The Oncosearch | Oncotarget

Haploinsufficiency of the c-myc transcriptional repressor FIR, as a dominant negative-alternative splicing model, promoted p53-dependent T-cell acute lymphoblastic leukemia progression by activating Notch1 Research Paper

Kazuyuki Matsushita, Kouichi Kitamura, Bahityar Rahmutulla, Nobuko Tanaka, Takayuki Ishige, Mamoru Satoh, Tyuji Hoshino, Satoru Miyagi, Takeshi Mori, Sakae Itoga, Hideaki Shimada, Takeshi Tomonaga, Minoru Kito, Yaeko Nakajima-Takagi, Shuji Kubo, Chiaki Nakaseko, Masahiko Hatano, Takashi Miki, Masafumi Matsuo, Masaki Fukuyo, Atsushi Kaneda, Atsushi Iwama, Fumio Nomura

Published Dec 31, 2014 · Vol. 6, No. 7 · pp. 5102-5117

Expression of the potential therapeutic target CXXC5 in primary acute myeloid leukemia cells - high expression is associated with adverse prognosis as well as altered intracellular signaling and transcriptional regulation Research Paper

Ã˜ystein Bruserud, HÃ¥kon Reikvam, Hanne Fredly, JÃ¸rn Skavland, Karen-Marie Hagen, Tuyen Thy van Hoang, Annette K. Brenner, Amir Kadi, Audrey Astori, BjÃ¸rn Tore Gjertsen, Frederic Pendino

Published Dec 26, 2014 · Vol. 6, No. 5 · pp. 2794-2811

A role for BMP-induced homeobox gene MIXL1 in acute myelogenous leukemia and identification of type I BMP receptor as a potential target for therapy Research Paper

Aaron Raymond, Bin Liu, Hong Liang, Ciamaio Wei, Michele Guindani, Yue Lu, Shoudan Liang, Lisa S. St. John, Jeff Molldrem, Lalitha Nagarajan

Published Dec 17, 2014 · Vol. 5, No. 24 · pp. 12675-12693

mTOR kinase inhibitors synergize with histone deacetylase inhibitors to kill B-cell acute lymphoblastic leukemia cells Research Paper

Brandon R. Beagle, Duc M. Nguyen, Sharmila Mallya, Sarah S. Tang, Mengrou Lu, Zhihong Zeng, Marina Konopleva, Thanh-Trang Vo, David A. Fruman

Published Dec 12, 2014 · Vol. 6, No. 4 · pp. 2088-2100

Resistance to everolimus driven by epigenetic regulation of MYC in ER+ breast cancers Research Paper

Teeru Bihani, Scott A. Ezell, Brendon Ladd, Shaun E. Grosskurth, Anne Marie Mazzola, Mark Pietras, Corinne Reimer, Michael Zinda, Stephen Fawell, Celina M. Dâ€™Cruz

Published Dec 11, 2014 · Vol. 6, No. 4 · pp. 2407-2420

Proteolytic systems and AMP-activated protein kinase are critical targets of acute myeloid leukemia therapeutic approaches Research Paper

Ã‚ngela Fernandes, Maria M. Azevedo, Olga Pereira, BelÃ©m Sampaio-Marques, Artur Paiva, Margarida Correia-Neves, Isabel Castro, Paula Ludovico

Published Dec 10, 2014 · Vol. 6, No. 31 · pp. 31428-31440

New insights into the genetics of glioblastoma multiforme by familial exome sequencing Research Paper

Christina Backes, Christian Harz, Ulrike Fischer, Jana Schmitt, Nicole Ludwig, Britt-Sabina Petersen, Sabine C. Mueller, Yoo-Jin Kim, Nadine M. Wolf, Hugo A. Katus, Benjamin Meder, Rhoikos FurtwÃ¤ngler, Andre Franke, Rainer Bohle, Wolfram Henn, Norbert Graf, Andreas Keller, Eckart Meese

Published Dec 10, 2014 · Vol. 6, No. 8 · pp. 5918-5931

Novel receptor tyrosine kinase targeted combination therapies for imatinib-resistant gastrointestinal stromal tumors (GIST) Research Paper

Daruka Mahadevan, Noah Theiss, Carla Morales, Amy E. Stejskal, Laurence S. Cooke, Min Zhu, Drew Kurtzman, Rachel Swart, Evan Ong, Wenqing Qi

Published Dec 10, 2014 · Vol. 6, No. 4 · pp. 1954-1966

Targeting of hyperactivated mTOR signaling in high-risk acute lymphoblastic leukemia in a pre-clinical model Priority Research Paper

Md. Nabiul Hasan, Manon Queudeville, Luca Trentin, Sarah Mirjam Eckhoff, Ilaria Bronzini, Chiara Palmi, Thomas Barth, Giovanni Cazzaniga, Geertruy te Kronnie, Klaus-Michael Debatin, LÃ¼der Hinrich Meyer

Published Dec 2, 2014 · Vol. 6, No. 3 · pp. 1382-1395

HDAC2 deregulation in tumorigenesis is causally connected to repression of immune modulation and defense escape Research Paper

