The Oncosearch | Oncotarget

Outcomes of patients with advanced cancer and KRAS mutations in phase I clinical trials Clinical Research Papers

Rabih Said, Yang Ye, Gerald Steven Falchook, Filip Janku, Aung Naing, Ralph Zinner, George R. Blumenschein Jr, Siqing Fu, David S. Hong, Sarina Anne Piha-Paul, Jennifer J. Wheler, Razelle Kurzrock, Gary A. Palmer, Kenneth Aldape, Kenneth . R Hess, Apostolia Maria Tsimberidou

Published Aug 10, 2014 · Vol. 5, No. 19 · pp. 8937-8946

Structural basis of nSH2 regulation and lipid binding in PI3KÎ± Priority Research Paper

Michelle S. Miller, Oleg Schmidt-Kittler, David M. Bolduc, Evan T. Brower, Daniele Chaves-Moreira, Marc Allaire, Kenneth W. Kinzler, Ian G. Jennings, Philip E. Thompson, Philip A. Cole, L. Mario Amzel, Bert Vogelstein, Sandra B. Gabelli

Published Jul 25, 2014 · Vol. 5, No. 14 · pp. 5198-5208

Deregulation of the EGFR/PI3K/PTEN/Akt/mTORC1 pathway in breast cancer: possibilities for therapeutic intervention Review

Nicole M. Davis, Melissa Sokolosky, Kristin Stadelman, Stephen L. Abrams, Massimo Libra, Saverio Candido, Ferdinando Nicoletti, Jerry Polesel, Roberta Maestro, Antonino Dâ€™Assoro, Lyudmyla Drobot, Dariusz Rakus, Agnieszka Gizak, Piotr Laidler, Joanna DuliÅ„ska-Litewka, Joerg Basecke, Sanja Mijatovic, Danijela Maksimovic-Ivanic, Giuseppe Montalto, Melchiorre Cervello, Timothy L. Fitzgerald, Zoya N. Demidenko, Alberto M. Martelli, Lucio Cocco, Linda S. Steelman, James A. McCubrey

Published Jul 12, 2014 · Vol. 5, No. 13 · pp. 4603-4650

Loss of ARID1A expression sensitizes cancer cells to PI3K- and AKT-inhibition Research Paper

Eleftherios P. Samartzis, Katrin Gutsche, Konstantin J. Dedes, Daniel Fink, Manuel Stucki, Patrick Imesch

Published Jun 11, 2014 · Vol. 5, No. 14 · pp. 5295-5303

ERBB3 knockdown induces cell cycle arrest and activation of Bak and Bax-dependent apoptosis in colon cancer cells Research Paper

Hyunji Lee, Hyunjung Lee, Hyunjung Chin, Kyoungmi Kim, Daekee Lee

Published Jun 11, 2014 · Vol. 5, No. 13 · pp. 5138-5152

Identification of novel therapeutic targets in the PI3K/AKT/mTOR pathway in hepatocellular carcinoma using targeted next generation sequencing Research Paper

Filip Janku, Ahmed O. Kaseb, Apostolia M. Tsimberidou, Robert A. Wolff, Razelle Kurzrock

Published May 30, 2014 · Vol. 5, No. 10 · pp. 3012-3022

Keywords: hepatocellular carcinoma, PI3K, AKT, mTOR, next generation sequencing

Oncobiguanides: Paracelsusâ€™ law and nonconventional routes for administering diabetobiguanides for cancer treatment Research Perspective

Javier A. Menendez, Rosa Quirantes-PinÃ©, Esther RodrÃguez-Gallego, SÃlvia CufÃ, Bruna Corominas-Faja, Elisabet CuyÃ s, Joaquim Bosch-Barrera, BegoÃ±a Martin-Castillo, Antonio Segura-Carretero, Jorge Joven

Published May 13, 2014 · Vol. 5, No. 9 · pp. 2344-2348

Unique molecular signatures as a hallmark of patients with metastatic breast cancer: Implications for current treatment paradigms Research Perspective

Jennifer J. Wheler, Barbara A. Parker, Jack J. Lee, Johnique T. Atkins, Filip Janku, Apostolia M. Tsimberidou, Ralph Zinner, Vivek Subbiah, Siqing Fu, Richard Schwab, Stacy Moulder, Vicente Valero, Maria Schwaederle, Roman Yelensky, Vincent A. Miller, M Philip J. Stephens, Funda Meric-Bernstam, Razelle Kurzrock

