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Phosphatase inhibitor, sodium stibogluconate, in combination with interferon (IFN) alpha 2b: phase I trials to identify pharmacodynamic and clinical effects Research Paper

Taolin Yi, Paul Elson, Masato Mitsuhashi, Barbara Jacobs, Emese Hollovary, G. Thomas Budd, Timothy Spiro, Pierre Triozzi, Ernest Borden

Published Dec 22, 2011 · Vol. 2, No. 12 · pp. 1155-1164

Geminin overexpression induces mammary tumors via suppressing cytokinesis. Research Paper

Zannel Blanchard, Rohit Malik, Nicole Mullins, Christine Maric, Hugh Luk, David Horio, Brenda Hernandez, Jeffrey Killeen, Wael M. ElShamy

Published Dec 17, 2011 · Vol. 2, No. 12 · pp. 1011-1027

Keywords: Geminin, breast cancer, aneuploidy, Aurora B kinase, xenograft and orthotopic mouse tumors.

PinX1: a sought-after major tumor suppressor at human chromosome 8p23 Research Perspective

Xiao Zhen Zhou

Published Oct 20, 2011 · Vol. 2, No. 10 · pp. 810-819

Keywords: Tumor suppressor, telomerase inhibitor, PinX1, chromosome instabilty, 8p23, LOH

Propranolol potentiates the anti-angiogenic effects and anti-tumor efficacy of chemotherapy agents: implication in breast cancer treatment Research Paper

Eddy Pasquier, Joseph Ciccolini, Manon Carre, Sarah Giacometti, Raphaelle Fanciullino, Charlotte Pouchy, Marie-Pierre Montero, Cindy Serdjebi, Maria Kavallaris, Nicolas Andre

Published Oct 17, 2011 · Vol. 2, No. 10 · pp. 797-809

Keywords: breast cancer, angiogenesis, propranolol, beta-adrenergic receptor antagonist, chemotherapy, combination therapy

Lithocholic bile acid selectively kills neuroblastoma cells, while sparing normal neuronal cells Research Paper

Alexander A. Goldberg, Adam Beach, Gerald F. Davies, Troy A.A. Harkness, AndrÃ©a LeBlanc, Vladimir I. Titorenko

Published Oct 11, 2011 · Vol. 2, No. 10 · pp. 761-782

Keywords: age-related diseases, cancer, neuroblastoma, breast cancer, glioma, anti-cancer drugs, apoptosis, bile acids, lithocholic acid

Identification and enumeration of circulating tumor cells in the cerebrospinal fluid of breast cancer patients with central nervous system metastases Research Paper

Akshal S. Patel, Joshua E. Allen, David T. Dicker, Kristi L. Peters, Jonas M. Sheehan, Michael J. Glantz, Wafik S. El-Deiry

Published Oct 8, 2011 · Vol. 2, No. 10 · pp. 752-760

Keywords: circulating tumor cells, carcinomatous meningitis, breast cancer, brain metastases, intrathecal chemotherapy, cancer monitoring

Wiring the oncogenic circuitry: Pin1 unleashes mutant p53 Editorial Comments

Marco Napoli, Javier E. Girardini, Silvano Piazza, Giannino Del Sal

Published Sep 15, 2011 · Vol. 2, No. 9 · pp. 654-656

Keywords: Mutant p53 gain of function, prolyl isomerase Pin1, breast cancer

Assessment of EGFR/HER2 dimerization by FRET-FLIM utilizing Alexa-conjugated secondary antibodies in relation to targeted therapies in cancers Methodological Reports

Benjamin R. Waterhouse, Merel Gijsen, Paul R. Barber, Iain D.C. Tullis, Borivoj Vojnovic, Anthony Kong

Published Sep 8, 2011 · Vol. 2, No. 9 · pp. 728-736

Keywords: HER (ErbB) receptors, EGFR, HER2 (ErbB2), dimerization, FRET, FLIM

Global 5-hydroxymethylcytosine content is significantly reduced in tissue stem/progenitor cell compartments and in human cancers Research Paper

Michael Christoph Haffner, Alcides Chaux, Alan K Meeker, David Esopi, Jonathan Gerber, Laxmi G. Pellakuru, Antoun Toubaji, Pedram Argani, Christine Iacobuzio-Donahue, William G. Nelson, George J. Netto, Angelo DeMarzo, Srinivasan Yegnasubramanian

Published Sep 2, 2011 · Vol. 2, No. 8 · pp. 627-637

Keywords: 5-hydroxymethylcytosine, 5hmC, DNA methylation, differentiation, cancer, tissue stem / progenitor cells

Cooperative Effects of Akt-1 and Raf-1 on the Induction of Cellular Senescence in Doxorubicin or Tamoxifen Treated Breast Cancer Cells Research Paper

