The Oncosearch | Oncotarget

Stratifying the stratifiers of triple negative breast cancer Editorial

Dong-Yu Wang, Zhe Jiang, Eldad Zacksenhaus

Published Jan 18, 2020 · Vol. 11, No. 4 · pp. 306-308

Keywords: triple negative breast cancer, molecular stratification, prognostication, microRNA, immunomodulation

Circulating tumor DNA analysis in the era of precision oncology Review

Rabih Said, Nicolas Guibert, Geoffrey R. Oxnard, Apostolia M. Tsimberidou

Published Jan 14, 2020 · Vol. 11, No. 2 · pp. 188-211

Keywords: circulating tumor DNA analysis, clinical trials, targeted therapy, genomic profiling

Deregulation of cancer-stem-cell-associated miRNAs in tissues and sera of colorectal cancer patients Research Paper

Cristiano Farace, Andrea Pisano, Carmen Griñan-Lison, Giuliana Solinas, Gema Jiménez, Marina Serra, Esmeralda Carrillo, Fabrizio Scognamillo, Federico Attene, Andrea Montella, Juan Antonio Marchal, Roberto Madeddu

Published Jan 14, 2020 · Vol. 11, No. 2 · pp. 116-130

Keywords: colorectal cancer, metastasis, cancer stem cell, microRNA, biomarker

The targeted LHRH analog AEZS-108 alters expression of genes related to angiogenesis and development of metastasis in uveal melanoma Research Paper

Klara Fodor, Nikoletta Dobos, Andrew Schally, Zita Steiber, Gabor Olah, Eva Sipos, Lorant Szekvolgyi, Gabor Halmos

Published Jan 14, 2020 · Vol. 11, No. 2 · pp. 175-187

Keywords: uveal melanoma, luteinizing hormone-releasing hormone (LHRH) receptor, angiogenesis, MASPIN/SERPINB5, AEZS-108 (AN-152/Zoptarelin Doxorubicin Acetate)

A novel function of AAA-ATPase p97/VCP in the regulation of cell motility Research Paper

Zi-Jia Khong, Soak-Kuan Lai, Cheng-Gee Koh, Susana Geifman-Shochat, Hoi-Yeung Li

Published Jan 7, 2020 · Vol. 11, No. 1 · pp. 74-85

Keywords: p97/VCP, AAA-ATPase, ROCK, RhoA, cell motility

Pathogenic mutations and overall survival in 3,084 patients with cancer: the Hellenic Cooperative Oncology Group Precision Medicine Initiative Research Paper

Elena Fountzilas, Vassiliki Kotoula, Georgia-Angeliki Koliou, Eleni Giannoulatou, Helen Gogas, Christos Papadimitriou, Ioannis Tikas, Jianhua Zhang, Kyriaki Papadopoulou, Flora Zagouri, Christos Christodoulou, Angelos Koutras, Thomas Makatsoris, Sofia Chrisafi, Helena Linardou, Ioannis Varthalitis, George Papatsibas, Evangelia Razis, Pavlos Papakostas, Epaminontas Samantas, Gerasimos Aravantinos, Dimitrios Bafaloukos, Paris Kosmidis, Anna Koumarianou, Amanda Psyrri, Georgios Pentheroudakis, Dimitrios Pectasides, Andrew Futreal, George Fountzilas, Apostolia M. Tsimberidou

Published Jan 7, 2020 · Vol. 11, No. 1 · pp. 1-14

Keywords: actionable gene, next-generation sequencing, pathogenic mutation, precision oncology, prognosis

Toxoplasma gondii GRA8-derived peptide immunotherapy improves tumor targeting of colorectal cancer Research Paper

Jae-Sung Kim, Daeun Lee, Donggyu Kim, Seok-Jun Mun, Euni Cho, Wooic Son, Chul-Su Yang

Published Jan 7, 2020 · Vol. 11, No. 1 · pp. 62-73

Keywords: Toxoplasma gondii GRA8 peptide, mitochondria, tumor-targeting, metabolism

Identification of signature genes associated with therapeutic resistance to anti-VEGF therapy Research Paper

Pharavee Jaiprasart, Samrita Dogra, Deepika Neelakantan, Bharat Devapatla, Sukyung Woo

