The Oncosearch | Oncotarget

Challenges and resistance mechanisms to EGFR targeted therapies in head and neck cancers and breast cancer: Insights into RTK dependent and independent mechanisms Review

Shreya Shyamsunder, Zhixin Lu, Vinita Takiar, Susan E. Waltz

Published Jun 16, 2025 · Vol. 16, No. 1 · pp. 508-530

Keywords: EGFR, RTKs, breast cancer, head and neck cancer, resistance mechanisms

Next-generation cell-penetrating antibodies for tumor targeting and RAD51 inhibition Research Paper

Madison Rackear, Elias Quijano, Zaira Ianniello, Daniel A. Colón-Ríos, Adam Krysztofiak, Rashed Abdullah, Yanfeng Liu, Faye A. Rogers, Dale L. Ludwig, Rohini Dwivedi, Franziska Bleichert, Peter M. Glazer

Published Sep 20, 2024 · Vol. 15, No. 1 · pp. 699-713

Keywords: 3E10, cell penetration, nucleic acid binding, nucleic acid delivery, RAD51

A nanobody against the V-ATPase c subunit inhibits metastasis of 4T1-12B breast tumor cells to lung in mice Research Paper

Zhen Li, Mohammed A. Alshagawi, Rebecca A. Oot, Mariam K. Alamoudi, Kevin Su, Wenhui Li, Michael P. Collins, Stephan Wilkens, Michael Forgac

Published Aug 5, 2024 · Vol. 15, No. 1 · pp. 575-587

Keywords: vacuolar ATPase, breast cancer, invasion, tumor metastasis, tumor growth

INT-1B3, an LNP formulated miR-193a-3p mimic, promotes anti-tumor immunity by enhancing T cell mediated immune responses via modulation of the tumor microenvironment and induction of immunogenic cell death Research Paper

Chantal L. Duurland, Thijs de Gunst, Harm C. den Boer, Marion T.J. van den Bosch, Bryony J. Telford, Rogier M. Vos, Xiaolei Xie, Mingfa Zang, Fang Wang, Yingying Shao, Xiaoyu An, Jingjing Wang, Jie Cai, Ludovic Bourré, Laurens A.H. van Pinxteren, Roel Q.J. Schaapveld, Michel Janicot, Sanaz Yahyanejad

Published Jul 4, 2024 · Vol. 15, No. 1 · pp. 470-485

Keywords: miR-193a-3p, microRNA mimic, T cell mediated immunity, immunogenic cell death, cancer

Osteopontin induces mitochondrial biogenesis in deadherent cancer cells Research Paper

Gulimirerouzi Fnu, Georg F. Weber

Published Nov 24, 2023 · Vol. 14, No. 1 · pp. 957-969

Keywords: metastasis, metabolism, anchorage independence, mitochondrial mass, peroxide

ACSL4: biomarker, mediator and target in quadruple negative breast cancer Review

Marie E. Monaco

Published Jun 5, 2023 · Vol. 14, No. 1 · pp. 563-575

Keywords: ACSL4, breast cancer, ferroptosis, molecular subtype, quadruple negative breast cancer

Role of creatine shuttle in colorectal cancer cells Research Paper

Mayu Kita, Rina Fujiwara-Tani, Shingo Kishi, Shiori Mori, Hitoshi Ohmori, Chie Nakashima, Kei Goto, Takamitsu Sasaki, Kiyomu Fujii, Isao Kawahara, Ujjal Kumar Bhawal, Yi Luo, Hiroki Kuniyasu

Published May 12, 2023 · Vol. 14, No. 1 · pp. 485-501

Keywords: creatine kinase B, mitochondrial creatine kinase, ATP metabolism, phosphorylation signal, stemness

Targeting cellular respiration as a therapeutic strategy in glioblastoma Research Perspective

Enyuan Shang, Trang Thi Thu Nguyen, Mike-Andrew Westhoff, Georg Karpel-Massler, Markus D. Siegelin

