The Oncosearch | Oncotarget

Overall survival in patients with lung adenocarcinoma harboring “niche” mutations: an observational study Research Paper

Beatrice Aramini, Federico Banchelli, Stefania Bettelli, Samantha Manfredini, Roberto D’Amico, Valentina Masciale, Massimo Pinelli, Margherita Moretti, Alessandro Stefani, Federica Bertolini, Massimo Dominici, Uliano Morandi, Antonino Maiorana

Published Feb 4, 2020 · Vol. 11, No. 5 · pp. 550-559

Keywords: somatic mutations, non-small cell lung cancer (NSCLC), lung cancer treatment, overall survival, target therapy

Resistance to allosteric SHP2 inhibition in FGFR-driven cancers through rapid feedback activation of FGFR Research Paper

Hengyu Lu, Chen Liu, Hung Huynh, Thi Bich Uyen Le, Matthew J. LaMarche, Morvarid Mohseni, Jeffrey A. Engelman, Peter S. Hammerman, Giordano Caponigro, Huai-Xiang Hao

Published Jan 21, 2020 · Vol. 11, No. 3 · pp. 265-281

Keywords: SHP2, FGFR, resistance, feedback activation

Circulating tumor DNA analysis in the era of precision oncology Review

Rabih Said, Nicolas Guibert, Geoffrey R. Oxnard, Apostolia M. Tsimberidou

Published Jan 14, 2020 · Vol. 11, No. 2 · pp. 188-211

Keywords: circulating tumor DNA analysis, clinical trials, targeted therapy, genomic profiling

The targeted LHRH analog AEZS-108 alters expression of genes related to angiogenesis and development of metastasis in uveal melanoma Research Paper

Klara Fodor, Nikoletta Dobos, Andrew Schally, Zita Steiber, Gabor Olah, Eva Sipos, Lorant Szekvolgyi, Gabor Halmos

Published Jan 14, 2020 · Vol. 11, No. 2 · pp. 175-187

Keywords: uveal melanoma, luteinizing hormone-releasing hormone (LHRH) receptor, angiogenesis, MASPIN/SERPINB5, AEZS-108 (AN-152/Zoptarelin Doxorubicin Acetate)

Resistance to allosteric SHP2 inhibition in FGFR-driven cancers through rapid feedback activation of FGFR Research Paper

Hengyu Lu, Chen Liu, Hung Huynh, Thi Bich Uyen Le, Matthew LaMarche, Morvarid Mohseni, Jeffrey A. Engelman, Peter S. Hammerman, Giordano Caponigro, Huai-Xiang Hao

Published Jan 6, 2020

Keywords: SHP2, FGFR, resistance, feedback activation

Gas6/MerTK signaling is negatively regulated by NF-κB and supports lung carcinogenesis Research Paper

Sergey V. Novitskiy, Rinat Zaynagetdinov, Georgii Vasiukov, Sergey Gutor, Wei Han, Ana Serezani, Anton Matafonov, Linda A. Gleaves, Taylor P. Sherrill, Vasiliy V. Polosukhin, Timothy S. Blackwell

Published Dec 17, 2019 · Vol. 10, No. 66 · pp. 7031-7042

Keywords: lung cancer, NF-κB, Mer-TK, macrophage, Kras

PTPRS drives adaptive resistance to MEK/ERK inhibitors through SRC Priority Research Paper

Thomas B. Davis, Mingli Yang, Heiman Wang, Changgong Lee, Timothy J. Yeatman, W. Jack Pledger

Published Nov 26, 2019 · Vol. 10, No. 63 · pp. 6768-6780

Keywords: colorectal cancer, PTPRS, ERK, SRC, adaptive resistance

Lactate induces PD-L1 in HRAS^G12V-positive oropharyngeal squamous cell carcinoma Research Paper

