AMPK-mediated energetic re-programming Research Paper

Veronica Martinez-Marignac, Nader Toban, Miguel Bazile, Raquel Aloyz

Published Nov 7, 2013 · Vol. 4, No. 12 · pp. 2550-2566

Keywords: CLL, AMPK, Dasatinib, kinase inhibitor, metabolism, glycolysis, OXPHOS

The discovery of potent ribosomal S6 kinase inhibitors by high-throughput screening and structure-guided drug design Research Paper

Sylvain Couty, Isaac M. Westwood, Andrew Kalusa, Celine Cano, Jon Travers, Kathy Boxall, Chiau Ling Chow, Sam Burns, Jessica Schmitt, Lisa Pickard, Caterina Barillari, P. Craig McAndrew, Paul A. Clarke, Spiros Linardopoulos, Roger J. Griffin, G. Wynne Aherne, Florence I. Raynaud, Paul Workman, Keith Jones, Rob L.M. van Montfort

Published Aug 25, 2013 · Vol. 4, No. 10 · pp. 1647-1661

Keywords: S6 kinase, P70S6K, cancer, inhibitor, structure-based drug design

Dysfunctional oxidative phosphorylation makes malignant melanoma cells addicted to glycolysis driven by the V600EBRAF oncogene Research Paper

Arnaldur Hall, Kathrine Damm Meyle, Marina Krarup Lange, Martin Klima, May Sanderhoff, Christina Dahl, Cecilie Abildgaard, Katrine Thorup, Seyed Moein Moghimi, Per Bo Jensen, Jiri Bartek, Per Guldberg, Claus Christensen

Published Apr 8, 2013 · Vol. 4, No. 4 · pp. 584-599

Keywords: Oncogene addiction, melanoma, V600EBRAF, the Warburg effect, glycolysis, oxidative phosphorylation

BRAF Mutant Gastrointestinal Stromal Tumor: First report of regression with BRAF inhibitor dabrafenib (GSK2118436) and whole exomic sequencing for analysis of acquired resistance Research Paper

Gerald S. Falchook, Jonathan C. Trent, Michael C. Heinrich, Carol Beadling, Janice Patterson, Christel C. Bastida, Samuel C. Blackman, Razelle Kurzrock

Published Feb 25, 2013 · Vol. 4, No. 2 · pp. 310-315

Keywords: Gastrointestinal stromal tumor, Dabrafenib, GSK2118436, BRAF mutation, BRAF inhibition, V600E

Harnessing the PI3K/Akt/mTOR pathway in T-cell acute lymphoblastic leukemia: Eliminating activity by targeting at different levels Research Paper

Daniela Bressanin, Camilla Evangelisti, Francesca Ricci, Giovanna Tabellini, Francesca Chiarini, Pier Luigi Tazzari, Fraia Melchionda, Francesca Buontempo, Pasqualepaolo Pagliaro, Andrea Pession, James A McCubrey, Alberto M. Martelli

Published Aug 9, 2012 · Vol. 3, No. 8 · pp. 811-823

Keywords: acute leukemia, targeted therapy, signal transduction modulators, PI3K/PDK1, vertical inhibition

Mitochondrial Fission Induces Glycolytic Reprogramming in Cancer-Associated Myofibroblasts, Driving Stromal Lactate Production, and Early Tumor Growth Research Paper

Carmela Guido, Diana Whitaker-Menezes, Zhao Lin, Richard G. Pestell, Anthony Howell, Teresa A. Zimmers, Mathew C. Casimiro, Saveria Aquila, Sebastiano Ando, Ubaldo E. Martinez-Outschoorn, Federica Sotgia, Michael P. Lisanti

Published Aug 7, 2012 · Vol. 3, No. 8 · pp. 798-810

Computer-Based Identification of a Novel LIMK1/2 Inhibitor that Synergizes with Salirasib to Destabilize the Actin Cytoskeleton Research Paper

Efrat Mashiach Farkash, Roni Rak, Galit Elad-Sfadia, Roni Haklai, Shmuel Carmeli, Yoel Kloog, Haim Wolfson

Published Jul 7, 2012 · Vol. 3, No. 6 · pp. 629-639

Keywords: Cofilin, Ras, Rac, Rho, LIMK

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Structural basis of nSH2 regulation and lipid binding in PI3KÎ± Priority Research Paper

Fructose-2,6-Bisphosphate synthesis by 6-Phosphofructo-2-Kinase/Fructose-2,6-Bisphosphatase 4 (PFKFB4) is required for the glycolytic response to hypoxia and tumor growth Research Paper

MicroRNA-25 regulates chemoresistance-associated autophagy in breast cancer cells, a process modulated by the natural autophagy inducer isoliquiritigenin Research Paper

Guggulsterone inhibits prostate cancer growth via inactivation of Akt regulated by ATP citrate lyase signaling Advance Publication

Discovery of novel non-ATP competitive FGFR1 inhibitors and evaluation of their anti-tumor activity in non-small cell lung cancer in vitro and in vivo Research Paper

Inhibition of glucose turnover by 3-bromopyruvate counteracts pancreatic cancer stem cell features and sensitizes cells to gemcitabine Research Paper

