The Oncosearch | Oncotarget

The pro-apoptotic actions of 2-methoxyestradiol against ovarian cancer involve catalytic activation of PKCδ signaling Research Paper

Purab Pal, Karen Hales, Dale Buchanan Hales

Published Sep 21, 2020 · Vol. 11, No. 40 · pp. 3646-3659

Keywords: 2-methoxyestradiol, ovarian cancer, protein kinase Cδ, p38 MAPK, apoptosis

Evaluation of cancer-derived myocardial impairments using a mouse model Research Paper

Yoshihiro Miyagawa, Shota Nukaga, Takuya Mori, Rina Fujiwara-Tani, Kiyomu Fujii, Shiori Mori, Kei Goto, Shingo Kishi, Takamitsu Sasaki, Chie Nakashima, Hitoshi Ohmori, Isao Kawahara, Yi Luo, Hiroki Kuniyasu

Published Sep 20, 2020 · Vol. 11, No. 41 · pp. 3712-3722

Keywords: cachexia, myocardium, atrophy, mitochondria, oxidative stress

Evaluation of cellular alterations and inflammatory profile of mesothelial cells and/or neoplastic cells exposed to talc used for pleurodesis Research Paper

Milena Marques Pagliarelli Acencio, Bruna Rocha Silva, Lisete Ribeiro Teixeira, Vanessa Adélia Alvarenga, Carlos Sérgio Rocha Silva, Aline Graças Pereira da Silva, Vera Luiza Capelozzi, Evaldo Marchi

Published Sep 9, 2020 · Vol. 11, No. 41 · pp. 3730-3736

Keywords: pleural mesothelial cells, talc, pleurodesis, malignant pleural effusion, cellular alterations

Ferroptosis of epithelial ovarian cancer: genetic determinants and therapeutic potential Research Perspective

Chao-Chieh Lin, Jen-Tsan Chi

Published Sep 9, 2020 · Vol. 11, No. 39 · pp. 3562-3570

Keywords: ferroptosis, cystine, ovarian cancer, GPX4, NADPH oxidase

Targeting breast cancer metabolism with a novel inhibitor of mitochondrial ATP synthesis Research Paper

Myoung Sook Kim, Ramkishore Gernapudi, Yessenia Cedeño Cedeño, Brian M. Polster, Ramon Martinez, Paul Shapiro, Santosh Kesari, Elmar Nurmemmedov, Antonino Passaniti

Published Sep 3, 2020 · Vol. 11, No. 43 · pp. 3863-3885

Keywords: mitochondrial ATP synthase, oxygen consumption rate, ATP synthesis, reactive oxygen species,

Deconstructing tumor heterogeneity: the stromal perspective Meeting Report

Renee E. Vickman, Douglas V. Faget, Philip Beachy, David Beebe, Neil A. Bhowmick, Edna Cukierman, Wu-Min Deng, James G. Granneman, Jeffrey Hildesheim, Raghu Kalluri, Ken S. Lau, Ernst Lengyel, Joakim Lundeberg, Jorge Moscat, Peter S. Nelson, Kristian Pietras, Katerina Politi, Ellen Puré, Ruth Scherz-Shouval, Mara H. Sherman, David Tuveson, Ashani T. Weeraratna, Richard M. White, Melissa H. Wong, Elisa C. Woodhouse, Ying Zheng, Simon W. Hayward, Sheila A. Stewart

Published Aug 29, 2020 · Vol. 11, No. 40 · pp. 3621-3632

Keywords: tumor microenvironment, stromal heterogeneity, extracellular matrix, cellular plasticity, therapy resistance

Advances in epidermal growth factor receptor specific immunotherapy: lessons to be learned from armed antibodies Review

Fleury Augustin Nsole Biteghe, Neelakshi Mungra, Nyangone Ekome Toung Chalomie, Jean De La Croix Ndong, Jean Engohang-Ndong, Guillaume Vignaux, Eden Padayachee, Krupa Naran, Stefan Barth

Published Aug 26, 2020 · Vol. 11, No. 38 · pp. 3531-3557

Keywords: epidermal growth factor receptor (EGFR), recombinant immunotoxins (ITs), targeted human cytolytic fusion proteins (hCFPs), recombinant antibody-drug conjugates (rADCs), recombinant antibody photoimmunoconjugates (rAPCs)

