The Oncosearch | Oncotarget

Clinically relevant genes and regulatory pathways associated with NRAS^Q61 mutations in melanoma through an integrative genomics approach Research Paper

Wei Jiang, Peilin Jia, Katherine E. Hutchinson, Douglas B. Johnson, Jeffrey A. Sosman, Zhongming Zhao

Published Dec 10, 2014 · Vol. 6, No. 4 · pp. 2496-2508

Whole exome sequencing identifies a recurrent RQCD1 P131L mutation in cutaneous melanoma Research Paper

Stephen Q. Wong, Andreas Behren, Victoria J. Mar, Katherine Woods, Jason Li, Claire Martin, Karen E. Sheppard, Rory Wolfe, John Kelly, Jonathan Cebon, Alexander Dobrovic, Grant A. McArthur

Published Dec 6, 2014 · Vol. 6, No. 2 · pp. 1115-1127

Keywords: Melanoma, RQCD1, exome sequencing

Overcoming resistance to BRAF inhibition in BRAF-mutated metastatic melanoma Review

Francesco Spagnolo, Paola Ghiorzo, Paola Queirolo

Published Nov 15, 2014 · Vol. 5, No. 21 · pp. 10206-10221

Truncated RAF kinases drive resistance to MET inhibition in MET-addicted cancer cells Research Paper

Consalvo Petti, Gabriele Picco, Maria Luisa Martelli, Elena Trisolini, Enrico Bucci, Timothy Perera, Claudio Isella, Enzo Medico

Published Nov 15, 2014 · Vol. 6, No. 1 · pp. 221-233

BRAF vs RAS oncogenes: Are mutations of the same pathway equal? Differential signalling and therapeutic implications Review

Eftychia Oikonomou, Evangelos Koustas, Maria Goulielmaki, Alexander Pintzas

Published Oct 21, 2014 · Vol. 5, No. 23 · pp. 11752-11777

B-Raf inhibitor vemurafenib in combination with temozolomide and fotemustine in the killing response of malignant melanoma cells Research Paper

Wynand P. Roos, Steve Quiros, Andrea Krumm, Stephanie Merz, Olivier JÃ©rÃ´me Switzeny, Markus Christmann, Carmen Loquai, Bernd Kaina

Published Oct 21, 2014 · Vol. 5, No. 24 · pp. 12607-12620

Noxa upregulation by oncogenic activation of MEK/ERK through CREB promotes autophagy in human melanoma cells Research Paper

Yi Lun Liu, Fritz Lai, James S. Wilmott, Xu Guang Yan, Xiao Ying Liu, Qi Luan, Su Tang Guo, Chen Chen Jiang, Hsin-Yi Tseng, Richard A. Scolyer, Lei Jin, Xu Dong Zhang

Published Oct 21, 2014 · Vol. 5, No. 22 · pp. 11237-11251

TRIM16 inhibits proliferation and migration through regulation of interferon beta 1 in melanoma cells Research Paper

Selina K. Sutton, Jessica Koach, Owen Tan, Bing Liu, Daniel R. Carter, James S. Wilmott, Benafsha Yosufi, Lauren E. Haydu, Graham J. Mann, John F. Thompson, Georgina V. Long, Tao Liu, Grant McArthur, Xu Dong Zhang, Richard A. Scolyer, Belamy B. Cheung, Glenn M. Marshall

Published Sep 20, 2014 · Vol. 5, No. 20 · pp. 10127-10139

Keywords: Melanoma, TRIM16, BRAF inhibitor, cell migration, IFNÎ²1

BRAF-mutant hematopoietic malignancies Editorial Materials

Omar Abdel-Wahab, Christopher Y. Park

Published Sep 8, 2014 · Vol. 5, No. 18 · pp. 7980-7981

miR-524-5p suppresses the growth of oncogenic BRAF melanoma by targeting BRAF and ERK2 Research Paper

Szu-Mam Liu, Jean Lu, Hoong-Chien Lee, Feng-Hsiang Chung, Nianhan Ma

Published Sep 8, 2014 · Vol. 5, No. 19 · pp. 9444-9459

Melanoma patient-derived xenografts accurately model the disease and develop fast enough to guide treatment decisions Clinical Research Papers

Berglind O. Einarsdottir, Roger Olofsson Bagge, Joydeep Bhadury, Henrik Jespersen, Jan Mattsson, Lisa M. Nilsson, Katarina TruvÃ©, Marcela DÃ¡vila LÃ³pez, Peter Naredi, Ola Nilsson, Ulrika Stierner, Lars Ny, Jonas A. Nilsson

Published Sep 8, 2014 · Vol. 5, No. 20 · pp. 9609-9618

Targeted ultra-deep sequencing reveals recurrent and mutually exclusive mutations of cancer genes in blastic plasmacytoid dendritic cell neoplasm Research Paper

