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Efficacy of azacitidine is independent of molecular and clinical characteristics - an analysis of 128 patients with myelodysplastic syndromes or acute myeloid leukemia and a review of the literature Clinical Review

Andrea Kuendgen, Catharina MÃ¼ller-Thomas, Michael Lauseker, Torsten Haferlach, Petra Urbaniak, Thomas Schroeder, Carolin Brings, Michael Wulfert, Manja Meggendorfer, Barbara Hildebrandt, Beate Betz, Brigitte Royer-Pokora, Norbert Gattermann, Rainer Haas, Ulrich Germing, Katharina S. GÃ¶tze

Published Jun 12, 2018 · Vol. 9, No. 45 · pp. 27882-27894

Correction: Discovery of a FLT3 inhibitor LDD1937 as an anti-leukemic agent for acute myeloid leukemia Correction

Hyo Jeong Lee, Jungeun Lee, Pyeonghwa Jeong, Jungil Choi, Juhwa Baek, Su Jin Ahn, Yeongyu Moon, Jeong Doo Heo, Young Hee Choi, Young-Won Chin, Yong-Chul Kim, Sun-Young Han

Published Apr 13, 2018 · Vol. 9, No. 28 · pp. 20219-20219

A novel, dual pan-PIM/FLT3 inhibitor SEL24 exhibits broad therapeutic potential in acute myeloid leukemia Research Paper

Wojciech Czardybon, Renata Windak, Aniela GoÅ‚as, MichaÅ‚ GaÅ‚Ä™zowski, Aleksandra Sabiniarz, Izabela Dolata, Magdalena SalwiÅ„ska, PaweÅ‚ Guzik, Magdalena Zawadzka, Ewelina Gabor-Worwa, BoÅ¼ena Winnik, MaÅ‚gorzata Å»urawska, Ewa KolasiÅ„ska, Ewelina Wincza, Marta Bugaj, Monika Danielewicz, Eliza Majewska, Milena Mazan, Grzegorz Dubin, Monika Noyszewska-Kania, Ewa JabÅ‚oÅ„ska, Maciej SzydÅ‚owski, Tomasz Sewastianik, Bartosz PuÅ‚a, Anna Szumera-CieÄ‡kiewicz, Monika Prochorec-Sobieszek, ElÅ¼bieta MÄ…dro, Ewa Lech-MaraÅ„da, Krzysztof Warzocha, Jerome Tamburini, PrzemysÅ‚aw JuszczyÅ„ski, Krzysztof BrzÃ³zka

Published Mar 30, 2018 · Vol. 9, No. 24 · pp. 16917-16931

Association analysis of SNPs present in plasma with adverse events and population pharmacokinetics in Chinese sunitinib treated patients with renal cell carcinoma Research Paper

Yuanyuan Zhang, Haixing Mai, Gang Guo, Guofang Bi, Guangtao Hao, Yuanyuan Li, Xiaofang Wang, Longmei Cheng, Jing Wang, Ruihua Dong, Zeyuan Liu, Lijun Chen, Hengyan Qu

Published Mar 6, 2018 · Vol. 9, No. 18 · pp. 14109-14123

Mixed phenotype acute leukemia contains heterogeneous genetic mutations by next-generation sequencing Research Paper

AndrÃ©s E. Quesada, Zhihong Hu, Mark J. Routbort, Keyur P. Patel, Rajyalakshmi Luthra, Sanam Loghavi, Zhuang Zuo, C. Cameron Yin, Rashmi Kanagal-Shamanna, Sa A. Wang, Jeffrey L. Jorgensen, L. Jeffrey Medeiros, Chi Young Ok

Published Jan 3, 2018 · Vol. 9, No. 9 · pp. 8441-8449

Consecutive epigenetically-active agent combinations act in ID1-RUNX3-TET2 and HOXA pathways for Flt3ITD+ve AML Research Paper

Hamid Sayar, Yan Liu, Rui Gao, Mohammad Abu Zaid, Larry D. Cripe, Jill Weisenbach, Katie J. Sargent, Mehdi Nassiri, Lang Li, Heiko Konig, Attaya Suvannasankha, Feng Pan, Rajasubramaniam Shanmugam, Chirayu Goswami, Reuben Kapur, Mingjiang Xu, H. Scott Boswell

