The Oncosearch | Oncotarget

Development of an orally-administrative MELK-targeting inhibitor that suppresses the growth of various types of human cancer Research Paper

Suyoun Chung, Hanae Suzuki, Takashi Miyamoto, Naofumi Takamatsu, Ayako Tatsuguchi, Koji Ueda, Kyoko Kijima, Yusuke Nakamura, Yo Matsuo

Published Dec 21, 2012 · Vol. 3, No. 12 · pp. 1629-1640

Keywords: oncogene, drug discovery, kinase inhibitor, cancer stem cell

High-throughput RNAi screening for novel modulators of vimentin expression identifies MTHFD2 as a regulator of breast cancer cell migration and invasion Research Paper

Laura Lehtinen, Kirsi Ketola, Rami MÃ¤kelÃ¤, John-Patrick Mpindi, Miro Viitala, Olli Kallioniemi, Kristiina Iljin

Published Dec 17, 2012 · Vol. 4, No. 1 · pp. 48-63

Keywords: Breast cancer, vimentin, MTHFD2

Functional analysis of non-hotspot AKT1 mutants found in human breast cancers identifies novel driver mutations: implications for personalized medicine Research Paper

Kyung H Yi, Jossette Axtmayer, John P Gustin, Anandita Rajpurohit, Josh Lauring

Published Nov 29, 2012 · Vol. 4, No. 1 · pp. 29-34

Keywords: AKT1, mutation, personalized, cancer, therapy

Autophagy-related gene 12 (ATG12) is a novel determinant of primary resistance to HER2-targeted therapies: Utility of transcriptome analysis of the autophagy interactome to guide breast cancer treatment Research Paper

SÃlvia CufÃ, Alejandro Vazquez-Martin, Ceistina Oliveras-Ferraros, Bruna Corominas-Faja, Ander Urruticoechea, BegoÃ±a Martin-Castillo, Javier A Menendez

Published Nov 17, 2012 · Vol. 3, No. 12 · pp. 1600-1614

Keywords: Autophagy, ATG genes, HER2, trastuzumab, lapatinib

Identification of acetylation-dependent regulatory mechanisms that govern the oncogenic functions of Skp2 Research Perspective

Zhiwei Wang, Hiroyuki Inuzuka, Jiateng Zhong, Pengda Liu, Fakul H Sarkar, Yi Sun, Wenyi Wei

Published Nov 16, 2012 · Vol. 3, No. 11 · pp. 1294-1300

Keywords: acetylation, cancer, deacetylation, SIRT3, oncoprotein, ubiquitination, phosphorylation, F-box protein, Skp2, therapy

MicroRNA miR-98 inhibits tumor angiogenesis and invasion by targeting activin receptor-like kinase-4 and matrix metalloproteinase-11 Research Paper

Vinayakumar Siragam, Zina Jeyapalan Rutnam, Weining Yang, Ling Fang, Linlin Luo, Xiangling Yan, Minhui Li, Zhaoqun Deng, Jun Qian, Chun Peng, Burton B. Yang

Published Nov 6, 2012 · Vol. 3, No. 11 · pp. 1370-1385

Keywords: microRNA, miR-98, angiogenesis, tumorigenesis, invasion

Effects of Ectopic Expression of NGAL on Doxorubicin Sensitivity. Research Paper

William H Chappell, Stephen L. Abrams, Richard A Franklin, Giuseppe Montalto, Melchiorre Cervello, Alberto M Martelli, Saverio Candido, Massimo Libra, Jerry Polesel, Renato Talamini, Ralph Arlinghaus, Linda S Steelman, James A McCubrey

Published Oct 20, 2012 · Vol. 3, No. 10 · pp. 1236-1245

Keywords: NGAL, Lcn2, Doxorubicin, lipocalins, siderocalins, iron transport, MMP-9, drug resistance

Genes affected by mouse mammary tumor virus (MMTV) proviral insertions in mouse mammary tumors are deregulated or mutated in primary human mammary tumors. Research Paper

Robert Callahan, Uma Mudunuri, Sharon Bargo, Ahmed Raafat, David McCurdy, Corinne Boulanger, William Lowther, Robert Stephens, Brian T. Luke, Claudia Stewart, Xiaolin Wu, David Munroe, Gilbert H. Smith

Published Oct 17, 2012 · Vol. 3, No. 11 · pp. 1320-1334

Keywords: mouse mammary tumor virus, premalignant lesions, mammary tumors, genes, human breast carcinomas, metastases

Phenotypic Screening Reveals Topoisomerase I as a Breast Cancer Stem Cell Therapeutic Target Research Paper

Fang Zhang, Kristi Rothermund, Sajithal B. Gangadharan, Yves Pommier, Edward V. Prochownik, John S. Lazo

Published Aug 31, 2012 · Vol. 3, No. 9 · pp. 998-1010

Keywords: : cancer stem cell, Topoisomerase I, small molecule inhibitor, compound library screening

