The Oncosearch | Oncotarget

Posttranslational modification and conformational state of Heat Shock Protein 90 differentially affect binding of chemically diverse small molecule inhibitors Research Paper

Kristin Beebe, Mehdi Mollapour, Bradley Scroggins, Chrisostomos Prodromou, Wanping Xu, Mari Tokita, Tony Taldone, Lester Pullen, Bettina K Zierer, Min-Jung Lee, Jane Trepel, Johannes Buchner, Daniel Bolon, Gabriela Chiosis, Len Neckers

Published Jul 7, 2013 · Vol. 4, No. 7 · pp. 1065-1074

Keywords: Hsp90, posttranslational modification, phosphorylation, drug binding, Hsp90 inhibitor

DNA damage-induced ubiquitylation of proteasome controls its proteolytic activity Research Paper

Tatiana N Moiseeva, Andrew Bottrill, Gerry Melino, Nickolai A Barlev

Published Jun 29, 2013 · Vol. 4, No. 9 · pp. 1338-1348

Keywords: proteasome, DNA damage, proteolytic activities, ubiquitylation

Radiation therapy induces the DNA damage response in peripheral blood Research Paper

Christopher J Bakkenist, R Kenneth Czambel, David A Clump, Joel S Greenberger, Jan H Beumer, John C Schmitz

Published Jun 26, 2013 · Vol. 4, No. 8 · pp. 1143-1148

Keywords: DNA damage response, ATM

Therapy-resistant acute lymphoblastic leukemia (ALL) cells inactivate FOXO3 to escape apoptosis induction by TRAIL and Noxa Research Paper

Michael J Ausserlechner, Christina Salvador, Andrea Deutschmann, Martin Bodner, Giampietro Viola, Roberta Bortolozzi, Guiseppe Basso, Judith Hagenbuchner, Petra Obexer

Published Jun 25, 2013 · Vol. 4, No. 7 · pp. 995-1007

Keywords: FOXO3/FKHRL1, T-ALL, p16/INK4A, BH3-only proteins, TRAIL

Acetylation of the Cell-Fate Factor Dachshund Determines p53 Binding and Signaling Modules in Breast Cancer Research Paper

Ke Chen, Kongming Wu, Michael Gormley, Adam Ertel, Wei Zhang, Jie Zhou, Gabriele DiSante, Zhiping Li, Hallgeir Rui, Andrew A. Quong, Steven B. McMahon, Haiteng Deng, Michael P. Lisanti, Chenguang Wang, Richard G. Pestell

Published Jun 21, 2013 · Vol. 4, No. 6 · pp. 923-935

Keywords: p53, breast cancer, cell fate, stem cells, dach

Mechanism of DNA damage responses induced by exposure to an oligonucleotide homologous to the telomere overhang in melanoma Research Paper

Ryan T Pitman, Luke Wojdyla, Neelu Puri

Published Jun 3, 2013 · Vol. 4, No. 5 · pp. 761-771

Keywords: T-oligo, Tankyrase, TRF1, telomere, p53, melanoma

CK2-NCoR signaling cascade promotes prostate tumorigenesis Research Paper

Jung-Yoon Yoo, Beom Jin Lim, Hyo-Kyoung Choi, Soon Won Hong, Ho Sung Jang, Changsoo Kim, Kyung-Hee Chun, Kyung-Chul Choi, HoGeun Yoon

Published May 11, 2013 · Vol. 4, No. 7 · pp. 972-983

Keywords: CK2, NCoR, Prostate cancer, IP-10, transcriptional regulation

FAM83B-mediated activation of PI3K/AKT and MAPK signaling cooperates to promote epithelial cell transformation and resistance to targeted therapies. Research Paper

Rocky Cipriano, Kristy L.S. Miskimen, Benjamin L. Bryson, Chase R. Foy, Courtney A. Bartel, Mark W Jackson

Published May 11, 2013 · Vol. 4, No. 5 · pp. 729-738

Keywords: FAM83B, transformation, drug resistance, CRAF, PI3K

Dysfunctional oxidative phosphorylation makes malignant melanoma cells addicted to glycolysis driven by the V600EBRAF oncogene Research Paper

