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A tyrosine kinase-STAT5-miR21-PDCD4 regulatory axis in chronic and acute myeloid leukemia cells Research Paper

Anne-Sophie Espadinha, ValÃ©rie Prouzet-MaulÃ©on, StÃ©phane Claverol, ValÃ©rie Lagarde, Marc Bonneu, FranÃ§ois-Xavier Mahon, Bruno Cardinaud

Published Jul 12, 2017 · Vol. 8, No. 44 · pp. 76174-76188

Characterization of midostaurin as a dual inhibitor of FLT3 and SYK and potentiation of FLT3 inhibition against FLT3-ITD-driven leukemia harboring activated SYK kinase Priority Research Paper

Ellen L. Weisberg, Alexandre Puissant, Richard Stone, Martin Sattler, Sara J. Buhrlage, Jing Yang, Paul W. Manley, Chengcheng Meng, Michael Buonopane, John F. Daley, Suzan Lazo, Renee Wright, David M. Weinstock, Amanda L. Christie, Kimberly Stegmaier, James D. Griffin

Published Jul 6, 2017 · Vol. 8, No. 32 · pp. 52026-52044

Acute myeloid leukemia cells require 6-phosphogluconate dehydrogenase for cell growth and NADPH-dependent metabolic reprogramming Research Paper

Haymanti Bhanot, Ellen L. Weisberg, Mamatha M. Reddy, Atsushi Nonami, Donna Neuberg, Richard M. Stone, Klaus Podar, Ravi Salgia, James D. Griffin, Martin Sattler

Published Jun 28, 2017 · Vol. 8, No. 40 · pp. 67639-67650

Combined inhibition of GLI and FLT3 signaling leads to effective anti-leukemic effects in human acute myeloid leukemia Research Paper

Emily-Marie Latuske, Hauke Stamm, Marianne Klokow, Gabi Vohwinkel, Jana Muschhammer, Carsten Bokemeyer, Manfred JÃ¼cker, Maxim Kebenko, Walter Fiedler, Jasmin Wellbrock

Published Mar 16, 2017 · Vol. 8, No. 17 · pp. 29187-29201

Synergistic killing of FLT3ITD-positive AML cells by combined inhibition of tyrosine-kinase activity and N-glycosylation Research Paper

Dimitrios Tsitsipatis, Ashok Kumar Jayavelu, JÃ¶rg P. MÃ¼ller, Reinhard Bauer, Dirk Schmidt-Arras, Siavosh Mahboobi, Tina M. SchnÃ¶der, Florian Heidel, Frank D. BÃ¶hmer

Published Feb 28, 2017 · Vol. 8, No. 16 · pp. 26613-26624

Stat5 deficiency decreases transcriptional heterogeneity and supports emergence of hematopoietic sub-populations Research Paper

Zhengqi Wang, Kevin D. Bunting

Published Feb 9, 2017 · Vol. 8, No. 14 · pp. 22477-22482

ABL2 suppresses FLT3-ITD-induced cell proliferation through negative regulation of AKT signaling Research Paper

Julhash U. Kazi, Kaja Rupar, Alissa MarhÃ¤ll, Sausan A. Moharram, Fatima Khanum, Kinjal Shah, Mohiuddin Gazi, Sachin Raj M. Nagaraj, Jianmin Sun, Rohit A. Chougule, Lars RÃ¶nnstrand

Published Jan 10, 2017 · Vol. 8, No. 7 · pp. 12194-12202

FLT3 activating mutations display differential sensitivity to multiple tyrosine kinase inhibitors Research Paper

Bao Nguyen, Allen B. Williams, David J. Young, Hayley Ma, Li Li, Mark Levis, Patrick Brown, Donald Small

Published Jan 6, 2017 · Vol. 8, No. 7 · pp. 10931-10944

The combination effect of homoharringtonine and ibrutinib on FLT3-ITD mutant acute myeloid leukemia Research Paper

Xia Li, Xiufeng Yin, Huafeng Wang, Jiansong Huang, Mengxia Yu, Zhixin Ma, Chenying Li, Yile Zhou, Xiao Yan, ShuJuan Huang, Jie Jin

Published Jan 3, 2017 · Vol. 8, No. 8 · pp. 12764-12774

Recurrent genetic defects on chromosome 5q in myeloid neoplasms Research Paper

Naoko Hosono, Hideki Makishima, Reda Mahfouz, Bartlomiej Przychodzen, Kenichi Yoshida, Andres Jerez, Thomas LaFramboise, Chantana Polprasert, Michael J. Clemente, Yuichi Shiraishi, Kenichi Chiba, Hiroko Tanaka, Satoru Miyano, Masashi Sanada, Edward Cui, Amit K. Verma, Michael A. McDevit, Alan F. List, Yogen Saunthararajah, Mikkael A. Sekeres, Jacqueline Boultwood, Seishi Ogawa, Jaroslaw P. Maciejewski

