The Oncosearch | Oncotarget

Coordinated Targeting of the EGFR Signaling Axis by MicroRNA-27a* Research Paper

Xiaoli Wu, Mihir K. Bhayani, Cristina T. Dodge, Milena S. Nicoloso, Yunyun Chen, Xiaofeng Yan, Makoto Adachi, Ligy Thomas, Chad E. Galer, Tilahun Jiffar, Curtis R. Pickering, Michael E. Kupferman, Jeffrey N. Myers, George A. Calin, Stephen Y. Lai

Published Aug 6, 2013 · Vol. 4, No. 9 · pp. 1388-1398

Keywords: miRNA EGFR AKT1 mTOR miRNA-27a* miRNA-27a-5p

A differential role for CXCR4 in the regulation of normal versus malignant breast stem cell activity Research Paper

Matthew P Ablett, Ciara S O'Brien, Andrew H Sims, Gillian Farnie, Robert B Clarke

Published Jul 30, 2013 · Vol. 5, No. 3 · pp. 599-612

Keywords: CXCR4, stem cells, breast cancer, mammospheres, AMD3100, SDF-1

Accumulation of autophagosomes in breast cancer cells induces TRAIL resistance through downregulation of surface expression of death receptors 4 and 5 Research Paper

Xu Di, Guofeng Zhang, Yaqin Zhang, Kazuyo Takeda, Leslie A. Rivera Rosado, Baolin Zhang

Published Jul 27, 2013 · Vol. 4, No. 9 · pp. 1349-1364

Keywords: TRAIL resistance, basal autophagosomes, death receptors, cell surface expression

Combination therapy with anti-ErbB3 monoclonal antibodies and EGFR TKIs potently inhibits Non-small Cell Lung Cancer Research Paper

Alessia Noto, Claudia De Vitis, Giuseppe Roscilli, Luigi Fattore, Debora Malpicci, Emanuele Marra, Laura Luberto, Antonio D'Andrilli, Pierpaolo Coluccia, Maria Rosaria Giovagnoli, Nicola Normanno, Luigi Ruco, Luigi Aurisicchio, Rita Mancini, Gennaro Ciliberto

Published Jul 21, 2013 · Vol. 4, No. 8 · pp. 1253-1265

Keywords: Lung cancer, primary cultures, TKIs, ErbB3, monoclonal antibodies

A novel Mcl1 variant inhibits apoptosis via increased Bim sequestration Research Paper

Judith Hagenbuchner, Ursula Kiechl-Kohlendorfer, Petra Obexer, Michael J. Ausserlechner

Published Jul 15, 2013 · Vol. 4, No. 8 · pp. 1241-1252

Keywords: BCL2 proteins, TRAIL, Fas-induced apoptosis, Noxa

AKT in Stromal Fibroblasts Controls Invasion of Epithelial Cells Research Paper

Ann-Christin Cichon, Adam Pickard, Simon S McDade, Daniel J Sharpe, Michael Moran, Jacqueline A James, Dennis J McCance

Published Jul 14, 2013 · Vol. 4, No. 7 · pp. 1103-1116

Keywords: stroma, invasion, AKT, Caspase 1, HPV, mdm2, interleukin 1, KGF, cancer

Small Molecule-Induced Mitochondrial Disruption Directs Prostate Cancer Inhibition via Unfolded Protein Response Signaling Research Paper

Elizabeth Rico-Bautista, Wenhong Zhu, Shinichi Kitada, Suthakar Ganapathy, Eric Lau, Stan Krajewski, Joel Ramirez, Jason A. Bush, Zhimin Yuan, Dieter A. Wolf

Published Jul 14, 2013 · Vol. 4, No. 8 · pp. 1212-1229

Keywords: Prostate cancer, cell cycle arrest, apoptosis, oxidative stress, small molecule inhibitor, mitochondrial function

Targeting mixed lineage kinases in ER-positive breast cancer cells leads to G2/M cell cycle arrest and apoptosis. Research Paper

Limin Wang, Kathleen A Gallo, Susan E Conrad

Published Jul 7, 2013 · Vol. 4, No. 8 · pp. 1158-1171

Keywords: breast cancer, kinase inhibitors, cell cycle, apoptosis

The tumor suppressor TERE1 (UBIAD1) prenyltransferase regulates the elevated cholesterol phenotype in castration resistant prostate cancer by controlling a program of ligand dependent SXR target genes. Research Paper

William J. Fredericks, Jorge Sepulveda, Priti Lal, John E. Tomaszewski, Ming-Fong Lin, Terry McGarvey, Frank J. Rauscher III, S. Bruce Malkowicz

Published Jul 7, 2013 · Vol. 4, No. 7 · pp. 1075-1092

Keywords: TERE1, UBIAD1, prostate cancer, castrate resistant prostate cancer, CRPC, LnCaP, cholesterol, SXR, androgen catabolism, Vitamin K-2

Blockade of the PDGFR family together with SRC leads to diminished proliferation of colorectal cancer cells Research Paper

Silke KaulfuÃŸ, Henning Seemann, Rovena Kampe, Julia Meyer, Ralf Dressel, Britta KÃ¶nig, Jens-Gerd Scharf, Peter Burfeind

