The Oncosearch | Oncotarget

PTPRS drives adaptive resistance to MEK/ERK inhibitors through SRC Priority Research Paper

Thomas B. Davis, Mingli Yang, Heiman Wang, Changgong Lee, Timothy J. Yeatman, W. Jack Pledger

Published Nov 26, 2019 · Vol. 10, No. 63 · pp. 6768-6780

Keywords: colorectal cancer, PTPRS, ERK, SRC, adaptive resistance

The impact of systemic precision medicine and immunotherapy treatments on brain metastases Review

Rowland H. Han, Gavin P. Dunn, Milan G. Chheda, Albert H. Kim

Published Nov 19, 2019 · Vol. 10, No. 62 · pp. 6739-6753

Keywords: brain metastases, targeted therapy, precision medicine, immunotherapy, systemic therapy

Targeted enhancement of the therapeutic window of L19-TNF by transient and selective inhibition of RIPK1-signaling cascade Research Paper

Sheila Dakhel, Tiziano Ongaro, Baptiste Gouyou, Mattia Matasci, Alessandra Villa, Dario Neri, Samuele Cazzamalli

Published Nov 19, 2019 · Vol. 10, No. 62 · pp. 6678-6690

Keywords: tumor targeting, antibody-cytokine fusions, targeted-tumor necrosis factor, EDB-fibronectin, intracellular RIPK1-inhibitors

Correction: Co-targeting the MAPK and PI3K/AKT/mTOR pathways in two genetically engineered mouse models of schwann cell tumors reduces tumor grade and multiplicity Correction

Adrienne L. Watson, Bryant J. Keller, Kyle A. Williams, Namrata N. Damle, Samuel J. Finnerty, Leah K. Anderson, Andrew D. Greeley, Vincent W. Keng, Eric P. Rahrmann, Amanda L. Halfond, Natasha M. Powell, Margaret H. Collins, Tilat Rizvi, Christopher L. Moertel, Nancy Ratner, David A. Largaespada

Published Nov 15, 2019 · Vol. 11, No. 39 · pp. 3618-3620

Tumor mutational burden in lung cancer: a systematic literature review Review

Connor Willis, Michelle Fiander, Dao Tran, Beata Korytowsky, John-Michael Thomas, Florencio Calderon, Teresa M. Zyczynski, Diana Brixner, David D. Stenehjem

Published Nov 12, 2019 · Vol. 10, No. 61 · pp. 6604-6622

Keywords: biomarkers, chemotherapy, immunotherapy, lung cancer, PD-L1

Improved surgical resection of metastatic pancreatic cancer using uPAR targeted in vivo fluorescent guidance: comparison with traditional white light surgery Research Paper

Karina Juhl, Anders Christensen, Niclas Rubek, Kirstine Kim Schmidt Karnov, Christian von Buchwald, Andreas Kjaer

Published Oct 29, 2019 · Vol. 10, No. 59 · pp. 6308-6316

Keywords: optical imaging, near-infrared imaging (NIR), NIR-I, urokinase plasminogen activator receptor (uPAR), cancer

Targeted photodynamic therapy treatment of in vitro A375 metastatic melanoma cells Research Paper

Channay Naidoo, Cherie Ann Kruger, Heidi Abrahamse

Published Oct 22, 2019 · Vol. 10, No. 58 · pp. 6079-6095

Keywords: metastatic melanoma, nano active targeting, zinc phthalocyanine tetra-sulphonic acid, photodynamic therapy

Preclinical analysis of human mesenchymal stem cells: tumor tropism and therapeutic efficiency of local HSV-TK suicide gene therapy in glioblastoma Research Paper

Lasse Dührsen, Sophie Hartfuß, Daniela Hirsch, Sabine Geiger, Cecile L. Maire, Jan Sedlacik, Christine Guenther, Manfred Westphal, Katrin Lamszus, Felix G. Hermann, Nils Ole Schmidt

