The Oncosearch | Oncotarget

Lymphoid enhancer binding factor-1 (LEF1) expression as a prognostic factor in adult acute promyelocytic leukemia Research Paper

Francesco Albano, Antonella Zagaria, Luisa Anelli, Paola Orsini, Crescenzio F Minervini, Luciana Impera, Paola Casieri, Nicoletta Coccaro, Giuseppina Tota, Claudia Brunetti, Angela Minervini, Domenico Pastore, Paola Carluccio, Anna Mestice, Angelo Cellamare, Giorgina Specchia

Published Dec 19, 2013 · Vol. 5, No. 3 · pp. 649-658

Keywords: acute promyelocytic leukemia, LEF1, prognosis, outcome

ERG induces a mesenchymal-like state associated with chemoresistance in leukemia cells Research Paper

Liliana H. Mochmann, Martin Neumann, Eva K. von Der Heide, Verena Nowak, Anja A. KÃ¼hl, Jutta Ortiz-Tanchez, Juliane Bock, Wolf K Hofmann, Claudia D Baldus

Published Dec 4, 2013 · Vol. 5, No. 2 · pp. 351-362

Keywords: ERG, ERK, EMT, Chemoresistance

High Mdm4 levels suppress p53 activity and enhance its half-life in acute myeloid leukaemia Research Paper

Ban Xiong Tan, Kian Hoe Khoo, Tit Meng Lim, David Philip Lane

Published Nov 22, 2013 · Vol. 5, No. 4 · pp. 933-943

Keywords: p53, AML, Mdm4

Chemokines in tumor progression and metastasis Review

Purvaba J. Sarvaiya, Donna Guo, Ilya V. Ulasov, Patrik Gabikian, Maciej S. Lesniak

Published Nov 9, 2013 · Vol. 4, No. 12 · pp. 2171-2185

Keywords: Chemokines, chemokine receptors, cancer, metastasis

Indoleamine 2,3-dioxygenase 1 (IDO1) activity in leukemia blasts correlates with poor outcome in childhood acute myeloid leukemia Research Paper

Valentina Folgiero, Bianca M. Goffredo, Perla Filippini, Riccardo Masetti, Giuseppina Bonanno, Roberta Caruso, Valentina Bertaina, Angela Mastronuzzi, Stefania Gaspari, Marco Zecca, Giovanni F Torelli, Anna M Testi, Andrea Pession, Franco Locatelli, Sergio Rutella

Published Oct 30, 2013 · Vol. 5, No. 8 · pp. 2052-2064

Keywords: Acute myeloid leukemia, IDO1, immune escape, regulatory T cells

MYCN is a novel oncogenic target in pediatric T-cell Acute Lymphoblastic Leukemia Research Paper

Annalisa Astolfi, Francesca Vendemini, Milena Urbini, Fraia Melchionda, Riccardo Masetti, Monica Franzoni, Virginia Libri, Salvatore Serravalle, Marco Togni, Giuseppina Paone, Luca Montemurro, Daniela Bressanin, Francesca Chiarini, Alberto M Martelli, Roberto Tonelli, Andrea Pession

Published Sep 29, 2013 · Vol. 5, No. 1 · pp. 120-130

Keywords: pediatric T-ALL, MYCN, peptide nucleic acid, TAL1

HoxA9 regulated Bcl-2 expression mediates survival of myeloid progenitors and the severity of HoxA9-dependent leukemia Research Paper

Gabriela Brumatti, Marika Salmanidis, Chung H Kok, Rebecca A Bilardi, Jarrod J Sandow, Natasha Silke, Kylie Manson, Jolanda Visser, Anissa M Jabbour, Stefan P Glaser, Toru Okamoto, Philippe Bouillet, Richard J D'Andrea, Paul G Ekert

Published Sep 15, 2013 · Vol. 4, No. 11 · pp. 1933-1947

Keywords: HoxA9, Bcl-2, Leukemia, apoptosis

DHH-RHEBL1 fusion transcript: a novel recurrent feature in the new landscape of pediatric CBFA2T3-GLIS2-positive acute myeloid leukemia Research Paper