Jackson R. Taylor, Brian D. Lehmann, William H. Chappell, Stephen L. Abrams, Linda S. Steelman, James A. McCubrey

Published Aug 30, 2011 · Vol. 2, No. 8 · pp. 610-626

Keywords: Akt, ERK, mTOR, Senescence, Drug Resistance, Tamoxifen

Unraveling the complexity of basal-like breast cancer Editorial Comments

Lauren L. C. Marotta, Kornelia Polyak

Published Aug 28, 2011 · Vol. 2, No. 8 · pp. 588-589

Involvement of Akt-1 and mTOR in Sensitivity of Breast Cancer to Targeted Therapy Research Paper

Melissa L. Sokolosky, Kristin M. Stadelman, William H. Chappell, Stephen L. Abrams, Alberto M. Martelli, Franca Stivala, Massimo Libra, Ferdinando Nicoletti, Lyudmyla B. Drobot, Richard A. Franklin, Linda S. Steelman, James A. McCubrey

Published Jul 1, 2011 · Vol. 2, No. 7 · pp. 538-550

Keywords: Akt, mTOR, Targeted Therapy, Drug Resistance

Targeting invadopodia to block breast cancer metastasis Research Perspective

Mark A Eckert, Jing Yang

Published Jun 30, 2011 · Vol. 2, No. 7 · pp. 562-568

Keywords: Twist1, PDGFR, Src, MMP, MT1-MMP, SFK, metastasis, invasion, breast cancer, invadopodia, podosomes

A breast cancer meta-analysis of two expression measures of chromosomal instability reveals a relationship with younger age at diagnosis and high risk histopathological variables Research Paper

David Endesfelder, Nicholas McGranahan, Nicolai Juul Birkbak, Zoltan Szallasi, Maik Kschischo, Trevor Graham, Charles Swanton

Published Jun 25, 2011 · Vol. 2, No. 7 · pp. 529-537

Keywords: breast cancer, age, chromosomal instability, histopathological parameters

Lemur tyrosine kinase-3 (LMTK3) in cancer and evolution Editorial

Justin Stebbing, Aleksandra FilipoviÄ‡, Georgios Giamas

Published Jun 16, 2011 · Vol. 2, No. 6 · pp. 428-429

Keywords: breast cancer, LMTK3, evolution

p21-activated kinase 1: PAKâ€™ed with potential Research Perspective

Christy Ong, Adrian Jubb, Wei Zhou, Peter Haverty, Adrian Harris, Marcia Belvin, Lori Friedman, Hartmut Koeppen, Klaus Hoeflich

Published Jun 7, 2011 · Vol. 2, No. 6 · pp. 491-496

Keywords: PAK1, apoptosis, squamous, lung cancer, breast cancer

Elevated PI3K signaling drives multiple Breast Cancer subtypes Review

Jessica Adams, Nathan F. Schachter, Jeff C. Liu, Eldad Zacksenhaus, Sean Eoin Egan

Published Jun 5, 2011 · Vol. 2, No. 6 · pp. 435-447

Keywords: PIK3CA, Mouse models, Breast Cancer, PTEN, Akt, Metastasis

Network Modeling of MDM2 Inhibitor-Oxaliplatin Combination Reveals Biological Synergy in wt-p53 solid tumors Research Paper

Asfar S. Azmi, Sanjeev Banerjee, Shadan Ali, Zhiwei Wang, Bin Bao, Frances WJ Beck, Anthony F. Shields, Philip Philip, Fazlul H. Sarkar, Ramzi M. Mohammad

Published May 16, 2011 · Vol. 2, No. 5 · pp. 378-392

Keywords: p53, MDM2, MDM2 inhibitor, oxaliplatin, Systems biology, Network Modeling, Combination Synergy, Pancreatic ductal adenocarcinoma

Thioaptamer Conjugated Liposomes for Tumor Vasculature Targeting Research Paper

Aman P. Mann, Rohan C. Bhavane, Anoma Somasunderam, Brenda Liz Montalvo-Ortiz, Ketan B. Ghaghada, David Volk, RenÃ© Nieves-Alicea, K. Stephen Suh, Mauro Ferrari, Ananth Annapragada, David G. Gorenstein, Takemi Tanaka

Published May 7, 2011 · Vol. 2, No. 4 · pp. 298-304

Keywords: drug delivery, aptamer, E-selectin

Netrin-1 overexpression is predictive of ovarian malignancies Research Paper

Anastasios D. Papanastasiou, Georgios Pampalakis, Dionyssios Katsaros, Georgia Sotiropoulou

