The Oncosearch | Oncotarget

PI3K pan-inhibition impairs more efficiently proliferation and survival of T-cell acute lymphoblastic leukemia cell lines when compared to isoform-selective PI3K inhibitors Research Paper

Annalisa Lonetti, Alessandra Cappellini, Antonino Maria SpartÃ, Francesca Chiarini, Francesca Buontempo, Camilla Evangelisti, Cecilia Evangelisti, Ester Orsini, James A. McCubrey, Alberto Maria Martelli

Published Mar 16, 2015 · Vol. 6, No. 12 · pp. 10399-10414

FLT3-ITD confers resistance to the PI3K/Akt pathway inhibitors by protecting the mTOR/4EBP1/Mcl-1 pathway through STAT5 activation in acute myeloid leukemia Research Paper

Ayako Nogami, Gaku Oshikawa, Keigo Okada, Shusaku Fukutake, Yoshihiro Umezawa, Toshikage Nagao, Tetsuya Kurosu, Osamu Miura

Published Mar 16, 2015 · Vol. 6, No. 11 · pp. 9189-9205

A critical role of nicotinamide phosphoribosyltransferase in human telomerase reverse transcriptase induction by resveratrol in aortic smooth muscle cells Research Paper

Peixin Huang, Sean M. Riordan, Daniel P. Heruth, Dmitry N. Grigoryev, Li Qin Zhang, Shui Qing Ye

Published Mar 14, 2015 · Vol. 6, No. 13 · pp. 10812-10824

Aberrant nuclear factor-kappa B activity in acute myeloid Leukemia: from molecular pathogenesis to therapeutic target Review

Jianbiao Zhou, Ying Qing Ching, Wee-Joo Chng

Published Mar 12, 2015 · Vol. 6, No. 8 · pp. 5490-5500

High expression of inositol 1,4,5-trisphosphate receptor, type 2 (ITPR2) as a novel biomarker for worse prognosis in cytogenetically normal acute myeloid leukemia Research Paper

Jin-long Shi, Lin Fu, Wei-dong Wang

Published Mar 12, 2015 · Vol. 6, No. 7 · pp. 5299-5309

GSK3 is required for rapalogs to induce degradation of some oncogenic proteins and to suppress cancer cell growth Research Paper

Junghui Koo, Xuerong Wang, Taofeek K. Owonikoko, Suresh S. Ramalingam, Fadlo R. Khuri, Shi-Yong Sun

Published Mar 12, 2015 · Vol. 6, No. 11 · pp. 8974-8987

Dual targeting of acute myeloid leukemia progenitors by catalytic mTOR inhibition and blockade of the p110Î± subunit of PI3 kinase Research Paper

Marco Colamonici, Gavin Blyth, Diana Saleiro, Amy Szilard, Meghan Bliss-Moreau, Francis J. Giles, Jessica K. Altman, Elspeth M. Beauchamp, Leonidas C. Platanias

Published Mar 10, 2015 · Vol. 6, No. 10 · pp. 8062-8070

Mitogen-activated protein kinase binding protein 1 (MAPKBP1) is an unfavorable prognostic biomarker in cytogenetically normal acute myeloid leukemia Research Paper

Lin Fu, Jinlong Shi, Kai Hu, Jijun Wang, Weidong Wang, Xiaoyan Ke

Published Mar 10, 2015 · Vol. 6, No. 10 · pp. 8144-8154

Tetrandrine induces autophagy and differentiation by activating ROS and Notch1 signaling in leukemia cells Research Paper

Ting Liu, Qiuxu Men, Guixian Wu, Chunrong Yu, Zan Huang, Xin Liu, Wenhua Li

Published Mar 10, 2015 · Vol. 6, No. 10 · pp. 7992-8006

Triple Akt inhibition as a new therapeutic strategy in T-cell acute lymphoblastic leukemia Research Paper