Alexander K. Verma, Shanta M. Messerli, W. Keith Miskimins

Published Nov 15, 2019 · Vol. 11, No. 17 · pp. 1493-1504

Keywords: oropharyngeal cancer, lactate, Ras, anti-tumor immunity, PD-L1

Investigating the duality of Inpp4b function in the cellular transformation of mouse fibroblasts Research Paper

Emily Marie Mangialardi, Keyue Chen, Brittany Salmon, Jean Vacher, Leonardo Salmena

Published Oct 29, 2019 · Vol. 10, No. 59 · pp. 6378-6390

Keywords: Inpp4b, MEF, RAS, E1A, SV40-T-Large

The multikinase inhibitor RXDX-105 is effective against neuroblastoma in vitro and in vivo Research Paper

Sean M. Flynn, Jacqueline Lesperance, Andrew Macias, Nikki Phanhthilath, Megan Rose Paul, Jong Wook Kim, Pablo Tamayo, Peter E. Zage

Published Oct 29, 2019 · Vol. 10, No. 59 · pp. 6323-6333

Keywords: neuroblastoma, RXDX-105, CEP-32496, RET, BRAF

Kallikrein 6 protease advances colon tumorigenesis via induction of the high mobility group A2 protein Research Paper

Hwudaurw Chen, Earlphia Sells, Ritu Pandey, Edward R. Abril, Chiu-Hsieh Hsu, Robert S. Krouse, Raymond B. Nagle, Georgios Pampalakis, Georgia Sotiropoulou, Natalia A. Ignatenko

Published Oct 22, 2019 · Vol. 10, No. 58 · pp. 6062-6078

Keywords: colorectal cancer, kallikrein-related peptidase 6 or KLK6, SMAD2/3, epithelial-mesenchymal transition, HMGA2

Targeting glutaminase1 and synergizing with clinical drugs achieved more promising antitumor activity on multiple myeloma Research Paper

Qiang Qiu, Mengyuan Li, Linyu Yang, Minghai Tang, Li Zheng, Fang Wang, Huandi Qiu, Cailing Liang, Ning Li, Dongni Yi, Yuyao Yi, Cong Pan, Shengyong Yang, Lijuan Chen, Yiguo Hu

Published Oct 15, 2019 · Vol. 10, No. 57 · pp. 5993-6005

Keywords: glutaminase1, multiple myeloma, BPTES, cMYC/KRAS12V-transduced plasmacytoma, mouse model

New insights into the genomic landscape of meningiomas identified FGFR3 in a subset of patients with favorable prognoses Research Paper

Aysha AlSahlawi, Rasha Aljelaify, Amna Magrashi, Mariam AlSaeed, Amal Almutairi, Fatimah Alqubaishi, Abdulellah Alturkistani, Abdullah AlObaid, Mohamed Abouelhoda, Latifa AlMubarak, Nada AlTassan, Malak Abedalthagafi

Published Sep 17, 2019 · Vol. 10, No. 53 · pp. 5549-5559

Keywords: meningioma, FGFR3, NGS, genomics, CNS

Ras functional proximity proteomics establishes mTORC2 as new direct ras effector Research Perspective

Joanna R. Kovalski, Ronald L. Shanderson, Paul A. Khavari

Published Aug 27, 2019 · Vol. 10, No. 50 · pp. 5126-5135

Keywords: Ras, BioID, proteomics, CRISPR, mTORC2

Prognostic value of tumor growth kinetic parameters in prostate cancer patients Research Paper

Gennady M. Zharinov, Oleg A. Bogomolov, Natalia Yu. Neklasova, Grigory A. Raskin, Irina V. Chepurnaya, Sergey N. Bugrov, Vladimir N. Anisimov

Published Aug 20, 2019 · Vol. 10, No. 49 · pp. 5020-5027

Keywords: prostate cancer, cellular lost factor, Ki-67, prostate specific antigen doubling time, prognostic factors

Correction: HDAC inhibitors enhance neratinib activity and when combined enhance the actions of an anti-PD-1 immunomodulatory antibody in vivo Correction