Published May 2, 2023 · Vol. 14, No. 1 · pp. 419-425

Keywords: glioblastoma, metabolism, lactate, carbon tracing, central carbon metabolism

Using cancer proteomics data to identify gene candidates for therapeutic targeting Research Perspective

Diana Monsivais, Sydney E. Parks, Darshan S. Chandrashekar, Sooryanarayana Varambally, Chad J. Creighton

Published Apr 28, 2023 · Vol. 14, No. 1 · pp. 399-412

Keywords: proteomics, proteogenomics, multi-omics, cancer, TTK protein kinase

Calcium signaling induced by 15-deoxy-prostamide-J₂ promotes cell death by activating PERK, IP3R, and the mitochondrial permeability transition pore Research Paper

Daniel A. Ladin, Margaret M. Nelson, Estefani Cota, Catherine Colonna, Colin Burns, Jacques Robidoux, Kelsey H. Fisher-Wellman, Rukiyah Van Dross-Anderson

Published Dec 14, 2022 · Vol. 13, No. 1 · pp. 1380-1396

Keywords: calcium, mitochondrial respiration, endoplasmic reticulum stress, cancer, prostamide

MK256 is a novel CDK8 inhibitor with potent antitumor activity in AML through downregulation of the STAT pathway Research Paper

Jen-Chieh Lee, Shu Liu, Yucheng Wang, You Liang, David M. Jablons

Published Oct 26, 2022 · Vol. 13, No. 1 · pp. 1217-1236

Keywords: AML, CDK8, kinase inhibitor, STAT pathway, xenograft

In vitro chemotherapy-associated muscle toxicity is attenuated with nutritional support, while treatment efficacy is retained Research Paper

Liza A. Wijler, Francina J. Dijk, Hanil Quirindongo, Danielle A.E. Raats, Bram Dorresteijn, Matthew J.W. Furber, Anne M. May, Onno Kranenburg, Miriam van Dijk

Published Sep 27, 2022 · Vol. 13, No. 1 · pp. 1094-1108

Keywords: C2C12 myotubes, chemotherapy, chemotherapy-associated toxicity, colorectal cancer, nutrients, tumor (organoid) cells

Targeting lipid metabolism in the treatment of ovarian cancer Review

Saliha Chaudhry, Stefani N. Thomas, Glenn E. Simmons Jr.

Published May 18, 2022 · Vol. 13, No. 1 · pp. 768-783

Keywords: ovarian cancer, lipid metabolism, biomarkers, microenvironment, fatty acid

Optimization of tumor spheroid model in mesothelioma and lung cancers and anti-cancer drug testing in H2052/484 spheroids Research Paper

Dylan A.J. Gendre, Edis Ameti, Wolfram Karenovics, Nadja Perriraz-Mayer, Frédéric Triponez, Véronique Serre-Beinier

Published Nov 15, 2021 · Vol. 12, No. 24 · pp. 2375-2387

Keywords: cancer patient, lung tumor, pleura mesothelioma, tumor spheroid, chemosensitivity

Dishevelled-1 DIX and PDZ domain lysine residues regulate oncogenic Wnt signaling Research Paper

Monica Sharma, Isabel Castro-Piedras, Fahmida Rasha, Sabarish Ramachandran, Souad R. Sennoune, Kathryn Furr, Sharilyn Almodovar, Vadivel Ganapathy, Matthew B. Grisham, Rakhshanda Layeequr Rahman, Kevin Pruitt

Published Sep 28, 2021 · Vol. 12, No. 22 · pp. 2234-2251

Keywords: dishevelled (DVL), post-translational modification, lysine residue, gene expression, chromatin immunoprecipitation (ChIP)

P10s-PADRE vaccine combined with neoadjuvant chemotherapy in ER-positive breast cancer patients induces humoral and cellular immune responses Research Paper