Published Dec 23, 2016 · Vol. 8, No. 4 · pp. 6483-6495

The implication of FLT3 amplification for FLT targeted therapeutics in solid tumors Research Paper

Sung Hee Lim, Sun-Young Kim, Kyung Kim, Hyojin Jang, Soomin Ahn, Kyoung-Mee Kim, Nayoung K.D. Kim, Woongyang Park, Su Jin Lee, Seung Tae Kim, Se Hoon Park, Joon Oh Park, Young Suk Park, Se-Hoon Lee, Ho Yeong Lim, Keunchil Park, Won Ki Kang, Jeeyun Lee

Published Nov 29, 2016 · Vol. 8, No. 2 · pp. 3237-3245

NT1721, a novel epidithiodiketopiperazine, exhibits potent in vitro and in vivo efficacy against acute myeloid leukemia Research Paper

Claudia M. Kowolik, Min Lin, Jun Xie, Larry E. Overman, David A. Horne

Published Nov 15, 2016 · Vol. 7, No. 52 · pp. 86186-86197

Discovery of BPR1K871, a quinazoline based, multi-kinase inhibitor for the treatment of AML and solid tumors: Rational design, synthesis, in vitro and in vivo evaluation Research Paper

Yung Chang Hsu, Mohane Selvaraj Coumar, Wen-Chieh Wang, Hui-Yi Shiao, Yi-Yu Ke, Wen-Hsing Lin, Ching-Chuan Kuo, Chun-Wei Chang, Fu-Ming Kuo, Pei-Yi Chen, Sing-Yi Wang, An-Siou Li, Chun-Hwa Chen, Po-Chu Kuo, Ching-Ping Chen, Ming-Hsine Wu, Chen-Lung Huang, Kuei-Jung Yen, Yun-I Chang, John T.-A. Hsu, Chiung-Tong Chen, Teng-Kuang Yeh, Jen-Shin Song, Chuan Shih, Hsing-Pang Hsieh

Published Nov 15, 2016 · Vol. 7, No. 52 · pp. 86239-86256

MEK1 is required for the development of NRAS-driven leukemia Priority Research Paper

Joanna D. Nowacka, Christian Baumgartner, Cristiana Pelorosso, Mareike Roth, Johannes Zuber, Manuela Baccarini

Published Oct 10, 2016 · Vol. 7, No. 49 · pp. 80113-80130

Prognostic nomogram for previously untreated adult patients with acute myeloid leukemia Research Paper

Zhuojun Zheng, Xiaodong Li, Yuandong Zhu, Weiying Gu, Xiaobao Xie, Jingting Jiang

Published Sep 26, 2016 · Vol. 7, No. 44 · pp. 71526-71535

Clonal and microclonal mutational heterogeneity in high hyperdiploid acute lymphoblastic leukemia Research Paper

Adam J. de Smith, Juhi Ojha, Stephen S. Francis, Erica Sanders, Alyson A. Endicott, Helen M. Hansen, Ivan Smirnov, Amanda M. Termuhlen, Kyle M. Walsh, Catherine Metayer, Joseph L. Wiemels

Published Sep 24, 2016 · Vol. 7, No. 45 · pp. 72733-72745

Dnmt3a deletion cooperates with the Flt3/ITD mutation to drive leukemogenesis in a murine model Priority Research Paper

Jennifer L. Poitras, Diane Heiser, Li Li, Bao Nguyen, Kozo Nagai, Amy S. Duffield, Christopher Gamper, Donald Small

Published Sep 12, 2016 · Vol. 7, No. 43 · pp. 69124-69135

MYSM1/miR-150/FLT3 inhibits B1a cell proliferation Research Paper

Xiao-Xia Jiang, Yu Liu, Hong Li, Yaping Gao, Rong Mu, Jianping Guo, Jing Zhang, Yan-Mei Yang, Fengjun Xiao, Bing Liu, Changyong Wang, Beifen Shen, Si-Yi Chen, Zhanguo Li, Guang Yang

Published Aug 31, 2016 · Vol. 7, No. 42 · pp. 68086-68096

RIPK3-dependent cell death and inflammasome activation in FLT3-ITD expressing LICs Commentary

Ulrike HÃ¶ckendorf, Monica Yabal, Philipp J. Jost

Published Aug 10, 2016 · Vol. 7, No. 36 · pp. 57483-57484

Genomic complexity and dynamics of clonal evolution in childhood acute myeloid leukemia studied with whole-exome sequencing Research Paper

Riccardo Masetti, Ilaria Castelli, Annalisa Astolfi, Salvatore Nicola Bertuccio, Valentina Indio, Marco Togni, Tamara Belotti, Salvatore Serravalle, Giuseppe Tarantino, Marco Zecca, Martina Pigazzi, Giuseppe Basso, Andrea Pession, Franco Locatelli

Published Jul 22, 2016 · Vol. 7, No. 35 · pp. 56746-56757

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A tyrosine kinase-STAT5-miR21-PDCD4 regulatory axis in chronic and acute myeloid leukemia cells Research Paper