Published Oct 22, 2019 · Vol. 10, No. 58 · pp. 6049-6061

Keywords: glioblastoma, brain tumor, stem cells, gene therapy, migration

Preferential targeting of MCL-1 by a hydrocarbon-stapled BIM BH3 peptide Research Paper

Abbas Hadji, Greta K. Schmitt, Mathew R. Schnorenberg, Lauren Roach, Connie M. Hickey, Logan B. Leak, Matthew V. Tirrell, James L. LaBelle

Published Oct 22, 2019 · Vol. 10, No. 58 · pp. 6219-6233

Keywords: MCL-1, BIM, BH3 mimetic, stapled peptides, apoptosis

The proteasome deubiquitinase inhibitor bAP15 downregulates TGF-β/Smad signaling and induces apoptosis via UCHL5 inhibition in ovarian cancer Research Paper

Shiho Fukui, Kazunori Nagasaka, Yuko Miyagawa, Ryoko Kikuchi-Koike, Yoshiko Kawata, Ranka Kanda, Takayuki Ichinose, Takeru Sugihara, Haruko Hiraike, Osamu Wada-Hiraike, Yuko Sasajima, Takuya Ayabe

Published Oct 15, 2019 · Vol. 10, No. 57 · pp. 5932-5948

Keywords: ovarian cancer, bAP15, TGF-β/Smad signaling, UCHL5, apoptosis

Germline mutations in cancer-predisposition genes in patients with biliary tract cancer Research Paper

Takeshi Terashima, Kumiko Umemoto, Hideaki Takahashi, Hiroko Hosoi, Erina Takai, Shunsuke Kondo, Yasunari Sakamoto, Shuichi Mitsunaga, Izumi Ohno, Yusuke Hashimoto, Mitsuhito Sasaki, Masafumi Ikeda, Kazuaki Shimada, Shuichi Kaneko, Shinichi Yachida, Kokichi Sugano, Takuji Okusaka, Chigusa Morizane

Published Oct 15, 2019 · Vol. 10, No. 57 · pp. 5949-5957

Keywords: germline mutations, biliary tract cancer, hereditary breast cancer syndrome, hereditary ovarian cancer syndrome, cancer-predisposition genes

PTEN deletion drives acute myeloid leukemia resistance to MEK inhibitors Research Paper

Amanda M. Smith, Christine R.C. Zhang, Alexandre S. Cristino, John P. Grady, J. Lynn Fink, Andrew S. Moore

Published Oct 8, 2019 · Vol. 10, No. 56 · pp. 5755-5767

Keywords: myeloid leukemia, therapy, drug resistance, hematological malignancies, gene mutation

Engineered human platelet-derived microparticles as natural vectors for targeted drug delivery Research Paper

Jyotsna Kailashiya, Vineeta Gupta, Debabrata Dash

Published Oct 8, 2019 · Vol. 10, No. 56 · pp. 5835-5846

Keywords: cancer targeting, drug-delivery vector, doxorubicin, leukemia, platelet-derived microparticles

Fewer actionable mutations but higher tumor mutational burden characterizes NSCLC in black patients at an urban academic medical center Research Paper

Noura J. Choudhury, Mansooreh Eghtesad, Sabah Kadri, John Cursio, Lauren Ritterhouse, Jeremy Segal, Aliya Husain, Jyoti D. Patel

Published Oct 8, 2019 · Vol. 10, No. 56 · pp. 5817-5823

Keywords: non-small cell lung cancer, healthcare disparities, targeted therapies, immunotherapies, biomarkers

A side-by-side evaluation of [¹⁸F]FDOPA enantiomers for non-invasive detection of neuroendocrine tumors by positron emission tomography Research Paper

Athira Narayan, Yu Yan, Ala Lisok, Mary Brummet, Martin G. Pomper, Wojciech G. Lesniak, Robert F. Dannals, Vanessa F. Merino, Babak Behnam Azad