Albrecht Stenzinger, Volker Endris, Nicole Pfarr, Mindaugas Andrulis, Korinna JÃ¶hrens, Frederick Klauschen, Udo Siebolts, Thomas Wolf, Philipp-Sebastian Koch, Miriam Schulz, Wolfgang Hartschuh, Sergij Goerdt, Jochen K. Lennerz, Claudia Wickenhauser, Wolfram Klapper, Ioannis Anagnostopoulos, Wilko Weichert

Published Jul 16, 2014 · Vol. 5, No. 15 · pp. 6404-6413

Combined BRAF^V600E- and SRC-inhibition induces apoptosis, evokes an immune response and reduces tumor growth in an immunocompetent orthotopic mouse model of anaplastic thyroid cancer Priority Research Paper

Pierre Vanden Borre, Viswanath Gunda, David G. McFadden, Peter M. Sadow, Shohreh Varmeh, Maria Bernasconi, Sareh Parangi

Published Jun 26, 2014 · Vol. 5, No. 12 · pp. 3996-4010

Usp5 links suppression of p53 and FAS levels in melanoma to the BRAF pathway Research Paper

Harish Potu, Luke F. Peterson, Anupama Pal, Monique Verhaegen, Juxiang Cao, Moshe Talpaz, Nicholas J. Donato

Published Jun 26, 2014 · Vol. 5, No. 14 · pp. 5559-5569

The MAPK pathway as an apoptosis enhancer in melanoma Research Paper

Johannes M. Haydn, Anita Hufnagel, Johannes Grimm, Katja Maurus, Manfred Schartl, Svenja Meierjohann

Published Jun 8, 2014 · Vol. 5, No. 13 · pp. 5040-5053

Potential clinical implications of BRAF mutations in histiocytic proliferations Clinical Research Papers

Anna-Maria Bubolz, Stephanie E. Weissinger, Albrecht Stenzinger, Annette Arndt, Konrad Steinestel, Silke BrÃ¼derlein, Holger Cario, Anneli Lubatschofski, Claudia Welke, Ioannis Anagnostopoulos, Thomas F. E. Barth, Ambros J. Beer, Peter MÃ¶ller, Martin Gottstein, Andreas Viardot, Jochen K. Lennerz

Published Jun 6, 2014 · Vol. 5, No. 12 · pp. 4060-4070

Histone deacetylase inhibitor-temozolomide co-treatment inhibits melanoma growth through suppression of Chemokine (C-C motif) ligand 2-driven signals Research Paper

Laura Gatti, Alexandra Sevko, Michelandrea De Cesare, Noemi Arrighetti, Giacomo Manenti, Emilio Ciusani, Paolo Verderio, Chiara M. Ciniselli, Denis Cominetti, Nives Carenini, Elisabetta Corna, Nadia Zaffaroni, Monica Rodolfo, Licia Rivoltini, Viktor Umansky, Paola Perego

Published Jun 6, 2014 · Vol. 5, No. 12 · pp. 4516-4528

BRAF V600E mutations in urine and plasma cell-free DNA from patients with Erdheim-Chester disease Research Paper

Filip Janku, Cecile Rose T. Vibat, Karena Kosco, Veronica R. Holley, Goran Cabrilo, Funda Meric-Bernstam, Vanda M. Stepanek, Patrick P. Lin, Lorieta Leppin, Latifa Hassaine, Jason C. Poole, Razelle Kurzrock, Mark G. Erlander

Published May 13, 2014 · Vol. 5, No. 11 · pp. 3607-3610

Multigene mutational profiling of cholangiocarcinomas identifies actionable molecular subgroups Research Paper

Michele Simbolo, Matteo Fassan, Andrea Ruzzenente, Andrea Mafficini, Laura D. Wood, Vincenzo Corbo, Davide Melisi, Giuseppe Malleo, Caterina Vicentini, Giorgio Malpeli, Davide Antonello, Nicola Sperandio, Paola Capelli, Anna Tomezzoli, Calogero Iacono, Rita T. Lawlor, Claudio Bassi, Ralph H. Hruban, Alfredo Guglielmi, Giampaolo Tortora, Filippo de Braud, Aldo Scarpa

Published May 1, 2014 · Vol. 5, No. 9 · pp. 2839-2852

Targeting human apurinic/apyrimidinic endonuclease 1 (APE1) in phosphatase and tensin homolog (PTEN) deficient melanoma cells for personalized therapy Research Paper

Rachel Abbotts, Rosalyn Jewell, JÃ©rÃ©mie Nsengimana, David J. Maloney, Anton Simeonov, Claire Seedhouse, Faye Elliott, Jon Laye, Christy Walker, Ajit Jadhav, Anna Grabowska, Graham Ball, Poulam M. Patel, Julia Newton-Bishop, David M. Wilson III, Srinivasan Madhusudan

Published Apr 27, 2014 · Vol. 5, No. 10 · pp. 3273-3286

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Clinically relevant genes and regulatory pathways associated with NRAS^Q61 mutations in melanoma through an integrative genomics approach Research Paper

Whole exome sequencing identifies a recurrent RQCD1 P131L mutation in cutaneous melanoma Research Paper