Downregulation of angulin-1/LSR induces malignancy via upregulation of EGF-dependent claudin-2 and TGF-β-dependent cell metabolism in human lung adenocarcinoma A549 cells Research Paper

Wataru Arai, Takumi Konno, Takayuki Kohno, Yuki Kodera, Mitsuhiro Tsujiwaki, Yuma Shindo, Hirofumi Chiba, Masahiro Miyajima, Yuji Sakuma, Atsushi Watanabe, Takashi Kojima

Published Aug 24, 2020 · Vol. 14, No. 1 · pp. 261-275

Keywords: angulin-1/LSR, claudin-2, cell metabolism, malignancy, lung adenocarcinoma

NRXN1 as a novel potential target of antibody-drug conjugates for small cell lung cancer Research Paper

Takuma Yotsumoto, Keita Maemura, Kousuke Watanabe, Yosuke Amano, Yoko Matsumoto, Koichi Zokumasu, Takahiro Ando, Masanori Kawakami, Hidenori Kage, Jun Nakajima, Yutaka Yatomi, Takahide Nagase, Daiya Takai

Published Aug 14, 2020 · Vol. 11, No. 39 · pp. 3590-3600

Keywords: antibody-drug conjugates, small cell lung cancer, novel molecular targets, NRXN1, cell adhesion molecule

Down syndrome iPSC model: endothelial perspective on tumor development Research Paper

Mariana Perepitchka, Yekaterina Galat, Igor P. Beletsky, Philip M. Iannaccone, Vasiliy Galat

Published Aug 12, 2020 · Vol. 11, No. 36 · pp. 3387-3404

Keywords: Down syndrome, iPSC-derived endothelial model, T21 genome-wide Implications, meta-analysis, tumor microenvironment

Targeted CRM1-inhibition perturbs leukemogenic NUP214 fusion proteins and exerts anti-cancer effects in leukemia cell lines with NUP214 rearrangements Research Paper

Adélia Mendes, Ramona Jühlen, Valérie Martinelli, Birthe Fahrenkrog

Published Aug 11, 2020 · Vol. 11, No. 36 · pp. 3371-3386

Keywords: CRM1, NUP214, leukemia, nuclear export, nucleoporin

Therapeutic applications of the selective high affinity ligand drug SH7139 extend beyond non-Hodgkin’s lymphoma to many other types of solid cancers Research Paper

Rod Balhorn, Monique Cosman Balhorn

Published Aug 5, 2020 · Vol. 11, No. 35 · pp. 3315-3349

Keywords: HLA-DR, selective high affinity ligand, SH7139, SH7129, solid cancers

The temporal effects of topical NF-κB inhibition, in the in vivo prevention of bile-related oncogenic mRNA and miRNA phenotypes in murine hypopharyngeal mucosa: a preclinical model Research Paper

Dimitra P. Vageli, David Kasle, Sotirios G. Doukas, Panagiotis G. Doukas, Clarence T. Sasaki

Published Aug 3, 2020 · Vol. 11, No. 35 · pp. 3303-3314

Keywords: NF-κB inhibition, BAY 11-7082, bile, laryngopharyngeal reflux, hypopharyngeal cancer

Sequencing for an interdisciplinary molecular tumor board in patients with advanced breast cancer: experiences from a case series Research Paper

Christina Walter, Andreas Hartkopf, Andre Koch, Marion Klaumünzer, Martin Schulze, Eva-Maria Grischke, Florin-Andrei Taran, Sara Brucker, Florian Battke, Saskia Biskup

Published Aug 1, 2020 · Vol. 11, No. 35 · pp. 3279-3285

Keywords: breast cancer, genetics, next-generation sequencing, actionable mutations

A case report of metastatic giant sarcomatoid melanoma with BRAF V600E mutation: a complete response to targeted therapy Case Report

Matteo Torresetti, Donatella Brancorsini, Francesca Morgese, Valeria Cognigni, Alessandro Scalise, Rossana Berardi, Giovanni Di Benedetto

Published Jul 30, 2020 · Vol. 11, No. 34 · pp. 3256-3262

Keywords: sarcomatoid melanoma, giant melanoma, BRAF mutation, targeted therapy, next-generation sequencing

The bromodomain inhibitor IBET-151 attenuates vismodegib-resistant esophageal adenocarcinoma growth through reduction of GLI signaling Research Paper

Annamil Alvarez-Trotta, Zhiqiang Wang, Elena Shersher, Bin Li, Jun Long, Ines Lohse, Claes Wahlestedt, Wael El-Rifai, David J. Robbins, Anthony J. Capobianco