Published May 2, 2014 · Vol. 5, No. 9 · pp. 2349-2354

Multigene mutational profiling of cholangiocarcinomas identifies actionable molecular subgroups Research Paper

Michele Simbolo, Matteo Fassan, Andrea Ruzzenente, Andrea Mafficini, Laura D. Wood, Vincenzo Corbo, Davide Melisi, Giuseppe Malleo, Caterina Vicentini, Giorgio Malpeli, Davide Antonello, Nicola Sperandio, Paola Capelli, Anna Tomezzoli, Calogero Iacono, Rita T. Lawlor, Claudio Bassi, Ralph H. Hruban, Alfredo Guglielmi, Giampaolo Tortora, Filippo de Braud, Aldo Scarpa

Published May 1, 2014 · Vol. 5, No. 9 · pp. 2839-2852

Anastrozole and everolimus in advanced gynecologic and breast malignancies: activity and molecular alterations in the PI3K/AKT/mTOR pathway Research Paper

Jennifer J. Wheler, Stacy L. Moulder, Aung Naing, Filip Janku, Sarina A. Piha-Paul, Gerald S. Falchook, Ralph Zinner, Apostolia M. Tsimberidou, Siqing Fu, David S. Hong, Johnique T. Atkins, Roman Yelensky, Philip J. Stephens, Razelle Kurzrock

Published Mar 14, 2014 · Vol. 5, No. 10 · pp. 3029-3038

WNT signaling and distant metastasis in colon cancer through transcriptional activity of nuclear Î²-Catenin depend on active PI3K signaling Research Paper

Steffen Ormanns, Jens Neumann, David Horst, Thomas Kirchner, Andreas Jung

Published Feb 19, 2014 · Vol. 5, No. 10 · pp. 2999-3011

Keywords: WNT, Î²-Catenin, PI3K, colon cancer, metastasis

Broad-spectrum anti-tumor and anti-metastatic DNA vaccine based on p62-encoding vector Research Paper

Franco Venanzi, Victor Shifrin, Michael Y. Sherman, Vladimir Gabai, Oleg Kisilev, Andrey Komissarov, Mikhail Grudinin, Maria Shartakova, Ekaterina Romanovskaya-Romanko, Yuri Kudryavets, Natalya Bezdenezhnykh, Oleksandra Lykhova, Nadiia Semesyuk, Antonio Concetti, Anatoly Tsyb, Marina Filimonova, Victoria Makarchuk, Raisa Yakubovsky, Andrey Chursov, Vita Shcherbinina, Alexander Shneider

Published Oct 2, 2013 · Vol. 4, No. 10 · pp. 1829-1835

Keywords: cancer immunotherapy, DNA vaccine, autophagy, metastases

Dietary restriction-resistant human tumors harboring the PIK3CA-activating mutation H1047R are sensitive to metformin Research Paper

Silvia Cufi, Bruna Corominas-Faja, Eugeni Lopez-Bonet, Rosa Bonavia, Sonia Pernas, Isabel Alvarez Lopez, Joan Dorca, Susana Martinez, Norberto Batista Lopez, Severina Dominguez Martinez, Elisabet Cuyas, Joana Visa, Esther Rodriguez-Gallego, Rosa Quirantes-Pine, Antonio Segura-Carretero, Jorge Joven, Begona Martin-Castillo, Javier A Menendez

Published Aug 21, 2013 · Vol. 4, No. 9 · pp. 1484-1495

Keywords: Metformin, cancer, PI3K, PIK3CA mutations, dietary restriction, calorie restriction, rapamycin

Thymoma Patients Treated in a Phase I Clinic at MD Anderson Cancer Center: Responses to mTOR Inhibitors and Molecular Analyses Research Paper

Jennifer J. Wheler, David Hong, Stephen G. Swisher, Gerald S. Falchook, Apostolia Maria Tsimberidou, Thorunn Helgason, Aung Naing, Bettzy Stephen, Filip Janku, Philip J. Stephens, Roman Yelensky, Razelle Kurzrock

