The Oncosearch | Oncotarget

First Mnks degrading agents block phosphorylation of eIF4E, induce apoptosis, inhibit cell growth, migration and invasion in triple negative and Her2-overexpressing breast cancer cell lines Research Paper

Senthilmurugan Ramalingam, Lalji Gediya, Andrew K. Kwegyir-Afful, Vidya P. Ramamurthy, Puranik Purushottamachar, Hannah Mbatia, Vincent C.O. Njar

Published Jan 25, 2014 · Vol. 5, No. 2 · pp. 530-543

Keywords: Breast cancer, RAMBA retinamides, eukaryotic initiation factor 4E, Mnk1/2

Hypoxia inducible factor-1 alpha as a therapeutic target in multiple myeloma Research Paper

Enrica Borsi, Giulia Perrone, Carolina Terragna, Marina Martello, Angela F Dico, Giancarlo Solaini, Alessandra Baracca, Gianluca Sgarbi, Gianandrea Pasquinelli, Sabrina Valente, Elena Zamagni, Paola Tacchetti, Giovanni Martinelli, Michele Cavo

Published Jan 23, 2014 · Vol. 5, No. 7 · pp. 1779-1792

Keywords: HIF-1Î±, Multiple Myeloma, Cell cycle, Mitochondria, Warburg effect

Sulforaphane counteracts aggressiveness of pancreatic cancer driven by dysregulated Cx43-mediated gap junctional intercellular communication Research Paper

Tobias Forster, Vanessa Rausch, Yiyao Zhang, Orkhan Isayev, Katharina Heilmann, Frank Schoensiegel, Li Liu, Michelle Nessling, Karsten Richter, Sabrina Labsch, Clifford C. Nwaeburu, Juergen Mattern, Jury Gladkich, Nathalia Giese, Jens Werner, Peter Schemmer, Wolfgang Gross, Martha M. Gebhard, Clarissa Gerhauser, Michael Schaefer, Ingrid Herr

Published Jan 22, 2014 · Vol. 5, No. 6 · pp. 1621-1634

SCF^Î²-TRCP-mediated degradation of NEDD4 inhibits tumorigenesis through modulating the PTEN/Akt signaling pathway Research Paper

Jia Liu, Lixin Wan, Pengda Liu, Hiroyuki Inuzuka, Jiankang Liu, Zhiwei Wang, Wenyi Wei

Published Jan 20, 2014 · Vol. 5, No. 4 · pp. 1026-1037

Keywords: Î²-TRCP, NEDD4, degradation, PTEN, Akt, cancer, phosphorylation, ubiquitination, therapy

Constitutive IDO expression in human cancer is sustained by an autocrine signaling loop involving IL-6, STAT3 and the AHR Research Paper

Ulrike M. Litzenburger, Christiane A. Opitz, Felix Sahm, Katharina J. Rauschenbach, Saskia Trump, Marcus Winter, Martina Ott, Katharina Ochs, Christian Lutz, Xiangdong Liu, Natasa Anastasov, Irina Lehmann, Thomas HÃ¶fer, Andreas von Deimling, Wolfgang Wick, Michael Platten

Published Jan 20, 2014 · Vol. 5, No. 4 · pp. 1038-1051

Keywords: IDO, immunosuppression, autoactivation loop

Indirect targeting of IGF receptor signaling in vivo by substrate-selective inhibition of PAPP-A proteolytic activity Research Paper

Jakob H. Mikkelsen, Zachary T. Resch, Bhanu Kalra, Gopal Savjani, Ajay Kumar, Cheryl A. Conover, Claus Oxvig

Published Jan 17, 2014 · Vol. 5, No. 4 · pp. 1014-1025

Keywords: insulin-like growth factor receptor, pregnancy-associated plasma protein-A, proteolytic inhibition, therapeutic antibody, xenograft mouse model

AKT mediates actinomycin D-induced p53 expression Research Paper

Chih-Shou Chen, Dong-Ru Ho, Fei-Yun Chen, Chang-Rong Chen, Yu-De Ke, Jyan-Gwo J Su

Published Jan 11, 2014 · Vol. 5, No. 3 · pp. 693-703

Keywords: Actinomycin D, AKT, p53

Rac1b negatively regulates TGF-Î²1-induced cell motility in pancreatic ductal epithelial cells by suppressing Smad signalling Research Paper

Hendrik Ungefroren, Susanne Sebens, Klaudia Giehl, Ole Helm, Stephanie Groth, Fred Faendrich, Christoph Roecken, Bence Sipos, Hendrik Lehnert, Frank Gieseler