Published Jun 30, 2013 · Vol. 4, No. 7 · pp. 1037-1049

Keywords: colorectal cancer, PDGF receptor, c-KIT, SRC, cell proliferation, apoptosis, RNA interference, targeted therapy

Anti-c-Met antibodies recognising a temperature sensitive epitope, inhibit cell growth Research Paper

Julin Shuxian Wong, Emma Warbrick, Borek Vojtesek, Jeffrey Hill, David Philip Lane

Published Jun 29, 2013 · Vol. 4, No. 7 · pp. 1019-1036

Keywords: c-Met, seeMet 2, monoclonal antibody, temperature sensitive & cryptic epitope

Antiestrogen-binding site ligands induce autophagy in myeloma cells that proceeds through alteration of cholesterol metabolism Research Paper

Brigitte Sola, Marc Poirot, Philippe de Medina, Sophie Bustany, VÃ©ronique Marsaud, Sandrine Sivente-Poirot, Jack-Michel Renoir

Published Jun 11, 2013 · Vol. 4, No. 6 · pp. 911-922

Keywords: multiple myeloma, tamoxifen, autophagy, apoptosis, cholesterol metabolism

Germline PTPRD Mutations in Ewing Sarcoma: Biologic and Clinical Implications Research Paper

Yunyun Jiang, Filip Janku, Vivek Subbiah, Laura S. Angelo, Aung Naing, Peter M. Anderson, Cynthia E. Herzog, Siqing Fu, Robert S. Benjamin, Razelle Kurzrock

Published Jun 5, 2013 · Vol. 4, No. 6 · pp. 884-889

Keywords: Ewing sarcoma, PTPRD, mutation, germline

pRb controls Estrogen Receptor alpha protein stability and activity Research Paper

Isabella Caligiuri, Giuseppe Toffoli, Antonio Giordano, Flavio Rizzolio

Published Jun 3, 2013 · Vol. 4, No. 6 · pp. 875-883

Keywords: pRb, Estrogen receptor alpha, proteasome, chaperone proteins, breast cancer

Powerful Inhibition of Experimental Human Pancreatic Cancers by Receptor Targeted Cytotoxic LH-RH analog AEZS-108 Research Paper

Karoly Szepeshazi, Andrew V. Schally, Norman L. Block, Gabor Halmos, Mehrdad Nadji, Luca Szalontay, Irving Vidaurre, Andrew Abi-Chaker, Ferenc G. Rick

Published Jun 3, 2013 · Vol. 4, No. 5 · pp. 751-760

Keywords: pancreatic carcinoma, targeted therapy, LH-RH receptor, cytotoxic LHRH analog, GnRH, doxorubicin, peptide therapy

Constitutively-active androgen receptor variants function independently of the HSP90 chaperone but do not confer resistance to HSP90 inhibitors Research Paper

Joanna L Gillis, Luke A Selth, Margaret M Centenera, Scott L Townley, Shihua Sun, Stephen R Plymate, Wayne D Tilley, Lisa M Butler

Published Apr 25, 2013 · Vol. 4, No. 5 · pp. 691-704

Keywords: androgen receptor, variant, HSP90, HSP90 inhibitor, prostate cancer

Cell death sensitization of leukemia cells by opioid receptor activation Research Paper

Claudia Friesen, Mareike Roscher, Inis Hormann, Iduna Fichtner, Andreas Alt, Ralf Hilger, Klaus-Michael Debatin, Erich Miltner

Published Apr 16, 2013 · Vol. 4, No. 5 · pp. 677-690

Keywords: opioids, methadone, doxorubicin, cAMP, apoptosis, acute lymphoblastic leukemia

Combinatorial drug screening identifies compensatory pathway interactions and adaptive resistance mechanisms Research Paper

Mark J Axelrod, Vicki Gordon, Mark Conaway, Adel Tarcsafalvi, Daniel J Neitzke, Daniel Gioeli, Michael J Weber

Published Apr 10, 2013 · Vol. 4, No. 4 · pp. 622-635

Keywords: Targeted therapies, Compensatory signaling, Pathway interactions, Crosstalk, Feedback inhibition

Epidermal Growth Factor Receptor Tyrosine Kinase Inhibition Up-regulates Interleukin-6 in Cancer Cells and Induces Subsequent Development of Interstitial Pneumonia Research Paper

Yukari Ishiguro, Hitoshi Ishiguro, Hiroshi Miyamoto

Published Mar 31, 2013 · Vol. 4, No. 4 · pp. 550-559

Keywords: fibrosis, EGFR-TKI, IL-6, cytokine, side-effect

A kinase-independent biological activity for insulin growth factor-1 receptor (IGF-1R) : implications for inhibition of the IGF-1R signal Research Paper

Filip Janku, Helen J. Huang, Laura S. Angelo, Razelle Kurzrock

Published Mar 23, 2013 · Vol. 4, No. 3 · pp. 463-473

Keywords: IGF-1R, OSI-906, intracellular glucose, autophagy, MCF7, HEK293

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Coordinated Targeting of the EGFR Signaling Axis by MicroRNA-27a* Research Paper