Published May 2, 2011 · Vol. 2, No. 5 · pp. 363-367

Keywords: Netrin-1 (NTN1), ovarian cancer, biomarker

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Phosphatase inhibitor, sodium stibogluconate, in combination with interferon (IFN) alpha 2b: phase I trials to identify pharmacodynamic and clinical effects Research Paper

Geminin overexpression induces mammary tumors via suppressing cytokinesis. Research Paper

PinX1: a sought-after major tumor suppressor at human chromosome 8p23 Research Perspective

Propranolol potentiates the anti-angiogenic effects and anti-tumor efficacy of chemotherapy agents: implication in breast cancer treatment Research Paper

Lithocholic bile acid selectively kills neuroblastoma cells, while sparing normal neuronal cells Research Paper

Identification and enumeration of circulating tumor cells in the cerebrospinal fluid of breast cancer patients with central nervous system metastases Research Paper

Wiring the oncogenic circuitry: Pin1 unleashes mutant p53 Editorial Comments

Assessment of EGFR/HER2 dimerization by FRET-FLIM utilizing Alexa-conjugated secondary antibodies in relation to targeted therapies in cancers Methodological Reports

Global 5-hydroxymethylcytosine content is significantly reduced in tissue stem/progenitor cell compartments and in human cancers Research Paper

Cooperative Effects of Akt-1 and Raf-1 on the Induction of Cellular Senescence in Doxorubicin or Tamoxifen Treated Breast Cancer Cells Research Paper

Unraveling the complexity of basal-like breast cancer Editorial Comments

Involvement of Akt-1 and mTOR in Sensitivity of Breast Cancer to Targeted Therapy Research Paper

Targeting invadopodia to block breast cancer metastasis Research Perspective

A breast cancer meta-analysis of two expression measures of chromosomal instability reveals a relationship with younger age at diagnosis and high risk histopathological variables Research Paper

Lemur tyrosine kinase-3 (LMTK3) in cancer and evolution Editorial

p21-activated kinase 1: PAKâ€™ed with potential Research Perspective

Elevated PI3K signaling drives multiple Breast Cancer subtypes Review

Network Modeling of MDM2 Inhibitor-Oxaliplatin Combination Reveals Biological Synergy in wt-p53 solid tumors Research Paper

Thioaptamer Conjugated Liposomes for Tumor Vasculature Targeting Research Paper

Netrin-1 overexpression is predictive of ovarian malignancies Research Paper

Publication Alerts

European Cancer and Oncology Congress

Oncoscience

Post-Publication Promotion

Search Oncotarget

Phosphatase inhibitor, sodium stibogluconate, in combination with interferon (IFN) alpha 2b: phase I trials to identify pharmacodynamic and clinical effects Research Paper

Geminin overexpression induces mammary tumors via suppressing cytokinesis. Research Paper

PinX1: a sought-after major tumor suppressor at human chromosome 8p23 Research Perspective

Propranolol potentiates the anti-angiogenic effects and anti-tumor efficacy of chemotherapy agents: implication in breast cancer treatment Research Paper

Lithocholic bile acid selectively kills neuroblastoma cells, while sparing normal neuronal cells Research Paper

Identification and enumeration of circulating tumor cells in the cerebrospinal fluid of breast cancer patients with central nervous system metastases Research Paper

Wiring the oncogenic circuitry: Pin1 unleashes mutant p53 Editorial Comments

Assessment of EGFR/HER2 dimerization by FRET-FLIM utilizing Alexa-conjugated secondary antibodies in relation to targeted therapies in cancers Methodological Reports

Global 5-hydroxymethylcytosine content is significantly reduced in tissue stem/progenitor cell compartments and in human cancers Research Paper

Cooperative Effects of Akt-1 and Raf-1 on the Induction of Cellular Senescence in Doxorubicin or Tamoxifen Treated Breast Cancer Cells Research Paper

Unraveling the complexity of basal-like breast cancer Editorial Comments

Involvement of Akt-1 and mTOR in Sensitivity of Breast Cancer to Targeted Therapy Research Paper

Targeting invadopodia to block breast cancer metastasis Research Perspective

A breast cancer meta-analysis of two expression measures of chromosomal instability reveals a relationship with younger age at diagnosis and high risk histopathological variables Research Paper

Lemur tyrosine kinase-3 (LMTK3) in cancer and evolution Editorial

p21-activated kinase 1: PAKâ€™ed with potential Research Perspective

Elevated PI3K signaling drives multiple Breast Cancer subtypes Review

Network Modeling of MDM2 Inhibitor-Oxaliplatin Combination Reveals Biological Synergy in wt-p53 solid tumors Research Paper

Thioaptamer Conjugated Liposomes for Tumor Vasculature Targeting Research Paper

Netrin-1 overexpression is predictive of ovarian malignancies Research Paper