The Oncosearch | Oncotarget

Actionability evaluation of biliary tract cancer by genome transcriptome analysis and Asian cancer knowledgebase Research Paper

Yuki Okawa, Nobutaka Ebata, Nayoung K.D. Kim, Masashi Fujita, Kazuhiro Maejima, Shota Sasagawa, Toru Nakamura, Woong-Yang Park, Satoshi Hirano, Hidewaki Nakagawa

Published Jun 28, 2021 · Vol. 12, No. 15 · pp. 1540-1552

Keywords: biliary tract cancer, mutation, immunotherapic biomarker, knowledgebase, molecular targeted therapy

Interferon-γ/IRF-1 pathway regulatory mechanisms of PD-L1 expression and relevance for immune checkpoint blockade in hepatocellular carcinoma (HCC) Editorial

Yihe Yan, Leting Zheng, Qiang Du, David A. Geller

Published Jun 14, 2021 · Vol. 12, No. 23 · pp. 2316-2317

Keywords: hepatocellular carcinoma, HCC, immune checkpoint, PD-L1, IRF-1

Human papilloma virus circulating tumor DNA assay predicts treatment response in recurrent/metastatic head and neck squamous cell carcinoma Research Paper

Catherine T. Haring, Chandan Bhambhani, Collin Brummel, Brittany Jewell, Emily Bellile, Molly E. Heft Neal, Erin Sandford, Ryan M. Spengler, Apurva Bhangale, Matthew E. Spector, Jonathan McHugh, Mark E. Prince, Michelle Mierzwa, Francis P. Worden, Muneesh Tewari, Paul L. Swiecicki, J. Chad Brenner

Published Jun 11, 2021 · Vol. 12, No. 13 · pp. 1214-1229

Keywords: HPV, head and neck cancer, oropharyngeal cancer, ctDNA, circulating tumor DNA

Targeting cancer stem cells via integrin β4 Research Perspective

Hannah E. Dobson, Shasha Ruan, Alfred E. Chang, Max S. Wicha, Qiao Li

Published May 21, 2021 · Vol. 12, No. 18 · pp. 1850-1858

Keywords: cancer stem cells, ITGβ4, dendritic cell vaccine, bispecific antibody, T cells

A Dynamic Energy Budget (DEB) based modeling framework to describe tumor-in-host growth inhibition and cachexia onset during anticancer treatment in in vivo xenograft studies Research Perspective

Elena Maria Tosca, Maurizio Rocchetti, Paolo Magni

Published May 6, 2021 · Vol. 12, No. 14 · pp. 1434-1441

Keywords: PK-PD modeling, tumor-growth-inhibition model, dynamic energy budget theory, cancer cachexia, xenograft model

Activation of plasmacytoid dendritic cells promotes AML-cell fratricide Research Paper

Kavin Fatehchand, Payal Mehta, Christopher B. Colvin, Nathaniel J. Buteyn, Ramasamy Santhanam, Giovanna Merchand-Reyes, Hafza Inshaar, Brenda Shen, Xiaokui Mo, Bethany Mundy-Bosse, Susheela Tridandapani, Jonathan P. Butchar

Published Apr 12, 2021 · Vol. 12, No. 9 · pp. 878-890

Keywords: plasmacytoid dendritic cells, interferon-beta, acute myeloid leukemia, fratricide

Immunotherapy and fatigue: what we know and what we don’t know News

Muhammad Azeem Khan, Vaia Florou, Umang Swami

Published Apr 7, 2021 · Vol. 12, No. 8 · pp. 719-720

Keywords: fatigue, PD-1, CTLA-4, testosterone, immunotherapy-related fatigue

High in vitro and in vivo synergistic activity between mTORC1 and PLK1 inhibition in adenocarcinoma NSCLC Research Paper

