The Oncosearch | Oncotarget

PDGFRÎ± up-regulation mediated by Sonic Hedgehog pathway activation leads to BRAF inhibitor resistance in melanoma cells with BRAF mutation Research Paper

Francesco Sabbatino, Yangyang Wang, Xinhui Wang, Keith T. Flaherty, Ling Yu, David Pepin, Giosueâ€™ Scognamiglio, Stefano Pepe, John M. Kirkwood, Zachary A. Cooper, Dennie T. Frederick, Jennifer A. Wargo, Soldano Ferrone, Cristina R. Ferrone

Published Mar 31, 2014 · Vol. 5, No. 7 · pp. 1926-1941

Mapping of actionable mutations to histological subtype domains in lung adenocarcinoma: implications for precision medicine Research Paper

Gavin M. Wright, Hongdo Do, Jonathan Weiss, Naveed Alam, Vivek Rathi, Marzena Walkiewicz, Thomas John, Prudence Russell, Alexander Dobrovic

Published Mar 22, 2014 · Vol. 5, No. 8 · pp. 2107-2115

miR-199a-3p displays tumor suppressor functions in papillary thyroid carcinoma Research Paper

Emanuela Minna, Paola Romeo, Loris De Cecco, Matteo Dugo, Giuliana Cassinelli, Silvana Pilotti, Debora Deglâ€™Innocenti, Cinzia Lanzi, Patrizia Casalini, Marco A. Pierotti, Angela Greco, Maria Grazia Borrello

Published Mar 16, 2014 · Vol. 5, No. 9 · pp. 2513-2528

SIRT1 promotes proliferation and inhibits the senescence-like phenotype in human melanoma cells Research Paper

MickaÃ«l Ohanna, Caroline Bonet, Karine Bille, Maryline Allegra, Irwin Davidson, Philippe Bahadoran, Jean-Philippe Lacour, Robert Ballotti, Corine Bertolotto

Published Feb 19, 2014 · Vol. 5, No. 8 · pp. 2085-2095

Mitochondrial oxidative stress is the achilleâ€™s heel of melanoma cells resistant to Braf-mutant inhibitor Research Paper

Paola Corazao-Rozas, Pierre Guerreschi, Manel Jendoubi, Fanny AndrÃ©, AurÃ©lie Jonneaux, Camille Scalbert, Guillaume GarÃ§on, Myriam Mallet-Martino, StÃ©phane Balayssac, Stephane Rocchi, Ariel Savina, Pierre Formstecher, Laurent Mortier, Jerome Kluza, Philippe Marchetti

Published Oct 6, 2013 · Vol. 4, No. 11 · pp. 1986-1998

Keywords: metabolism, oxidative phosphorylation, elesclomol, ROS

Radiation lays down covering fire for viral shock troops Editorial Materials

Joan N Kyula, Aadil A Khan, Michelle J Wilkinson, David Mansfield, Kevin J Harrington

Published Jul 19, 2013 · Vol. 4, No. 9 · pp. 1329-1330

Keywords: GLV-1h68, RT, BRAF-mt, JNK, TNF-Î±, apoptosis

Exomic Sequencing of Four Rare Central Nervous System Tumor Types Research Paper

Chetan Bettegowda, Nishant Agrawal, Yuchen Jiao, Yuxuan Wang, Laura D. Wood, Fausto J. Rodriguez, Ralph H. Hruban, Gary L. Gallia, Zev A. Binder, Callen J. Riggins, Vafi Salmasi, Gregory J. Riggins, Zachary J. Reitman, Ahmed Rasheed, Stephen Keir, Sueli Shinjo, Suely Marie, Roger McLendon, George Jallo, Bert Vogelstein, Darrell Bigner, Hai Yan, Kenneth W. Kinzler, Nickolas Papadopoulos

