The Oncosearch | Oncotarget

An innovative diagnostic strategy for the detection of rare molecular targets to select cancer patients for tumor-agnostic treatments Research Paper

Antonio Marchetti, Alessia Di Lorito, Lara Felicioni, Fiamma Buttitta

Published Dec 10, 2019 · Vol. 10, No. 65 · pp. 6957-6968

Keywords: tumor-agnostic treatments, microsatellite instability (MSI), neurotrophic receptor tyrosine kinase (NRTK), tissue microarrays (TMAs), tissue slice arrays (TSAs)

Analog-sensitive cell line identifies cellular substrates of CDK9 Research Paper

Tim-Michael Decker, Ignasi Forné, Tobias Straub, Hesham Elsaman, Guoli Ma, Nilay Shah, Axel Imhof, Dirk Eick

Published Dec 10, 2019 · Vol. 10, No. 65 · pp. 6934-6943

Keywords: CDK9, protein kinase, transcription, RNA splicing, phosphoproteomics

p53-inducible SESTRINs might play opposite roles in the regulation of early and late stages of lung carcinogenesis Research Paper

Boxiao Ding, Alexander Haidurov, Ayesha Chawla, Anita Parmigiani, Gerarda van de Kamp, Alexandra Dalina, Fang Yuan, Jun Hee Lee, Peter M. Chumakov, Steven R. Grossman, Andrei V. Budanov

Published Dec 10, 2019 · Vol. 10, No. 65 · pp. 6997-7009

Keywords: SESTRINs, lung cancer, mouse model, mTORC1/2, tumor suppression

Modulation of proliferation factors in lung adenocarcinoma with an analysis of the transcriptional consequences of genomic EGFR activation Research Paper

Melanie Haas Kucherlapati

Published Dec 10, 2019 · Vol. 10, No. 65 · pp. 6913-6933

Keywords: proliferation, mutation, transcription, EGFR, lung adenocarcinoma

Flow cytometric significance of cellular alkaline phosphatase activity in acute myeloid leukemia Research Paper

Laura G. Rico, Jordi Juncà, Michael D. Ward, Jolene A. Bradford, Jordi Petriz

Published Dec 10, 2019 · Vol. 10, No. 65 · pp. 6969-6980

Keywords: alkaline phosphatase, acute myeloid leukemia, stem cells, leukemic stem cells, CD34

A mouse model of prostate cancer bone metastasis in a syngeneic immunocompetent host Research Paper

Brian W. Simons, Vishal Kothari, Benjamin Benzon, Kamyar Ghabili, Robert Hughes, Jelani C. Zarif, Ashley E. Ross, Paula J. Hurley, Edward M. Schaeffer

Published Dec 3, 2019 · Vol. 10, No. 64 · pp. 6845-6854

Keywords: prostate cancer, bone metastasis, murine model

A way forward for cancer prevention therapy: personalized risk assessment Review

Zhenzhen Zhang, Jeffrey Bien, Motomi Mori, Sonali Jindal, Raymond Bergan

Published Dec 3, 2019 · Vol. 10, No. 64 · pp. 6898-6912

Keywords: cancer, prevention, prevention therapy, multiple risk factors, screening

Mesangiogenic progenitor cells are forced toward the angiogenic fate, in multiple myeloma Research Paper

Simone Pacini, Marina Montali, Francesco Mazziotta, Claudia P. Schifone, Lucia Macchia, Vittoria Carnicelli, Francesca M. Panvini, Serena Barachini, Laura Notarfranchi, Giovanni Battista Previti, Gabriele Buda, Mario Petrini

Published Nov 26, 2019 · Vol. 10, No. 63 · pp. 6781-6790

Keywords: multiple myeloma, bone marrow microenvironment, angiogenesis, osteogenesis, mesangiogenic progenitor cells

Sequential somatic mutations upon secondary anti-HER2 treatment resistance in metastatic ERBB2^S310F mutated extramammary Paget’s disease Research Paper

