The Oncosearch | Oncotarget

Low-dose metronomic cyclophosphamide complements the actions of an intratumoral C-class CpG TLR9 agonist to potentiate innate immunity and drive potent T cell-mediated anti-tumor responses Research Paper

Weng In Leong, Rachel Y. Ames, Jessica M. Haverkamp, Laura Torres, Janine Kline, Ashil Bans, Lauren Rocha, Marilena Gallotta, Cristiana Guiducci, Robert L. Coffman, Mary J. Janatpour

Published Dec 31, 2019 · Vol. 10, No. 68 · pp. 7220-7237

Keywords: TLR9, SD-101, cyclophosphamide, immune therapy, innate immunity

A mouse model of prostate cancer bone metastasis in a syngeneic immunocompetent host Research Paper

Brian W. Simons, Vishal Kothari, Benjamin Benzon, Kamyar Ghabili, Robert Hughes, Jelani C. Zarif, Ashley E. Ross, Paula J. Hurley, Edward M. Schaeffer

Published Dec 3, 2019 · Vol. 10, No. 64 · pp. 6845-6854

Keywords: prostate cancer, bone metastasis, murine model

The impact of systemic precision medicine and immunotherapy treatments on brain metastases Review

Rowland H. Han, Gavin P. Dunn, Milan G. Chheda, Albert H. Kim

Published Nov 19, 2019 · Vol. 10, No. 62 · pp. 6739-6753

Keywords: brain metastases, targeted therapy, precision medicine, immunotherapy, systemic therapy

Lactate induces PD-L1 in HRAS^G12V-positive oropharyngeal squamous cell carcinoma Research Paper

Alexander K. Verma, Shanta M. Messerli, W. Keith Miskimins

Published Nov 15, 2019 · Vol. 11, No. 17 · pp. 1493-1504

Keywords: oropharyngeal cancer, lactate, Ras, anti-tumor immunity, PD-L1

Tumor mutational burden in lung cancer: a systematic literature review Review

Connor Willis, Michelle Fiander, Dao Tran, Beata Korytowsky, John-Michael Thomas, Florencio Calderon, Teresa M. Zyczynski, Diana Brixner, David D. Stenehjem

Published Nov 12, 2019 · Vol. 10, No. 61 · pp. 6604-6622

Keywords: biomarkers, chemotherapy, immunotherapy, lung cancer, PD-L1

The multifaceted anti-cancer effects of BRAF-inhibitors Review

Laura Croce, Francesca Coperchini, Flavia Magri, Luca Chiovato, Mario Rotondi

Published Nov 12, 2019 · Vol. 10, No. 61 · pp. 6623-6640

Keywords: BRAF, BRAF-inhibitors, tumor microenvironment, chemokines, CXCL8

Evaluation of a ConvitVax/anti-PD-1 combined immunotherapy for breast cancer treatment Research Paper

María José Godoy-Calderón, Eglys González-Marcano, Jeismar Carballo, Ana Federica Convit

Published Nov 12, 2019 · Vol. 10, No. 61 · pp. 6546-6560

Keywords: combination immunotherapies, cancer immunotherapy, breast cancer, autologous tumor cells vaccine, anti-PD-1

Characterizing CD44 regulatory microRNAs as putative therapeutic agents in human melanoma Research Paper

Johannes Fänder, Heike Kielstein, Maximilian Büttner, Peter Koelblinger, Reinhard Dummer, Marcus Bauer, Diana Handke, Claudia Wickenhauser, Barbara Seliger, Simon Jasinski-Bergner

Published Nov 5, 2019 · Vol. 10, No. 60 · pp. 6509-6525

Keywords: CD44, CD44v6, melanoma, microRNA, immune cell infiltration

Efficacy and safety of buparlisib, a PI3K inhibitor, in patients with malignancies harboring a PI3K pathway activation: a phase 2, open-label, single-arm study Research Paper