Published Jul 28, 2020 · Vol. 11, No. 33 · pp. 3174-3187

Keywords: IBET-151, esophageal adenocarcinoma, GDC-0449 resistance, patient-derived xenografts, Hedgehog/GLI signaling pathway

An integrative microenvironment approach for follicular lymphoma: roles of inflammatory cell subsets and immune-response polymorphisms on disease clinical course Research Paper

Guilherme Rossi Assis-Mendonça, André Fattori, Rafael Malagoli Rocha, Gustavo Jacob Lourenço, Márcia Torresan Delamain, Suely Nonogaki, Vladmir Cláudio Cordeiro de Lima, Gisele Wally Braga Colleoni, Cármino Antonio de Souza, Fernando Augusto Soares, Carmen Silvia Passos Lima, José Vassallo

Published Jul 25, 2020 · Vol. 11, No. 33 · pp. 3153-3173

Keywords: follicular lymphoma, tumor microenvironment, immunohistochemistry, single nucleotide polymorphisms, prognosis

Urinary glycoproteomic profiling of non-muscle invasive and muscle invasive bladder carcinoma patients reveals distinct N-glycosylation pattern of CD44, MGAM, and GINM1 Research Paper

Gajanan Sathe, Irene A. George, Barnali Deb, Ankit P. Jain, Krishna Patel, Brusabhanu Nayak, Subhradip Karmakar, Amlesh Seth, Akhilesh Pandey, Prashant Kumar

Published Jul 23, 2020 · Vol. 11, No. 34 · pp. 3244-3255

Keywords: urothelial carcinoma, N-linked glycoproteomics, urine proteomics, NMIBC, MIBC

Differentially expressed full-length, fusion and novel isoforms transcripts-based signature of well-differentiated keratinized oral squamous cell carcinoma Research Paper

Neetu Singh, Dinesh Kumar Sahu, Ratnesh Kumar Tripathi, Archana Mishra, Hari Shyam, Pratap Shankar, Mayank Jain, Nawazish Alam, Anil Kumar, Abhishek Mishra, Rebecca Chowdhry, Anjana Singh, Sameer Gupta, Divya Mehrotra, Preeti Agarwal, Madhu Mati Goel, Arun Chaturvedi, Satya Prakash Agarwal, Manish Bajpai, Devendra Kumar Gupta, Madan Lal Brahma Bhatt, Ravi Kant

Published Jul 22, 2020 · Vol. 11, No. 34 · pp. 3227-3243

Keywords: oral tongue squamous cell carcinoma, microarray, transcriptomics, integrative bioinformatics, differentially expressed gene

Molecular profiling of melanoma brain metastases compared to primary cutaneous melanoma and to extracranial metastases Research Paper

Gino K. In, Kelsey Poorman, Michelle Saul, Steven O’Day, Jeffrey M. Farma, Anthony J. Olszanski, Michael S. Gordon, Jacob S. Thomas, Burton Eisenberg, Lawrence Flaherty, Amy Weise, Steven Daveluy, Geoffrey Gibney, Michael B. Atkins, Ari Vanderwalde

Published Jul 16, 2020 · Vol. 11, No. 33 · pp. 3118-3128

Keywords: melanoma, brain metastases, BRAF, PD-L1, TMB

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The pro-apoptotic actions of 2-methoxyestradiol against ovarian cancer involve catalytic activation of PKCδ signaling Research Paper

Evaluation of cancer-derived myocardial impairments using a mouse model Research Paper

Evaluation of cellular alterations and inflammatory profile of mesothelial cells and/or neoplastic cells exposed to talc used for pleurodesis Research Paper

Ferroptosis of epithelial ovarian cancer: genetic determinants and therapeutic potential Research Perspective

Targeting breast cancer metabolism with a novel inhibitor of mitochondrial ATP synthesis Research Paper

Deconstructing tumor heterogeneity: the stromal perspective Meeting Report

Advances in epidermal growth factor receptor specific immunotherapy: lessons to be learned from armed antibodies Review

Downregulation of angulin-1/LSR induces malignancy via upregulation of EGF-dependent claudin-2 and TGF-β-dependent cell metabolism in human lung adenocarcinoma A549 cells Research Paper

NRXN1 as a novel potential target of antibody-drug conjugates for small cell lung cancer Research Paper