Thierry M. Nordmann, Olivia Messerli-Odermatt, Larissa Meier, Sara Micaletto, Thomas Coppetti, Mirjam Nägeli, Jivko Kamarachev, Ken Kudura, Sandra N. Freiberger, Tamara Rordorf, Joanna Mangana, Ralph Braun, Reinhard Dummer

Published Nov 19, 2019 · Vol. 10, No. 62 · pp. 6647-6650

Keywords: ERBB2 protein, Paget disease, extramammary, trastuzumab, lapatinib

Caveolin-1 Y14 phosphorylation suppresses tumor growth while promoting invasion Research Paper

Bharat Joshi, Judy Pawling, Jay Shankar, Karina Pacholczyk, Yohan Kim, Wynn Tran, Fanrui Meng, Anas M. Abdel Rahman, Leonard J. Foster, Hon S. Leong, James W. Dennis, Ivan R. Nabi

Published Nov 19, 2019 · Vol. 10, No. 62 · pp. 6668-6677

Keywords: caveolin-1, TP53, tumor suppressor, tumor cell metabolism, invadopodia

Tumor tissue hnRNP M and HSP 90α as potential predictors of disease-specific mortality in patients with early-stage cutaneous head and neck melanoma: A proteomics-based study Research Paper

Andro Košec, Ruđer Novak, Paško Konjevoda, Vladimir Trkulja, Vladimir Bedeković, Lovorka Grgurević

Published Nov 19, 2019 · Vol. 10, No. 62 · pp. 6713-6722

Keywords: melanoma, early stage, proteomics, tissue, biomarkers

A squalamine derivative, NV669, as a novel PTP1B inhibitor: in vitro and in vivo effects on pancreatic and hepatic tumor growth Research Paper

Sylvie Carmona, Jean-Michel Brunel, Rénaté Bonier, Véronique Sbarra, Stéphane Robert, Patrick Borentain, Dominique Lombardo, Eric Mas, René Gerolami

Published Nov 19, 2019 · Vol. 10, No. 62 · pp. 6651-6667

Keywords: aminosterol, pancreas, liver, PTP1B, cancer

The impact of systemic precision medicine and immunotherapy treatments on brain metastases Review

Rowland H. Han, Gavin P. Dunn, Milan G. Chheda, Albert H. Kim

Published Nov 19, 2019 · Vol. 10, No. 62 · pp. 6739-6753

Keywords: brain metastases, targeted therapy, precision medicine, immunotherapy, systemic therapy

Targeted enhancement of the therapeutic window of L19-TNF by transient and selective inhibition of RIPK1-signaling cascade Research Paper

Sheila Dakhel, Tiziano Ongaro, Baptiste Gouyou, Mattia Matasci, Alessandra Villa, Dario Neri, Samuele Cazzamalli

Published Nov 19, 2019 · Vol. 10, No. 62 · pp. 6678-6690

Keywords: tumor targeting, antibody-cytokine fusions, targeted-tumor necrosis factor, EDB-fibronectin, intracellular RIPK1-inhibitors

The growth of a xenograft breast cancer tumor model with engineered hyaluronan-accumulating stroma is dependent on hyaluronan and independent of CD44 Research Paper

Chunmei Zhao, Benjamin J. Thompson, Kelly Chen, Feng Gao, Barbara Blouw, Mathieu Marella, Susan Zimmerman, Trevor Kimbler, Sheryl Garrovillo, Jesse Bahn, Lei Huang, Zhongdong Huang, H. Michael Shepard, Sanna Rosengren, Christopher D. Thanos, Daniel C. Maneval

