The Oncosearch | Oncotarget

Individualized strategies to target specific mechanisms of disease in malignant melanoma patients displaying unique mutational signatures Research Paper

Soraya Curiel-Olmo, Almudena GarcÃa-CastaÃ±o, Rebeca Vidal, Helena Pisonero, Ignacio Varela, Alicia LeÃ³n-Castillo, Eugenio Trillo, Carmen GonzÃ¡lez-Vela, Nuria GarcÃa-Diaz, Carmen Almaraz, Thaidy Moreno, Laura Cereceda, Rebeca Madureira, Nerea Martinez, Pablo Ortiz-Romero, Elsa ValdizÃ¡n, Miguel Angel Piris, JosÃ© Pedro VaquÃ©

Published Jul 25, 2015 · Vol. 6, No. 28 · pp. 25452-25465

New findings on primary and acquired resistance to anti-EGFR therapy in metastatic colorectal cancer: do all roads lead to RAS? Review

Giuseppe Bronte, Nicola Silvestris, Marta Castiglia, Antonio Galvano, Francesco Passiglia, Giovanni Sortino, Giuseppe Cicero, Christian Rolfo, Marc Peeters, Viviana Bazan, Daniele Fanale, Antonio Giordano, Antonio Russo

Published Jul 22, 2015 · Vol. 6, No. 28 · pp. 24780-24796

Loss of tumor suppressors KAI1 and p27 identifies a unique subgroup of primary melanoma patients with poor ÂÂprognosis Clinical Research Papers

Guohong Zhang, Yabin Cheng, Guangdi Chen, Yun Tang, Gholamreza Ardekani, Anand Rotte, Magdalena Martinka, Kevin McElwee, Xuezhu Xu, Qi Wang, Youwen Zhou

Published Jul 14, 2015 · Vol. 6, No. 26 · pp. 23026-23035

AKT3 promotes prostate cancer proliferation cells through regulation of Akt, B-Raf & TSC1/TSC2 Research Paper

Hui-Ping Lin, Ching-Yu Lin, Chieh Huo, Yee-Jee Jan, Jen-Chih Tseng, Shih Sheng Jiang, Ying-Yu Kuo, Shyh-Chang Chen, Chih-Ting Wang, Tzu-Min Chan, Jun-Yang Liou, John Wang, Wun-Shaing Wayne Chang, Chung-Ho Chang, Hsing-Jien Kung, Chih-Pin Chuu

Published Jul 10, 2015 · Vol. 6, No. 29 · pp. 27097-27112

Combination of antibodies directed against different ErbB3 surface epitopes prevents the establishment of resistance to BRAF/MEK inhibitors in melanoma Research Paper

Luigi Fattore, Debora Malpicci, Emanuele Marra, Francesca Belleudi, Alessia Noto, Claudia De Vitis, Maria Elena Pisanu, Pierpaolo Coluccia, Rosa Camerlingo, Giuseppe Roscilli, Antoni Ribas, Arianna Di Napoli, Maria Rosaria Torrisi, Luigi Aurisicchio, Paolo Antonio Ascierto, Rita Mancini, Gennaro Ciliberto

Published Jul 7, 2015 · Vol. 6, No. 28 · pp. 24823-24841

Molecular characterization of a selected cohort of patients affected by pulmonary metastases of malignant melanoma: Hints from BRAF, NRAS and EGFR evaluation Clinical Research Papers

Alessandra Ulivieri, Giuseppe Cardillo, Liborio Manente, Gregorino Paone, Andrea Petricca Mancuso, Leonardo Vigna, Enrico Di Stasio, Rita Gasbarra, Salvatore Girlando, Alvaro Leone

Published Jul 4, 2015 · Vol. 6, No. 23 · pp. 19868-19879

MGL ligand expression is correlated to BRAF mutation and associated with poor survival of stage III colon cancer patients Research Paper

Kristiaan Lenos, Jeroen A.C.M. Goos, Ilona M. Vuist, Sjoerd H. den Uil, Pien M. Delis-van Diemen, Eric J.Th. Belt, Hein B.A.C. Stockmann, Herman Bril, Meike de Wit, Beatriz Carvalho, Susan Giblett, Catrin A. Pritchard, Gerrit A. Meijer, Yvette van Kooyk, Remond J.A. Fijneman, Sandra J. van Vliet