Elodie Montaudon, Rania El Botty, Sophie Vacher, Olivier Déas, Adnan Naguez, Sophie Chateau-Joubert, Damien Treguer, Ludmilla de Plater, Leïla Zemoura, Fariba Némati, André Nicolas, Alain Chapelier, Alain Livartowski, Stefano Cairo, Catherine Daniel, Marie Brevet, Elisabetta Marangoni, Didier Meseure, Sergio Roman-Roman, Ivan Bieche, Nicolas Girard, Didier Decaudin

Published Mar 26, 2021 · Vol. 12, No. 8 · pp. 859-872

Keywords: NSCLC, Pi3K signalling pathway, mTORC1, RAD001 (everolimus), PLK1

Mutually exclusive lymphangiogenesis or perineural infiltration in human skin squamous-cell carcinoma Research Paper

Julien Schaller, Hélène Maby-El Hajjami, Sylvie Rusakiewicz, Kalliopi Ioannidou, Nathalie Piazzon, Alexandra Miles, Déla Golshayan, Olivier Gaide, Daniel Hohl, Daniel E. Speiser, Karin Schaeuble

Published Mar 5, 2021 · Vol. 12, No. 7 · pp. 638-648

Keywords: lymphatic vessel, CD8+ T cell, perineural infiltration, skin squamous-cell carcinoma, tumor immunology

Genomic and neoantigen evolution from primary tumor to first metastases in head and neck squamous cell carcinoma Research Paper

Charles R. Schutt, Hua Sun, Jaya Sarin Pradhan, Yvonne Saenger, Jessica Ley, Douglas Adkins, Matthew Ingham, Li Ding, Brian A. Van Tine

Published Feb 21, 2021 · Vol. 12, No. 6 · pp. 534-548

Keywords: head and neck squamous cell carcinoma, neoantigens, mutational evolution, tumor relapse, immune cell infiltration

The role of immune surveillance in malignant transformation of benign salivary gland tumors Research Perspective

Maximilian Linxweiler, Jingming Wang, Luc G.T. Morris

Published Feb 10, 2021 · Vol. 12, No. 7 · pp. 592-595

Keywords: salivary tumor, salivary cancer, pleomorphic adenoma, immune surveillance

Intratumoral immunotherapy with STING agonist, ADU-S100, induces CD8+ T-cell mediated anti-tumor immunity in an esophageal adenocarcinoma model Research Paper

Ali H. Zaidi, Ronan J. Kelly, Anastasia Gorbunova, Ashten N. Omstead, Madison S. Salvitti, Ping Zheng, Juliann E. Kosovec, Soyoung Lee, Shahin Ayazi, Laila Babar, Gene G. Finley, Ajay Goel, Blair A. Jobe

Published Feb 1, 2021 · Vol. 12, No. 4 · pp. 292-303

Keywords: esophageal adenocarcinoma, STING, PD-L1, CD8+ T-cells, IFNβ

Tumor mutational burden as a predictor of immunotherapy response in breast cancer Research Perspective

Tess A. O’Meara, Sara M. Tolaney

Published Jan 23, 2021 · Vol. 12, No. 5 · pp. 394-400

Keywords: breast cancer, immunotherapy, tumor mutational burden

Characterization of FGFR signaling in prostate cancer stem cells and inhibition via TKI treatment Research Paper

Juyeon Ko, April N. Meyer, Martin Haas, Daniel J. Donoghue

Published Dec 23, 2020 · Vol. 12, No. 1 · pp. 22-36

Keywords: metastatic castrate-resistant prostate cancer, spheroid culture, tyrosine kinase inhibitor

Successful administration of sequential TVEC and pembrolizumab followed by Temozolomide in immunotherapy refractory intracranial metastatic melanoma with acquired B2M mutation Case Report

Karam Khaddour, Joshua Dowling, Jiayi Huang, Martha Council, David Chen, Lynn Cornelius, Tanner Johanns, Sonika Dahiya, George Ansstas

Published Dec 13, 2020 · Vol. 11, No. 52 · pp. 4836-4844

Keywords: metastatic melanoma, immune checkpoint inhibitor, temozolomide, acquired resistance, beta-2 microglobulin