Published Nov 12, 2019 · Vol. 10, No. 61 · pp. 6561-6576

Keywords: hyaluronan, breast cancer, xenograft, tumor microenvironment, CD44

The multifaceted anti-cancer effects of BRAF-inhibitors Review

Laura Croce, Francesca Coperchini, Flavia Magri, Luca Chiovato, Mario Rotondi

Published Nov 12, 2019 · Vol. 10, No. 61 · pp. 6623-6640

Keywords: BRAF, BRAF-inhibitors, tumor microenvironment, chemokines, CXCL8

miR-151a enhances Slug dependent angiogenesis Priority Research Paper

Douglas Jury, Iben Daugaard, Katie J. Sanders, Lise Lotte Hansen, Dritan Agalliu, Irene Munk Pedersen

Published Nov 7, 2019 · Vol. 11, No. 23 · pp. 2160-2171

Keywords: angiogenesis, miR-151a, Slug, tumor microenvironment, endothelial cell

MYCN expression induces replication stress and sensitivity to PARP inhibition in neuroblastoma Priority Research Paper

David King, Xiao Dun Li, Gilberto S. Almeida, Colin Kwok, Polly Gravells, Daniel Harrison, Saoirse Burke, Albert Hallsworth, Yann Jamin, Sally George, Simon P. Robinson, Christopher J. Lord, Evon Poon, Daniel Yeomanson, Louis Chesler, Helen E. Bryant

Published Nov 6, 2019 · Vol. 11, No. 23 · pp. 2141-2159

Keywords: PARP inhibitor, neuroblastoma, MYCN, replication stress, replication fork stalling

Molecular profiling of radical prostatectomy tissue from patients with no sign of progression identifies ERG as the strongest independent predictor of recurrence Research Paper

Wusheng Yan, Muhammad Jamal, Shyh-Han Tan, Yingjie Song, Denise Young, Yongmei Chen, Shilpa Katta, Kai Ying, Lakshmi Ravindranath, Tarah Woodle, Indu Kohaar, Jennifer Cullen, Jacob Kagan, Sudhir Srivastava, Albert Dobi, David G. McLeod, Inger L. Rosner, Isabell A. Sesterhenn, Alagarsamy Srinivasan, Shiv Srivastava, Gyorgy Petrovics

Published Nov 5, 2019 · Vol. 10, No. 60 · pp. 6466-6483

Keywords: prostate cancer, NanoString, prognostic biomarker, biochemical recurrence, ERG

Efficacy and safety of buparlisib, a PI3K inhibitor, in patients with malignancies harboring a PI3K pathway activation: a phase 2, open-label, single-arm study Research Paper

Sarina A. Piha-Paul, Matthew H. Taylor, Daniel Spitz, Lee Schwartzberg, J. Thaddeus Beck, Todd M. Bauer, Funda Meric-Bernstam, Das Purkayastha, Linda Karpiak, Sebastian Szpakowski, Fadi Braiteh

Published Nov 5, 2019 · Vol. 10, No. 60 · pp. 6526-6535

Keywords: phosphatidylinositol 3-kinase pathway, buparlisib, advanced malignancies, molecular selection, tissue agnostic

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An innovative diagnostic strategy for the detection of rare molecular targets to select cancer patients for tumor-agnostic treatments Research Paper

Analog-sensitive cell line identifies cellular substrates of CDK9 Research Paper

p53-inducible SESTRINs might play opposite roles in the regulation of early and late stages of lung carcinogenesis Research Paper

Modulation of proliferation factors in lung adenocarcinoma with an analysis of the transcriptional consequences of genomic EGFR activation Research Paper

Flow cytometric significance of cellular alkaline phosphatase activity in acute myeloid leukemia Research Paper

A mouse model of prostate cancer bone metastasis in a syngeneic immunocompetent host Research Paper

A way forward for cancer prevention therapy: personalized risk assessment Review

Mesangiogenic progenitor cells are forced toward the angiogenic fate, in multiple myeloma Research Paper

Sequential somatic mutations upon secondary anti-HER2 treatment resistance in metastatic ERBB2^S310F mutated extramammary Paget’s disease Research Paper

Caveolin-1 Y14 phosphorylation suppresses tumor growth while promoting invasion Research Paper