Published Jul 2, 2015 · Vol. 6, No. 28 · pp. 26278-26290

ErbB-3 activation by NRG-1Î² sustains growth and promotes vemurafenib resistance in BRAF-V600E colon cancer stem cells (CSCs) Priority Research Paper

Pramudita R. Prasetyanti, Emily Capone, Daniela Barcaroli, Daniela Dâ€™Agostino, Silvia Volpe, Antonina Benfante, Sander van Hooff, Valentina Iacobelli, Cosmo Rossi, Stefano Iacobelli, Jan Paul Medema, Vincenzo De Laurenzi, Gianluca Sala

Published Jun 25, 2015 · Vol. 6, No. 19 · pp. 16902-16911

Analysis of the molecular features of rectal carcinoid tumors to identify new biomarkers that predict biological malignancy Research Paper

Kei Mitsuhashi, Itaru Yamamoto, Hiroyoshi Kurihara, Shinichi Kanno, Miki Ito, Hisayoshi Igarashi, Keisuke Ishigami, Yasutaka Sukawa, Mami Tachibana, Hiroaki Takahashi, Takashi Tokino, Reo Maruyama, Hiromu Suzuki, Kohzoh Imai, Yasuhisa Shinomura, Hiroyuki Yamamoto, Katsuhiko Nosho

Published Jun 17, 2015 · Vol. 6, No. 26 · pp. 22114-22125

Targeting TRAP1 as a downstream effector of BRAF cytoprotective pathway: a novel strategy for human BRAF-driven colorectal carcinoma Research Paper

Valentina Condelli, Francesca Maddalena, Lorenza Sisinni, Giacomo Lettini, Danilo Swann Matassa, Annamaria Piscazzi, Giuseppe Palladino, Maria Rosaria Amoroso, Franca Esposito, Matteo Landriscina

Published Jun 13, 2015 · Vol. 6, No. 26 · pp. 22298-22309

ERBB activation modulates sensitivity to MEK1/2 inhibition in a subset of driver-negative melanoma Research Paper

Katherine E. Hutchinson, Douglas B. Johnson, Adam S. Johnson, Violeta Sanchez, Maria Kuba, Pengcheng Lu, Xi Chen, Mark C. Kelley, Qingguo Wang, Zhongming Zhao, Mark Kris, Michael F. Berger, Jeffrey A. Sosman, William Pao

Published Jun 13, 2015 · Vol. 6, No. 26 · pp. 22348-22360

Molecular spectrum of BRAF, NRAS and KRAS gene mutations in plasma cell dyscrasias: implication for MEK-ERK pathway activation Research Paper

Marta Lionetti, Marzia Barbieri, Katia Todoerti, Luca Agnelli, Simona Marzorati, Sonia Fabris, Gabriella Ciceri, Serena Galletti, Giulia Milesi, Martina Manzoni, Mara Mazzoni, Angela Greco, Giovanni Tonon, Pellegrino Musto, Luca Baldini, Antonino Neri

Published Jun 10, 2015 · Vol. 6, No. 27 · pp. 24205-24217

Therapeutic efficacy of combined BRAF and MEK inhibition in metastatic melanoma: a comprehensive network meta-analysis of randomized controlled trials Clinical Research Papers

Ruiqin Mai, Songxia Zhou, Weixiang Zhong, Siming Rong, Zhichao Cong, Yunxian Li, Qizhi Xie, Huanming Chen, Xiaoyun Li, Shuhui Liu, Yabin Cheng, Yuanshen Huang, Youwen Zhou, Guohong Zhang

Published Jun 8, 2015 · Vol. 6, No. 29 · pp. 28502-28512

Disseminated histiocytoses biomarkers beyond BRAFV600E: frequent expression of PD-L1 Research Paper

Zoran Gatalica, Nurija Bilalovic, Juan P. Palazzo, Ryan P. Bender, Jeffrey Swensen, Sherri Z. Millis, Semir Vranic, Daniel Von Hoff, Robert J. Arceci

Published Jun 8, 2015 · Vol. 6, No. 23 · pp. 19819-19825

Combining BET and HDAC inhibitors synergistically induces apoptosis of melanoma and suppresses AKT and YAP signaling Research Paper