Published Oct 8, 2019 · Vol. 10, No. 56 · pp. 5731-5744

Keywords: FDOPA, PET, neuroendocrine tumors, Fluorine-18, molecular imaging

Mutation of the co-chaperone Tsc1 in bladder cancer diminishes Hsp90 acetylation and reduces drug sensitivity and selectivity Research Paper

Mark R. Woodford, Michael Hughes, Rebecca A. Sager, Sarah J. Backe, Alexander J. Baker-Williams, Michael S. Bratslavsky, Joseph M. Jacob, Oleg Shapiro, Michael Wong, Gennady Bratslavsky, Dimitra Bourboulia, Mehdi Mollapour

Published Oct 8, 2019 · Vol. 10, No. 56 · pp. 5824-5834

Keywords: tuberous sclerosis complex (TSC), Tsc1 (Hamartin), Tsc2 (Tuberin), heat shock protein (Hsp90), bladder cancer

Comparison of different semi-automated cfDNA extraction methods in combination with UMI-based targeted sequencing Research Paper

Anna Streubel, Albrecht Stenzinger, Susann Stephan-Falkenau, Jens Kollmeier, Daniel Misch, Torsten Gerriet Blum, Torsten Bauer, Olfert Landt, Alexander Am Ende, Peter Schirmacher, Thomas Mairinger, Volker Endris

Published Oct 1, 2019 · Vol. 10, No. 55 · pp. 5690-5702

Keywords: lung cancer, liquid biopsy, cfDNA, molecular diagnostics, T790M

New insights into the genomic landscape of meningiomas identified FGFR3 in a subset of patients with favorable prognoses Research Paper

Aysha AlSahlawi, Rasha Aljelaify, Amna Magrashi, Mariam AlSaeed, Amal Almutairi, Fatimah Alqubaishi, Abdulellah Alturkistani, Abdullah AlObaid, Mohamed Abouelhoda, Latifa AlMubarak, Nada AlTassan, Malak Abedalthagafi

Published Sep 17, 2019 · Vol. 10, No. 53 · pp. 5549-5559

Keywords: meningioma, FGFR3, NGS, genomics, CNS

Tumor penetrating nanomedicine targeting both an oncomiR and an oncogene in pancreatic cancer Research Paper

Maud-Emmanuelle Gilles, Liangliang Hao, Kaelyn Brown, Jihoon Lim, Sangeeta N. Bhatia, Frank J. Slack

Published Sep 3, 2019 · Vol. 10, No. 51 · pp. 5349-5358

Keywords: miRNAs, KRAS, RNA-based-therapy, PDAC, tumor-penetrating nanocomplexes

Targeted drug combination therapy design based on driver genes Research Paper

Lilian Zsákai, Anna Sipos, Judit Dobos, Dániel Erős, Csaba Szántai-Kis, Péter Bánhegyi, János Pató, László Őrfi, Zsolt Matula, Gábor Mikala, György Kéri, István Peták, István Vályi-Nagy

Published Sep 3, 2019 · Vol. 10, No. 51 · pp. 5255-5266

Keywords: combination therapy, cancer driver gene, primary culture, small molecule compound, multiple myeloma

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PTPRS drives adaptive resistance to MEK/ERK inhibitors through SRC Priority Research Paper

The impact of systemic precision medicine and immunotherapy treatments on brain metastases Review

Targeted enhancement of the therapeutic window of L19-TNF by transient and selective inhibition of RIPK1-signaling cascade Research Paper

Correction: Co-targeting the MAPK and PI3K/AKT/mTOR pathways in two genetically engineered mouse models of schwann cell tumors reduces tumor grade and multiplicity Correction

Tumor mutational burden in lung cancer: a systematic literature review Review

Improved surgical resection of metastatic pancreatic cancer using uPAR targeted in vivo fluorescent guidance: comparison with traditional white light surgery Research Paper

Targeted photodynamic therapy treatment of in vitro A375 metastatic melanoma cells Research Paper

Preclinical analysis of human mesenchymal stem cells: tumor tropism and therapeutic efficiency of local HSV-TK suicide gene therapy in glioblastoma Research Paper