Alice Cani, Carolina Simioni, Alberto M. Martelli, Giorgio Zauli, Giovanna Tabellini, Simona Ultimo, James A. McCubrey, Silvano Capitani, Luca M. Neri

Published Mar 2, 2015 · Vol. 6, No. 9 · pp. 6597-6610

Role of ASXL1 and TP53 mutations in the molecular classification and prognosis of acute myeloid leukemias with myelodysplasia-related changes Clinical Research Papers

Raynier Devillier, VÃ©ronique Mansat-De Mas, Veronique Gelsi-Boyer, Cecile Demur, Anne Murati, Jill Corre, Thomas Prebet, Sarah Bertoli, Mandy Brecqueville, Christine Arnoulet, Christian Recher, Norbert Vey, Marie-Joelle Mozziconacci, Eric Delabesse, Daniel Birnbaum

Published Feb 28, 2015 · Vol. 6, No. 10 · pp. 8388-8396

MAP17 (PDZKIP1) as a novel prognostic biomarker for laryngeal cancer Research Paper

MarÃa-JosÃ© de Miguel-Luken, Manuel Chaves-Conde, VerÃ³nica de Miguel-Luken, Sandra MuÃ±oz-GalvÃ¡n, JosÃ© Luis LÃ³pez-Guerra, Juan C. Mateos, JerÃ³nimo PachÃ³n, David ChinchÃ³n, Vladimir Suarez, Amancio Carnero

Published Feb 28, 2015 · Vol. 6, No. 14 · pp. 12625-12636

SKI2162, an inhibitor of the TGF-Î² type I receptor (ALK5), inhibits radiation-induced fibrosis in mice Research Paper

Jin-hong Park, Seung-Hee Ryu, Eun Kyung Choi, Seung Do Anh, Euisun Park, Kyung-Chul Choi, Sang-wook Lee

Published Feb 17, 2015 · Vol. 6, No. 6 · pp. 4171-4179

Keywords: Radiation, Fibrosis, TGF-Î²1, ALK5, SKI2162

Efficacy of a Mer and Flt3 tyrosine kinase small molecule inhibitor, UNC1666, in acute myeloid leukemia Research Paper

Alisa B. Lee-Sherick, Weihe Zhang, Kelly K. Menachof, Amanda A. Hill, Sean Rinella, Gregory Kirkpatrick, Lauren S. Page, Michael A. Stashko, Craig T. Jordan, Qi Wei, Jing Liu, Dehui Zhang, Deborah DeRyckere, Xiaodong Wang, Stephen Frye, H. Shelton Earp, Douglas K. Graham

Published Feb 10, 2015 · Vol. 6, No. 9 · pp. 6722-6736

Efficacy and safety of decitabine in combination with G-CSF, low-dose cytarabine and aclarubicin in newly diagnosed elderly patients with acute myeloid leukemia Clinical Research Papers

Jianyong Li, Yaoyu Chen, Yu Zhu, Jianfeng Zhou, Yanli Xu, Yan Li, Kang Yu, Ling Pan, Jianmin Wang, Jiahua Ding, Jian Gu, Shanhua Zhou, Jinning Shi, Ming Hong, Ji Xu, Liangqin Pan, Limin Duan, Run Zhang, Sujiang Zhang, Huayuan Zhu, Hua Lu, Peng Liu, Hongxia Qiu, Hanxin Wu, Sixuan Qian

Published Jan 31, 2015 · Vol. 6, No. 8 · pp. 6448-6458

Dihydroartemisinin and its derivative induce apoptosis in acute myeloid leukemia through Noxa-mediated pathway requiring iron and endoperoxide moiety Research Paper

Xuan Zhao, Hang Zhong, Rui Wang, Dan Liu, Samuel Waxman, Linxiang Zhao, Yongkui Jing

Published Jan 21, 2015 · Vol. 6, No. 8 · pp. 5582-5596

p19ARF is a critical mediator of both cellular senescence and an innate immune response associated with MYC inactivation in mouse model of acute leukemia Priority Research Paper