Mariarosaria Conte, Carmela Dellâ€™Aversana, Rosaria Benedetti, Francesca Petraglia, Annamaria Carissimo, Valeria Belsito Petrizzi, Alfonso Maria Dâ€™Arco, Ciro Abbondanza, Angela Nebbioso, Lucia Altucci

Published Nov 25, 2014 · Vol. 6, No. 2 · pp. 886-901

Axl as a mediator of cellular growth and survival Review

Haley Axelrod, Kenneth J. Pienta

Published Nov 11, 2014 · Vol. 5, No. 19 · pp. 8818-8852

How mRNA is misspliced in acute myelogenous leukemia (AML)? Review

Aminetou Mint Mohamed, Morgan ThÃ©noz, FranÃ§oise Solly, Marie Balsat, Franck Mortreux, Eric Wattel

Published Nov 8, 2014 · Vol. 5, No. 20 · pp. 9534-9545

Image-based RNA interference screening reveals an individual dependence of acute lymphoblastic leukemia on stromal cysteine support Research Paper

Jeannette Boutter, Yun Huang, Blerim Marovca, Andreas Vonderheit, Michael A. Grotzer, Cornelia Eckert, Gunnar Cario, Bernd Wollscheid, Peter Horvath, Beat C. Bornhauser, Jean-Pierre Bourquin

Published Nov 1, 2014 · Vol. 5, No. 22 · pp. 11501-11512

Preclinical efficacy of maternal embryonic leucine-zipper kinase (MELK) inhibition in acute myeloid leukemia Research Paper

Houda Alachkar, Martin B.G. Mutonga, Klaus H. Metzeler, Noreen Fulton, Gregory Malnassy, Tobias Herold, Karsten Spiekermann, Stefan K. Bohlander, Wolfgang Hiddemann, Yo Matsuo, Wendy Stock, Yusuke Nakamura

Published Oct 28, 2014 · Vol. 5, No. 23 · pp. 12371-12382

Simultaneous targeting of PI3KÎ´ and a PI3KÎ´-dependent MEK1/2-Erk1/2 pathway for therapy in pediatric B-cell acute lymphoblastic leukemia Research Paper

Xiang Wang, Xi Zhang, Ben-shang Li, Xiaowen Zhai, Zhuo Yang, Li-xia Ding, Hongsheng Wang, Chris Liang, Weiliang Zhu, Jian Ding, Ling-hua Meng

Published Sep 26, 2014 · Vol. 5, No. 21 · pp. 10732-10744

Activity of the novel mTOR inhibitor Torin-2 in B-precursor acute lymphoblastic leukemia and its therapeutic potential to prevent Akt reactivation Research Paper

Carolina Simioni, Alice Cani, Alberto M. Martelli, Giorgio Zauli, Giovanna Tabellini, James McCubrey, Silvano Capitani, Luca M. Neri

Published Sep 16, 2014 · Vol. 5, No. 20 · pp. 10034-10047

Ibrutinib inhibits SDF1/CXCR4 mediated migration in AML Research Paper

Lyubov Zaitseva, Megan Y. Murray, Manar S. Shafat, Matthew J. Lawes, David J. MacEwan, Kristian M. Bowles, Stuart A. Rushworth

Published Sep 16, 2014 · Vol. 5, No. 20 · pp. 9930-9938

Multidrug resistance protein 4/ ATP binding cassette transporter 4: a new potential therapeutic target for acute myeloid leukemia Research Paper

Sabrina Copsel, Ariana Bruzzone, Maria May, Julien Beyrath, Victoria Wargon, Jeannette Cany, Frans G.M. Russel, Carina Shayo, Carlos Davio

Published Sep 2, 2014 · Vol. 5, No. 19 · pp. 9308-9321

Plerixafor as a chemosensitizing agent in pediatric acute lymphoblastic leukemia: efficacy and potential mechanisms of resistance to CXCR4 inhibition Clinical Research Papers

Edward Allan R. Sison, Daniel Magoon, Li Li, Colleen E. Annesley, Donald Small, Patrick Brown

Published Aug 29, 2014 · Vol. 5, No. 19 · pp. 8947-8958

Binding of a Smad4/Ets-1 complex to a novel intragenic regulatory element in exon12 of FPGS underlies decreased gene expression and antifolate resistance in leukemia Research Paper

Shachar Raz, Michal Stark, Yehuda G. Assaraf

Published Aug 27, 2014 · Vol. 5, No. 19 · pp. 9183-9198

Publication Alerts

European Cancer and Oncology Congress

Post-Publication Promotion

Search Oncotarget

Haploinsufficiency of the c-myc transcriptional repressor FIR, as a dominant negative-alternative splicing model, promoted p53-dependent T-cell acute lymphoblastic leukemia progression by activating Notch1 Research Paper

Expression of the potential therapeutic target CXXC5 in primary acute myeloid leukemia cells - high expression is associated with adverse prognosis as well as altered intracellular signaling and transcriptional regulation Research Paper