Treatment of elderly patients with refractory/relapsed multiple myeloma: oral drugs adherence and the COVID-19 outbreak Research Perspective

Flávia Dias Xavier, Fernando Sergio Blumm Ferreira, Rodrigo Martins Abreu

Published Nov 10, 2020 · Vol. 11, No. 47 · pp. 4371-4386

Keywords: healthcare, multiple myeloma, adherence, elderly, refractory/relapsed

Immune profiling of the bone marrow microenvironment in patients with high-risk localized prostate cancer Research Paper

Erika Heninger, Nan Sethakorn, David Kosoff, Peiman Hematti, Morgan D. Kuczler, Kenneth J. Pienta, Joshua M. Lang

Published Nov 10, 2020 · Vol. 11, No. 46 · pp. 4253-4265

Keywords: prostate cancer, bone marrow, tumor microenvironment, immune profiling, immune landscape

Baseline CD44v6-positive circulating tumor cells to predict first-line treatment failure in patients with metastatic colorectal cancer Research Paper

Chiara Nicolazzo, Flavia Loreni, Salvatore Caponnetto, Valentina Magri, Anna Rita Vestri, Rita Zamarchi, Angela Gradilone, Antonella Facchinetti, Elisabetta Rossi, Enrico Cortesi, Paola Gazzaniga

Published Oct 24, 2020 · Vol. 11, No. 45 · pp. 4115-4122

Keywords: cancer stem cells, CD44v6, circulating tumor cells, colorectal cancer, CellSearch^®

Phase I trial of TRC102 (methoxyamine HCl) in combination with temozolomide in patients with relapsed solid tumors and lymphomas Research Paper

Geraldine O'Sullivan Coyne, Shivaani Kummar, Robert S. Meehan, Khanh Do, Jerry M. Collins, Larry Anderson, Kazusa Ishii, Naoko Takebe, Jennifer Zlott, Lamin Juwara, Richard Piekarz, Howard Streicher, Elad Sharon, Larry Rubinstein, Andrea Regier Voth, Jay Lozier, Angie B. Dull, Deborah Wilsker, Toshinori Hinoue, Peter W. Laird, Katherine V. Ferry-Galow, Robert J. Kinders, Ralph E. Parchment, James H. Doroshow, Alice P. Chen

Published Oct 12, 2020 · Vol. 11, No. 44 · pp. 3959-3971

Keywords: DNA damage repair, base excision repair, MGMT, rational combination therapy, molecular pharmacodynamics

Evaluations of CRC2631 toxicity, tumor colonization, and genetic stability in the TRAMP prostate cancer model Research Paper

Robert A. Kazmierczak, Bakul Dhagat-Mehta, Elke Gulden, Li Lee, Lixin Ma, Clintin P. Davis-Stober, Austen A. Barnett, Chiswili Yves Chabu

Published Oct 4, 2020 · Vol. 11, No. 44 · pp. 3943-3958

Keywords: salmonella, cancer targeting, prostate cancer, immunotherapy, TRAMP

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Actionability evaluation of biliary tract cancer by genome transcriptome analysis and Asian cancer knowledgebase Research Paper

Interferon-γ/IRF-1 pathway regulatory mechanisms of PD-L1 expression and relevance for immune checkpoint blockade in hepatocellular carcinoma (HCC) Editorial

Human papilloma virus circulating tumor DNA assay predicts treatment response in recurrent/metastatic head and neck squamous cell carcinoma Research Paper

Targeting cancer stem cells via integrin β4 Research Perspective

A Dynamic Energy Budget (DEB) based modeling framework to describe tumor-in-host growth inhibition and cachexia onset during anticancer treatment in in vivo xenograft studies Research Perspective

Activation of plasmacytoid dendritic cells promotes AML-cell fratricide Research Paper

Immunotherapy and fatigue: what we know and what we don’t know News

High in vitro and in vivo synergistic activity between mTORC1 and PLK1 inhibition in adenocarcinoma NSCLC Research Paper

Mutually exclusive lymphangiogenesis or perineural infiltration in human skin squamous-cell carcinoma Research Paper