Overcoming resistance to BRAF inhibition in BRAF-mutated metastatic melanoma Review

Truncated RAF kinases drive resistance to MET inhibition in MET-addicted cancer cells Research Paper

BRAF vs RAS oncogenes: Are mutations of the same pathway equal? Differential signalling and therapeutic implications Review

B-Raf inhibitor vemurafenib in combination with temozolomide and fotemustine in the killing response of malignant melanoma cells Research Paper

Noxa upregulation by oncogenic activation of MEK/ERK through CREB promotes autophagy in human melanoma cells Research Paper

TRIM16 inhibits proliferation and migration through regulation of interferon beta 1 in melanoma cells Research Paper

BRAF-mutant hematopoietic malignancies Editorial Materials

miR-524-5p suppresses the growth of oncogenic BRAF melanoma by targeting BRAF and ERK2 Research Paper

Melanoma patient-derived xenografts accurately model the disease and develop fast enough to guide treatment decisions Clinical Research Papers

Targeted ultra-deep sequencing reveals recurrent and mutually exclusive mutations of cancer genes in blastic plasmacytoid dendritic cell neoplasm Research Paper

Combined BRAF^V600E- and SRC-inhibition induces apoptosis, evokes an immune response and reduces tumor growth in an immunocompetent orthotopic mouse model of anaplastic thyroid cancer Priority Research Paper

Usp5 links suppression of p53 and FAS levels in melanoma to the BRAF pathway Research Paper

The MAPK pathway as an apoptosis enhancer in melanoma Research Paper

Potential clinical implications of BRAF mutations in histiocytic proliferations Clinical Research Papers

Histone deacetylase inhibitor-temozolomide co-treatment inhibits melanoma growth through suppression of Chemokine (C-C motif) ligand 2-driven signals Research Paper

BRAF V600E mutations in urine and plasma cell-free DNA from patients with Erdheim-Chester disease Research Paper

Multigene mutational profiling of cholangiocarcinomas identifies actionable molecular subgroups Research Paper

Targeting human apurinic/apyrimidinic endonuclease 1 (APE1) in phosphatase and tensin homolog (PTEN) deficient melanoma cells for personalized therapy Research Paper

Publication Alerts

European Cancer and Oncology Congress

Oncoscience

Post-Publication Promotion

Search Oncotarget

Clinically relevant genes and regulatory pathways associated with NRASQ61 mutations in melanoma through an integrative genomics approach Research Paper

Whole exome sequencing identifies a recurrent RQCD1 P131L mutation in cutaneous melanoma Research Paper

Overcoming resistance to BRAF inhibition in BRAF-mutated metastatic melanoma Review

Truncated RAF kinases drive resistance to MET inhibition in MET-addicted cancer cells Research Paper

BRAF vs RAS oncogenes: Are mutations of the same pathway equal? Differential signalling and therapeutic implications Review

B-Raf inhibitor vemurafenib in combination with temozolomide and fotemustine in the killing response of malignant melanoma cells Research Paper

Noxa upregulation by oncogenic activation of MEK/ERK through CREB promotes autophagy in human melanoma cells Research Paper

TRIM16 inhibits proliferation and migration through regulation of interferon beta 1 in melanoma cells Research Paper

BRAF-mutant hematopoietic malignancies Editorial Materials

miR-524-5p suppresses the growth of oncogenic BRAF melanoma by targeting BRAF and ERK2 Research Paper

Melanoma patient-derived xenografts accurately model the disease and develop fast enough to guide treatment decisions Clinical Research Papers

Targeted ultra-deep sequencing reveals recurrent and mutually exclusive mutations of cancer genes in blastic plasmacytoid dendritic cell neoplasm Research Paper

Combined BRAFV600E- and SRC-inhibition induces apoptosis, evokes an immune response and reduces tumor growth in an immunocompetent orthotopic mouse model of anaplastic thyroid cancer Priority Research Paper

Usp5 links suppression of p53 and FAS levels in melanoma to the BRAF pathway Research Paper

The MAPK pathway as an apoptosis enhancer in melanoma Research Paper

Potential clinical implications of BRAF mutations in histiocytic proliferations Clinical Research Papers

Histone deacetylase inhibitor-temozolomide co-treatment inhibits melanoma growth through suppression of Chemokine (C-C motif) ligand 2-driven signals Research Paper

BRAF V600E mutations in urine and plasma cell-free DNA from patients with Erdheim-Chester disease Research Paper

Multigene mutational profiling of cholangiocarcinomas identifies actionable molecular subgroups Research Paper

Targeting human apurinic/apyrimidinic endonuclease 1 (APE1) in phosphatase and tensin homolog (PTEN) deficient melanoma cells for personalized therapy Research Paper

Clinically relevant genes and regulatory pathways associated with NRAS^Q61 mutations in melanoma through an integrative genomics approach Research Paper

Combined BRAF^V600E- and SRC-inhibition induces apoptosis, evokes an immune response and reduces tumor growth in an immunocompetent orthotopic mouse model of anaplastic thyroid cancer Priority Research Paper