Alper Yetil, Benedict Anchang, Arvin M. Gouw, Stacey J. Adam, Tahera Zabuawala, Ramya Parameswaran, Jan van Riggelen, Sylvia Plevritis, Dean W. Felsher

Published Jan 13, 2015 · Vol. 6, No. 6 · pp. 3563-3577

Asparaginase induces apoptosis and cytoprotective autophagy in chronic myeloid leukemia cells Research Paper

Ping Song, Li Ye, Jiajun Fan, Yubin Li, Xian Zeng, Ziyu Wang, Shaofei Wang, Guoping Zhang, Ping Yang, Zhonglian Cao, Dianwen Ju

Published Jan 8, 2015 · Vol. 6, No. 6 · pp. 3861-3873

Keywords: asparaginase, autophagy, apoptosis, chronic myeloid leukemia

LCK over-expression drives STAT5 oncogenic signaling in PAX5 translocated BCP-ALL patients Research Paper

Valeria Cazzaniga, Cristina Bugarin, Michela Bardini, Marco Giordan, Geertruy te Kronnie, Giuseppe Basso, Andrea Biondi, Grazia Fazio, Giovanni Cazzaniga

Published Jan 8, 2015 · Vol. 6, No. 3 · pp. 1569-1581

The DNA methylation inhibitor induces telomere dysfunction and apoptosis of leukemia cells that is attenuated by telomerase over-expression Research Paper

Xiaolu Zhang, Bingnan Li, Nick de Jonge, Magnus BjÃ¶rkholm, Dawei Xu

Published Jan 6, 2015 · Vol. 6, No. 7 · pp. 4888-4900

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PI3K pan-inhibition impairs more efficiently proliferation and survival of T-cell acute lymphoblastic leukemia cell lines when compared to isoform-selective PI3K inhibitors Research Paper

FLT3-ITD confers resistance to the PI3K/Akt pathway inhibitors by protecting the mTOR/4EBP1/Mcl-1 pathway through STAT5 activation in acute myeloid leukemia Research Paper

A critical role of nicotinamide phosphoribosyltransferase in human telomerase reverse transcriptase induction by resveratrol in aortic smooth muscle cells Research Paper

Aberrant nuclear factor-kappa B activity in acute myeloid Leukemia: from molecular pathogenesis to therapeutic target Review

High expression of inositol 1,4,5-trisphosphate receptor, type 2 (ITPR2) as a novel biomarker for worse prognosis in cytogenetically normal acute myeloid leukemia Research Paper

GSK3 is required for rapalogs to induce degradation of some oncogenic proteins and to suppress cancer cell growth Research Paper

Dual targeting of acute myeloid leukemia progenitors by catalytic mTOR inhibition and blockade of the p110Î± subunit of PI3 kinase Research Paper

Mitogen-activated protein kinase binding protein 1 (MAPKBP1) is an unfavorable prognostic biomarker in cytogenetically normal acute myeloid leukemia Research Paper

Tetrandrine induces autophagy and differentiation by activating ROS and Notch1 signaling in leukemia cells Research Paper

Triple Akt inhibition as a new therapeutic strategy in T-cell acute lymphoblastic leukemia Research Paper

Role of ASXL1 and TP53 mutations in the molecular classification and prognosis of acute myeloid leukemias with myelodysplasia-related changes Clinical Research Papers

MAP17 (PDZKIP1) as a novel prognostic biomarker for laryngeal cancer Research Paper

SKI2162, an inhibitor of the TGF-Î² type I receptor (ALK5), inhibits radiation-induced fibrosis in mice Research Paper

Efficacy of a Mer and Flt3 tyrosine kinase small molecule inhibitor, UNC1666, in acute myeloid leukemia Research Paper