Published Jun 10, 2013 · Vol. 4, No. 6 · pp. 890-898

Keywords: advanced thymoma, mTOR inhibitors, targeted therapy, thymic carcinoma

Allosteric activation of PI3KÎ± by oncogenic mutations Editorial

John E Burke, Olga Perisic, Roger L Williams

Published Feb 28, 2013 · Vol. 4, No. 2 · pp. 180-181

Keywords: PIK3CA, PIK3R1, HDX-MS, PI3K

BRAF Mutant Gastrointestinal Stromal Tumor: First report of regression with BRAF inhibitor dabrafenib (GSK2118436) and whole exomic sequencing for analysis of acquired resistance Research Paper

Gerald S. Falchook, Jonathan C. Trent, Michael C. Heinrich, Carol Beadling, Janice Patterson, Christel C. Bastida, Samuel C. Blackman, Razelle Kurzrock

Published Feb 25, 2013 · Vol. 4, No. 2 · pp. 310-315

Keywords: Gastrointestinal stromal tumor, Dabrafenib, GSK2118436, BRAF mutation, BRAF inhibition, V600E

PI3KÎ² downstream of GPCRs â€“ crucial partners in oncogenesis Editorial

Hashem A Dbouk, Oscar Vadas, Roger L Williams, Jonathan M Backer

Published Dec 18, 2012 · Vol. 3, No. 12 · pp. 1485-1486

Keywords: PI 3-kinase, PIK3CB, G protein coupled receptors, PTEN

PIK3CA Mutations in Advanced Cancers: Characteristics and Outcomes Research Paper

Filip Janku, Jennifer J. Wheler, Aung Naing, Vanda M. T. Stepanek, Gerald S. Falchook, Siqing Fu, Ignacio Garrido-Laguna, Apostolia M. Tsimberidou, Sarina A. Piha-Paul, Stacy L. Moulder, J. Jack Lee, Rajyalakshmi Luthra, David S. Hong, Razelle Kurzrock

Published Nov 30, 2012 · Vol. 3, No. 12 · pp. 1566-1575

Keywords: PIK3CA mutation, phenotypic taxonomy, clinical outcome

Mutations and Deregulation of Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR Cascades Which Alter Therapy Response. Review

James Andrew McCubrey, Linda Steeman, William Chappell, Stephen Abrams, Giuseppe Montalto, Melchiorre Cervello, Ferdinando Nicoletti, Paolo Fagone, Grazia Malaponte, Maria Mazzarino, Saverio Candido, Massimo Libra, Jorg Basecke, Sanja Mijatovic, Danijela Maksimovic-Ivanic, Michele Milella, Agostino Tafuri, Lucio Cocco, Camilla Evangelisti, Francesca Chiarini, Alberto Martelli

Published Sep 20, 2012 · Vol. 3, No. 9 · pp. 954-987

Keywords: targeted therapy, therapy resistance, mutations, Raf, Akt, PI3K, mTOR

Abrogation of PIK3CA or PIK3R1 reduces proliferation, migration, and invasion in glioblastoma multiforme cells Research Paper

Genevieve L. Weber, Marie-Odile Parat, Zev A. Binder, Gary L. Gallia, Gregory J. Riggins

Published Nov 5, 2011 · Vol. 2, No. 11 · pp. 833-849

Keywords: glioblastoma, pathway analysis, PIK3CA, PIK3R1, invasion, PI3K

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European Cancer and Oncology Congress

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Outcomes of patients with advanced cancer and KRAS mutations in phase I clinical trials Clinical Research Papers

Structural basis of nSH2 regulation and lipid binding in PI3KÎ± Priority Research Paper

Deregulation of the EGFR/PI3K/PTEN/Akt/mTORC1 pathway in breast cancer: possibilities for therapeutic intervention Review

Loss of ARID1A expression sensitizes cancer cells to PI3K- and AKT-inhibition Research Paper

ERBB3 knockdown induces cell cycle arrest and activation of Bak and Bax-dependent apoptosis in colon cancer cells Research Paper

Identification of novel therapeutic targets in the PI3K/AKT/mTOR pathway in hepatocellular carcinoma using targeted next generation sequencing Research Paper

Oncobiguanides: Paracelsusâ€™ law and nonconventional routes for administering diabetobiguanides for cancer treatment Research Perspective