Sarina A. Piha-Paul, Matthew H. Taylor, Daniel Spitz, Lee Schwartzberg, J. Thaddeus Beck, Todd M. Bauer, Funda Meric-Bernstam, Das Purkayastha, Linda Karpiak, Sebastian Szpakowski, Fadi Braiteh

Published Nov 5, 2019 · Vol. 10, No. 60 · pp. 6526-6535

Keywords: phosphatidylinositol 3-kinase pathway, buparlisib, advanced malignancies, molecular selection, tissue agnostic

Extramammary Paget disease shows differential expression of B7 family members B7-H3, B7-H4, PD-L1, PD-L2 and cancer/testis antigens NY-ESO-1 and MAGE-A Research Paper

Maryam Pourmaleki, Jonathan H. Young, Nicholas D. Socci, Sarah Chiang, Marcia Edelweiss, Yanyun Li, Mianlei Zhang, Lev Roshal, Dennis S. Chi, Klaus J. Busam, Ingo K. Mellinghoff, Travis J. Hollmann

Published Oct 22, 2019 · Vol. 10, No. 58 · pp. 6152-6167

Keywords: extramammary paget disease, B7 family, cancer/testis antigens, targetable molecules, immunotherapy

Assessment of circularized E7 RNA, GLUT1, and PD-L1 in anal squamous cell carcinoma Research Paper

Bahir H. Chamseddin, Eunice E. Lee, Jiwoong Kim, Xiaowei Zhan, Rong Yang, Kathleen M. Murphy, Cheryl Lewis, Gregory A. Hosler, Suntrea T. Hammer, Richard C. Wang

Published Oct 15, 2019 · Vol. 10, No. 57 · pp. 5958-5969

Keywords: anal squamous cell carcinoma, circular RNA, GLUT1, human papillomavirus, PD-L1

Fewer actionable mutations but higher tumor mutational burden characterizes NSCLC in black patients at an urban academic medical center Research Paper

Noura J. Choudhury, Mansooreh Eghtesad, Sabah Kadri, John Cursio, Lauren Ritterhouse, Jeremy Segal, Aliya Husain, Jyoti D. Patel

Published Oct 8, 2019 · Vol. 10, No. 56 · pp. 5817-5823

Keywords: non-small cell lung cancer, healthcare disparities, targeted therapies, immunotherapies, biomarkers

Mechanisms by which PE21, an extract from the white willow Salix alba, delays chronological aging in budding yeast Research Paper

Younes Medkour, Karamat Mohammad, Anthony Arlia-Ciommo, Veronika Svistkova, Pamela Dakik, Darya Mitrofanova, Monica Enith Lozano Rodriguez, Jennifer Anne Baratang Junio, Tarek Taifour, Paola Escudero, Fani-Fay Goltsios, Sahar Soodbakhsh, Hana Maalaoui, Éric Simard, Vladimir I. Titorenko

Published Oct 8, 2019 · Vol. 10, No. 56 · pp. 5780-5816

Keywords: cellular aging, geroprotectors, lipid metabolism, necrotic cell death, mitochondria

Anti-VEGFR2 therapy delays growth of preclinical pediatric tumor models and enhances anti-tumor activity of chemotherapy Research Paper

Caitlin D. Lowery, Wayne Blosser, Michele Dowless, Matthew Renschler, Lisa V. Perez, Jennifer Stephens, Bronislaw Pytowski, Heather Wasserstrom, Louis F. Stancato, Beverly Falcon

Published Sep 17, 2019 · Vol. 10, No. 53 · pp. 5523-5533

Keywords: angiogenesis, pediatric cancer, VEGFR2, ramucirumab, DC101

Mechanisms by which PE21, an extract from the white willow Salix alba, delays chronological aging in budding yeast Research Paper