Arnaldur Hall, Kathrine Damm Meyle, Marina Krarup Lange, Martin Klima, May Sanderhoff, Christina Dahl, Cecilie Abildgaard, Katrine Thorup, Seyed Moein Moghimi, Per Bo Jensen, Jiri Bartek, Per Guldberg, Claus Christensen

Published Apr 8, 2013 · Vol. 4, No. 4 · pp. 584-599

Keywords: Oncogene addiction, melanoma, V600EBRAF, the Warburg effect, glycolysis, oxidative phosphorylation

Characterizing the convergence of protein kinase CK2 and caspase-3 reveals isoform-specific phosphorylation of caspase-3 by CK2Î±â€²: implications for pathological roles of CK2 in promoting cancer cell survival. Research Paper

Jacob P Turowec, Greg Vilk, Michelle Gabriel, David W Litchfield

Published Mar 31, 2013 · Vol. 4, No. 4 · pp. 560-571

Keywords: protein kinase CK2, caspase 3, isozyme-specific substrate

Growth of poorly differentiated endometrial carcinoma is inhibited by combined action of medroxyprogesterone acetate and the Ras inhibitor Salirasib Research Paper

Raya Faigenbaum, Roni Haklai, Gilad Ben-Baruch, Yoel Kloog

Published Feb 27, 2013 · Vol. 4, No. 2 · pp. 316-328

Keywords: Endometrial cancer, medroxyprogesterone acetate, FTS, Ras, ERÎ±, ERÎ²

Simalikalactone E (SkE), a new weapon in the armamentarium of drugs targeting cancers that exhibit constitutive activation of the ERK pathway Research Paper

Guillaume Robert, ValÃ©rie Jullian, Arnaud Jacquel, ClÃ©mence Ginet, Maeva Dufies, Stephanie Torino, AnaÃ¯s Pottier, Frederic Peyrade, Sophie Tartare-Deckert, GeneviÃ¨ve Bourdy, Eric Deharo, Patrick Auberger

Published Dec 30, 2012 · Vol. 3, No. 12 · pp. 1688-1699

Keywords: Simalikalactone E, B-Raf inhibitor, CML, Melanoma, Hairy Cell Leukemia, ERK pathway

Development of an orally-administrative MELK-targeting inhibitor that suppresses the growth of various types of human cancer Research Paper

Suyoun Chung, Hanae Suzuki, Takashi Miyamoto, Naofumi Takamatsu, Ayako Tatsuguchi, Koji Ueda, Kyoko Kijima, Yusuke Nakamura, Yo Matsuo

Published Dec 21, 2012 · Vol. 3, No. 12 · pp. 1629-1640

Keywords: oncogene, drug discovery, kinase inhibitor, cancer stem cell

Identification and Characterization of a Novel Chemotype MEK Inhibitor Able to Alter the Phosphorylation State of MEK1/2 Research Paper

Takayuki Yoshida, Junya Kakegawa, Takayuki Yamaguchi, Yoshiji Hantani, Nobuyuki Okajima, Toshiyuki Sakai, Yoshihiro Watanabe, Motonao Nakamura

Published Dec 1, 2012 · Vol. 3, No. 12 · pp. 1533-1545

Keywords: MEK inhibitor, JTP-74057/GSK1120212/trametinib, chemical probe-affinity chromatography, target identification, unphosphorylated MEK (u-MEK)

Functional analysis of non-hotspot AKT1 mutants found in human breast cancers identifies novel driver mutations: implications for personalized medicine Research Paper

Kyung H Yi, Jossette Axtmayer, John P Gustin, Anandita Rajpurohit, Josh Lauring

Published Nov 29, 2012 · Vol. 4, No. 1 · pp. 29-34

Keywords: AKT1, mutation, personalized, cancer, therapy

Identification of acetylation-dependent regulatory mechanisms that govern the oncogenic functions of Skp2 Research Perspective