Laurence Booth, Jane L. Roberts, Andrew Poklepovic, Francesca Avogadri-Connors, Richard E. Cutler, Alshad S. Lalani, Paul Dent

Published Aug 16, 2019 · Vol. 10, No. 49 · pp. 5120-5122

Precision delivery of RAS-inhibiting siRNA to KRAS driven cancer via peptide-based nanoparticles Research Paper

Matthew S. Strand, Bradley A. Krasnick, Hua Pan, Xiuli Zhang, Ye Bi, Candace Brooks, Christopher Wetzel, Narendra Sankpal, Timothy Fleming, S. Peter Goedegebuure, David G. DeNardo, William E. Gillanders, William G. Hawkins, Samuel A. Wickline, Ryan C. Fields

Published Jul 30, 2019 · Vol. 10, No. 46 · pp. 4761-4775

Keywords: nanoparticle agents, pancreatic cancer, gastrointestinal cancer, oncoprotein

Tumor-associated macrophages and individual chemo-susceptibility are influenced by iron chelation in human slice cultures of gastric cancer Research Paper

Sebastian Prill, Jakob Rebstock, Anja Tennemann, Justus Körfer, Rasmus Sönnichsen, René Thieme, Ines Gockel, Orestis Lyros, Astrid Monecke, Christian Wittekind, Arved Weimann, Kerstin Grosser, Volker Wiechmann, Christoph Kubick, Ingo Bechmann, Florian Lordick, Sonja Kallendrusch

Published Jul 30, 2019 · Vol. 10, No. 46 · pp. 4731-4742

Keywords: tumor-associated macrophages, tumor slice cultures, deferoxamine, gastric cancer, iron

Targeting cyclin-dependent kinase 9 by a novel inhibitor enhances radiosensitization and identifies Axl as a novel downstream target in esophageal adenocarcinoma Research Paper

Omkara Lakshmi Veeranki, Zhimin Tong, Rashmi Dokey, Alicia Mejia, Jianhu Zhang, Yawei Qiao, Pankaj Kumar Singh, Riham Katkhuda, Barbara Mino, Ramesh Tailor, Jaime Rodriguez Canales, Roland Bassett, Jaffer Ajani, Ji Yuan Wu, Scott Kopetz, Mariela Blum, Wayne Hofstetter, Michael Tetzlaff, Sunil Krishnan, Steven H. Lin, Dipen Maru

Published Jul 23, 2019 · Vol. 10, No. 45 · pp. 4703-4718

Keywords: CDK 9 Inhibitor, esophageal adenocarcinoma, radiation, Axl

Fibroblast-derived Gremlin1 localises to epithelial cells at the base of the intestinal crypt Research Paper

Louise R. Dutton, Owen P. Hoare, Amy M.B. McCorry, Keara L. Redmond, Noor Eisa Adam, Shannon Canamara, Victoria Bingham, Paul B. Mullan, Mark Lawler, Philip D. Dunne, Derek P. Brazil

Published Jul 23, 2019 · Vol. 10, No. 45 · pp. 4630-4639

Keywords: Gremlin1, colorectal cancer, fibroblasts, stroma, pathology

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Overall survival in patients with lung adenocarcinoma harboring “niche” mutations: an observational study Research Paper

Resistance to allosteric SHP2 inhibition in FGFR-driven cancers through rapid feedback activation of FGFR Research Paper

Circulating tumor DNA analysis in the era of precision oncology Review

The targeted LHRH analog AEZS-108 alters expression of genes related to angiogenesis and development of metastasis in uveal melanoma Research Paper

Resistance to allosteric SHP2 inhibition in FGFR-driven cancers through rapid feedback activation of FGFR Research Paper

Gas6/MerTK signaling is negatively regulated by NF-κB and supports lung carcinogenesis Research Paper

PTPRS drives adaptive resistance to MEK/ERK inhibitors through SRC Priority Research Paper

Lactate induces PD-L1 in HRAS^G12V-positive oropharyngeal squamous cell carcinoma Research Paper