Younes Medkour, Karamat Mohammad, Anthony Arlia-Ciommo, Veronika Svistkova, Pamela Dakik, Darya Mitrofanova, Monica Enith Lozano Rodriguez, Jennifer Anne Baratang Junio, Tarek Taifour, Paola Escudero, Fani-Fay Goltsios, Sahar Soodbakhsh, Hana Maalaoui, Éric Simard, Vladimir I. Titorenko

Published Sep 5, 2019

Keywords: cellular aging, geroprotectors, lipid metabolism, necrotic cell death, mitochondria

Preliminary observations on soluble programmed cell death protein-1 as a prognostic and predictive biomarker in patients with metastatic melanoma treated with patient-specific autologous vaccines Research Paper

Robert O. Dillman, Gabriel I. Nistor, Bryce T. McLelland, Candace Hsieh, Aleksandra J. Poole, Andrew N. Cornforth, Hans S. Keirstead

Published Sep 3, 2019 · Vol. 10, No. 51 · pp. 5359-5371

Keywords: programmed cell death protein -1 (PD-1), dendritic cell vaccines, metastatic melanoma

TAK228 enhances antitumor activity of eribulin in triple negative breast cancer Research Paper

Nicci Owusu-Brackett, Kurt W. Evans, Argun Akcakanat, Erkan Yuca, Coya Tapia, Yasmeen Qamar Rizvi, Ecaterina Ileana Dumbrava, Filip Janku, Funda Meric-Bernstam

Published Aug 20, 2019 · Vol. 10, No. 49 · pp. 5011-5019

Keywords: breast cancer, TAK228, PI3K, PTEN, TNBC

Correction: HDAC inhibitors enhance neratinib activity and when combined enhance the actions of an anti-PD-1 immunomodulatory antibody in vivo Correction

Laurence Booth, Jane L. Roberts, Andrew Poklepovic, Francesca Avogadri-Connors, Richard E. Cutler, Alshad S. Lalani, Paul Dent

Published Aug 16, 2019 · Vol. 10, No. 49 · pp. 5120-5122

Chemo-/immuno-/radiotherapy combination in treatment of solid cancer Editorial

Lukas Käsmann, Julian Taugner, Farkhad Manapov

Published Aug 2, 2019 · Vol. 10, No. 52 · pp. 5387-5388

Keywords: multimodal treatment, radiotherapy, immune checkpoint inhibition, chemotherapy, PD-1/PD-L1

The landscape of novel and complementary targets for immunotherapy: an analysis of gene expression in the tumor microenvironment Research Paper

Stephen G. Gaffney, Elizabeth B. Perry, Ping-Min Chen, Andrew Greenstein, Susan M. Kaech, Jeffrey P. Townsend

Published Jul 16, 2019 · Vol. 10, No. 44 · pp. 4532-4545

Keywords: immunotherapy, tumor microenvironment, T lymphocyte, cancer genomics, RNA-seq

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Low-dose metronomic cyclophosphamide complements the actions of an intratumoral C-class CpG TLR9 agonist to potentiate innate immunity and drive potent T cell-mediated anti-tumor responses Research Paper

A mouse model of prostate cancer bone metastasis in a syngeneic immunocompetent host Research Paper

The impact of systemic precision medicine and immunotherapy treatments on brain metastases Review

Lactate induces PD-L1 in HRAS^G12V-positive oropharyngeal squamous cell carcinoma Research Paper

Tumor mutational burden in lung cancer: a systematic literature review Review

The multifaceted anti-cancer effects of BRAF-inhibitors Review

Evaluation of a ConvitVax/anti-PD-1 combined immunotherapy for breast cancer treatment Research Paper

Characterizing CD44 regulatory microRNAs as putative therapeutic agents in human melanoma Research Paper

Efficacy and safety of buparlisib, a PI3K inhibitor, in patients with malignancies harboring a PI3K pathway activation: a phase 2, open-label, single-arm study Research Paper

Extramammary Paget disease shows differential expression of B7 family members B7-H3, B7-H4, PD-L1, PD-L2 and cancer/testis antigens NY-ESO-1 and MAGE-A Research Paper

