The Oncosearch | Oncotarget

Role of aberrant PI3K pathway activation in gallbladder tumorigenesis Priority Research Paper

Andrea Lunardi, Kaitlyn A. Webster, Antonella Papa, Bhavik Padmani, John G. Clohessy, Roderick T. Bronson, Pier Paolo Pandolfi

Published Mar 10, 2014 · Vol. 5, No. 4 · pp. 894-900

Epigenetic repression of phosphatidylethanolamine N-methyltransferase (PEMT) in BRCA1-mutated breast cancer Research Paper

Da Li, Fang-Fang Bi, Na-Na Chen, Ji-Min Cao, Wu-Ping Sun, Yi-Ming Zhou, Chen Cao, Chun-Yan Li, Qing Yang

Published Feb 27, 2014 · Vol. 5, No. 5 · pp. 1315-1325

WNT signaling and distant metastasis in colon cancer through transcriptional activity of nuclear Î²-Catenin depend on active PI3K signaling Research Paper

Steffen Ormanns, Jens Neumann, David Horst, Thomas Kirchner, Andreas Jung

Published Feb 19, 2014 · Vol. 5, No. 10 · pp. 2999-3011

Keywords: WNT, Î²-Catenin, PI3K, colon cancer, metastasis

SIRT1 promotes proliferation and inhibits the senescence-like phenotype in human melanoma cells Research Paper

MickaÃ«l Ohanna, Caroline Bonet, Karine Bille, Maryline Allegra, Irwin Davidson, Philippe Bahadoran, Jean-Philippe Lacour, Robert Ballotti, Corine Bertolotto

Published Feb 19, 2014 · Vol. 5, No. 8 · pp. 2085-2095

PHLPP2 suppresses the NF-ÎºB pathway by inactivating IKKÎ² kinase Research Paper

Nitin Kumar Agarwal, Xiaoping Zhu, Mihai Gagea, Charles L. White, Gilbert Cote, Maria-Magdalena Georgescu

Published Feb 13, 2014 · Vol. 5, No. 3 · pp. 815-823

Hypomethylation of the CTCFL/BORIS promoter and aberrant expression during endometrial cancer progression suggests a role as an Epi-driver gene Research Paper

Erling A. Hoivik, Kanthida Kusonmano, Mari K. Halle, Anna Berg, Elisabeth Wik, Henrica M. J. Werner, Kjell Petersen, Anne M. Oyan, Karl-Henning Kalland, Camilla Krakstad, Jone Trovik, Martin Widschwendter, Helga B. Salvesen

Published Jan 28, 2014 · Vol. 5, No. 4 · pp. 1052-1061

Keywords: CTCFL/BORIS, endometrial cancer, Epi-driver gene, recurrence, metastasis

Vaccinia-related kinase 1 (VRK1) confers resistance to DNA-damaging agents in human breast cancer by affecting DNA damage response Research Paper

Marcella Salzano, Marta VÃ¡zquez-Cedeira, Marta Sanz-GarcÃa, Alberto Valbuena, Sandra Blanco, Isabel F. FernÃ¡ndez, Pedro A. Lazo

Published Jan 17, 2014 · Vol. 5, No. 7 · pp. 1770-1778

Keywords: Breast cancer, VRK1, Radiation, doxorubicin, chemotherapy, DNA damage, 53BP1

Repression of PLA2R1 by c-MYC and HIF-2alpha promotes cancer growth Research Paper

David Vindrieux, Guillaume Devailly, Arnaud Augert, Benjamin Le Calve, Mylene Ferrand, Pascal Pigny, Lea Payen, Gerard Lambeau, Michael Perrais, Sebastien Aubert, HÃ©lÃ¨ne Simonnet, Robert Dante, David Bernard

Published Jan 16, 2014 · Vol. 5, No. 4 · pp. 1004-1013

Keywords: VHL, MYC, HIF, PLA2R1, tumor suppressor

Role of miR-34a as a suppressor of L1CAM in endometrial carcinoma Research Paper

Uwe Schirmer, Kai Doberstein, Anne-Kathleen Rupp, Niko P. Bretz, Daniela Wuttig, Helena Kiefel, Christian Breunig, Heidi Fiegl, Elisabeth MÃ¼ller-Holzner, Robert Zeillinger, Eva Schuster, Alain G. Zeimet, Holger SÃ¼ltmann, Peter Altevogt