Characterization of midostaurin as a dual inhibitor of FLT3 and SYK and potentiation of FLT3 inhibition against FLT3-ITD-driven leukemia harboring activated SYK kinase Priority Research Paper

Acute myeloid leukemia cells require 6-phosphogluconate dehydrogenase for cell growth and NADPH-dependent metabolic reprogramming Research Paper

Combined inhibition of GLI and FLT3 signaling leads to effective anti-leukemic effects in human acute myeloid leukemia Research Paper

Synergistic killing of FLT3ITD-positive AML cells by combined inhibition of tyrosine-kinase activity and N-glycosylation Research Paper

Stat5 deficiency decreases transcriptional heterogeneity and supports emergence of hematopoietic sub-populations Research Paper

ABL2 suppresses FLT3-ITD-induced cell proliferation through negative regulation of AKT signaling Research Paper

FLT3 activating mutations display differential sensitivity to multiple tyrosine kinase inhibitors Research Paper

The combination effect of homoharringtonine and ibrutinib on FLT3-ITD mutant acute myeloid leukemia Research Paper

Recurrent genetic defects on chromosome 5q in myeloid neoplasms Research Paper

The implication of FLT3 amplification for FLT targeted therapeutics in solid tumors Research Paper

NT1721, a novel epidithiodiketopiperazine, exhibits potent in vitro and in vivo efficacy against acute myeloid leukemia Research Paper

Discovery of BPR1K871, a quinazoline based, multi-kinase inhibitor for the treatment of AML and solid tumors: Rational design, synthesis, in vitro and in vivo evaluation Research Paper

MEK1 is required for the development of NRAS-driven leukemia Priority Research Paper

Prognostic nomogram for previously untreated adult patients with acute myeloid leukemia Research Paper

Clonal and microclonal mutational heterogeneity in high hyperdiploid acute lymphoblastic leukemia Research Paper

Dnmt3a deletion cooperates with the Flt3/ITD mutation to drive leukemogenesis in a murine model Priority Research Paper

MYSM1/miR-150/FLT3 inhibits B1a cell proliferation Research Paper

RIPK3-dependent cell death and inflammasome activation in FLT3-ITD expressing LICs Commentary

Genomic complexity and dynamics of clonal evolution in childhood acute myeloid leukemia studied with whole-exome sequencing Research Paper

Publication Alerts

European Cancer and Oncology Congress

Oncoscience

Post-Publication Promotion

Search Oncotarget

A tyrosine kinase-STAT5-miR21-PDCD4 regulatory axis in chronic and acute myeloid leukemia cells Research Paper

Characterization of midostaurin as a dual inhibitor of FLT3 and SYK and potentiation of FLT3 inhibition against FLT3-ITD-driven leukemia harboring activated SYK kinase Priority Research Paper

Acute myeloid leukemia cells require 6-phosphogluconate dehydrogenase for cell growth and NADPH-dependent metabolic reprogramming Research Paper

Combined inhibition of GLI and FLT3 signaling leads to effective anti-leukemic effects in human acute myeloid leukemia Research Paper

Synergistic killing of FLT3ITD-positive AML cells by combined inhibition of tyrosine-kinase activity and N-glycosylation Research Paper

Stat5 deficiency decreases transcriptional heterogeneity and supports emergence of hematopoietic sub-populations Research Paper

ABL2 suppresses FLT3-ITD-induced cell proliferation through negative regulation of AKT signaling Research Paper

FLT3 activating mutations display differential sensitivity to multiple tyrosine kinase inhibitors Research Paper

The combination effect of homoharringtonine and ibrutinib on FLT3-ITD mutant acute myeloid leukemia Research Paper

Recurrent genetic defects on chromosome 5q in myeloid neoplasms Research Paper

The implication of FLT3 amplification for FLT targeted therapeutics in solid tumors Research Paper

NT1721, a novel epidithiodiketopiperazine, exhibits potent in vitro and in vivo efficacy against acute myeloid leukemia Research Paper

Discovery of BPR1K871, a quinazoline based, multi-kinase inhibitor for the treatment of AML and solid tumors: Rational design, synthesis, in vitro and in vivo evaluation Research Paper

MEK1 is required for the development of NRAS-driven leukemia Priority Research Paper

Prognostic nomogram for previously untreated adult patients with acute myeloid leukemia Research Paper

Clonal and microclonal mutational heterogeneity in high hyperdiploid acute lymphoblastic leukemia Research Paper

Dnmt3a deletion cooperates with the Flt3/ITD mutation to drive leukemogenesis in a murine model Priority Research Paper

MYSM1/miR-150/FLT3 inhibits B1a cell proliferation Research Paper

RIPK3-dependent cell death and inflammasome activation in FLT3-ITD expressing LICs Commentary

Genomic complexity and dynamics of clonal evolution in childhood acute myeloid leukemia studied with whole-exome sequencing Research Paper