Preferential targeting of MCL-1 by a hydrocarbon-stapled BIM BH3 peptide Research Paper

The proteasome deubiquitinase inhibitor bAP15 downregulates TGF-β/Smad signaling and induces apoptosis via UCHL5 inhibition in ovarian cancer Research Paper

Germline mutations in cancer-predisposition genes in patients with biliary tract cancer Research Paper

PTEN deletion drives acute myeloid leukemia resistance to MEK inhibitors Research Paper

Engineered human platelet-derived microparticles as natural vectors for targeted drug delivery Research Paper

Fewer actionable mutations but higher tumor mutational burden characterizes NSCLC in black patients at an urban academic medical center Research Paper

A side-by-side evaluation of [¹⁸F]FDOPA enantiomers for non-invasive detection of neuroendocrine tumors by positron emission tomography Research Paper

Mutation of the co-chaperone Tsc1 in bladder cancer diminishes Hsp90 acetylation and reduces drug sensitivity and selectivity Research Paper

Comparison of different semi-automated cfDNA extraction methods in combination with UMI-based targeted sequencing Research Paper

New insights into the genomic landscape of meningiomas identified FGFR3 in a subset of patients with favorable prognoses Research Paper

Tumor penetrating nanomedicine targeting both an oncomiR and an oncogene in pancreatic cancer Research Paper

Targeted drug combination therapy design based on driver genes Research Paper

Publication Alerts

European Cancer and Oncology Congress

Oncoscience

Post-Publication Promotion

Search Oncotarget

PTPRS drives adaptive resistance to MEK/ERK inhibitors through SRC Priority Research Paper

The impact of systemic precision medicine and immunotherapy treatments on brain metastases Review

Targeted enhancement of the therapeutic window of L19-TNF by transient and selective inhibition of RIPK1-signaling cascade Research Paper

Correction: Co-targeting the MAPK and PI3K/AKT/mTOR pathways in two genetically engineered mouse models of schwann cell tumors reduces tumor grade and multiplicity Correction

Tumor mutational burden in lung cancer: a systematic literature review Review

Improved surgical resection of metastatic pancreatic cancer using uPAR targeted in vivo fluorescent guidance: comparison with traditional white light surgery Research Paper

Targeted photodynamic therapy treatment of in vitro A375 metastatic melanoma cells Research Paper

Preclinical analysis of human mesenchymal stem cells: tumor tropism and therapeutic efficiency of local HSV-TK suicide gene therapy in glioblastoma Research Paper

Preferential targeting of MCL-1 by a hydrocarbon-stapled BIM BH3 peptide Research Paper

The proteasome deubiquitinase inhibitor bAP15 downregulates TGF-β/Smad signaling and induces apoptosis via UCHL5 inhibition in ovarian cancer Research Paper

Germline mutations in cancer-predisposition genes in patients with biliary tract cancer Research Paper

PTEN deletion drives acute myeloid leukemia resistance to MEK inhibitors Research Paper

Engineered human platelet-derived microparticles as natural vectors for targeted drug delivery Research Paper

Fewer actionable mutations but higher tumor mutational burden characterizes NSCLC in black patients at an urban academic medical center Research Paper

A side-by-side evaluation of [18F]FDOPA enantiomers for non-invasive detection of neuroendocrine tumors by positron emission tomography Research Paper

Mutation of the co-chaperone Tsc1 in bladder cancer diminishes Hsp90 acetylation and reduces drug sensitivity and selectivity Research Paper

Comparison of different semi-automated cfDNA extraction methods in combination with UMI-based targeted sequencing Research Paper

New insights into the genomic landscape of meningiomas identified FGFR3 in a subset of patients with favorable prognoses Research Paper

Tumor penetrating nanomedicine targeting both an oncomiR and an oncogene in pancreatic cancer Research Paper

Targeted drug combination therapy design based on driver genes Research Paper

A side-by-side evaluation of [¹⁸F]FDOPA enantiomers for non-invasive detection of neuroendocrine tumors by positron emission tomography Research Paper