Investigating the duality of Inpp4b function in the cellular transformation of mouse fibroblasts Research Paper

The multikinase inhibitor RXDX-105 is effective against neuroblastoma in vitro and in vivo Research Paper

Kallikrein 6 protease advances colon tumorigenesis via induction of the high mobility group A2 protein Research Paper

Targeting glutaminase1 and synergizing with clinical drugs achieved more promising antitumor activity on multiple myeloma Research Paper

New insights into the genomic landscape of meningiomas identified FGFR3 in a subset of patients with favorable prognoses Research Paper

Ras functional proximity proteomics establishes mTORC2 as new direct ras effector Research Perspective

Prognostic value of tumor growth kinetic parameters in prostate cancer patients Research Paper

Correction: HDAC inhibitors enhance neratinib activity and when combined enhance the actions of an anti-PD-1 immunomodulatory antibody in vivo Correction

Precision delivery of RAS-inhibiting siRNA to KRAS driven cancer via peptide-based nanoparticles Research Paper

Tumor-associated macrophages and individual chemo-susceptibility are influenced by iron chelation in human slice cultures of gastric cancer Research Paper

Targeting cyclin-dependent kinase 9 by a novel inhibitor enhances radiosensitization and identifies Axl as a novel downstream target in esophageal adenocarcinoma Research Paper

Fibroblast-derived Gremlin1 localises to epithelial cells at the base of the intestinal crypt Research Paper

Publication Alerts

European Cancer and Oncology Congress

Oncoscience

Post-Publication Promotion

Search Oncotarget

Overall survival in patients with lung adenocarcinoma harboring “niche” mutations: an observational study Research Paper

Resistance to allosteric SHP2 inhibition in FGFR-driven cancers through rapid feedback activation of FGFR Research Paper

Circulating tumor DNA analysis in the era of precision oncology Review

The targeted LHRH analog AEZS-108 alters expression of genes related to angiogenesis and development of metastasis in uveal melanoma Research Paper

Resistance to allosteric SHP2 inhibition in FGFR-driven cancers through rapid feedback activation of FGFR Research Paper

Gas6/MerTK signaling is negatively regulated by NF-κB and supports lung carcinogenesis Research Paper

PTPRS drives adaptive resistance to MEK/ERK inhibitors through SRC Priority Research Paper

Lactate induces PD-L1 in HRASG12V-positive oropharyngeal squamous cell carcinoma Research Paper

Investigating the duality of Inpp4b function in the cellular transformation of mouse fibroblasts Research Paper

The multikinase inhibitor RXDX-105 is effective against neuroblastoma in vitro and in vivo Research Paper

Kallikrein 6 protease advances colon tumorigenesis via induction of the high mobility group A2 protein Research Paper

Targeting glutaminase1 and synergizing with clinical drugs achieved more promising antitumor activity on multiple myeloma Research Paper

New insights into the genomic landscape of meningiomas identified FGFR3 in a subset of patients with favorable prognoses Research Paper

Ras functional proximity proteomics establishes mTORC2 as new direct ras effector Research Perspective

Prognostic value of tumor growth kinetic parameters in prostate cancer patients Research Paper

Correction: HDAC inhibitors enhance neratinib activity and when combined enhance the actions of an anti-PD-1 immunomodulatory antibody in vivo Correction

Precision delivery of RAS-inhibiting siRNA to KRAS driven cancer via peptide-based nanoparticles Research Paper

Tumor-associated macrophages and individual chemo-susceptibility are influenced by iron chelation in human slice cultures of gastric cancer Research Paper

Targeting cyclin-dependent kinase 9 by a novel inhibitor enhances radiosensitization and identifies Axl as a novel downstream target in esophageal adenocarcinoma Research Paper

Fibroblast-derived Gremlin1 localises to epithelial cells at the base of the intestinal crypt Research Paper

Lactate induces PD-L1 in HRAS^G12V-positive oropharyngeal squamous cell carcinoma Research Paper