The Oncosearch | Oncotarget

A differential role for CXCR4 in the regulation of normal versus malignant breast stem cell activity Research Paper

Matthew P Ablett, Ciara S O'Brien, Andrew H Sims, Gillian Farnie, Robert B Clarke

Published Jul 30, 2013 · Vol. 5, No. 3 · pp. 599-612

Keywords: CXCR4, stem cells, breast cancer, mammospheres, AMD3100, SDF-1

Crucial Role for Early Growth Response-1 in the Transcriptional Regulation of miR-20b in Breast Cancer Research Paper

Dongping Li, Yaroslav Ilnytskyy, Anna Kovalchuk, Levon M. Khachigian, Roderick T. Bronson, Bo Wang, Olga Kovalchuk

Published Jul 28, 2013 · Vol. 4, No. 9 · pp. 1373-1387

Keywords: EGR1, miR-20b, transcription, PTEN, BRCA1, breast cancer, proliferation, migration, cell cycle arrest

Accumulation of autophagosomes in breast cancer cells induces TRAIL resistance through downregulation of surface expression of death receptors 4 and 5 Research Paper

Xu Di, Guofeng Zhang, Yaqin Zhang, Kazuyo Takeda, Leslie A. Rivera Rosado, Baolin Zhang

Published Jul 27, 2013 · Vol. 4, No. 9 · pp. 1349-1364

Keywords: TRAIL resistance, basal autophagosomes, death receptors, cell surface expression

A Tumor initiating cell-enriched prognostic signature for HER2+:ERÎ±- breast cancer; rationale, new features, controversies and future directions Research Perspective

Jeff C. Liu, Sean E. Egan, Eldad Zacksenhaus

Published Jul 26, 2013 · Vol. 4, No. 8 · pp. 1317-1328

Keywords: Breast Cancer, HER2, prognostic signature, tumor-initiating cells

Neratinib overcomes trastuzumab resistance in HER2 amplified breast cancer Research Paper

Alexandra Canonici, Merel Gijsen, Maeve Mullooly, Ruth Bennett, Noujoude Bouguern, Kasper Pedersen, Neil A Oâ€™Brien, Ioannis Roxanis, Ji-Liang Li, Esther Bridge, Richard Finn, Dennis Slamon, Patricia McGowan, Michael J. Duffy, Norma Oâ€™Donovan, John Crown, Anthony Kong

Published Jul 25, 2013 · Vol. 4, No. 10 · pp. 1592-1605

Keywords: breast cancer, HER2/ErbB2, trastuzumab (Herceptin), neratinib, panHER inhibitor

Cancer Metabolism: New Validated Targets for Drug Discovery Research Perspective

Federica Sotgia, Ubaldo E. Martinez-Outschoorn, Michael P Lisanti

Published Jul 22, 2013 · Vol. 4, No. 8 · pp. 1309-1316

Keywords: cancer metabolism, therapeutic targets, drug discovery

A new Achilles Heel in breast cancer? Editorial Broadcast

George Sflomos, Cathrin Brisken

Published Jul 15, 2013 · Vol. 4, No. 8 · pp. 1126-1127

Small Molecule-Induced Mitochondrial Disruption Directs Prostate Cancer Inhibition via Unfolded Protein Response Signaling Research Paper

Elizabeth Rico-Bautista, Wenhong Zhu, Shinichi Kitada, Suthakar Ganapathy, Eric Lau, Stan Krajewski, Joel Ramirez, Jason A. Bush, Zhimin Yuan, Dieter A. Wolf

Published Jul 14, 2013 · Vol. 4, No. 8 · pp. 1212-1229

Keywords: Prostate cancer, cell cycle arrest, apoptosis, oxidative stress, small molecule inhibitor, mitochondrial function

HMGA1 promotes metastatic processes in basal-like breast cancer regulating EMT and stemness Research Paper

Silvia Pegoraro, Gloria Ros, Silvano Piazza, Roberta Sommaggio, Yari Ciani, Antonio Rosato, Riccardo Sgarra, Giannino Del Sal, Guidalberto Manfioletti

Published Jul 9, 2013 · Vol. 4, No. 8 · pp. 1293-1308

Keywords: Epithelial to mesenchymal transition, stemness, HMGA1, breast cancer, invasion, metastasis, gene-signature

Targeting mixed lineage kinases in ER-positive breast cancer cells leads to G2/M cell cycle arrest and apoptosis. Research Paper

Limin Wang, Kathleen A Gallo, Susan E Conrad

Published Jul 7, 2013 · Vol. 4, No. 8 · pp. 1158-1171

Keywords: breast cancer, kinase inhibitors, cell cycle, apoptosis

Targeting Mutant p53 by a SIRT1 Activator YK-3-237 Inhibits the Proliferation of Triple-Negative Breast Cancer Cells Research Paper