Zhiwei Wang, Hiroyuki Inuzuka, Jiateng Zhong, Pengda Liu, Fakul H Sarkar, Yi Sun, Wenyi Wei

Published Nov 16, 2012 · Vol. 3, No. 11 · pp. 1294-1300

Keywords: acetylation, cancer, deacetylation, SIRT3, oncoprotein, ubiquitination, phosphorylation, F-box protein, Skp2, therapy

DNA damage-induced activation of ATM promotes Î²-TRCP-mediated Mdm2 ubiquitination and destruction Research Paper

Zhiwei Wang, Hiroyuki Inuzuka, Jiateng Zhong, Hidefumi Fukushima, Lixin Wan, Pengda Liu, Wenyi Wei

Published Sep 11, 2012 · Vol. 3, No. 9 · pp. 1026-1035

Keywords: Mdm2, ATM, CKI, phosphorylation, beta-TRCP, ubiquitination, DNA damage

The promise of anti-ErbB3 monoclonals as new cancer therapeutics Review

Luigi Aurisicchio, Emanuele Marra, Giuseppe Roscilli, Rita Mancini, Gennaro Ciliberto

Published Aug 10, 2012 · Vol. 3, No. 8 · pp. 744-758

Keywords: cancer, ErbB3, monoclonal antibodies, mechanism of action, clinical trials

Computer-Based Identification of a Novel LIMK1/2 Inhibitor that Synergizes with Salirasib to Destabilize the Actin Cytoskeleton Research Paper

Efrat Mashiach Farkash, Roni Rak, Galit Elad-Sfadia, Roni Haklai, Shmuel Carmeli, Yoel Kloog, Haim Wolfson

Published Jul 7, 2012 · Vol. 3, No. 6 · pp. 629-639

Keywords: Cofilin, Ras, Rac, Rho, LIMK

Singular v Dual Inhibition of SNF2L and Its Isoform, SNF2LT, Have Similar Effects on DNA Damage but Opposite Effects on the DNA Damage Response, Cancer Cell Growth Arrest and Apoptosis Research Paper

Yin Ye, Yi Xiao, Wenting Wang, Jian-Xin Gao, Kurtis Yearsley, Quintao Yan, Sanford H. Barsky

Published May 9, 2012 · Vol. 3, No. 4 · pp. 475-489

Keywords: SNF2LT, chromatin remodelling ATPase, cell cycle checkpoints

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Posttranslational modification and conformational state of Heat Shock Protein 90 differentially affect binding of chemically diverse small molecule inhibitors Research Paper

DNA damage-induced ubiquitylation of proteasome controls its proteolytic activity Research Paper

Radiation therapy induces the DNA damage response in peripheral blood Research Paper

Therapy-resistant acute lymphoblastic leukemia (ALL) cells inactivate FOXO3 to escape apoptosis induction by TRAIL and Noxa Research Paper

Acetylation of the Cell-Fate Factor Dachshund Determines p53 Binding and Signaling Modules in Breast Cancer Research Paper

Mechanism of DNA damage responses induced by exposure to an oligonucleotide homologous to the telomere overhang in melanoma Research Paper

CK2-NCoR signaling cascade promotes prostate tumorigenesis Research Paper

FAM83B-mediated activation of PI3K/AKT and MAPK signaling cooperates to promote epithelial cell transformation and resistance to targeted therapies. Research Paper

Dysfunctional oxidative phosphorylation makes malignant melanoma cells addicted to glycolysis driven by the V600EBRAF oncogene Research Paper

Characterizing the convergence of protein kinase CK2 and caspase-3 reveals isoform-specific phosphorylation of caspase-3 by CK2Î±â€²: implications for pathological roles of CK2 in promoting cancer cell survival. Research Paper

Growth of poorly differentiated endometrial carcinoma is inhibited by combined action of medroxyprogesterone acetate and the Ras inhibitor Salirasib Research Paper

Simalikalactone E (SkE), a new weapon in the armamentarium of drugs targeting cancers that exhibit constitutive activation of the ERK pathway Research Paper