Published Apr 6, 2013 · Vol. 4, No. 4 · pp. 572-583

Keywords: CNS tumors, PXA, GBM, ependymoma, exomic sequencing, BRAF, mTOR

BRAF Mutant Gastrointestinal Stromal Tumor: First report of regression with BRAF inhibitor dabrafenib (GSK2118436) and whole exomic sequencing for analysis of acquired resistance Research Paper

Gerald S. Falchook, Jonathan C. Trent, Michael C. Heinrich, Carol Beadling, Janice Patterson, Christel C. Bastida, Samuel C. Blackman, Razelle Kurzrock

Published Feb 25, 2013 · Vol. 4, No. 2 · pp. 310-315

Keywords: Gastrointestinal stromal tumor, Dabrafenib, GSK2118436, BRAF mutation, BRAF inhibition, V600E

Simalikalactone E (SkE), a new weapon in the armamentarium of drugs targeting cancers that exhibit constitutive activation of the ERK pathway Research Paper

Guillaume Robert, ValÃ©rie Jullian, Arnaud Jacquel, ClÃ©mence Ginet, Maeva Dufies, Stephanie Torino, AnaÃ¯s Pottier, Frederic Peyrade, Sophie Tartare-Deckert, GeneviÃ¨ve Bourdy, Eric Deharo, Patrick Auberger

Published Dec 30, 2012 · Vol. 3, No. 12 · pp. 1688-1699

Keywords: Simalikalactone E, B-Raf inhibitor, CML, Melanoma, Hairy Cell Leukemia, ERK pathway

PIK3CA Mutations in Advanced Cancers: Characteristics and Outcomes Research Paper

Filip Janku, Jennifer J. Wheler, Aung Naing, Vanda M. T. Stepanek, Gerald S. Falchook, Siqing Fu, Ignacio Garrido-Laguna, Apostolia M. Tsimberidou, Sarina A. Piha-Paul, Stacy L. Moulder, J. Jack Lee, Rajyalakshmi Luthra, David S. Hong, Razelle Kurzrock

Published Nov 30, 2012 · Vol. 3, No. 12 · pp. 1566-1575

Keywords: PIK3CA mutation, phenotypic taxonomy, clinical outcome

Loss of expression of the double strand break repair protein ATM is associated with worse prognosis in colorectal cancer and loss of Ku70 expression is associated with CIN Research Paper

Andrew D Beggs, Enric Domingo, Megan McGregor, Mikael Presz, Elaine Johnstone, Rachel Midgley, David Kerr, Dahmane Oukrif, Marco Novelli, Muti Abulafi, Shirley V Hodgson, Wakkas Fadhil, Mohammed Ilyas, Ian P Tomlinson

Published Oct 28, 2012 · Vol. 3, No. 11 · pp. 1348-1355

Keywords: Double strand break repair, ATM, g-H2AX, colorectal cancer, prognosis

Up-regulation of c-MYC and SIRT1 expression correlates with malignant transformation in the serrated route to colorectal cancer Research Paper

Lydia Kriegl, Michael Vieth, Thomas Kirchner, Antje Menssen

Published Oct 3, 2012 · Vol. 3, No. 10 · pp. 1182-1193

Keywords: Serrated route, colorectal cancer, SIRT1, c-MYC, BRAF and KRAS mutation, wnt signalling

Mutations and Deregulation of Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR Cascades Which Alter Therapy Response. Review

James Andrew McCubrey, Linda Steeman, William Chappell, Stephen Abrams, Giuseppe Montalto, Melchiorre Cervello, Ferdinando Nicoletti, Paolo Fagone, Grazia Malaponte, Maria Mazzarino, Saverio Candido, Massimo Libra, Jorg Basecke, Sanja Mijatovic, Danijela Maksimovic-Ivanic, Michele Milella, Agostino Tafuri, Lucio Cocco, Camilla Evangelisti, Francesca Chiarini, Alberto Martelli