Inhibition of Lon blocks cell proliferation, enhances chemosensitivity by promoting apoptosis and decreases cellular bioenergetics of bladder cancer: potential roles of Lon as a prognostic marker and therapeutic target in baldder cancer Research Paper

Mitophagy switches cell death from apoptosis to necrosis in NSCLC cells treated with oncolytic measles virus Research Paper

Targeting Aerobic Glycolysis and HIF-1Î± Expression Enhance Imiquimod-induced Apoptosis in Cancer Cells Research Paper

Hypomethylation of the CTCFL/BORIS promoter and aberrant expression during endometrial cancer progression suggests a role as an Epi-driver gene Research Paper

Hypoxia inducible factor-1 alpha as a therapeutic target in multiple myeloma Research Paper

Metformin sensitizes anticancer effect of dasatinib in head and neck squamous cell carcinoma cells through AMPK-dependent ER stress Research Paper

Radiation-induced immunogenic modulation of tumor enhances antigen processing and calreticulin exposure, resulting in enhanced T-cell killing Research Paper

Resistance to Dasatinib in primary chronic lymphocytic leukemia lymphocytes involves AMPK-mediated energetic re-programming Research Paper

The discovery of potent ribosomal S6 kinase inhibitors by high-throughput screening and structure-guided drug design Research Paper

Dysfunctional oxidative phosphorylation makes malignant melanoma cells addicted to glycolysis driven by the V600EBRAF oncogene Research Paper

BRAF Mutant Gastrointestinal Stromal Tumor: First report of regression with BRAF inhibitor dabrafenib (GSK2118436) and whole exomic sequencing for analysis of acquired resistance Research Paper

Harnessing the PI3K/Akt/mTOR pathway in T-cell acute lymphoblastic leukemia: Eliminating activity by targeting at different levels Research Paper

Mitochondrial Fission Induces Glycolytic Reprogramming in Cancer-Associated Myofibroblasts, Driving Stromal Lactate Production, and Early Tumor Growth Research Paper

Computer-Based Identification of a Novel LIMK1/2 Inhibitor that Synergizes with Salirasib to Destabilize the Actin Cytoskeleton Research Paper

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European Cancer and Oncology Congress

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Post-Publication Promotion

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Structural basis of nSH2 regulation and lipid binding in PI3KÎ± Priority Research Paper

Fructose-2,6-Bisphosphate synthesis by 6-Phosphofructo-2-Kinase/Fructose-2,6-Bisphosphatase 4 (PFKFB4) is required for the glycolytic response to hypoxia and tumor growth Research Paper

MicroRNA-25 regulates chemoresistance-associated autophagy in breast cancer cells, a process modulated by the natural autophagy inducer isoliquiritigenin Research Paper

Guggulsterone inhibits prostate cancer growth via inactivation of Akt regulated by ATP citrate lyase signaling Advance Publication

Discovery of novel non-ATP competitive FGFR1 inhibitors and evaluation of their anti-tumor activity in non-small cell lung cancer in vitro and in vivo Research Paper

Inhibition of glucose turnover by 3-bromopyruvate counteracts pancreatic cancer stem cell features and sensitizes cells to gemcitabine Research Paper

Inhibition of Lon blocks cell proliferation, enhances chemosensitivity by promoting apoptosis and decreases cellular bioenergetics of bladder cancer: potential roles of Lon as a prognostic marker and therapeutic target in baldder cancer Research Paper

Mitophagy switches cell death from apoptosis to necrosis in NSCLC cells treated with oncolytic measles virus Research Paper

Targeting Aerobic Glycolysis and HIF-1Î± Expression Enhance Imiquimod-induced Apoptosis in Cancer Cells Research Paper

Hypomethylation of the CTCFL/BORIS promoter and aberrant expression during endometrial cancer progression suggests a role as an Epi-driver gene Research Paper

Hypoxia inducible factor-1 alpha as a therapeutic target in multiple myeloma Research Paper

Metformin sensitizes anticancer effect of dasatinib in head and neck squamous cell carcinoma cells through AMPK-dependent ER stress Research Paper

Radiation-induced immunogenic modulation of tumor enhances antigen processing and calreticulin exposure, resulting in enhanced T-cell killing Research Paper

Resistance to Dasatinib in primary chronic lymphocytic leukemia lymphocytes involves AMPK-mediated energetic re-programming Research Paper

The discovery of potent ribosomal S6 kinase inhibitors by high-throughput screening and structure-guided drug design Research Paper

Dysfunctional oxidative phosphorylation makes malignant melanoma cells addicted to glycolysis driven by the V600EBRAF oncogene Research Paper

BRAF Mutant Gastrointestinal Stromal Tumor: First report of regression with BRAF inhibitor dabrafenib (GSK2118436) and whole exomic sequencing for analysis of acquired resistance Research Paper

Harnessing the PI3K/Akt/mTOR pathway in T-cell acute lymphoblastic leukemia: Eliminating activity by targeting at different levels Research Paper

Mitochondrial Fission Induces Glycolytic Reprogramming in Cancer-Associated Myofibroblasts, Driving Stromal Lactate Production, and Early Tumor Growth Research Paper

Computer-Based Identification of a Novel LIMK1/2 Inhibitor that Synergizes with Salirasib to Destabilize the Actin Cytoskeleton Research Paper