Published Jan 12, 2014 · Vol. 5, No. 2 · pp. 462-472

Keywords: miR-34a, endometrial carcinoma, L1CAM, ovarian carcinoma

RB1 gene inactivation by chromothripsis in human retinoblastoma Research Paper

Justina McEvoy, Panduka Nagahawatte, David Finkelstein, Jennifer Richards-Yutz, Marcus Valentine, Jing Ma, Charles Mullighan, Guangchun Song, Xiang Chen, Matthew Wilson, Rachel Brennan, Stanely Pounds, Jared Becksfort, Robert Huether, Charles Lu, Robert S. Fulton, Lucinda L. Fulton, Xin Hong, David J. Dooling, Kerri Ochoa, Elaine R. Mardis, Richard K. Wilson, John Easton, Jinghui Zhang, James R. Downing, Arupa Ganguly, Michael A. Dyer

Published Jan 11, 2014 · Vol. 5, No. 2 · pp. 438-450

Keywords: chromothripsis, retinoblastoma, RB1, MYCN

WNT-pathway components as predictive markers useful for diagnosis, prevention and therapy in inflammatory bowel disease and sporadic colorectal cancer Research Paper

Annalucia Serafino, Noemi Moroni, Manuela Zonfrillo, Federica Andreola, Luana Mercuri, Giuseppe Nicotera, Joseph Nunziata, Riccardo Ricci, Armando Antinori, Guido Rasi, Pasquale Pierimarchi

Published Jan 11, 2014 · Vol. 5, No. 4 · pp. 978-992

Keywords: Wnt/Î²-catenin pathway, Colorectal carcinogenesis, Inflammatory Bowel Disease, Diagnostic/therapeutic biomarkers, Multiparametric analysis

Targeting CDC25C, PLK1 and CHEK1 to overcome Docetaxel resistance induced by loss of LZTS1 in prostate cancer Research Paper

Nader Al Nakouzi, Sophie Cotteret, FrÃ©dÃ©ric Commo, Catherine Gaudin, Shanna Rajpar, Philippe Dessen, Philippe Vielh, Karim Fizazi, Anne Chauchereau

Published Jan 6, 2014 · Vol. 5, No. 3 · pp. 667-678

Keywords: Prostate cancer, chemoresistance, LZTS1, CDC25C, PLK1, CHEK1

A loss-of-function mutation in PTCH1 suggests a role for autocrine hedgehog signaling in colorectal tumorigenesis Brief Reports

Jon H. Chung, Fred Bunz

Published Dec 11, 2013 · Vol. 4, No. 12 · pp. 2208-2211

Keywords: Hedgehog, colorectal cancer, Patched, vismodegib, autocrine

The polycomb group protein EZH2 is a novel therapeutic target in tongue cancer Research Paper

Zhongwu li, Yanling Wang, Jing Qiu, Qiang Li, Chunping Yuan, Wei Zhang, Dongmiao Wang, Jinhai Ye, Hongbin Jiang, Jianrong Yang, Jie Cheng

Published Dec 7, 2013 · Vol. 4, No. 12 · pp. 2532-2549

Keywords: tongue squamous cell carcinoma, polycomb complex, EZH2, DZNep

Glycogen synthase kinase-3Î² inhibition depletes the population of prostate cancer stem/progenitor-like cells and attenuates metastatic growth Research Paper

Jan Kroon, Lars S. in 't Veld, Jeroen T. Buijs, Henry Cheung, Geertje van der Horst, Gabri van der Pluijm

Published Dec 5, 2013 · Vol. 5, No. 19 · pp. 8986-8994

Keywords: Cancer Stem Cells, GSK-3Î², Metastasis, Prostate Cancer, Wnt signaling

Epigenetic silencing of microRNA-199b-5p is associated with acquired chemoresistance via activation of JAG1-Notch1 signaling in ovarian cancer Research Paper