Published Dec 25, 2017 · Vol. 9, No. 5 · pp. 5703-5715

Flow cytometric characterization of acute leukemia reveals a distinctive â€œblast gateâ€ of murine T-lymphoblastic leukemia/lymphoma Research Paper

Zengkai Pan, Min Yang, Kezhi Huang, Guntram BÃ¼sche, Silke Glage, Arnold Ganser, Zhixiong Li

Published Dec 18, 2017 · Vol. 9, No. 2 · pp. 2320-2328

Acute myeloid leukemia with t(4;12)(q12;p13): an aggressive disease with frequent involvement of PDGFRA and ETV6 Research Paper

Jingyi Li, Jie Xu, Lynne V. Abruzzo, Guilin Tang, Shaoying Li, M. James You, Gary Lu, Elias J. Jabbour, Qi Deng, Carlos E. Bueso-Ramos, L. Jeffrey Medeiros, C. Cameron Yin

Published Dec 15, 2017 · Vol. 9, No. 13 · pp. 10987-10994

Discovery of a FLT3 inhibitor LDD1937 as an anti-leukemic agent for acute myeloid leukemia Research Paper

Hyo Jeong Lee, Jungeun Lee, Pyeonghwa Jeong, Jungil Choi, Juhwa Baek, Su Jin Ahn, Yeongyu Moon, Jeong Doo Heo, Young Hee Choi, Young-Won Chin, Yong-Chul Kim, Sun-Young Han

Published Dec 14, 2017 · Vol. 9, No. 1 · pp. 924-936

FLT3-ITD induces expression of Pim kinases through STAT5 to confer resistance to the PI3K/Akt pathway inhibitors on leukemic cells by enhancing the mTORC1/Mcl-1 pathway Research Paper

Keigo Okada, Ayako Nogami, Shinya Ishida, Hiroki Akiyama, Cheng Chen, Yoshihiro Umezawa, Osamu Miura

Published Dec 4, 2017 · Vol. 9, No. 10 · pp. 8870-8886

Inhibition of SDF-1-induced migration of oncogene-driven myeloid leukemia by the L-RNA aptamer (Spiegelmer), NOX-A12, and potentiation of tyrosine kinase inhibition Research Paper

Ellen L. Weisberg, Martin Sattler, Abdel Kareem Azab, Dirk Eulberg, Anna Kruschinski, Paul W. Manley, Richard Stone, James D. Griffin

Published Nov 6, 2017 · Vol. 8, No. 66 · pp. 109973-109984

Nuclear membrane-localised NOX4D generates pro-survival ROS in FLT3-ITD-expressing AML Research Paper

Jennifer N. Moloney, Ashok Kumar Jayavelu, Joanna Stanicka, Sarah L. Roche, Rebecca L. Oâ€™Brien, Sebastian Scholl, Frank-D. BÃ¶hmer, Thomas G. Cotter

Published Nov 1, 2017 · Vol. 8, No. 62 · pp. 105440-105457

High Tim-3 expression on AML blasts could enhance chemotherapy sensitivity Research Paper

Liangjing Xu, Jinge Xu, Shoubao Ma, Xiaoli Li, Mingqing Zhu, Suning Chen, Yue Han, Xiaowen Tang, Zhengzheng Fu, Huiying Qiu, Jianhua Yu, Depei Wu, Xiaojin Wu

Published Oct 27, 2017 · Vol. 8, No. 60 · pp. 102088-102096

Azacitidine combined with the selective FLT3 kinase inhibitor crenolanib disrupts stromal protection and inhibits expansion of residual leukemia-initiating cells in FLT3-ITD AML with concurrent epigenetic mutations Research Paper

Anne-Kathrin Garz, Saskia Wolf, Sonja Grath, Verena Gaidzik, Stefan Habringer, Binje Vick, Martina Rudelius, Christoph Ziegenhain, Sylvia Herold, Marie-Theresa Weickert, Martha Smets, Christian Peschel, Robert A.J. Oostendorp, Sebastian Bultmann, Irmela Jeremias, Christian Thiede, Konstanze DÃ¶hner, Ulrich Keller, Katharina S. GÃ¶tze