Riccardo Masetti, Marco Togni, Annalisa Astolfi, Martina Pigazzi, Elena Manara, Valentina Indio, Carmelo Rizzari, Sergio Rutella, Giuseppe Basso, Andrea Pession, Franco Locatelli

Published Sep 7, 2013 · Vol. 4, No. 10 · pp. 1712-1720

Keywords: pediatric acute myeloid leukemia, citogenetically normal acute myeloid leuekemia, whole-transcriptome massively parallel sequencing, CBFA2T3-GLIS2 fusion transcript, DHH-RHEBL1 fusion transcript.

CXXC5 (Retinoid-Inducible Nuclear Factor, RINF) is a Potential Therapeutic Target in High-Risk Human Acute Myeloid Leukemia Research Paper

Andrey Astori, Hanne Kristin Fredly, Thomas Aquinas Aloysius, Lars Bullinger, VÃ©ronique Mansat-De Mas, Pierre de la Grange, Francois Delhommeau, Karen Marie Hagen, Christian RÃ©cher, Isabelle Dusanter-Fourt, Stian Knappskog, Johan Richard Lillehaug, Frederic Pendino, Ã˜ystein Bruserud

Published Aug 15, 2013 · Vol. 4, No. 9 · pp. 1438-1448

Keywords: CXXC5, mRNA, acute myeloid leukemia, chemotherapy, apoptosis

Overcoming treatment resistance in acute promyelocytic leukemia and beyond Editorial Broadcast

Tsz Kan Fung, Chi Wai Eric So

Published Aug 4, 2013 · Vol. 4, No. 8 · pp. 1128-1129

Therapy-resistant acute lymphoblastic leukemia (ALL) cells inactivate FOXO3 to escape apoptosis induction by TRAIL and Noxa Research Paper

Michael J Ausserlechner, Christina Salvador, Andrea Deutschmann, Martin Bodner, Giampietro Viola, Roberta Bortolozzi, Guiseppe Basso, Judith Hagenbuchner, Petra Obexer

Published Jun 25, 2013 · Vol. 4, No. 7 · pp. 995-1007

Keywords: FOXO3/FKHRL1, T-ALL, p16/INK4A, BH3-only proteins, TRAIL

Potent antitumor activity of oncolytic adenovirus expressing Beclin-1 via induction of autophagic cell death in leukemia Research Paper

Yin Tong, Liangshun You, Hui Liu, Lu Li, Haitao Meng, Qijun Qian, Wenbin Qian

Published Jun 3, 2013 · Vol. 4, No. 6 · pp. 860-874

Keywords: leukemia, oncolytic adenovirus, autophagy, Beclin-1, autophagic cell death, UVRAG

Pharmacologic targeting of the PI3K/mTOR pathway controls release of angioregulators from primary human acute myeloid leukemia cells and their neighboring stromal cells Research Paper

HÃ¥kon Reikvam, Ina Nepstad, Ã˜ystein Bruserud, Kimberley Joanne Hatfield

Published May 11, 2013 · Vol. 4, No. 6 · pp. 830-843

Keywords: mTOR â€“ PI3K â€“ Angiogenesis â€“ Bone marrow microenvironment â€“ Pharmacological intervention

Cell death sensitization of leukemia cells by opioid receptor activation Research Paper

Claudia Friesen, Mareike Roscher, Inis Hormann, Iduna Fichtner, Andreas Alt, Ralf Hilger, Klaus-Michael Debatin, Erich Miltner

Published Apr 16, 2013 · Vol. 4, No. 5 · pp. 677-690

Keywords: opioids, methadone, doxorubicin, cAMP, apoptosis, acute lymphoblastic leukemia

Epidermal Growth Factor Receptor Tyrosine Kinase Inhibition Up-regulates Interleukin-6 in Cancer Cells and Induces Subsequent Development of Interstitial Pneumonia Research Paper