A differential role for CXCR4 in the regulation of normal versus malignant breast stem cell activity Research Paper

Accumulation of autophagosomes in breast cancer cells induces TRAIL resistance through downregulation of surface expression of death receptors 4 and 5 Research Paper

Combination therapy with anti-ErbB3 monoclonal antibodies and EGFR TKIs potently inhibits Non-small Cell Lung Cancer Research Paper

A novel Mcl1 variant inhibits apoptosis via increased Bim sequestration Research Paper

AKT in Stromal Fibroblasts Controls Invasion of Epithelial Cells Research Paper

Small Molecule-Induced Mitochondrial Disruption Directs Prostate Cancer Inhibition via Unfolded Protein Response Signaling Research Paper

Targeting mixed lineage kinases in ER-positive breast cancer cells leads to G2/M cell cycle arrest and apoptosis. Research Paper

The tumor suppressor TERE1 (UBIAD1) prenyltransferase regulates the elevated cholesterol phenotype in castration resistant prostate cancer by controlling a program of ligand dependent SXR target genes. Research Paper

Blockade of the PDGFR family together with SRC leads to diminished proliferation of colorectal cancer cells Research Paper

Anti-c-Met antibodies recognising a temperature sensitive epitope, inhibit cell growth Research Paper

Antiestrogen-binding site ligands induce autophagy in myeloma cells that proceeds through alteration of cholesterol metabolism Research Paper

Germline PTPRD Mutations in Ewing Sarcoma: Biologic and Clinical Implications Research Paper

pRb controls Estrogen Receptor alpha protein stability and activity Research Paper

Powerful Inhibition of Experimental Human Pancreatic Cancers by Receptor Targeted Cytotoxic LH-RH analog AEZS-108 Research Paper

Constitutively-active androgen receptor variants function independently of the HSP90 chaperone but do not confer resistance to HSP90 inhibitors Research Paper

Cell death sensitization of leukemia cells by opioid receptor activation Research Paper

Combinatorial drug screening identifies compensatory pathway interactions and adaptive resistance mechanisms Research Paper

Epidermal Growth Factor Receptor Tyrosine Kinase Inhibition Up-regulates Interleukin-6 in Cancer Cells and Induces Subsequent Development of Interstitial Pneumonia Research Paper

A kinase-independent biological activity for insulin growth factor-1 receptor (IGF-1R) : implications for inhibition of the IGF-1R signal Research Paper

Publication Alerts

European Cancer and Oncology Congress

Oncoscience

Post-Publication Promotion

Search Oncotarget

Coordinated Targeting of the EGFR Signaling Axis by MicroRNA-27a* Research Paper

A differential role for CXCR4 in the regulation of normal versus malignant breast stem cell activity Research Paper

Accumulation of autophagosomes in breast cancer cells induces TRAIL resistance through downregulation of surface expression of death receptors 4 and 5 Research Paper

Combination therapy with anti-ErbB3 monoclonal antibodies and EGFR TKIs potently inhibits Non-small Cell Lung Cancer Research Paper

A novel Mcl1 variant inhibits apoptosis via increased Bim sequestration Research Paper

AKT in Stromal Fibroblasts Controls Invasion of Epithelial Cells Research Paper

Small Molecule-Induced Mitochondrial Disruption Directs Prostate Cancer Inhibition via Unfolded Protein Response Signaling Research Paper

Targeting mixed lineage kinases in ER-positive breast cancer cells leads to G2/M cell cycle arrest and apoptosis. Research Paper

The tumor suppressor TERE1 (UBIAD1) prenyltransferase regulates the elevated cholesterol phenotype in castration resistant prostate cancer by controlling a program of ligand dependent SXR target genes. Research Paper

Blockade of the PDGFR family together with SRC leads to diminished proliferation of colorectal cancer cells Research Paper

Anti-c-Met antibodies recognising a temperature sensitive epitope, inhibit cell growth Research Paper

Antiestrogen-binding site ligands induce autophagy in myeloma cells that proceeds through alteration of cholesterol metabolism Research Paper

Germline PTPRD Mutations in Ewing Sarcoma: Biologic and Clinical Implications Research Paper

pRb controls Estrogen Receptor alpha protein stability and activity Research Paper

Powerful Inhibition of Experimental Human Pancreatic Cancers by Receptor Targeted Cytotoxic LH-RH analog AEZS-108 Research Paper

Constitutively-active androgen receptor variants function independently of the HSP90 chaperone but do not confer resistance to HSP90 inhibitors Research Paper

Cell death sensitization of leukemia cells by opioid receptor activation Research Paper

Combinatorial drug screening identifies compensatory pathway interactions and adaptive resistance mechanisms Research Paper

Epidermal Growth Factor Receptor Tyrosine Kinase Inhibition Up-regulates Interleukin-6 in Cancer Cells and Induces Subsequent Development of Interstitial Pneumonia Research Paper

A kinase-independent biological activity for insulin growth factor-1 receptor (IGF-1R) : implications for inhibition of the IGF-1R signal Research Paper