Published Sep 20, 2012 · Vol. 3, No. 9 · pp. 954-987

Keywords: targeted therapy, therapy resistance, mutations, Raf, Akt, PI3K, mTOR

Mutation specific antibodies: tool or dinosaur? Editorial

Andreas von Deimling, Felix Sahm, David Capper

Published Aug 30, 2012 · Vol. 3, No. 9 · pp. 907-908

Keywords: BRAFV600E, immunohistochemistry, VE1

The response to PAK1 inhibitor IPA3 distinguishes between cancer cells with mutations in BRAF and Ras oncogenes Research Paper

Ruchi Singhal, Eugene S. Kandel

Published Jul 31, 2012 · Vol. 3, No. 7 · pp. 700-708

Keywords: IPA3, PAK1, BRAF, NRAS, KRAS, melanoma, colon cancer, GDC-0879, AZD6244

Dramatic reduction of sequence artefacts from DNA isolated from formalin-fixed cancer biopsies by treatment with uracil-DNA glycosylase. Research Paper

Hongdo Do, Alexander Dobrovic

Published May 24, 2012 · Vol. 3, No. 5 · pp. 546-558

Keywords: FFPE, cancer biopsies, sequencing artefacts, EGFR mutation, BRAF mutation, closed-tube analysis

Aggressiveness of human melanoma xenograft models is promoted by aneuploidy-driven gene expression deregulation Research Paper

Veronique Mathieu, Christine Pirker, Wolfgang M Schmidt, Sabine Spiegl-Kreinecker, Daniela LÃ¶tsch, Petra Heffeter, Balazs Hegedus, Michael Grusch, Robert Kiss, Walter Berger

Published Apr 24, 2012 · Vol. 3, No. 4 · pp. 399-413

Keywords: malignant melanoma, aneuploidy, xenograft, aggressiveness, integrative genomics

Netrin-1 overexpression is predictive of ovarian malignancies Research Paper

Anastasios D. Papanastasiou, Georgios Pampalakis, Dionyssios Katsaros, Georgia Sotiropoulou

Published May 2, 2011 · Vol. 2, No. 5 · pp. 363-367

Keywords: Netrin-1 (NTN1), ovarian cancer, biomarker

Potential Therapeutic Strategies to Overcome Acquired Resistance to BRAF or MEK Inhibitors in BRAF Mutant Cancers Research Perspective

Ryan B. Corcoran, Jeffrey Settleman, Jeffrey A. Engelman

Published Apr 19, 2011 · Vol. 2, No. 4 · pp. 336-346

Keywords: BRAF, MEK, acquired resistance, melanoma, colorectal cancer, NRAS, IGF1R, PDGFR

Using quantitative proteomic analysis to understand genotype specific intrinsic drug resistance in melanoma Research Perspective

John M. Koomen, Keiran S. M. Smalley

Published Apr 15, 2011 · Vol. 2, No. 4 · pp. 329-335

Keywords: Oncogene, cancer, kinase, BRAF V600E, drug resistance, proteomics

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PDGFRÎ± up-regulation mediated by Sonic Hedgehog pathway activation leads to BRAF inhibitor resistance in melanoma cells with BRAF mutation Research Paper

Mapping of actionable mutations to histological subtype domains in lung adenocarcinoma: implications for precision medicine Research Paper

miR-199a-3p displays tumor suppressor functions in papillary thyroid carcinoma Research Paper

SIRT1 promotes proliferation and inhibits the senescence-like phenotype in human melanoma cells Research Paper

Mitochondrial oxidative stress is the achilleâ€™s heel of melanoma cells resistant to Braf-mutant inhibitor Research Paper

Radiation lays down covering fire for viral shock troops Editorial Materials

Exomic Sequencing of Four Rare Central Nervous System Tumor Types Research Paper

BRAF Mutant Gastrointestinal Stromal Tumor: First report of regression with BRAF inhibitor dabrafenib (GSK2118436) and whole exomic sequencing for analysis of acquired resistance Research Paper