Yong Weon Yi, Hyo Jin Kang, Hee Jeong Kim, Yali Kong, Milton M. Brown, Insoo Bae

Published Jul 5, 2013 · Vol. 4, No. 7 · pp. 984-994

Keywords: mutant p53 (mtp53), deacetylation, SIRT1, activator, triple-negative breast cancer (TNBC)

Acetylation of the Cell-Fate Factor Dachshund Determines p53 Binding and Signaling Modules in Breast Cancer Research Paper

Ke Chen, Kongming Wu, Michael Gormley, Adam Ertel, Wei Zhang, Jie Zhou, Gabriele DiSante, Zhiping Li, Hallgeir Rui, Andrew A. Quong, Steven B. McMahon, Haiteng Deng, Michael P. Lisanti, Chenguang Wang, Richard G. Pestell

Published Jun 21, 2013 · Vol. 4, No. 6 · pp. 923-935

Keywords: p53, breast cancer, cell fate, stem cells, dach

pRb controls Estrogen Receptor alpha protein stability and activity Research Paper

Isabella Caligiuri, Giuseppe Toffoli, Antonio Giordano, Flavio Rizzolio

Published Jun 3, 2013 · Vol. 4, No. 6 · pp. 875-883

Keywords: pRb, Estrogen receptor alpha, proteasome, chaperone proteins, breast cancer

Regulation of mechanical stress by mammary epithelial tissue structure controls breast cancer cell invasion Editorial

Derek C Radisky, Celeste M Nelson

Published Apr 12, 2013 · Vol. 4, No. 4 · pp. 498-499

Keywords: microenvironment, invasion, mechanical stress, host tissue

Prostate derived Ets transcription factor and Carcinoembryonic antigen related cell adhesion molecule 6 constitute a highly active oncogenic axis in breast cancer Research Paper

Alka Mukhopadhyay, Thaer Khoury, Leighton Stein, Protul Shrikant, Ashwani K. Sood

Published Apr 10, 2013 · Vol. 4, No. 4 · pp. 610-621

Keywords: PDEF, SPDEF, CEACAM6, Elevated co-expression, Tumor cell survival, PDEF-CEACAM6 oncogenic axis, Novel targets in breast cancer

Linked-In: Design and Efficacy of Antibody Drug Conjugates in Oncology Review

Jonathan Feld, Stefan K. Barta, Carolina Schinke, Ira Braunschweig, Yiyu Zhou, Amit K. Verma

Published Mar 26, 2013 · Vol. 4, No. 3 · pp. 397-412

Keywords: antibody drug conjugates, oncotargets, immunotoxins

A kinase-independent biological activity for insulin growth factor-1 receptor (IGF-1R) : implications for inhibition of the IGF-1R signal Research Paper

Filip Janku, Helen J. Huang, Laura S. Angelo, Razelle Kurzrock

Published Mar 23, 2013 · Vol. 4, No. 3 · pp. 463-473

Keywords: IGF-1R, OSI-906, intracellular glucose, autophagy, MCF7, HEK293

The Paradox of E-Cadherin: Role in response to hypoxia in the tumor microenvironment and regulation of energy metabolism Research Paper

Khoi Chu, Kimberkey M. Boley, Ricardo Moraes, Sanford H. Barsky, Fredika M. Robertson

Published Mar 21, 2013 · Vol. 4, No. 3 · pp. 446-462

Keywords: E-Cadherin, Inflammatory Breast Cander, Mesenchymal-Epithelial transition (MET), HIF-1Î±, Metabolism, Glycolysis

Luteolin is a novel p90 ribosomal S6 kinase (RSK) inhibitor that suppresses Notch4 signaling by blocking the activation of Y-box binding protein-1 (YB-1) Research Paper

Kristen M. Reipas, Jennifer H. Law, Nicole Couto, Sumaiya Islam, Yvonne Li, Huifang Li, Artem Cherkasov, Karen Jung, Amarpal S. Cheema, Steven J.M. Jones, John A. Hassell, Sandra E. Dunn

Published Feb 27, 2013 · Vol. 4, No. 2 · pp. 329-345

Keywords: Triple-negative breast cancer, p90 ribosomal S6 kinase, Y-box binding protein-1, tumor-initiating cells, drug repositioning

Comedo-DCIS is a precursor lesion for basal-like breast carcinoma: identification of a novel p63/Her2/neu expressing subgroup Research Paper

Malathy PV Shekhar, Ikuko Kato, Pratima Nangia-Makker, Larry Tait

Published Feb 24, 2013 · Vol. 4, No. 2 · pp. 231-241

Keywords: breast cancer, p63, Her2/neu, cytokeratin, EGFR

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A differential role for CXCR4 in the regulation of normal versus malignant breast stem cell activity Research Paper

Crucial Role for Early Growth Response-1 in the Transcriptional Regulation of miR-20b in Breast Cancer Research Paper