Assessment of circularized E7 RNA, GLUT1, and PD-L1 in anal squamous cell carcinoma Research Paper

Fewer actionable mutations but higher tumor mutational burden characterizes NSCLC in black patients at an urban academic medical center Research Paper

Mechanisms by which PE21, an extract from the white willow Salix alba, delays chronological aging in budding yeast Research Paper

Anti-VEGFR2 therapy delays growth of preclinical pediatric tumor models and enhances anti-tumor activity of chemotherapy Research Paper

Mechanisms by which PE21, an extract from the white willow Salix alba, delays chronological aging in budding yeast Research Paper

Preliminary observations on soluble programmed cell death protein-1 as a prognostic and predictive biomarker in patients with metastatic melanoma treated with patient-specific autologous vaccines Research Paper

TAK228 enhances antitumor activity of eribulin in triple negative breast cancer Research Paper

Correction: HDAC inhibitors enhance neratinib activity and when combined enhance the actions of an anti-PD-1 immunomodulatory antibody in vivo Correction

Chemo-/immuno-/radiotherapy combination in treatment of solid cancer Editorial

The landscape of novel and complementary targets for immunotherapy: an analysis of gene expression in the tumor microenvironment Research Paper

Publication Alerts

European Cancer and Oncology Congress

Oncoscience

Post-Publication Promotion

Search Oncotarget

Low-dose metronomic cyclophosphamide complements the actions of an intratumoral C-class CpG TLR9 agonist to potentiate innate immunity and drive potent T cell-mediated anti-tumor responses Research Paper

A mouse model of prostate cancer bone metastasis in a syngeneic immunocompetent host Research Paper

The impact of systemic precision medicine and immunotherapy treatments on brain metastases Review

Lactate induces PD-L1 in HRASG12V-positive oropharyngeal squamous cell carcinoma Research Paper

Tumor mutational burden in lung cancer: a systematic literature review Review

The multifaceted anti-cancer effects of BRAF-inhibitors Review

Evaluation of a ConvitVax/anti-PD-1 combined immunotherapy for breast cancer treatment Research Paper

Characterizing CD44 regulatory microRNAs as putative therapeutic agents in human melanoma Research Paper

Efficacy and safety of buparlisib, a PI3K inhibitor, in patients with malignancies harboring a PI3K pathway activation: a phase 2, open-label, single-arm study Research Paper

Extramammary Paget disease shows differential expression of B7 family members B7-H3, B7-H4, PD-L1, PD-L2 and cancer/testis antigens NY-ESO-1 and MAGE-A Research Paper

Assessment of circularized E7 RNA, GLUT1, and PD-L1 in anal squamous cell carcinoma Research Paper

Fewer actionable mutations but higher tumor mutational burden characterizes NSCLC in black patients at an urban academic medical center Research Paper

Mechanisms by which PE21, an extract from the white willow Salix alba, delays chronological aging in budding yeast Research Paper

Anti-VEGFR2 therapy delays growth of preclinical pediatric tumor models and enhances anti-tumor activity of chemotherapy Research Paper

Mechanisms by which PE21, an extract from the white willow Salix alba, delays chronological aging in budding yeast Research Paper

Preliminary observations on soluble programmed cell death protein-1 as a prognostic and predictive biomarker in patients with metastatic melanoma treated with patient-specific autologous vaccines Research Paper

TAK228 enhances antitumor activity of eribulin in triple negative breast cancer Research Paper

Correction: HDAC inhibitors enhance neratinib activity and when combined enhance the actions of an anti-PD-1 immunomodulatory antibody in vivo Correction

Chemo-/immuno-/radiotherapy combination in treatment of solid cancer Editorial

The landscape of novel and complementary targets for immunotherapy: an analysis of gene expression in the tumor microenvironment Research Paper

Lactate induces PD-L1 in HRAS^G12V-positive oropharyngeal squamous cell carcinoma Research Paper