Unique molecular signatures as a hallmark of patients with metastatic breast cancer: Implications for current treatment paradigms Research Perspective

Multigene mutational profiling of cholangiocarcinomas identifies actionable molecular subgroups Research Paper

Anastrozole and everolimus in advanced gynecologic and breast malignancies: activity and molecular alterations in the PI3K/AKT/mTOR pathway Research Paper

WNT signaling and distant metastasis in colon cancer through transcriptional activity of nuclear Î²-Catenin depend on active PI3K signaling Research Paper

Broad-spectrum anti-tumor and anti-metastatic DNA vaccine based on p62-encoding vector Research Paper

Dietary restriction-resistant human tumors harboring the PIK3CA-activating mutation H1047R are sensitive to metformin Research Paper

Thymoma Patients Treated in a Phase I Clinic at MD Anderson Cancer Center: Responses to mTOR Inhibitors and Molecular Analyses Research Paper

Allosteric activation of PI3KÎ± by oncogenic mutations Editorial

BRAF Mutant Gastrointestinal Stromal Tumor: First report of regression with BRAF inhibitor dabrafenib (GSK2118436) and whole exomic sequencing for analysis of acquired resistance Research Paper

PI3KÎ² downstream of GPCRs â€“ crucial partners in oncogenesis Editorial

PIK3CA Mutations in Advanced Cancers: Characteristics and Outcomes Research Paper

Mutations and Deregulation of Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR Cascades Which Alter Therapy Response. Review

Abrogation of PIK3CA or PIK3R1 reduces proliferation, migration, and invasion in glioblastoma multiforme cells Research Paper

Publication Alerts

European Cancer and Oncology Congress

Oncoscience

Post-Publication Promotion

Search Oncotarget

Outcomes of patients with advanced cancer and KRAS mutations in phase I clinical trials Clinical Research Papers

Structural basis of nSH2 regulation and lipid binding in PI3KÎ± Priority Research Paper

Deregulation of the EGFR/PI3K/PTEN/Akt/mTORC1 pathway in breast cancer: possibilities for therapeutic intervention Review

Loss of ARID1A expression sensitizes cancer cells to PI3K- and AKT-inhibition Research Paper

ERBB3 knockdown induces cell cycle arrest and activation of Bak and Bax-dependent apoptosis in colon cancer cells Research Paper

Identification of novel therapeutic targets in the PI3K/AKT/mTOR pathway in hepatocellular carcinoma using targeted next generation sequencing Research Paper

Oncobiguanides: Paracelsusâ€™ law and nonconventional routes for administering diabetobiguanides for cancer treatment Research Perspective

Unique molecular signatures as a hallmark of patients with metastatic breast cancer: Implications for current treatment paradigms Research Perspective

Multigene mutational profiling of cholangiocarcinomas identifies actionable molecular subgroups Research Paper

Anastrozole and everolimus in advanced gynecologic and breast malignancies: activity and molecular alterations in the PI3K/AKT/mTOR pathway Research Paper

WNT signaling and distant metastasis in colon cancer through transcriptional activity of nuclear Î²-Catenin depend on active PI3K signaling Research Paper

Broad-spectrum anti-tumor and anti-metastatic DNA vaccine based on p62-encoding vector Research Paper

Dietary restriction-resistant human tumors harboring the PIK3CA-activating mutation H1047R are sensitive to metformin Research Paper

Thymoma Patients Treated in a Phase I Clinic at MD Anderson Cancer Center: Responses to mTOR Inhibitors and Molecular Analyses Research Paper

Allosteric activation of PI3KÎ± by oncogenic mutations Editorial

BRAF Mutant Gastrointestinal Stromal Tumor: First report of regression with BRAF inhibitor dabrafenib (GSK2118436) and whole exomic sequencing for analysis of acquired resistance Research Paper

PI3KÎ² downstream of GPCRs â€“ crucial partners in oncogenesis Editorial

PIK3CA Mutations in Advanced Cancers: Characteristics and Outcomes Research Paper

Mutations and Deregulation of Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR Cascades Which Alter Therapy Response. Review

Abrogation of PIK3CA or PIK3R1 reduces proliferation, migration, and invasion in glioblastoma multiforme cells Research Paper