Antagonists of growth hormone-releasing hormone suppress in vivo tumor growth and gene expression in triple negative breast cancers Research Paper

Roberto Perez, Andrew V Schally, Irving Vidaurre, Ricardo Rincon, Norman L Block, Ferenc G Rick

Published Aug 30, 2012 · Vol. 3, No. 9 · pp. 988-997

Keywords: neuropeptide analog, tumor gene expression, receptor silencing, targeted therapy, inflammation

Tumor suppression by small molecule inhibitors of translation initiation Research Paper

Limo Chen, Bertal H Aktas, Yibo wang, Xiaoying He, Rupam Sahoo, Nancy Zhang, Severine Denoyelle, Eihab Kabha, Hongwei Yang, Revital Yefidoff Freedman, Jeffrey G. Supko, Michael Chorev, Gerhard Wagner, Jose A. Halperin

Published Aug 25, 2012 · Vol. 3, No. 8 · pp. 869-881

Keywords: translation initiation, eIF4F, eIF4E, eIF2a, eIF4G

Mislocalization of death receptors correlates with cellular resistance to their cognate ligands in human breast cancer cells Research Paper

Baolin Zhang, Jun-Jie Chen, Jennifer H.-C. Shen, Leslie Rivera Rosado, Yaqin Zhang, Xu Di

Published Aug 19, 2012 · Vol. 3, No. 8 · pp. 833-842

Keywords: death receptors, cellular localization, breast cancer, targeted cancer therapy, drug resistance

Mitochondrial Fission Induces Glycolytic Reprogramming in Cancer-Associated Myofibroblasts, Driving Stromal Lactate Production, and Early Tumor Growth Research Paper

Carmela Guido, Diana Whitaker-Menezes, Zhao Lin, Richard G. Pestell, Anthony Howell, Teresa A. Zimmers, Mathew C. Casimiro, Saveria Aquila, Sebastiano Ando, Ubaldo E. Martinez-Outschoorn, Federica Sotgia, Michael P. Lisanti

Published Aug 7, 2012 · Vol. 3, No. 8 · pp. 798-810

Wt p53 impairs response to chemotherapy: make lemonade to spare normal cells Research Perspective

Mikhail V. Blagosklonny

Published Jul 12, 2012 · Vol. 3, No. 6 · pp. 601-607

Targeting of Rac GTPases blocks the spread of intact human breast cancer Research Paper

Elad Katz, Andrew H. Sims, Duncan Sproul, Helen Caldwell, J. Michael Dixon, Richard R. Meehan, David J. Harrison

Published Jun 9, 2012 · Vol. 3, No. 6 · pp. 608-619

Keywords: breast cancer, gtpases, rac1, stat3, invasion

Targeting Protein-Tyrosine Phosphatases in Breast Cancer Editorial Comments

Nicola Aceto, Mohamed Bentires-Alj

Published May 18, 2012 · Vol. 3, No. 5 · pp. 514-515

Keywords: Breast cancer, Protein-tyrosine phosphatases, SHP2, PTP1B

Metformin-induced preferential killing of breast cancer initiating CD44+CD24-/low cells is sufficient to overcome primary resistance to trastuzumab in HER2+ human breast cancer xenografts Brief Reports

SÃlvia CufÃ, Bruna Corominas-Faja, Alejandro Vazquez-Martin, Cristina Oliveras-Ferraros, Joan Dorca, Joaquim Bosch-Barrera, BegoÃ±a Martin-Castillo, Javier A Menendez

Published May 4, 2012 · Vol. 3, No. 4 · pp. 395-398

Keywords: metformin, trastuzumab, HER2, cancer stem cells, breast cancer

BRCA1/p220 loss triggers BRCA1-IRIS overexpression via mRNA stabilization in breast cancer cells Research Paper

Yoshiko Shimizu, Nicole Mullins, Zannel Blanchard, Wael M. ElShamy

Published Mar 19, 2012 · Vol. 3, No. 3 · pp. 299-313

Keywords: BRCA1/p220, BRCA1-IRIS, breast cancer, RNA stability, survival, invasion/metastasis.

Will PI3K pathway inhibitors be effective as single agents in patients with cancer? Research Perspective

Joan T. Garrett, Anindita Chakrabarty, Carlos L. Arteaga

Published Dec 31, 2011 · Vol. 2, No. 12 · pp. 1314-1321

The suppression of FOXM1 and its targets in breast cancer xenograft tumors by siRNA Research Paper

Ming Wang, Andrei L. Gartel

Published Dec 25, 2011 · Vol. 2, No. 12 · pp. 1218-1226

Keywords: FOXM1, siRNA, breast cancer, Aurora B kinase

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Development of an orally-administrative MELK-targeting inhibitor that suppresses the growth of various types of human cancer Research Paper

High-throughput RNAi screening for novel modulators of vimentin expression identifies MTHFD2 as a regulator of breast cancer cell migration and invasion Research Paper