Published Dec 23, 2013 · Vol. 5, No. 1 · pp. 277-290

Keywords: Rac1b, Rac1, Smad, TGF-beta1, pancreatic ductal adenocarcinoma, cell migration

SCF^Î²-TRCP targets MTSS1 for ubiquitination-mediated destruction to regulate cancer cell proliferation and migration Research Paper

Jiateng Zhong, Shavali Shaik, Lixin Wan, Adriana E. Tron, Zhiwei Wang, Liankun Sun, Hiroyuki Inuzuka, Wenyi Wei

Published Nov 6, 2013 · Vol. 4, No. 12 · pp. 2339-2353

Keywords: tumor suppressor, MTSS1, ubiquitination, phosphorylation, migration

Indoleamine 2,3-dioxygenase 1 (IDO1) activity in leukemia blasts correlates with poor outcome in childhood acute myeloid leukemia Research Paper

Valentina Folgiero, Bianca M. Goffredo, Perla Filippini, Riccardo Masetti, Giuseppina Bonanno, Roberta Caruso, Valentina Bertaina, Angela Mastronuzzi, Stefania Gaspari, Marco Zecca, Giovanni F Torelli, Anna M Testi, Andrea Pession, Franco Locatelli, Sergio Rutella

Published Oct 30, 2013 · Vol. 5, No. 8 · pp. 2052-2064

Keywords: Acute myeloid leukemia, IDO1, immune escape, regulatory T cells

14-3-3Ïƒ attenuates RhoGDI2-induced cisplatin resistance through activation of Erk and p38 in gastric cancer cells Research Paper

In-Kyu Kim, Sun-Mi Park, Hee Jun Cho, Kyoung Eun Baek, In-Koo Nam, Seung-Ho Park, Ki-Jun Ryu, Jinhyun Ryu, Jungil Choi, Soon-Chan Hong, Jae Won Kim, Chang Won Lee, Sang Soo Kang, Jiyun Yoo

Published Oct 19, 2013 · Vol. 4, No. 11 · pp. 2045-2056

Keywords: RhoGDI2, 14-3-3Ïƒ, gastric cancer, chemoresistance, metastasis

Mitochondrial oxidative stress is the achilleâ€™s heel of melanoma cells resistant to Braf-mutant inhibitor Research Paper

Paola Corazao-Rozas, Pierre Guerreschi, Manel Jendoubi, Fanny AndrÃ©, AurÃ©lie Jonneaux, Camille Scalbert, Guillaume GarÃ§on, Myriam Mallet-Martino, StÃ©phane Balayssac, Stephane Rocchi, Ariel Savina, Pierre Formstecher, Laurent Mortier, Jerome Kluza, Philippe Marchetti

Published Oct 6, 2013 · Vol. 4, No. 11 · pp. 1986-1998

Keywords: metabolism, oxidative phosphorylation, elesclomol, ROS

The discovery of potent ribosomal S6 kinase inhibitors by high-throughput screening and structure-guided drug design Research Paper

Sylvain Couty, Isaac M. Westwood, Andrew Kalusa, Celine Cano, Jon Travers, Kathy Boxall, Chiau Ling Chow, Sam Burns, Jessica Schmitt, Lisa Pickard, Caterina Barillari, P. Craig McAndrew, Paul A. Clarke, Spiros Linardopoulos, Roger J. Griffin, G. Wynne Aherne, Florence I. Raynaud, Paul Workman, Keith Jones, Rob L.M. van Montfort

Published Aug 25, 2013 · Vol. 4, No. 10 · pp. 1647-1661

Keywords: S6 kinase, P70S6K, cancer, inhibitor, structure-based drug design

Notch3 inhibition enhances sorafenib cytotoxic efficacy by promoting GSK3Î² phosphorylation and p21 down-regulation in hepatocellular carcinoma Research Paper

Catia Giovannini, Michele Baglioni, Marco Baron Toaldo, Cristiano Ventrucci, Stefania D'Adamo, Mario Cipone, Pasquale Chieco, Laura Gramantieri, Luigi Bolondi

Published Aug 24, 2013 · Vol. 4, No. 10 · pp. 1618-1631

Keywords: ERK, drug resistance, angiogenesis, cell proliferation, Notch3

The AKT Inhibitor MK-2206 is Cytotoxic in Hepatocarcinoma Cells Displaying Hyperphosphorylated AKT-1 and Synergizes with Conventional Chemotherapy Research Paper