Tumor tissue hnRNP M and HSP 90α as potential predictors of disease-specific mortality in patients with early-stage cutaneous head and neck melanoma: A proteomics-based study Research Paper

A squalamine derivative, NV669, as a novel PTP1B inhibitor: in vitro and in vivo effects on pancreatic and hepatic tumor growth Research Paper

The impact of systemic precision medicine and immunotherapy treatments on brain metastases Review

Targeted enhancement of the therapeutic window of L19-TNF by transient and selective inhibition of RIPK1-signaling cascade Research Paper

The growth of a xenograft breast cancer tumor model with engineered hyaluronan-accumulating stroma is dependent on hyaluronan and independent of CD44 Research Paper

The multifaceted anti-cancer effects of BRAF-inhibitors Review

miR-151a enhances Slug dependent angiogenesis Priority Research Paper

MYCN expression induces replication stress and sensitivity to PARP inhibition in neuroblastoma Priority Research Paper

Molecular profiling of radical prostatectomy tissue from patients with no sign of progression identifies ERG as the strongest independent predictor of recurrence Research Paper

Efficacy and safety of buparlisib, a PI3K inhibitor, in patients with malignancies harboring a PI3K pathway activation: a phase 2, open-label, single-arm study Research Paper

Publication Alerts

European Cancer and Oncology Congress

Oncoscience

Post-Publication Promotion

Search Oncotarget

An innovative diagnostic strategy for the detection of rare molecular targets to select cancer patients for tumor-agnostic treatments Research Paper

Analog-sensitive cell line identifies cellular substrates of CDK9 Research Paper

p53-inducible SESTRINs might play opposite roles in the regulation of early and late stages of lung carcinogenesis Research Paper

Modulation of proliferation factors in lung adenocarcinoma with an analysis of the transcriptional consequences of genomic EGFR activation Research Paper

Flow cytometric significance of cellular alkaline phosphatase activity in acute myeloid leukemia Research Paper

A mouse model of prostate cancer bone metastasis in a syngeneic immunocompetent host Research Paper

A way forward for cancer prevention therapy: personalized risk assessment Review

Mesangiogenic progenitor cells are forced toward the angiogenic fate, in multiple myeloma Research Paper

Sequential somatic mutations upon secondary anti-HER2 treatment resistance in metastatic ERBB2S310F mutated extramammary Paget’s disease Research Paper

Caveolin-1 Y14 phosphorylation suppresses tumor growth while promoting invasion Research Paper

Tumor tissue hnRNP M and HSP 90α as potential predictors of disease-specific mortality in patients with early-stage cutaneous head and neck melanoma: A proteomics-based study Research Paper

A squalamine derivative, NV669, as a novel PTP1B inhibitor: in vitro and in vivo effects on pancreatic and hepatic tumor growth Research Paper

The impact of systemic precision medicine and immunotherapy treatments on brain metastases Review

Targeted enhancement of the therapeutic window of L19-TNF by transient and selective inhibition of RIPK1-signaling cascade Research Paper

The growth of a xenograft breast cancer tumor model with engineered hyaluronan-accumulating stroma is dependent on hyaluronan and independent of CD44 Research Paper

The multifaceted anti-cancer effects of BRAF-inhibitors Review

miR-151a enhances Slug dependent angiogenesis Priority Research Paper

MYCN expression induces replication stress and sensitivity to PARP inhibition in neuroblastoma Priority Research Paper

Molecular profiling of radical prostatectomy tissue from patients with no sign of progression identifies ERG as the strongest independent predictor of recurrence Research Paper

Efficacy and safety of buparlisib, a PI3K inhibitor, in patients with malignancies harboring a PI3K pathway activation: a phase 2, open-label, single-arm study Research Paper

Sequential somatic mutations upon secondary anti-HER2 treatment resistance in metastatic ERBB2^S310F mutated extramammary Paget’s disease Research Paper