Anja Heinemann, Carleen Cullinane, Ricardo De Paoli-Iseppi, James S. Wilmott, Dilini Gunatilake, Jason Madore, Dario Strbenac, Jean Y. Yang, Kavitha Gowrishankar, Jessamy C. Tiffen, Rab K. Prinjha, Nicholas Smithers, Grant A. McArthur, Peter Hersey, Stuart J. Gallagher

Published Jun 5, 2015 · Vol. 6, No. 25 · pp. 21507-21521

Identification and characterization of RET fusions in advanced colorectal cancer Research Paper

Anne-France Le Rolle, Samuel J. Klempner, Christopher R. Garrett, Tara Seery, Eric M. Sanford, Sohail Balasubramanian, Jeffrey S. Ross, Philip J. Stephens, Vincent A. Miller, Siraj M. Ali, Vi K. Chiu

Published May 30, 2015 · Vol. 6, No. 30 · pp. 28929-28937

EGFR blockade prevents glioma escape from BRAF^V600E targeted therapy Research Paper

Tsun-Wen Yao, Jie Zhang, Michael Prados, William A. Weiss, C. David James, Theodore Nicolaides

Published May 22, 2015 · Vol. 6, No. 26 · pp. 21993-22005

Radiosensitization and downregulation of heterogeneous nuclear ribonucleoprotein K (hnRNP K) upon inhibition of mitogen/extracellular signal-regulated kinase (MEK) in malignant melanoma cells Research Paper

Stefan Eder, Andreas Lamkowski, Markus Priller, Matthias Port, Konrad Steinestel

Published May 22, 2015 · Vol. 6, No. 19 · pp. 17178-17191

mTOR inhibitors sensitize thyroid cancer cells to cytotoxic effect of vemurafenib Research Paper

Elyse K. Hanly, Robert B. Bednarczyk, Neha Y. Tuli, Augustine L. Moscatello, H. Dorota Halicka, Jiangwei Li, Jan Geliebter, Zbigniew Darzynkiewicz, Raj K. Tiwari

Published May 9, 2015 · Vol. 6, No. 37 · pp. 39702-39713

The c-Jun/RHOB/AKT pathway confers resistance of BRAF-mutant melanoma cells to MAPK inhibitors Research Paper

Audrey Delmas, Julia Cherier, Magdalena Pohorecka, Claire Medale-Giamarchi, Nicolas Meyer, Anne Casanova, Olivier Sordet, Laurence Lamant, Ariel Savina, Anne Pradines, Gilles Favre

Published May 7, 2015 · Vol. 6, No. 17 · pp. 15250-15264

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Individualized strategies to target specific mechanisms of disease in malignant melanoma patients displaying unique mutational signatures Research Paper

New findings on primary and acquired resistance to anti-EGFR therapy in metastatic colorectal cancer: do all roads lead to RAS? Review

Loss of tumor suppressors KAI1 and p27 identifies a unique subgroup of primary melanoma patients with poor ÂÂprognosis Clinical Research Papers

AKT3 promotes prostate cancer proliferation cells through regulation of Akt, B-Raf & TSC1/TSC2 Research Paper

Combination of antibodies directed against different ErbB3 surface epitopes prevents the establishment of resistance to BRAF/MEK inhibitors in melanoma Research Paper

Molecular characterization of a selected cohort of patients affected by pulmonary metastases of malignant melanoma: Hints from BRAF, NRAS and EGFR evaluation Clinical Research Papers

MGL ligand expression is correlated to BRAF mutation and associated with poor survival of stage III colon cancer patients Research Paper

ErbB-3 activation by NRG-1Î² sustains growth and promotes vemurafenib resistance in BRAF-V600E colon cancer stem cells (CSCs) Priority Research Paper

Analysis of the molecular features of rectal carcinoid tumors to identify new biomarkers that predict biological malignancy Research Paper

Targeting TRAP1 as a downstream effector of BRAF cytoprotective pathway: a novel strategy for human BRAF-driven colorectal carcinoma Research Paper

ERBB activation modulates sensitivity to MEK1/2 inhibition in a subset of driver-negative melanoma Research Paper