Carolina Simioni, Alberto M. Martelli, Alice Cani, Rengul Cetin-Atalay, James A. McCubrey, Silvano Capitani, Luca M. Neri

Published Aug 24, 2013 · Vol. 4, No. 9 · pp. 1496-1506

Keywords: Hepatocellular carcinoma, MK-2206, Akt-1, targeted therapy, apoptosis, autophagy

Small-molecule targeting of translation initiation for cancer therapy Research Paper

Bertal H. Aktas, Yuan Qiao, Esra Ozdelen, Roland Schubert, Sema Sevinc, Fred Harbinski, Luciano Grubissich, Samuel Singer, Jose A. Halperin

Published Aug 14, 2013 · Vol. 4, No. 10 · pp. 1606-1617

Keywords: CANCER, TERNARY COMPLEX, TRANSLATION, eIF2, UTR

Combination therapy with anti-ErbB3 monoclonal antibodies and EGFR TKIs potently inhibits Non-small Cell Lung Cancer Research Paper

Alessia Noto, Claudia De Vitis, Giuseppe Roscilli, Luigi Fattore, Debora Malpicci, Emanuele Marra, Laura Luberto, Antonio D'Andrilli, Pierpaolo Coluccia, Maria Rosaria Giovagnoli, Nicola Normanno, Luigi Ruco, Luigi Aurisicchio, Rita Mancini, Gennaro Ciliberto

Published Jul 21, 2013 · Vol. 4, No. 8 · pp. 1253-1265

Keywords: Lung cancer, primary cultures, TKIs, ErbB3, monoclonal antibodies

PTEN loss represses glioblastoma tumor initiating cell differentiation via inactivation of Lgl1 Research Paper

Alexander Gont, Jennifer E. L. Hanson, Sylvie J. Lavictoire, Doris A. E. Parolin, Manijeh Daneshmand, Ian J. restall, Mathieu Soucie, Garth Nicholas, John Woulfe, Amin Kassam, Vasco F. Da Silva, Ian A. J. Lorimer

Published Jul 21, 2013 · Vol. 4, No. 8 · pp. 1266-1279

Keywords: glioblastoma, glioma, PTEN, atypical PKC, Lgl, tumor initiating cell

A novel Mcl1 variant inhibits apoptosis via increased Bim sequestration Research Paper

Judith Hagenbuchner, Ursula Kiechl-Kohlendorfer, Petra Obexer, Michael J. Ausserlechner

Published Jul 15, 2013 · Vol. 4, No. 8 · pp. 1241-1252

Keywords: BCL2 proteins, TRAIL, Fas-induced apoptosis, Noxa

AKT in Stromal Fibroblasts Controls Invasion of Epithelial Cells Research Paper

Ann-Christin Cichon, Adam Pickard, Simon S McDade, Daniel J Sharpe, Michael Moran, Jacqueline A James, Dennis J McCance

Published Jul 14, 2013 · Vol. 4, No. 7 · pp. 1103-1116

Keywords: stroma, invasion, AKT, Caspase 1, HPV, mdm2, interleukin 1, KGF, cancer

Publication Alerts

European Cancer and Oncology Congress

Post-Publication Promotion

Search Oncotarget

First Mnks degrading agents block phosphorylation of eIF4E, induce apoptosis, inhibit cell growth, migration and invasion in triple negative and Her2-overexpressing breast cancer cell lines Research Paper

Hypoxia inducible factor-1 alpha as a therapeutic target in multiple myeloma Research Paper

Sulforaphane counteracts aggressiveness of pancreatic cancer driven by dysregulated Cx43-mediated gap junctional intercellular communication Research Paper

SCF^Î²-TRCP-mediated degradation of NEDD4 inhibits tumorigenesis through modulating the PTEN/Akt signaling pathway Research Paper

Constitutive IDO expression in human cancer is sustained by an autocrine signaling loop involving IL-6, STAT3 and the AHR Research Paper

Indirect targeting of IGF receptor signaling in vivo by substrate-selective inhibition of PAPP-A proteolytic activity Research Paper

AKT mediates actinomycin D-induced p53 expression Research Paper

Rac1b negatively regulates TGF-Î²1-induced cell motility in pancreatic ductal epithelial cells by suppressing Smad signalling Research Paper

SCF^Î²-TRCP targets MTSS1 for ubiquitination-mediated destruction to regulate cancer cell proliferation and migration Research Paper