Development of an orally-administrative MELK-targeting inhibitor that suppresses the growth of various types of human cancer Research Paper

Identification and Characterization of a Novel Chemotype MEK Inhibitor Able to Alter the Phosphorylation State of MEK1/2 Research Paper

Functional analysis of non-hotspot AKT1 mutants found in human breast cancers identifies novel driver mutations: implications for personalized medicine Research Paper

Identification of acetylation-dependent regulatory mechanisms that govern the oncogenic functions of Skp2 Research Perspective

DNA damage-induced activation of ATM promotes Î²-TRCP-mediated Mdm2 ubiquitination and destruction Research Paper

The promise of anti-ErbB3 monoclonals as new cancer therapeutics Review

Computer-Based Identification of a Novel LIMK1/2 Inhibitor that Synergizes with Salirasib to Destabilize the Actin Cytoskeleton Research Paper

Singular v Dual Inhibition of SNF2L and Its Isoform, SNF2LT, Have Similar Effects on DNA Damage but Opposite Effects on the DNA Damage Response, Cancer Cell Growth Arrest and Apoptosis Research Paper

Publication Alerts

European Cancer and Oncology Congress

Oncoscience

Post-Publication Promotion

Search Oncotarget

Posttranslational modification and conformational state of Heat Shock Protein 90 differentially affect binding of chemically diverse small molecule inhibitors Research Paper

DNA damage-induced ubiquitylation of proteasome controls its proteolytic activity Research Paper

Radiation therapy induces the DNA damage response in peripheral blood Research Paper

Therapy-resistant acute lymphoblastic leukemia (ALL) cells inactivate FOXO3 to escape apoptosis induction by TRAIL and Noxa Research Paper

Acetylation of the Cell-Fate Factor Dachshund Determines p53 Binding and Signaling Modules in Breast Cancer Research Paper

Mechanism of DNA damage responses induced by exposure to an oligonucleotide homologous to the telomere overhang in melanoma Research Paper

CK2-NCoR signaling cascade promotes prostate tumorigenesis Research Paper

FAM83B-mediated activation of PI3K/AKT and MAPK signaling cooperates to promote epithelial cell transformation and resistance to targeted therapies. Research Paper

Dysfunctional oxidative phosphorylation makes malignant melanoma cells addicted to glycolysis driven by the V600EBRAF oncogene Research Paper

Characterizing the convergence of protein kinase CK2 and caspase-3 reveals isoform-specific phosphorylation of caspase-3 by CK2Î±â€²: implications for pathological roles of CK2 in promoting cancer cell survival. Research Paper

Growth of poorly differentiated endometrial carcinoma is inhibited by combined action of medroxyprogesterone acetate and the Ras inhibitor Salirasib Research Paper

Simalikalactone E (SkE), a new weapon in the armamentarium of drugs targeting cancers that exhibit constitutive activation of the ERK pathway Research Paper

Development of an orally-administrative MELK-targeting inhibitor that suppresses the growth of various types of human cancer Research Paper

Identification and Characterization of a Novel Chemotype MEK Inhibitor Able to Alter the Phosphorylation State of MEK1/2 Research Paper

Functional analysis of non-hotspot AKT1 mutants found in human breast cancers identifies novel driver mutations: implications for personalized medicine Research Paper

Identification of acetylation-dependent regulatory mechanisms that govern the oncogenic functions of Skp2 Research Perspective

DNA damage-induced activation of ATM promotes Î²-TRCP-mediated Mdm2 ubiquitination and destruction Research Paper

The promise of anti-ErbB3 monoclonals as new cancer therapeutics Review

Computer-Based Identification of a Novel LIMK1/2 Inhibitor that Synergizes with Salirasib to Destabilize the Actin Cytoskeleton Research Paper

Singular v Dual Inhibition of SNF2L and Its Isoform, SNF2LT, Have Similar Effects on DNA Damage but Opposite Effects on the DNA Damage Response, Cancer Cell Growth Arrest and Apoptosis Research Paper