Yukari Ishiguro, Hitoshi Ishiguro, Hiroshi Miyamoto

Published Mar 31, 2013 · Vol. 4, No. 4 · pp. 550-559

Keywords: fibrosis, EGFR-TKI, IL-6, cytokine, side-effect

Gfi1 as a regulator of p53 and a therapeutic target for ALL Broadcast

Cyrus Khandanpour, Tarik MÃ¶rÃ¶y

Published Mar 18, 2013 · Vol. 4, No. 3 · pp. 374-375

Keywords: Gfi1, Acute Lymphoblastic Leukemia, p53, LDS1

Deregulation of the CDX2-KLF4 axis in acute myeloid leukemia and colon cancer Editorial

Arefeh Rouhi, Stefan FrÃ¶hling

Published Feb 21, 2013 · Vol. 4, No. 2 · pp. 174-175

Coordinate PI3K pathway and Bcl-2 family disruption in AML Editorial

Prithviraj Bose, Mohamed Rahmani, Steven Grant

Published Dec 31, 2012 · Vol. 3, No. 12 · pp. 1499-1500

Keywords: Acute myeloid leukemia, AML, PI3 kinase, Akt, mTOR, Bcl-2, Bcl-xL, Mcl-1, ABT-737, targeted therapies

A combination of temsirolimus, an allosteric mTOR inhibitor, with clofarabine as a new therapeutic option for patients with acute myeloid leukemia Research Paper

Francesca Chiarini, Annalisa Lonetti, Gabriella Teti, Ester Orsini, Daniela Bressanin, Alessandra Cappellini, Francesca Ricci, Pier Luigi Tazzari, Andrea Ognibene, Mirella Falconi, Pasqualepaolo Pagliaro, Ilaria Iacobucci, Giovanni Martinelli, Sergio Amadori, James A McCubrey, Alberto M Martelli

Published Dec 18, 2012 · Vol. 3, No. 12 · pp. 1615-1628

Keywords: AML, PI3K/Akt/mTOR signaling, apoptosis, autophagy combination therapy, leukemia initiating cells

Small-molecule inhibition of BRD4 as a new potent approach to eliminate leukemic stem- and progenitor cells in acute myeloid leukemia (AML) Research Paper

Harald Herrmann, Katharina Blatt, Junwei Shi, Karoline V. Gleixner, Sabine Cerny-Reiterer, Leonhard MÃ¼llauer, Christopher R. Vakoc, Wolfgang R. Sperr, Hans-Peter Horny, James E. Bradner, Johannes Zuber, Peter Valent

Published Nov 27, 2012 · Vol. 3, No. 12 · pp. 1588-1599

Keywords: AML, leukemic stem cells, BRD4, JQ1, targeted therapy

Publication Alerts

European Cancer and Oncology Congress

Post-Publication Promotion

Search Oncotarget

Lymphoid enhancer binding factor-1 (LEF1) expression as a prognostic factor in adult acute promyelocytic leukemia Research Paper

ERG induces a mesenchymal-like state associated with chemoresistance in leukemia cells Research Paper

High Mdm4 levels suppress p53 activity and enhance its half-life in acute myeloid leukaemia Research Paper

Chemokines in tumor progression and metastasis Review

Indoleamine 2,3-dioxygenase 1 (IDO1) activity in leukemia blasts correlates with poor outcome in childhood acute myeloid leukemia Research Paper

MYCN is a novel oncogenic target in pediatric T-cell Acute Lymphoblastic Leukemia Research Paper

HoxA9 regulated Bcl-2 expression mediates survival of myeloid progenitors and the severity of HoxA9-dependent leukemia Research Paper

DHH-RHEBL1 fusion transcript: a novel recurrent feature in the new landscape of pediatric CBFA2T3-GLIS2-positive acute myeloid leukemia Research Paper

CXXC5 (Retinoid-Inducible Nuclear Factor, RINF) is a Potential Therapeutic Target in High-Risk Human Acute Myeloid Leukemia Research Paper

Overcoming treatment resistance in acute promyelocytic leukemia and beyond Editorial Broadcast