Molecular spectrum of BRAF, NRAS and KRAS gene mutations in plasma cell dyscrasias: implication for MEK-ERK pathway activation Research Paper

Therapeutic efficacy of combined BRAF and MEK inhibition in metastatic melanoma: a comprehensive network meta-analysis of randomized controlled trials Clinical Research Papers

Disseminated histiocytoses biomarkers beyond BRAFV600E: frequent expression of PD-L1 Research Paper

Combining BET and HDAC inhibitors synergistically induces apoptosis of melanoma and suppresses AKT and YAP signaling Research Paper

Identification and characterization of RET fusions in advanced colorectal cancer Research Paper

EGFR blockade prevents glioma escape from BRAF^V600E targeted therapy Research Paper

Radiosensitization and downregulation of heterogeneous nuclear ribonucleoprotein K (hnRNP K) upon inhibition of mitogen/extracellular signal-regulated kinase (MEK) in malignant melanoma cells Research Paper

mTOR inhibitors sensitize thyroid cancer cells to cytotoxic effect of vemurafenib Research Paper

The c-Jun/RHOB/AKT pathway confers resistance of BRAF-mutant melanoma cells to MAPK inhibitors Research Paper

Publication Alerts

European Cancer and Oncology Congress

Oncoscience

Post-Publication Promotion

Search Oncotarget

Individualized strategies to target specific mechanisms of disease in malignant melanoma patients displaying unique mutational signatures Research Paper

New findings on primary and acquired resistance to anti-EGFR therapy in metastatic colorectal cancer: do all roads lead to RAS? Review

Loss of tumor suppressors KAI1 and p27 identifies a unique subgroup of primary melanoma patients with poor Â­Â­prognosis Clinical Research Papers

AKT3 promotes prostate cancer proliferation cells through regulation of Akt, B-Raf & TSC1/TSC2 Research Paper

Combination of antibodies directed against different ErbB3 surface epitopes prevents the establishment of resistance to BRAF/MEK inhibitors in melanoma Research Paper

Molecular characterization of a selected cohort of patients affected by pulmonary metastases of malignant melanoma: Hints from BRAF, NRAS and EGFR evaluation Clinical Research Papers

MGL ligand expression is correlated to BRAF mutation and associated with poor survival of stage III colon cancer patients Research Paper

ErbB-3 activation by NRG-1Î² sustains growth and promotes vemurafenib resistance in BRAF-V600E colon cancer stem cells (CSCs) Priority Research Paper

Analysis of the molecular features of rectal carcinoid tumors to identify new biomarkers that predict biological malignancy Research Paper

Targeting TRAP1 as a downstream effector of BRAF cytoprotective pathway: a novel strategy for human BRAF-driven colorectal carcinoma Research Paper

ERBB activation modulates sensitivity to MEK1/2 inhibition in a subset of driver-negative melanoma Research Paper

Molecular spectrum of BRAF, NRAS and KRAS gene mutations in plasma cell dyscrasias: implication for MEK-ERK pathway activation Research Paper

Therapeutic efficacy of combined BRAF and MEK inhibition in metastatic melanoma: a comprehensive network meta-analysis of randomized controlled trials Clinical Research Papers

Disseminated histiocytoses biomarkers beyond BRAFV600E: frequent expression of PD-L1 Research Paper

Combining BET and HDAC inhibitors synergistically induces apoptosis of melanoma and suppresses AKT and YAP signaling Research Paper

Identification and characterization of RET fusions in advanced colorectal cancer Research Paper

EGFR blockade prevents glioma escape from BRAFV600E targeted therapy Research Paper

Radiosensitization and downregulation of heterogeneous nuclear ribonucleoprotein K (hnRNP K) upon inhibition of mitogen/extracellular signal-regulated kinase (MEK) in malignant melanoma cells Research Paper

mTOR inhibitors sensitize thyroid cancer cells to cytotoxic effect of vemurafenib Research Paper

The c-Jun/RHOB/AKT pathway confers resistance of BRAF-mutant melanoma cells to MAPK inhibitors Research Paper

Loss of tumor suppressors KAI1 and p27 identifies a unique subgroup of primary melanoma patients with poor ÂÂprognosis Clinical Research Papers

EGFR blockade prevents glioma escape from BRAF^V600E targeted therapy Research Paper