Efficacy and safety of decitabine in combination with G-CSF, low-dose cytarabine and aclarubicin in newly diagnosed elderly patients with acute myeloid leukemia Clinical Research Papers

Dihydroartemisinin and its derivative induce apoptosis in acute myeloid leukemia through Noxa-mediated pathway requiring iron and endoperoxide moiety Research Paper

p19ARF is a critical mediator of both cellular senescence and an innate immune response associated with MYC inactivation in mouse model of acute leukemia Priority Research Paper

Asparaginase induces apoptosis and cytoprotective autophagy in chronic myeloid leukemia cells Research Paper

LCK over-expression drives STAT5 oncogenic signaling in PAX5 translocated BCP-ALL patients Research Paper

The DNA methylation inhibitor induces telomere dysfunction and apoptosis of leukemia cells that is attenuated by telomerase over-expression Research Paper

Publication Alerts

European Cancer and Oncology Congress

Oncoscience

Post-Publication Promotion

Search Oncotarget

PI3K pan-inhibition impairs more efficiently proliferation and survival of T-cell acute lymphoblastic leukemia cell lines when compared to isoform-selective PI3K inhibitors Research Paper

FLT3-ITD confers resistance to the PI3K/Akt pathway inhibitors by protecting the mTOR/4EBP1/Mcl-1 pathway through STAT5 activation in acute myeloid leukemia Research Paper

A critical role of nicotinamide phosphoribosyltransferase in human telomerase reverse transcriptase induction by resveratrol in aortic smooth muscle cells Research Paper

Aberrant nuclear factor-kappa B activity in acute myeloid Leukemia: from molecular pathogenesis to therapeutic target Review

High expression of inositol 1,4,5-trisphosphate receptor, type 2 (ITPR2) as a novel biomarker for worse prognosis in cytogenetically normal acute myeloid leukemia Research Paper

GSK3 is required for rapalogs to induce degradation of some oncogenic proteins and to suppress cancer cell growth Research Paper

Dual targeting of acute myeloid leukemia progenitors by catalytic mTOR inhibition and blockade of the p110Î± subunit of PI3 kinase Research Paper

Mitogen-activated protein kinase binding protein 1 (MAPKBP1) is an unfavorable prognostic biomarker in cytogenetically normal acute myeloid leukemia Research Paper

Tetrandrine induces autophagy and differentiation by activating ROS and Notch1 signaling in leukemia cells Research Paper

Triple Akt inhibition as a new therapeutic strategy in T-cell acute lymphoblastic leukemia Research Paper

Role of ASXL1 and TP53 mutations in the molecular classification and prognosis of acute myeloid leukemias with myelodysplasia-related changes Clinical Research Papers

MAP17 (PDZKIP1) as a novel prognostic biomarker for laryngeal cancer Research Paper

SKI2162, an inhibitor of the TGF-Î² type I receptor (ALK5), inhibits radiation-induced fibrosis in mice Research Paper

Efficacy of a Mer and Flt3 tyrosine kinase small molecule inhibitor, UNC1666, in acute myeloid leukemia Research Paper

Efficacy and safety of decitabine in combination with G-CSF, low-dose cytarabine and aclarubicin in newly diagnosed elderly patients with acute myeloid leukemia Clinical Research Papers

Dihydroartemisinin and its derivative induce apoptosis in acute myeloid leukemia through Noxa-mediated pathway requiring iron and endoperoxide moiety Research Paper

p19ARF is a critical mediator of both cellular senescence and an innate immune response associated with MYC inactivation in mouse model of acute leukemia Priority Research Paper

Asparaginase induces apoptosis and cytoprotective autophagy in chronic myeloid leukemia cells Research Paper

LCK over-expression drives STAT5 oncogenic signaling in PAX5 translocated BCP-ALL patients Research Paper

The DNA methylation inhibitor induces telomere dysfunction and apoptosis of leukemia cells that is attenuated by telomerase over-expression Research Paper