Published Oct 16, 2017 · Vol. 8, No. 65 · pp. 108738-108759

DOCK2: A novel FLT3/ITD leukemia drug target Editorial

Min Wu, Donald Small, Amy S. Duffield

Published Sep 30, 2017 · Vol. 8, No. 51 · pp. 88253-88254

UCB HCT in FLT3+ AML Editorial

Celalettin Ustun, Annalisa Ruggeri, Daniel J. Weisdorf

Published Sep 19, 2017 · Vol. 8, No. 47 · pp. 81733-81734

Quizartinib (AC220) reverses ABCG2-mediated multidrug resistance: In vitro and in vivo studies Research Paper

Jun Li, Priyank Kumar, Nagaraju Anreddy, Yun-Kai Zhang, Yi-Jun Wang, Yanglu Chen, Tanaji T. Talele, Kanav Gupta, Louis D. Trombetta, Zhe-Sheng Chen

Published Sep 16, 2017 · Vol. 8, No. 55 · pp. 93785-93799

Crotonoside exhibits selective post-inhibition effect in AML cells via inhibition of FLT3 and HDAC3/6 Research Paper

Yu-Zhi Li, Si Yu, Pei-Ao Yan, Dao-Yin Gong, Fang-Li Wu, Zhi He, Yu-Yao Yuan, An-Yan Zhao, Xue Tang, Ruo-Qi Zhang, Cheng Peng, Zhi-Xing Cao

Published Sep 8, 2017 · Vol. 8, No. 61 · pp. 103087-103099

Crenolanib is a type I tyrosine kinase inhibitor that inhibits mutant KIT D816 isoforms prevalent in systemic mastocytosis and core binding factor leukemia Research Paper

Kerstin Maria Kampa-Schittenhelm, Julia Frey, Lara A. Haeusser, Barbara Illing, Ashly A. Pavlovsky, Gunnar Blumenstock, Marcus Matthias Schittenhelm

Published Aug 7, 2017 · Vol. 8, No. 47 · pp. 82897-82909

High expression of dedicator of cytokinesis 1 (DOCK1) confers poor prognosis in acute myeloid leukemia Research Paper

Sze-Hwei Lee, Yu-Chiao Chiu, Yi-Hung Li, Chien-Chin Lin, Hsin-An Hou, Wen-Chien Chou, Hwei-Fang Tien

Published Jul 31, 2017 · Vol. 8, No. 42 · pp. 72250-72259

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Efficacy of azacitidine is independent of molecular and clinical characteristics - an analysis of 128 patients with myelodysplastic syndromes or acute myeloid leukemia and a review of the literature Clinical Review

Correction: Discovery of a FLT3 inhibitor LDD1937 as an anti-leukemic agent for acute myeloid leukemia Correction

A novel, dual pan-PIM/FLT3 inhibitor SEL24 exhibits broad therapeutic potential in acute myeloid leukemia Research Paper

Association analysis of SNPs present in plasma with adverse events and population pharmacokinetics in Chinese sunitinib treated patients with renal cell carcinoma Research Paper

Mixed phenotype acute leukemia contains heterogeneous genetic mutations by next-generation sequencing Research Paper

Consecutive epigenetically-active agent combinations act in ID1-RUNX3-TET2 and HOXA pathways for Flt3ITD+ve AML Research Paper

Flow cytometric characterization of acute leukemia reveals a distinctive â€œblast gateâ€ of murine T-lymphoblastic leukemia/lymphoma Research Paper

Acute myeloid leukemia with t(4;12)(q12;p13): an aggressive disease with frequent involvement of PDGFRA and ETV6 Research Paper

Discovery of a FLT3 inhibitor LDD1937 as an anti-leukemic agent for acute myeloid leukemia Research Paper

FLT3-ITD induces expression of Pim kinases through STAT5 to confer resistance to the PI3K/Akt pathway inhibitors on leukemic cells by enhancing the mTORC1/Mcl-1 pathway Research Paper

Inhibition of SDF-1-induced migration of oncogene-driven myeloid leukemia by the L-RNA aptamer (Spiegelmer), NOX-A12, and potentiation of tyrosine kinase inhibition Research Paper