Issam Makhoul, Saddam Mohammed Ibrahim, Muhammad Abu-Rmaileh, Fariba Jousheghany, Eric R. Siegel, Lora J. Rogers, John J. Lee, Sergio Pina-Oviedo, Ginell R. Post, J. Thaddeus Beck, Thomas Kieber-Emmons, Behjatolah Monzavi-Karbassi

Published Sep 16, 2021 · Vol. 12, No. 22 · pp. 2252-2265

Keywords: cancer vaccine, peptide mimotopes, combination therapy, breast cancer

Inhibition of the MAP2K7-JNK pathway with 5Z-7-oxozeaenol induces apoptosis in T-cell acute lymphoblastic leukemia Research Paper

Taylor J. Chen, Wa Du, Jacob J. Junco, Cory Seth Bridges, Ye Shen, Monica Puppi, Karen R. Rabin, H. Daniel Lacorazza

Published Jul 31, 2021 · Vol. 12, No. 18 · pp. 1787-1801

Keywords: T-ALL, MAP2K7, 5z-7-oxozeaenol

High CD39 expression is associated with the non-muscle-invasive phenotype of human bladder cancer Research Paper

Janaina Mendes Ferreira, Luiz Henrique Gomes Matheus, Renato Vasconcelos Souza de Almeida, Petronio Augusto de Souza Melo, Kátia Ramos Moreira Leite, Claudio Bovolenta Murta, Joaquim Francisco de Almeida Claro, Cleber Pinto Camacho, José Pontes-Júnior, Humberto Dellê

Published Jul 16, 2021 · Vol. 12, No. 16 · pp. 1580-1586

Keywords: bladder cancer, purinergic signaling, ectonucleotidases, CD39

Frame-shift mediated reduction of gain-of-function p53 R273H and deletion of the R273H C-terminus in breast cancer cells result in replication-stress sensitivity Priority Research Paper

Viola Ellison, George K. Annor, Clara Freedman, Gu Xiao, Devon Lundine, Elzbieta Freulich, Carol Prives, Jill Bargonetti

Published May 20, 2021 · Vol. 12, No. 12 · pp. 1128-1146

Keywords: mutant p53, gain-of-function, oligomerization, DNA replication, frame-shift

Down regulation of lactate dehydrogenase initiates apoptosis in HeLa and MCF-7 cancer cells through increased voltage-dependent anion channel protein and inhibition of BCL2 Research Paper

Suhail Al-Salam, Karthishwaran Kandhan, Manjusha Sudhadevi

Published Apr 20, 2021 · Vol. 12, No. 9 · pp. 923-935

Keywords: cancer metabolism, LDHA, apoptosis, VDAC

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Challenges and resistance mechanisms to EGFR targeted therapies in head and neck cancers and breast cancer: Insights into RTK dependent and independent mechanisms Review

Next-generation cell-penetrating antibodies for tumor targeting and RAD51 inhibition Research Paper

A nanobody against the V-ATPase c subunit inhibits metastasis of 4T1-12B breast tumor cells to lung in mice Research Paper

INT-1B3, an LNP formulated miR-193a-3p mimic, promotes anti-tumor immunity by enhancing T cell mediated immune responses via modulation of the tumor microenvironment and induction of immunogenic cell death Research Paper

Osteopontin induces mitochondrial biogenesis in deadherent cancer cells Research Paper

ACSL4: biomarker, mediator and target in quadruple negative breast cancer Review

Role of creatine shuttle in colorectal cancer cells Research Paper

Targeting cellular respiration as a therapeutic strategy in glioblastoma Research Perspective

Using cancer proteomics data to identify gene candidates for therapeutic targeting Research Perspective

Calcium signaling induced by 15-deoxy-prostamide-J₂ promotes cell death by activating PERK, IP3R, and the mitochondrial permeability transition pore Research Paper

MK256 is a novel CDK8 inhibitor with potent antitumor activity in AML through downregulation of the STAT pathway Research Paper