Michelle X. Liu, Michelle KY. Siu, Stephanie S. Liu, Judy WP. Yam, Hextan YS. Ngan, David W. Chan

Published Dec 4, 2013 · Vol. 5, No. 4 · pp. 944-958

Keywords: MiR-199b-5p, JAG1-Notch1, acquired chemoresistance, epithelial ovarian cancer

Loss of E-cadherin activates EGFR-MEK/ERK signaling, which promotes invasion via the ZEB1/MMP2 axis in non-small cell lung cancer Research Paper

Gab-Yong Bae, So-Jung Choi, Ji-Seon Lee, Jisuk Jo, Jinseon Lee, Jhingook Kim, Hyuk-Jin Cha

Published Nov 29, 2013 · Vol. 4, No. 12 · pp. 2512-2522

Keywords: E-Cadherin, EGFR-MEK/ERK signaling, ZEB1, MMP2, Invasion

Ovarian cancer stem-like cells with induced translineage-differentiation capacity and are suppressed by alkaline phosphatase inhibitor Research Paper

Kuei-Chun Liu, Yi-Te Yo, Rui-Lan Huang, Yu-Chi Wang, Yu-Ping Liao, Tien-Shuo Huang, Tai-Kuang Chao, Chi-Kang Lin, Shao-Ju Weng, Kuo-Hsing Ma, Cheng-Chang Chang, Mu-Hsien Yu, Hung-Cheng Lai

Published Nov 16, 2013 · Vol. 4, No. 12 · pp. 2366-2382

Keywords: alkaline phosphatase, cancer stem-like cells, epithelial-mesenchymal transition, epithelial ovarian cancer, levamisole, trans-lineage differentiation

SCF^Î²-TRCP targets MTSS1 for ubiquitination-mediated destruction to regulate cancer cell proliferation and migration Research Paper

Jiateng Zhong, Shavali Shaik, Lixin Wan, Adriana E. Tron, Zhiwei Wang, Liankun Sun, Hiroyuki Inuzuka, Wenyi Wei

Published Nov 6, 2013 · Vol. 4, No. 12 · pp. 2339-2353

Keywords: tumor suppressor, MTSS1, ubiquitination, phosphorylation, migration

KMT2D maintains neoplastic cell proliferation and global histone H3 lysine 4 monomethylation Research Paper

Changcun Guo, Lee H. Chen, Yafen Huang, Chun-Chi Chang, Ping Wang, Christopher J. Pirozzi, Xiaoxia Qin, Xuhui Bao, Paula K. Greer, Roger E. McLendon, Hai Yan, Stephen T. Keir, Darell D. Bigner, Yiping He

Published Nov 3, 2013 · Vol. 4, No. 11 · pp. 2144-2153

Keywords: MLL2, isogenic cell line, gene knockout, enhancer

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Role of aberrant PI3K pathway activation in gallbladder tumorigenesis Priority Research Paper

Epigenetic repression of phosphatidylethanolamine N-methyltransferase (PEMT) in BRCA1-mutated breast cancer Research Paper

WNT signaling and distant metastasis in colon cancer through transcriptional activity of nuclear Î²-Catenin depend on active PI3K signaling Research Paper

SIRT1 promotes proliferation and inhibits the senescence-like phenotype in human melanoma cells Research Paper

PHLPP2 suppresses the NF-ÎºB pathway by inactivating IKKÎ² kinase Research Paper

Hypomethylation of the CTCFL/BORIS promoter and aberrant expression during endometrial cancer progression suggests a role as an Epi-driver gene Research Paper

Vaccinia-related kinase 1 (VRK1) confers resistance to DNA-damaging agents in human breast cancer by affecting DNA damage response Research Paper

Repression of PLA2R1 by c-MYC and HIF-2alpha promotes cancer growth Research Paper

Role of miR-34a as a suppressor of L1CAM in endometrial carcinoma Research Paper

RB1 gene inactivation by chromothripsis in human retinoblastoma Research Paper

WNT-pathway components as predictive markers useful for diagnosis, prevention and therapy in inflammatory bowel disease and sporadic colorectal cancer Research Paper