Indoleamine 2,3-dioxygenase 1 (IDO1) activity in leukemia blasts correlates with poor outcome in childhood acute myeloid leukemia Research Paper

14-3-3Ïƒ attenuates RhoGDI2-induced cisplatin resistance through activation of Erk and p38 in gastric cancer cells Research Paper

Mitochondrial oxidative stress is the achilleâ€™s heel of melanoma cells resistant to Braf-mutant inhibitor Research Paper

The discovery of potent ribosomal S6 kinase inhibitors by high-throughput screening and structure-guided drug design Research Paper

Notch3 inhibition enhances sorafenib cytotoxic efficacy by promoting GSK3Î² phosphorylation and p21 down-regulation in hepatocellular carcinoma Research Paper

The AKT Inhibitor MK-2206 is Cytotoxic in Hepatocarcinoma Cells Displaying Hyperphosphorylated AKT-1 and Synergizes with Conventional Chemotherapy Research Paper

Small-molecule targeting of translation initiation for cancer therapy Research Paper

Combination therapy with anti-ErbB3 monoclonal antibodies and EGFR TKIs potently inhibits Non-small Cell Lung Cancer Research Paper

PTEN loss represses glioblastoma tumor initiating cell differentiation via inactivation of Lgl1 Research Paper

A novel Mcl1 variant inhibits apoptosis via increased Bim sequestration Research Paper

AKT in Stromal Fibroblasts Controls Invasion of Epithelial Cells Research Paper

Publication Alerts

European Cancer and Oncology Congress

Oncoscience

Post-Publication Promotion

Search Oncotarget

First Mnks degrading agents block phosphorylation of eIF4E, induce apoptosis, inhibit cell growth, migration and invasion in triple negative and Her2-overexpressing breast cancer cell lines Research Paper

Hypoxia inducible factor-1 alpha as a therapeutic target in multiple myeloma Research Paper

Sulforaphane counteracts aggressiveness of pancreatic cancer driven by dysregulated Cx43-mediated gap junctional intercellular communication Research Paper

SCFÎ²-TRCP-mediated degradation of NEDD4 inhibits tumorigenesis through modulating the PTEN/Akt signaling pathway Research Paper

Constitutive IDO expression in human cancer is sustained by an autocrine signaling loop involving IL-6, STAT3 and the AHR Research Paper

Indirect targeting of IGF receptor signaling in vivo by substrate-selective inhibition of PAPP-A proteolytic activity Research Paper

AKT mediates actinomycin D-induced p53 expression Research Paper

Rac1b negatively regulates TGF-Î²1-induced cell motility in pancreatic ductal epithelial cells by suppressing Smad signalling Research Paper

SCFÎ²-TRCP targets MTSS1 for ubiquitination-mediated destruction to regulate cancer cell proliferation and migration Research Paper

Indoleamine 2,3-dioxygenase 1 (IDO1) activity in leukemia blasts correlates with poor outcome in childhood acute myeloid leukemia Research Paper

14-3-3Ïƒ attenuates RhoGDI2-induced cisplatin resistance through activation of Erk and p38 in gastric cancer cells Research Paper

Mitochondrial oxidative stress is the achilleâ€™s heel of melanoma cells resistant to Braf-mutant inhibitor Research Paper

The discovery of potent ribosomal S6 kinase inhibitors by high-throughput screening and structure-guided drug design Research Paper

Notch3 inhibition enhances sorafenib cytotoxic efficacy by promoting GSK3Î² phosphorylation and p21 down-regulation in hepatocellular carcinoma Research Paper

The AKT Inhibitor MK-2206 is Cytotoxic in Hepatocarcinoma Cells Displaying Hyperphosphorylated AKT-1 and Synergizes with Conventional Chemotherapy Research Paper

Small-molecule targeting of translation initiation for cancer therapy Research Paper

Combination therapy with anti-ErbB3 monoclonal antibodies and EGFR TKIs potently inhibits Non-small Cell Lung Cancer Research Paper

PTEN loss represses glioblastoma tumor initiating cell differentiation via inactivation of Lgl1 Research Paper

A novel Mcl1 variant inhibits apoptosis via increased Bim sequestration Research Paper

AKT in Stromal Fibroblasts Controls Invasion of Epithelial Cells Research Paper

SCF^Î²-TRCP-mediated degradation of NEDD4 inhibits tumorigenesis through modulating the PTEN/Akt signaling pathway Research Paper

SCF^Î²-TRCP targets MTSS1 for ubiquitination-mediated destruction to regulate cancer cell proliferation and migration Research Paper