In vitro chemotherapy-associated muscle toxicity is attenuated with nutritional support, while treatment efficacy is retained Research Paper

Targeting lipid metabolism in the treatment of ovarian cancer Review

Optimization of tumor spheroid model in mesothelioma and lung cancers and anti-cancer drug testing in H2052/484 spheroids Research Paper

Dishevelled-1 DIX and PDZ domain lysine residues regulate oncogenic Wnt signaling Research Paper

P10s-PADRE vaccine combined with neoadjuvant chemotherapy in ER-positive breast cancer patients induces humoral and cellular immune responses Research Paper

Inhibition of the MAP2K7-JNK pathway with 5Z-7-oxozeaenol induces apoptosis in T-cell acute lymphoblastic leukemia Research Paper

High CD39 expression is associated with the non-muscle-invasive phenotype of human bladder cancer Research Paper

Frame-shift mediated reduction of gain-of-function p53 R273H and deletion of the R273H C-terminus in breast cancer cells result in replication-stress sensitivity Priority Research Paper

Down regulation of lactate dehydrogenase initiates apoptosis in HeLa and MCF-7 cancer cells through increased voltage-dependent anion channel protein and inhibition of BCL2 Research Paper

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European Cancer and Oncology Congress

Oncoscience

Post-Publication Promotion

Search Oncotarget

Challenges and resistance mechanisms to EGFR targeted therapies in head and neck cancers and breast cancer: Insights into RTK dependent and independent mechanisms Review

Next-generation cell-penetrating antibodies for tumor targeting and RAD51 inhibition Research Paper

A nanobody against the V-ATPase c subunit inhibits metastasis of 4T1-12B breast tumor cells to lung in mice Research Paper

INT-1B3, an LNP formulated miR-193a-3p mimic, promotes anti-tumor immunity by enhancing T cell mediated immune responses via modulation of the tumor microenvironment and induction of immunogenic cell death Research Paper

Osteopontin induces mitochondrial biogenesis in deadherent cancer cells Research Paper

ACSL4: biomarker, mediator and target in quadruple negative breast cancer Review

Role of creatine shuttle in colorectal cancer cells Research Paper

Targeting cellular respiration as a therapeutic strategy in glioblastoma Research Perspective

Using cancer proteomics data to identify gene candidates for therapeutic targeting Research Perspective

Calcium signaling induced by 15-deoxy-prostamide-J2 promotes cell death by activating PERK, IP3R, and the mitochondrial permeability transition pore Research Paper

MK256 is a novel CDK8 inhibitor with potent antitumor activity in AML through downregulation of the STAT pathway Research Paper

In vitro chemotherapy-associated muscle toxicity is attenuated with nutritional support, while treatment efficacy is retained Research Paper

Targeting lipid metabolism in the treatment of ovarian cancer Review

Optimization of tumor spheroid model in mesothelioma and lung cancers and anti-cancer drug testing in H2052/484 spheroids Research Paper

Dishevelled-1 DIX and PDZ domain lysine residues regulate oncogenic Wnt signaling Research Paper

P10s-PADRE vaccine combined with neoadjuvant chemotherapy in ER-positive breast cancer patients induces humoral and cellular immune responses Research Paper

Inhibition of the MAP2K7-JNK pathway with 5Z-7-oxozeaenol induces apoptosis in T-cell acute lymphoblastic leukemia Research Paper

High CD39 expression is associated with the non-muscle-invasive phenotype of human bladder cancer Research Paper

Frame-shift mediated reduction of gain-of-function p53 R273H and deletion of the R273H C-terminus in breast cancer cells result in replication-stress sensitivity Priority Research Paper

Down regulation of lactate dehydrogenase initiates apoptosis in HeLa and MCF-7 cancer cells through increased voltage-dependent anion channel protein and inhibition of BCL2 Research Paper

Calcium signaling induced by 15-deoxy-prostamide-J₂ promotes cell death by activating PERK, IP3R, and the mitochondrial permeability transition pore Research Paper