Accumulation of autophagosomes in breast cancer cells induces TRAIL resistance through downregulation of surface expression of death receptors 4 and 5 Research Paper

A Tumor initiating cell-enriched prognostic signature for HER2+:ERÎ±- breast cancer; rationale, new features, controversies and future directions Research Perspective

Neratinib overcomes trastuzumab resistance in HER2 amplified breast cancer Research Paper

Cancer Metabolism: New Validated Targets for Drug Discovery Research Perspective

A new Achilles Heel in breast cancer? Editorial Broadcast

Small Molecule-Induced Mitochondrial Disruption Directs Prostate Cancer Inhibition via Unfolded Protein Response Signaling Research Paper

HMGA1 promotes metastatic processes in basal-like breast cancer regulating EMT and stemness Research Paper

Targeting mixed lineage kinases in ER-positive breast cancer cells leads to G2/M cell cycle arrest and apoptosis. Research Paper

Targeting Mutant p53 by a SIRT1 Activator YK-3-237 Inhibits the Proliferation of Triple-Negative Breast Cancer Cells Research Paper

Acetylation of the Cell-Fate Factor Dachshund Determines p53 Binding and Signaling Modules in Breast Cancer Research Paper

pRb controls Estrogen Receptor alpha protein stability and activity Research Paper

Regulation of mechanical stress by mammary epithelial tissue structure controls breast cancer cell invasion Editorial

Prostate derived Ets transcription factor and Carcinoembryonic antigen related cell adhesion molecule 6 constitute a highly active oncogenic axis in breast cancer Research Paper

Linked-In: Design and Efficacy of Antibody Drug Conjugates in Oncology Review

A kinase-independent biological activity for insulin growth factor-1 receptor (IGF-1R) : implications for inhibition of the IGF-1R signal Research Paper

The Paradox of E-Cadherin: Role in response to hypoxia in the tumor microenvironment and regulation of energy metabolism Research Paper

Luteolin is a novel p90 ribosomal S6 kinase (RSK) inhibitor that suppresses Notch4 signaling by blocking the activation of Y-box binding protein-1 (YB-1) Research Paper

Comedo-DCIS is a precursor lesion for basal-like breast carcinoma: identification of a novel p63/Her2/neu expressing subgroup Research Paper

Publication Alerts

European Cancer and Oncology Congress

Oncoscience

Post-Publication Promotion

Search Oncotarget

A differential role for CXCR4 in the regulation of normal versus malignant breast stem cell activity Research Paper

Crucial Role for Early Growth Response-1 in the Transcriptional Regulation of miR-20b in Breast Cancer Research Paper

Accumulation of autophagosomes in breast cancer cells induces TRAIL resistance through downregulation of surface expression of death receptors 4 and 5 Research Paper

A Tumor initiating cell-enriched prognostic signature for HER2+:ERÎ±- breast cancer; rationale, new features, controversies and future directions Research Perspective

Neratinib overcomes trastuzumab resistance in HER2 amplified breast cancer Research Paper

Cancer Metabolism: New Validated Targets for Drug Discovery Research Perspective

A new Achilles Heel in breast cancer? Editorial Broadcast

Small Molecule-Induced Mitochondrial Disruption Directs Prostate Cancer Inhibition via Unfolded Protein Response Signaling Research Paper

HMGA1 promotes metastatic processes in basal-like breast cancer regulating EMT and stemness Research Paper

Targeting mixed lineage kinases in ER-positive breast cancer cells leads to G2/M cell cycle arrest and apoptosis. Research Paper

Targeting Mutant p53 by a SIRT1 Activator YK-3-237 Inhibits the Proliferation of Triple-Negative Breast Cancer Cells Research Paper

Acetylation of the Cell-Fate Factor Dachshund Determines p53 Binding and Signaling Modules in Breast Cancer Research Paper

pRb controls Estrogen Receptor alpha protein stability and activity Research Paper

Regulation of mechanical stress by mammary epithelial tissue structure controls breast cancer cell invasion Editorial

Prostate derived Ets transcription factor and Carcinoembryonic antigen related cell adhesion molecule 6 constitute a highly active oncogenic axis in breast cancer Research Paper

Linked-In: Design and Efficacy of Antibody Drug Conjugates in Oncology Review

A kinase-independent biological activity for insulin growth factor-1 receptor (IGF-1R) : implications for inhibition of the IGF-1R signal Research Paper

The Paradox of E-Cadherin: Role in response to hypoxia in the tumor microenvironment and regulation of energy metabolism Research Paper

Luteolin is a novel p90 ribosomal S6 kinase (RSK) inhibitor that suppresses Notch4 signaling by blocking the activation of Y-box binding protein-1 (YB-1) Research Paper

Comedo-DCIS is a precursor lesion for basal-like breast carcinoma: identification of a novel p63/Her2/neu expressing subgroup Research Paper