Published Jan 7, 2020 · Vol. 11, No. 1 · pp. 99-114

Keywords: anti-VEGF resistance, angiogenesis, bevacizumab, next-generation sequencing (NGS), apelin

Resistance to allosteric SHP2 inhibition in FGFR-driven cancers through rapid feedback activation of FGFR Research Paper

Hengyu Lu, Chen Liu, Hung Huynh, Thi Bich Uyen Le, Matthew LaMarche, Morvarid Mohseni, Jeffrey A. Engelman, Peter S. Hammerman, Giordano Caponigro, Huai-Xiang Hao

Published Jan 6, 2020

Keywords: SHP2, FGFR, resistance, feedback activation

Thymoquinone induces apoptosis and DNA damage in 5-Fluorouracil-resistant colorectal cancer stem/progenitor cells Research Paper

Farah Ballout, Alissar Monzer, Maamoun Fatfat, Hala El Ouweini, Miran A. Jaffa, Rana Abdel-Samad, Nadine Darwiche, Wassim Abou-Kheir, Hala Gali-Muhtasib

Published Jan 3, 2020 · Vol. 11, No. 31 · pp. 2959-2972

Keywords: thymoquinone, colorectal cancer stem cells, 5-Fluorouracil resistance, colonospheres, apoptosis

Targeting the non-canonical roles of PCNA modifies and increases the response to targeted anti-cancer therapy Research Paper

Caroline K. Søgaard, Anala Nepal, Voin Petrovic, Animesh Sharma, Nina-Beate Liabakk, Tonje S. Steigedal, Marit Otterlei

Published Dec 31, 2019 · Vol. 10, No. 68 · pp. 7185-7197

Keywords: APIM, multi-targeting therapy, signaling pathways, autophagy, cancer

Head and neck squamous cancer progression is marked by CLIC4 attenuation in tumor epithelium and reciprocal stromal upregulation of miR-142-3p, a novel post-transcriptional regulator of CLIC4 Research Paper

Brandi L. Carofino, Kayla M. Dinshaw, Pui Yan Ho, Christophe Cataisson, Aleksandra M. Michalowski, Andrew Ryscavage, Addie Alkhas, Nathan W. Wong, Vishal Koparde, Stuart H. Yuspa

Published Dec 31, 2019 · Vol. 10, No. 68 · pp. 7251-7275

Keywords: in situ hybridization, single-cell RNA-sequencing, stroma, miRNA, immune infiltration

ISG15 induction is required during L1-mediated colon cancer progression and metastasis Research Paper

Sanith Cheriyamundath, Sayon Basu, Gal Haase, Harry Doernberg, Nancy Gavert, Thomas Brabletz, Avri Ben-Ze’ev

Published Dec 24, 2019 · Vol. 10, No. 67 · pp. 7122-7131

Keywords: ISG15, L1, colorectal cancer, metastasis

Nuclear up regulation of the BRCA1-associated ubiquitinase BAP1 is associated with tumor aggressiveness in prostate cancers lacking the TMPRSS2:ERG fusion Research Paper

Stefan Steurer, Lara Schwemmer, Claudia Hube-Magg, Franziska Büscheck, Doris Höflmayer, Maria Christina Tsourlakis, Till S. Clauditz, Andreas M. Luebke, Ronald Simon, Guido Sauter, Jakob Izbicki, Cornelia Schroeder, Thorsten Schlomm, Hartwig Huland, Hans Heinzer, Alexander Haese, Markus Graefen, Cosima Göbel, Sören Weidemann, Patrick Lebok, David Dum, Christoph Fraune, Sarah Minner, Jan Meiners

Published Dec 24, 2019 · Vol. 10, No. 67 · pp. 7096-7111

Keywords: BAP1, prostate cancer, prognosis, immunohistochemistry

HSP90 overexpression potentiates the B-cell receptor and fibroblast growth factor receptor survival signals in chronic lymphocytic leukemia cells Research Paper

Hasan Mahmud, Mariana Mendez, Bedabrata Mukhopadhyay, Jennifer Holter-Chakrabarty, Asish K. Ghosh

Published Dec 23, 2019 · Vol. 11, No. 22 · pp. 2037-2046

Keywords: CLL, HSP90, BCR, CD79a, PTPN22

A close relationship between HIF-1α expression and bone metastases in advanced NSCLC, a retrospective analysis Research Paper