Genomic and neoantigen evolution from primary tumor to first metastases in head and neck squamous cell carcinoma Research Paper

The role of immune surveillance in malignant transformation of benign salivary gland tumors Research Perspective

Intratumoral immunotherapy with STING agonist, ADU-S100, induces CD8+ T-cell mediated anti-tumor immunity in an esophageal adenocarcinoma model Research Paper

Tumor mutational burden as a predictor of immunotherapy response in breast cancer Research Perspective

Characterization of FGFR signaling in prostate cancer stem cells and inhibition via TKI treatment Research Paper

Successful administration of sequential TVEC and pembrolizumab followed by Temozolomide in immunotherapy refractory intracranial metastatic melanoma with acquired B2M mutation Case Report

Treatment of elderly patients with refractory/relapsed multiple myeloma: oral drugs adherence and the COVID-19 outbreak Research Perspective

Immune profiling of the bone marrow microenvironment in patients with high-risk localized prostate cancer Research Paper

Baseline CD44v6-positive circulating tumor cells to predict first-line treatment failure in patients with metastatic colorectal cancer Research Paper

Phase I trial of TRC102 (methoxyamine HCl) in combination with temozolomide in patients with relapsed solid tumors and lymphomas Research Paper

Evaluations of CRC2631 toxicity, tumor colonization, and genetic stability in the TRAMP prostate cancer model Research Paper

Publication Alerts

European Cancer and Oncology Congress

Oncoscience

Post-Publication Promotion

Search Oncotarget

Actionability evaluation of biliary tract cancer by genome transcriptome analysis and Asian cancer knowledgebase Research Paper

Interferon-γ/IRF-1 pathway regulatory mechanisms of PD-L1 expression and relevance for immune checkpoint blockade in hepatocellular carcinoma (HCC) Editorial

Human papilloma virus circulating tumor DNA assay predicts treatment response in recurrent/metastatic head and neck squamous cell carcinoma Research Paper

Targeting cancer stem cells via integrin β4 Research Perspective

A Dynamic Energy Budget (DEB) based modeling framework to describe tumor-in-host growth inhibition and cachexia onset during anticancer treatment in in vivo xenograft studies Research Perspective

Activation of plasmacytoid dendritic cells promotes AML-cell fratricide Research Paper

Immunotherapy and fatigue: what we know and what we don’t know News

High in vitro and in vivo synergistic activity between mTORC1 and PLK1 inhibition in adenocarcinoma NSCLC Research Paper

Mutually exclusive lymphangiogenesis or perineural infiltration in human skin squamous-cell carcinoma Research Paper

Genomic and neoantigen evolution from primary tumor to first metastases in head and neck squamous cell carcinoma Research Paper

The role of immune surveillance in malignant transformation of benign salivary gland tumors Research Perspective

Intratumoral immunotherapy with STING agonist, ADU-S100, induces CD8+ T-cell mediated anti-tumor immunity in an esophageal adenocarcinoma model Research Paper

Tumor mutational burden as a predictor of immunotherapy response in breast cancer Research Perspective

Characterization of FGFR signaling in prostate cancer stem cells and inhibition via TKI treatment Research Paper

Successful administration of sequential TVEC and pembrolizumab followed by Temozolomide in immunotherapy refractory intracranial metastatic melanoma with acquired B2M mutation Case Report

Treatment of elderly patients with refractory/relapsed multiple myeloma: oral drugs adherence and the COVID-19 outbreak Research Perspective

Immune profiling of the bone marrow microenvironment in patients with high-risk localized prostate cancer Research Paper

Baseline CD44v6-positive circulating tumor cells to predict first-line treatment failure in patients with metastatic colorectal cancer Research Paper

Phase I trial of TRC102 (methoxyamine HCl) in combination with temozolomide in patients with relapsed solid tumors and lymphomas Research Paper

Evaluations of CRC2631 toxicity, tumor colonization, and genetic stability in the TRAMP prostate cancer model Research Paper