Nuclear membrane-localised NOX4D generates pro-survival ROS in FLT3-ITD-expressing AML Research Paper

High Tim-3 expression on AML blasts could enhance chemotherapy sensitivity Research Paper

Azacitidine combined with the selective FLT3 kinase inhibitor crenolanib disrupts stromal protection and inhibits expansion of residual leukemia-initiating cells in FLT3-ITD AML with concurrent epigenetic mutations Research Paper

DOCK2: A novel FLT3/ITD leukemia drug target Editorial

UCB HCT in FLT3+ AML Editorial

Quizartinib (AC220) reverses ABCG2-mediated multidrug resistance: In vitro and in vivo studies Research Paper

Crotonoside exhibits selective post-inhibition effect in AML cells via inhibition of FLT3 and HDAC3/6 Research Paper

Crenolanib is a type I tyrosine kinase inhibitor that inhibits mutant KIT D816 isoforms prevalent in systemic mastocytosis and core binding factor leukemia Research Paper

High expression of dedicator of cytokinesis 1 (DOCK1) confers poor prognosis in acute myeloid leukemia Research Paper

Publication Alerts

European Cancer and Oncology Congress

Oncoscience

Post-Publication Promotion

Search Oncotarget

Efficacy of azacitidine is independent of molecular and clinical characteristics - an analysis of 128 patients with myelodysplastic syndromes or acute myeloid leukemia and a review of the literature Clinical Review

Correction: Discovery of a FLT3 inhibitor LDD1937 as an anti-leukemic agent for acute myeloid leukemia Correction

A novel, dual pan-PIM/FLT3 inhibitor SEL24 exhibits broad therapeutic potential in acute myeloid leukemia Research Paper

Association analysis of SNPs present in plasma with adverse events and population pharmacokinetics in Chinese sunitinib treated patients with renal cell carcinoma Research Paper

Mixed phenotype acute leukemia contains heterogeneous genetic mutations by next-generation sequencing Research Paper

Consecutive epigenetically-active agent combinations act in ID1-RUNX3-TET2 and HOXA pathways for Flt3ITD+ve AML Research Paper

Flow cytometric characterization of acute leukemia reveals a distinctive â€œblast gateâ€ of murine T-lymphoblastic leukemia/lymphoma Research Paper

Acute myeloid leukemia with t(4;12)(q12;p13): an aggressive disease with frequent involvement of PDGFRA and ETV6 Research Paper

Discovery of a FLT3 inhibitor LDD1937 as an anti-leukemic agent for acute myeloid leukemia Research Paper

FLT3-ITD induces expression of Pim kinases through STAT5 to confer resistance to the PI3K/Akt pathway inhibitors on leukemic cells by enhancing the mTORC1/Mcl-1 pathway Research Paper

Inhibition of SDF-1-induced migration of oncogene-driven myeloid leukemia by the L-RNA aptamer (Spiegelmer), NOX-A12, and potentiation of tyrosine kinase inhibition Research Paper

Nuclear membrane-localised NOX4D generates pro-survival ROS in FLT3-ITD-expressing AML Research Paper

High Tim-3 expression on AML blasts could enhance chemotherapy sensitivity Research Paper

Azacitidine combined with the selective FLT3 kinase inhibitor crenolanib disrupts stromal protection and inhibits expansion of residual leukemia-initiating cells in FLT3-ITD AML with concurrent epigenetic mutations Research Paper

DOCK2: A novel FLT3/ITD leukemia drug target Editorial

UCB HCT in FLT3+ AML Editorial

Quizartinib (AC220) reverses ABCG2-mediated multidrug resistance: In vitro and in vivo studies Research Paper

Crotonoside exhibits selective post-inhibition effect in AML cells via inhibition of FLT3 and HDAC3/6 Research Paper

Crenolanib is a type I tyrosine kinase inhibitor that inhibits mutant KIT D816 isoforms prevalent in systemic mastocytosis and core binding factor leukemia Research Paper

High expression of dedicator of cytokinesis 1 (DOCK1) confers poor prognosis in acute myeloid leukemia Research Paper

Flow cytometric characterization of acute leukemia reveals a distinctive â€œblast gateâ€ of murine T-lymphoblastic leukemia/lymphoma Research Paper