Therapy-resistant acute lymphoblastic leukemia (ALL) cells inactivate FOXO3 to escape apoptosis induction by TRAIL and Noxa Research Paper

Potent antitumor activity of oncolytic adenovirus expressing Beclin-1 via induction of autophagic cell death in leukemia Research Paper

Pharmacologic targeting of the PI3K/mTOR pathway controls release of angioregulators from primary human acute myeloid leukemia cells and their neighboring stromal cells Research Paper

Cell death sensitization of leukemia cells by opioid receptor activation Research Paper

Epidermal Growth Factor Receptor Tyrosine Kinase Inhibition Up-regulates Interleukin-6 in Cancer Cells and Induces Subsequent Development of Interstitial Pneumonia Research Paper

Gfi1 as a regulator of p53 and a therapeutic target for ALL Broadcast

Deregulation of the CDX2-KLF4 axis in acute myeloid leukemia and colon cancer Editorial

Coordinate PI3K pathway and Bcl-2 family disruption in AML Editorial

A combination of temsirolimus, an allosteric mTOR inhibitor, with clofarabine as a new therapeutic option for patients with acute myeloid leukemia Research Paper

Small-molecule inhibition of BRD4 as a new potent approach to eliminate leukemic stem- and progenitor cells in acute myeloid leukemia (AML) Research Paper

Publication Alerts

European Cancer and Oncology Congress

Oncoscience

Post-Publication Promotion

Search Oncotarget

Lymphoid enhancer binding factor-1 (LEF1) expression as a prognostic factor in adult acute promyelocytic leukemia Research Paper

ERG induces a mesenchymal-like state associated with chemoresistance in leukemia cells Research Paper

High Mdm4 levels suppress p53 activity and enhance its half-life in acute myeloid leukaemia Research Paper

Chemokines in tumor progression and metastasis Review

Indoleamine 2,3-dioxygenase 1 (IDO1) activity in leukemia blasts correlates with poor outcome in childhood acute myeloid leukemia Research Paper

MYCN is a novel oncogenic target in pediatric T-cell Acute Lymphoblastic Leukemia Research Paper

HoxA9 regulated Bcl-2 expression mediates survival of myeloid progenitors and the severity of HoxA9-dependent leukemia Research Paper

DHH-RHEBL1 fusion transcript: a novel recurrent feature in the new landscape of pediatric CBFA2T3-GLIS2-positive acute myeloid leukemia Research Paper

CXXC5 (Retinoid-Inducible Nuclear Factor, RINF) is a Potential Therapeutic Target in High-Risk Human Acute Myeloid Leukemia Research Paper

Overcoming treatment resistance in acute promyelocytic leukemia and beyond Editorial Broadcast

Therapy-resistant acute lymphoblastic leukemia (ALL) cells inactivate FOXO3 to escape apoptosis induction by TRAIL and Noxa Research Paper

Potent antitumor activity of oncolytic adenovirus expressing Beclin-1 via induction of autophagic cell death in leukemia Research Paper

Pharmacologic targeting of the PI3K/mTOR pathway controls release of angioregulators from primary human acute myeloid leukemia cells and their neighboring stromal cells Research Paper

Cell death sensitization of leukemia cells by opioid receptor activation Research Paper

Epidermal Growth Factor Receptor Tyrosine Kinase Inhibition Up-regulates Interleukin-6 in Cancer Cells and Induces Subsequent Development of Interstitial Pneumonia Research Paper

Gfi1 as a regulator of p53 and a therapeutic target for ALL Broadcast

Deregulation of the CDX2-KLF4 axis in acute myeloid leukemia and colon cancer Editorial

Coordinate PI3K pathway and Bcl-2 family disruption in AML Editorial

A combination of temsirolimus, an allosteric mTOR inhibitor, with clofarabine as a new therapeutic option for patients with acute myeloid leukemia Research Paper

Small-molecule inhibition of BRD4 as a new potent approach to eliminate leukemic stem- and progenitor cells in acute myeloid leukemia (AML) Research Paper