Down syndrome iPSC model: endothelial perspective on tumor development Research Paper

Targeted CRM1-inhibition perturbs leukemogenic NUP214 fusion proteins and exerts anti-cancer effects in leukemia cell lines with NUP214 rearrangements Research Paper

Therapeutic applications of the selective high affinity ligand drug SH7139 extend beyond non-Hodgkin’s lymphoma to many other types of solid cancers Research Paper

The temporal effects of topical NF-κB inhibition, in the in vivo prevention of bile-related oncogenic mRNA and miRNA phenotypes in murine hypopharyngeal mucosa: a preclinical model Research Paper

Sequencing for an interdisciplinary molecular tumor board in patients with advanced breast cancer: experiences from a case series Research Paper

A case report of metastatic giant sarcomatoid melanoma with BRAF V600E mutation: a complete response to targeted therapy Case Report

The bromodomain inhibitor IBET-151 attenuates vismodegib-resistant esophageal adenocarcinoma growth through reduction of GLI signaling Research Paper

An integrative microenvironment approach for follicular lymphoma: roles of inflammatory cell subsets and immune-response polymorphisms on disease clinical course Research Paper

Urinary glycoproteomic profiling of non-muscle invasive and muscle invasive bladder carcinoma patients reveals distinct N-glycosylation pattern of CD44, MGAM, and GINM1 Research Paper

Differentially expressed full-length, fusion and novel isoforms transcripts-based signature of well-differentiated keratinized oral squamous cell carcinoma Research Paper

Molecular profiling of melanoma brain metastases compared to primary cutaneous melanoma and to extracranial metastases Research Paper

Publication Alerts

European Cancer and Oncology Congress

Oncoscience

Post-Publication Promotion

Search Oncotarget

The pro-apoptotic actions of 2-methoxyestradiol against ovarian cancer involve catalytic activation of PKCδ signaling Research Paper

Evaluation of cancer-derived myocardial impairments using a mouse model Research Paper

Evaluation of cellular alterations and inflammatory profile of mesothelial cells and/or neoplastic cells exposed to talc used for pleurodesis Research Paper

Ferroptosis of epithelial ovarian cancer: genetic determinants and therapeutic potential Research Perspective

Targeting breast cancer metabolism with a novel inhibitor of mitochondrial ATP synthesis Research Paper

Deconstructing tumor heterogeneity: the stromal perspective Meeting Report

Advances in epidermal growth factor receptor specific immunotherapy: lessons to be learned from armed antibodies Review

Downregulation of angulin-1/LSR induces malignancy via upregulation of EGF-dependent claudin-2 and TGF-β-dependent cell metabolism in human lung adenocarcinoma A549 cells Research Paper

NRXN1 as a novel potential target of antibody-drug conjugates for small cell lung cancer Research Paper

Down syndrome iPSC model: endothelial perspective on tumor development Research Paper

Targeted CRM1-inhibition perturbs leukemogenic NUP214 fusion proteins and exerts anti-cancer effects in leukemia cell lines with NUP214 rearrangements Research Paper

Therapeutic applications of the selective high affinity ligand drug SH7139 extend beyond non-Hodgkin’s lymphoma to many other types of solid cancers Research Paper

The temporal effects of topical NF-κB inhibition, in the in vivo prevention of bile-related oncogenic mRNA and miRNA phenotypes in murine hypopharyngeal mucosa: a preclinical model Research Paper

Sequencing for an interdisciplinary molecular tumor board in patients with advanced breast cancer: experiences from a case series Research Paper

A case report of metastatic giant sarcomatoid melanoma with BRAF V600E mutation: a complete response to targeted therapy Case Report

The bromodomain inhibitor IBET-151 attenuates vismodegib-resistant esophageal adenocarcinoma growth through reduction of GLI signaling Research Paper

An integrative microenvironment approach for follicular lymphoma: roles of inflammatory cell subsets and immune-response polymorphisms on disease clinical course Research Paper

Urinary glycoproteomic profiling of non-muscle invasive and muscle invasive bladder carcinoma patients reveals distinct N-glycosylation pattern of CD44, MGAM, and GINM1 Research Paper

Differentially expressed full-length, fusion and novel isoforms transcripts-based signature of well-differentiated keratinized oral squamous cell carcinoma Research Paper

Molecular profiling of melanoma brain metastases compared to primary cutaneous melanoma and to extracranial metastases Research Paper