Simalikalactone E (SkE), a new weapon in the armamentarium of drugs targeting cancers that exhibit constitutive activation of the ERK pathway Research Paper

PIK3CA Mutations in Advanced Cancers: Characteristics and Outcomes Research Paper

Loss of expression of the double strand break repair protein ATM is associated with worse prognosis in colorectal cancer and loss of Ku70 expression is associated with CIN Research Paper

Up-regulation of c-MYC and SIRT1 expression correlates with malignant transformation in the serrated route to colorectal cancer Research Paper

Mutations and Deregulation of Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR Cascades Which Alter Therapy Response. Review

Mutation specific antibodies: tool or dinosaur? Editorial

The response to PAK1 inhibitor IPA3 distinguishes between cancer cells with mutations in BRAF and Ras oncogenes Research Paper

Dramatic reduction of sequence artefacts from DNA isolated from formalin-fixed cancer biopsies by treatment with uracil-DNA glycosylase. Research Paper

Aggressiveness of human melanoma xenograft models is promoted by aneuploidy-driven gene expression deregulation Research Paper

Netrin-1 overexpression is predictive of ovarian malignancies Research Paper

Potential Therapeutic Strategies to Overcome Acquired Resistance to BRAF or MEK Inhibitors in BRAF Mutant Cancers Research Perspective

Using quantitative proteomic analysis to understand genotype specific intrinsic drug resistance in melanoma Research Perspective

Publication Alerts

European Cancer and Oncology Congress

Oncoscience

Post-Publication Promotion

Search Oncotarget

PDGFRÎ± up-regulation mediated by Sonic Hedgehog pathway activation leads to BRAF inhibitor resistance in melanoma cells with BRAF mutation Research Paper

Mapping of actionable mutations to histological subtype domains in lung adenocarcinoma: implications for precision medicine Research Paper

miR-199a-3p displays tumor suppressor functions in papillary thyroid carcinoma Research Paper

SIRT1 promotes proliferation and inhibits the senescence-like phenotype in human melanoma cells Research Paper

Mitochondrial oxidative stress is the achilleâ€™s heel of melanoma cells resistant to Braf-mutant inhibitor Research Paper

Radiation lays down covering fire for viral shock troops Editorial Materials

Exomic Sequencing of Four Rare Central Nervous System Tumor Types Research Paper

BRAF Mutant Gastrointestinal Stromal Tumor: First report of regression with BRAF inhibitor dabrafenib (GSK2118436) and whole exomic sequencing for analysis of acquired resistance Research Paper

Simalikalactone E (SkE), a new weapon in the armamentarium of drugs targeting cancers that exhibit constitutive activation of the ERK pathway Research Paper

PIK3CA Mutations in Advanced Cancers: Characteristics and Outcomes Research Paper

Loss of expression of the double strand break repair protein ATM is associated with worse prognosis in colorectal cancer and loss of Ku70 expression is associated with CIN Research Paper

Up-regulation of c-MYC and SIRT1 expression correlates with malignant transformation in the serrated route to colorectal cancer Research Paper

Mutations and Deregulation of Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR Cascades Which Alter Therapy Response. Review

Mutation specific antibodies: tool or dinosaur? Editorial

The response to PAK1 inhibitor IPA3 distinguishes between cancer cells with mutations in BRAF and Ras oncogenes Research Paper

Dramatic reduction of sequence artefacts from DNA isolated from formalin-fixed cancer biopsies by treatment with uracil-DNA glycosylase. Research Paper

Aggressiveness of human melanoma xenograft models is promoted by aneuploidy-driven gene expression deregulation Research Paper

Netrin-1 overexpression is predictive of ovarian malignancies Research Paper

Potential Therapeutic Strategies to Overcome Acquired Resistance to BRAF or MEK Inhibitors in BRAF Mutant Cancers Research Perspective

Using quantitative proteomic analysis to understand genotype specific intrinsic drug resistance in melanoma Research Perspective