A role for BMP-induced homeobox gene MIXL1 in acute myelogenous leukemia and identification of type I BMP receptor as a potential target for therapy Research Paper

mTOR kinase inhibitors synergize with histone deacetylase inhibitors to kill B-cell acute lymphoblastic leukemia cells Research Paper

Resistance to everolimus driven by epigenetic regulation of MYC in ER+ breast cancers Research Paper

Proteolytic systems and AMP-activated protein kinase are critical targets of acute myeloid leukemia therapeutic approaches Research Paper

New insights into the genetics of glioblastoma multiforme by familial exome sequencing Research Paper

Novel receptor tyrosine kinase targeted combination therapies for imatinib-resistant gastrointestinal stromal tumors (GIST) Research Paper

Targeting of hyperactivated mTOR signaling in high-risk acute lymphoblastic leukemia in a pre-clinical model Priority Research Paper

HDAC2 deregulation in tumorigenesis is causally connected to repression of immune modulation and defense escape Research Paper

Axl as a mediator of cellular growth and survival Review

How mRNA is misspliced in acute myelogenous leukemia (AML)? Review

Image-based RNA interference screening reveals an individual dependence of acute lymphoblastic leukemia on stromal cysteine support Research Paper

Preclinical efficacy of maternal embryonic leucine-zipper kinase (MELK) inhibition in acute myeloid leukemia Research Paper

Simultaneous targeting of PI3KÎ´ and a PI3KÎ´-dependent MEK1/2-Erk1/2 pathway for therapy in pediatric B-cell acute lymphoblastic leukemia Research Paper

Activity of the novel mTOR inhibitor Torin-2 in B-precursor acute lymphoblastic leukemia and its therapeutic potential to prevent Akt reactivation Research Paper

Ibrutinib inhibits SDF1/CXCR4 mediated migration in AML Research Paper

Multidrug resistance protein 4/ ATP binding cassette transporter 4: a new potential therapeutic target for acute myeloid leukemia Research Paper

Plerixafor as a chemosensitizing agent in pediatric acute lymphoblastic leukemia: efficacy and potential mechanisms of resistance to CXCR4 inhibition Clinical Research Papers

Binding of a Smad4/Ets-1 complex to a novel intragenic regulatory element in exon12 of FPGS underlies decreased gene expression and antifolate resistance in leukemia Research Paper

Publication Alerts

European Cancer and Oncology Congress

Oncoscience

Post-Publication Promotion

Search Oncotarget

Haploinsufficiency of the c-myc transcriptional repressor FIR, as a dominant negative-alternative splicing model, promoted p53-dependent T-cell acute lymphoblastic leukemia progression by activating Notch1 Research Paper

Expression of the potential therapeutic target CXXC5 in primary acute myeloid leukemia cells - high expression is associated with adverse prognosis as well as altered intracellular signaling and transcriptional regulation Research Paper

A role for BMP-induced homeobox gene MIXL1 in acute myelogenous leukemia and identification of type I BMP receptor as a potential target for therapy Research Paper

mTOR kinase inhibitors synergize with histone deacetylase inhibitors to kill B-cell acute lymphoblastic leukemia cells Research Paper

Resistance to everolimus driven by epigenetic regulation of MYC in ER+ breast cancers Research Paper

Proteolytic systems and AMP-activated protein kinase are critical targets of acute myeloid leukemia therapeutic approaches Research Paper

New insights into the genetics of glioblastoma multiforme by familial exome sequencing Research Paper

Novel receptor tyrosine kinase targeted combination therapies for imatinib-resistant gastrointestinal stromal tumors (GIST) Research Paper

Targeting of hyperactivated mTOR signaling in high-risk acute lymphoblastic leukemia in a pre-clinical model Priority Research Paper

HDAC2 deregulation in tumorigenesis is causally connected to repression of immune modulation and defense escape Research Paper

Axl as a mediator of cellular growth and survival Review

How mRNA is misspliced in acute myelogenous leukemia (AML)? Review

Image-based RNA interference screening reveals an individual dependence of acute lymphoblastic leukemia on stromal cysteine support Research Paper

Preclinical efficacy of maternal embryonic leucine-zipper kinase (MELK) inhibition in acute myeloid leukemia Research Paper

Simultaneous targeting of PI3KÎ´ and a PI3KÎ´-dependent MEK1/2-Erk1/2 pathway for therapy in pediatric B-cell acute lymphoblastic leukemia Research Paper

Activity of the novel mTOR inhibitor Torin-2 in B-precursor acute lymphoblastic leukemia and its therapeutic potential to prevent Akt reactivation Research Paper

Ibrutinib inhibits SDF1/CXCR4 mediated migration in AML Research Paper

Multidrug resistance protein 4/ ATP binding cassette transporter 4: a new potential therapeutic target for acute myeloid leukemia Research Paper

Plerixafor as a chemosensitizing agent in pediatric acute lymphoblastic leukemia: efficacy and potential mechanisms of resistance to CXCR4 inhibition Clinical Research Papers

Binding of a Smad4/Ets-1 complex to a novel intragenic regulatory element in exon12 of FPGS underlies decreased gene expression and antifolate resistance in leukemia Research Paper