Functional analysis of non-hotspot AKT1 mutants found in human breast cancers identifies novel driver mutations: implications for personalized medicine Research Paper

Autophagy-related gene 12 (ATG12) is a novel determinant of primary resistance to HER2-targeted therapies: Utility of transcriptome analysis of the autophagy interactome to guide breast cancer treatment Research Paper

Identification of acetylation-dependent regulatory mechanisms that govern the oncogenic functions of Skp2 Research Perspective

MicroRNA miR-98 inhibits tumor angiogenesis and invasion by targeting activin receptor-like kinase-4 and matrix metalloproteinase-11 Research Paper

Effects of Ectopic Expression of NGAL on Doxorubicin Sensitivity. Research Paper

Genes affected by mouse mammary tumor virus (MMTV) proviral insertions in mouse mammary tumors are deregulated or mutated in primary human mammary tumors. Research Paper

Phenotypic Screening Reveals Topoisomerase I as a Breast Cancer Stem Cell Therapeutic Target Research Paper

Antagonists of growth hormone-releasing hormone suppress in vivo tumor growth and gene expression in triple negative breast cancers Research Paper

Tumor suppression by small molecule inhibitors of translation initiation Research Paper

Mislocalization of death receptors correlates with cellular resistance to their cognate ligands in human breast cancer cells Research Paper

Mitochondrial Fission Induces Glycolytic Reprogramming in Cancer-Associated Myofibroblasts, Driving Stromal Lactate Production, and Early Tumor Growth Research Paper

Wt p53 impairs response to chemotherapy: make lemonade to spare normal cells Research Perspective

Targeting of Rac GTPases blocks the spread of intact human breast cancer Research Paper

Targeting Protein-Tyrosine Phosphatases in Breast Cancer Editorial Comments

Metformin-induced preferential killing of breast cancer initiating CD44+CD24-/low cells is sufficient to overcome primary resistance to trastuzumab in HER2+ human breast cancer xenografts Brief Reports

BRCA1/p220 loss triggers BRCA1-IRIS overexpression via mRNA stabilization in breast cancer cells Research Paper

Will PI3K pathway inhibitors be effective as single agents in patients with cancer? Research Perspective

The suppression of FOXM1 and its targets in breast cancer xenograft tumors by siRNA Research Paper

Publication Alerts

European Cancer and Oncology Congress

Oncoscience

Post-Publication Promotion

Search Oncotarget

Development of an orally-administrative MELK-targeting inhibitor that suppresses the growth of various types of human cancer Research Paper

High-throughput RNAi screening for novel modulators of vimentin expression identifies MTHFD2 as a regulator of breast cancer cell migration and invasion Research Paper

Functional analysis of non-hotspot AKT1 mutants found in human breast cancers identifies novel driver mutations: implications for personalized medicine Research Paper

Autophagy-related gene 12 (ATG12) is a novel determinant of primary resistance to HER2-targeted therapies: Utility of transcriptome analysis of the autophagy interactome to guide breast cancer treatment Research Paper

Identification of acetylation-dependent regulatory mechanisms that govern the oncogenic functions of Skp2 Research Perspective

MicroRNA miR-98 inhibits tumor angiogenesis and invasion by targeting activin receptor-like kinase-4 and matrix metalloproteinase-11 Research Paper

Effects of Ectopic Expression of NGAL on Doxorubicin Sensitivity. Research Paper

Genes affected by mouse mammary tumor virus (MMTV) proviral insertions in mouse mammary tumors are deregulated or mutated in primary human mammary tumors. Research Paper

Phenotypic Screening Reveals Topoisomerase I as a Breast Cancer Stem Cell Therapeutic Target Research Paper

Antagonists of growth hormone-releasing hormone suppress in vivo tumor growth and gene expression in triple negative breast cancers Research Paper

Tumor suppression by small molecule inhibitors of translation initiation Research Paper

Mislocalization of death receptors correlates with cellular resistance to their cognate ligands in human breast cancer cells Research Paper

Mitochondrial Fission Induces Glycolytic Reprogramming in Cancer-Associated Myofibroblasts, Driving Stromal Lactate Production, and Early Tumor Growth Research Paper

Wt p53 impairs response to chemotherapy: make lemonade to spare normal cells Research Perspective

Targeting of Rac GTPases blocks the spread of intact human breast cancer Research Paper

Targeting Protein-Tyrosine Phosphatases in Breast Cancer Editorial Comments

Metformin-induced preferential killing of breast cancer initiating CD44+CD24-/low cells is sufficient to overcome primary resistance to trastuzumab in HER2+ human breast cancer xenografts Brief Reports

BRCA1/p220 loss triggers BRCA1-IRIS overexpression via mRNA stabilization in breast cancer cells Research Paper

Will PI3K pathway inhibitors be effective as single agents in patients with cancer? Research Perspective

The suppression of FOXM1 and its targets in breast cancer xenograft tumors by siRNA Research Paper