Aldo Pezzuto, Giuseppe Perrone, Nicoletta Orlando, Fabrizio Citarella, Massimo Ciccozzi, Simone Scarlata, Giuseppe Tonini

Published Dec 17, 2019 · Vol. 10, No. 66 · pp. 7071-7079

Keywords: HIF-1α expression, lung cancer, bone metastases, time to progression

A pan-cancer transcriptome analysis identifies replication fork and innate immunity genes as modifiers of response to the CHK1 inhibitor prexasertib Research Paper

Wayne D. Blosser, Jack A. Dempsey, Ann M. Mc Nulty, Xi Rao, Philip J. Ebert, Caitlin D. Lowery, Philip W. Iversen, Yue Wang Webster, Gregory P. Donoho, Xueqian Gong, Farhana F. Merzoug, Sean Buchanan, Karsten Boehnke, Chunping Yu, Xin Tian You, Richard P. Beckmann, Wenjuan Wu, Samuel C. McNeely, Aimee Bence Lin, Ricardo Martinez

Published Dec 16, 2019

Keywords: CHK1, prexasertib, replication stress, replication fork, innate immunity

A pan-cancer transcriptome analysis identifies replication fork and innate immunity genes as modifiers of response to the CHK1 inhibitor prexasertib Research Paper

Wayne D. Blosser, Jack A. Dempsey, Ann M. Mc Nulty, Xi Rao, Philip J. Ebert, Caitlin D. Lowery, Philip W. Iversen, Yue Wang Webster, Gregory P. Donoho, Xueqian Gong, Farhana F. Merzoug, Sean Buchanan, Karsten Boehnke, Chunping Yu, Xin Tian You, Richard P. Beckmann, Wenjuan Wu, Samuel C. McNeely, Aimee Bence Lin, Ricardo Martinez

Published Dec 16, 2019

Keywords: CHK1, prexasertib, replication stress, replication fork, innate immunity

A pan-cancer transcriptome analysis identifies replication fork and innate immunity genes as modifiers of response to the CHK1 inhibitor prexasertib Research Paper

Wayne D. Blosser, Jack A. Dempsey, Ann M. Mc Nulty, Xi Rao, Philip J. Ebert, Caitlin D. Lowery, Philip W. Iversen, Yue Wang Webster, Gregory P. Donoho, Xueqian Gong, Farhana F. Merzoug, Sean Buchanan, Karsten Boehnke, Chunping Yu, Xin Tian You, Richard P. Beckmann, Wenjuan Wu, Samuel C. McNeely, Aimee Bence Lin, Ricardo Martinez

Published Dec 16, 2019

Keywords: CHK1, prexasertib, replication stress, replication fork, innate immunity

A pan-cancer transcriptome analysis identifies replication fork and innate immunity genes as modifiers of response to the CHK1 inhibitor prexasertib Research Paper

Wayne D. Blosser, Jack A. Dempsey, Ann M. Mc Nulty, Xi Rao, Philip J. Ebert, Caitlin D. Lowery, Philip W. Iversen, Yue Wang Webster, Gregory P. Donoho, Xueqian Gong, Farhana F. Merzoug, Sean Buchanan, Karsten Boehnke, Chunping Yu, Xin Tian You, Richard P. Beckmann, Wenjuan Wu, Samuel C. McNeely, Aimee Bence Lin, Ricardo Martinez

Published Dec 16, 2019

Keywords: CHK1, prexasertib, replication stress, replication fork, innate immunity

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Stratifying the stratifiers of triple negative breast cancer Editorial

Circulating tumor DNA analysis in the era of precision oncology Review

Deregulation of cancer-stem-cell-associated miRNAs in tissues and sera of colorectal cancer patients Research Paper

The targeted LHRH analog AEZS-108 alters expression of genes related to angiogenesis and development of metastasis in uveal melanoma Research Paper

A novel function of AAA-ATPase p97/VCP in the regulation of cell motility Research Paper

Pathogenic mutations and overall survival in 3,084 patients with cancer: the Hellenic Cooperative Oncology Group Precision Medicine Initiative Research Paper

Toxoplasma gondii GRA8-derived peptide immunotherapy improves tumor targeting of colorectal cancer Research Paper

Identification of signature genes associated with therapeutic resistance to anti-VEGF therapy Research Paper

Resistance to allosteric SHP2 inhibition in FGFR-driven cancers through rapid feedback activation of FGFR Research Paper