Targeting CDC25C, PLK1 and CHEK1 to overcome Docetaxel resistance induced by loss of LZTS1 in prostate cancer Research Paper

A loss-of-function mutation in PTCH1 suggests a role for autocrine hedgehog signaling in colorectal tumorigenesis Brief Reports

The polycomb group protein EZH2 is a novel therapeutic target in tongue cancer Research Paper

Glycogen synthase kinase-3Î² inhibition depletes the population of prostate cancer stem/progenitor-like cells and attenuates metastatic growth Research Paper

Epigenetic silencing of microRNA-199b-5p is associated with acquired chemoresistance via activation of JAG1-Notch1 signaling in ovarian cancer Research Paper

Loss of E-cadherin activates EGFR-MEK/ERK signaling, which promotes invasion via the ZEB1/MMP2 axis in non-small cell lung cancer Research Paper

Ovarian cancer stem-like cells with induced translineage-differentiation capacity and are suppressed by alkaline phosphatase inhibitor Research Paper

SCF^Î²-TRCP targets MTSS1 for ubiquitination-mediated destruction to regulate cancer cell proliferation and migration Research Paper

KMT2D maintains neoplastic cell proliferation and global histone H3 lysine 4 monomethylation Research Paper

Publication Alerts

European Cancer and Oncology Congress

Oncoscience

Post-Publication Promotion

Search Oncotarget

Role of aberrant PI3K pathway activation in gallbladder tumorigenesis Priority Research Paper

Epigenetic repression of phosphatidylethanolamine N-methyltransferase (PEMT) in BRCA1-mutated breast cancer Research Paper

WNT signaling and distant metastasis in colon cancer through transcriptional activity of nuclear Î²-Catenin depend on active PI3K signaling Research Paper

SIRT1 promotes proliferation and inhibits the senescence-like phenotype in human melanoma cells Research Paper

PHLPP2 suppresses the NF-ÎºB pathway by inactivating IKKÎ² kinase Research Paper

Hypomethylation of the CTCFL/BORIS promoter and aberrant expression during endometrial cancer progression suggests a role as an Epi-driver gene Research Paper

Vaccinia-related kinase 1 (VRK1) confers resistance to DNA-damaging agents in human breast cancer by affecting DNA damage response Research Paper

Repression of PLA2R1 by c-MYC and HIF-2alpha promotes cancer growth Research Paper

Role of miR-34a as a suppressor of L1CAM in endometrial carcinoma Research Paper

RB1 gene inactivation by chromothripsis in human retinoblastoma Research Paper

WNT-pathway components as predictive markers useful for diagnosis, prevention and therapy in inflammatory bowel disease and sporadic colorectal cancer Research Paper

Targeting CDC25C, PLK1 and CHEK1 to overcome Docetaxel resistance induced by loss of LZTS1 in prostate cancer Research Paper

A loss-of-function mutation in PTCH1 suggests a role for autocrine hedgehog signaling in colorectal tumorigenesis Brief Reports

The polycomb group protein EZH2 is a novel therapeutic target in tongue cancer Research Paper

Glycogen synthase kinase-3Î² inhibition depletes the population of prostate cancer stem/progenitor-like cells and attenuates metastatic growth Research Paper

Epigenetic silencing of microRNA-199b-5p is associated with acquired chemoresistance via activation of JAG1-Notch1 signaling in ovarian cancer Research Paper

Loss of E-cadherin activates EGFR-MEK/ERK signaling, which promotes invasion via the ZEB1/MMP2 axis in non-small cell lung cancer Research Paper

Ovarian cancer stem-like cells with induced translineage-differentiation capacity and are suppressed by alkaline phosphatase inhibitor Research Paper

SCFÎ²-TRCP targets MTSS1 for ubiquitination-mediated destruction to regulate cancer cell proliferation and migration Research Paper

KMT2D maintains neoplastic cell proliferation and global histone H3 lysine 4 monomethylation Research Paper

SCF^Î²-TRCP targets MTSS1 for ubiquitination-mediated destruction to regulate cancer cell proliferation and migration Research Paper