Thymoquinone induces apoptosis and DNA damage in 5-Fluorouracil-resistant colorectal cancer stem/progenitor cells Research Paper

Targeting the non-canonical roles of PCNA modifies and increases the response to targeted anti-cancer therapy Research Paper

Head and neck squamous cancer progression is marked by CLIC4 attenuation in tumor epithelium and reciprocal stromal upregulation of miR-142-3p, a novel post-transcriptional regulator of CLIC4 Research Paper

ISG15 induction is required during L1-mediated colon cancer progression and metastasis Research Paper

Nuclear up regulation of the BRCA1-associated ubiquitinase BAP1 is associated with tumor aggressiveness in prostate cancers lacking the TMPRSS2:ERG fusion Research Paper

HSP90 overexpression potentiates the B-cell receptor and fibroblast growth factor receptor survival signals in chronic lymphocytic leukemia cells Research Paper

A close relationship between HIF-1α expression and bone metastases in advanced NSCLC, a retrospective analysis Research Paper

A pan-cancer transcriptome analysis identifies replication fork and innate immunity genes as modifiers of response to the CHK1 inhibitor prexasertib Research Paper

A pan-cancer transcriptome analysis identifies replication fork and innate immunity genes as modifiers of response to the CHK1 inhibitor prexasertib Research Paper

A pan-cancer transcriptome analysis identifies replication fork and innate immunity genes as modifiers of response to the CHK1 inhibitor prexasertib Research Paper

A pan-cancer transcriptome analysis identifies replication fork and innate immunity genes as modifiers of response to the CHK1 inhibitor prexasertib Research Paper

Publication Alerts

European Cancer and Oncology Congress

Oncoscience

Post-Publication Promotion

Search Oncotarget

Stratifying the stratifiers of triple negative breast cancer Editorial

Circulating tumor DNA analysis in the era of precision oncology Review

Deregulation of cancer-stem-cell-associated miRNAs in tissues and sera of colorectal cancer patients Research Paper

The targeted LHRH analog AEZS-108 alters expression of genes related to angiogenesis and development of metastasis in uveal melanoma Research Paper

A novel function of AAA-ATPase p97/VCP in the regulation of cell motility Research Paper

Pathogenic mutations and overall survival in 3,084 patients with cancer: the Hellenic Cooperative Oncology Group Precision Medicine Initiative Research Paper

Toxoplasma gondii GRA8-derived peptide immunotherapy improves tumor targeting of colorectal cancer Research Paper

Identification of signature genes associated with therapeutic resistance to anti-VEGF therapy Research Paper

Resistance to allosteric SHP2 inhibition in FGFR-driven cancers through rapid feedback activation of FGFR Research Paper

Thymoquinone induces apoptosis and DNA damage in 5-Fluorouracil-resistant colorectal cancer stem/progenitor cells Research Paper

Targeting the non-canonical roles of PCNA modifies and increases the response to targeted anti-cancer therapy Research Paper

Head and neck squamous cancer progression is marked by CLIC4 attenuation in tumor epithelium and reciprocal stromal upregulation of miR-142-3p, a novel post-transcriptional regulator of CLIC4 Research Paper

ISG15 induction is required during L1-mediated colon cancer progression and metastasis Research Paper

Nuclear up regulation of the BRCA1-associated ubiquitinase BAP1 is associated with tumor aggressiveness in prostate cancers lacking the TMPRSS2:ERG fusion Research Paper

HSP90 overexpression potentiates the B-cell receptor and fibroblast growth factor receptor survival signals in chronic lymphocytic leukemia cells Research Paper

A close relationship between HIF-1α expression and bone metastases in advanced NSCLC, a retrospective analysis Research Paper

A pan-cancer transcriptome analysis identifies replication fork and innate immunity genes as modifiers of response to the CHK1 inhibitor prexasertib Research Paper

A pan-cancer transcriptome analysis identifies replication fork and innate immunity genes as modifiers of response to the CHK1 inhibitor prexasertib Research Paper

A pan-cancer transcriptome analysis identifies replication fork and innate immunity genes as modifiers of response to the CHK1 inhibitor prexasertib Research Paper

A pan-cancer transcriptome analysis identifies replication fork and innate immunity genes as modifiers of response to the CHK1 inhibitor prexasertib Research Paper