Oncotarget

Oncotarget Special Collections

 

To see more Oncotarget special collections, please visit: www.oncotarget.com/collections/

 

 

Special Collection on Breast Cancer

Oncotarget: Camptothecin targets WRN protein: in clinical breast cancer

Here is a link to a video interview with Dr. Vihelm A. Bohr about this research on the Oncotarget YouTube Channel

Oncotarget published "Camptothecin targets WRN protein: mechanism and relevance in clinical breast cancer" which reported that in the cells treated with CPT, the authors observed distinct effects on WRN compared to other human RecQ helicases.

WRN knockdown cells as well as CPT treated cells became senescent and stained positive for senescence-associated β-galactosidase at a higher ... continue reading >>

Oncotarget: Osteoprotegerin rich tumor microenvironment: implications in breast cancer

Here is a link to a video interview with Dr. Neelam Sharma-Walia about this research on the Oncotarget YouTube Channel

Oncotarget published "Osteoprotegerin rich tumor microenvironment: implications in breast cancer" which reported that Osteoprotegerin is a soluble decoy receptor for tumor necrosis factor -related apoptosis inducing ligand.

Besides having anti-osteoclastic activity, OPG is thought to exert a protective anti-apoptotic action in OPG-expressing tumors by overcoming the... continue reading >>

Oncotarget: LINC00520 is induced by Src, STAT3, and PI3K in breast cancer

Here is a link to a video interview with Dr. Whitney S. Henry about this research on the Oncotarget YouTube Channel

Oncotarget published "LINC00520 is induced by Src, STAT3, and PI3K and plays a functional role in breast cancer" which reported that the authors performed global gene expression profiling of mammary epithelial cells transformed by oncogenic v-Src, and identified a large subset of uncharacterized lncRNAs potentially involved in breast cancer development.

Specifically, their... continue reading >>

Oncotarget: Sequencing interdisciplinary molecular tumor board in breast cancer patients

Oncotarget Volume 11, Issue 35 published "Sequencing for an interdisciplinary molecular tumor board in patients with advanced breast cancer–experiences from a case series" by Walter et, al. which reported that although prognosis of patients with early breast cancer has improved over the last decades, metastatic breast cancer remains incurable.

Despite increasing therapeutic options regarding systemic treatment, predicting efficacy of a targeted drug on a patient level is still challenging.... continue reading >>

Oncotarget: Induction of phenotypic changes in HER2-postive breast cancer cells

The cover for issue 30 of Oncotarget features Figure 4, "RNAseq results demonstrating differences between normal, cancer, and redirected cells," by Frank-Kamenetskii, et al. which reported that the influence of breast cancer cells on normal cells of the microenvironment, such as fibroblasts and macrophages, has been heavily studied but the influence of normal epithelial cells on breast cancer cells has not.

Here using in vivo and in vitro models the Oncotarget authors demonstrate the impact... continue reading >>

Oncotarget: Th1 cytokines potentiate apoptosis of breast cancer cells and suppress tumor growth

Volume 11, Issue 30 of Oncotarget reported that previously, the authors showed that anti-estrogen drugs combined with a dendritic cell-based anti-HER-2 vaccine known to induce strong Th1-polarized immunity dramatically improved clinical response rates in patients with HER-2pos/ERpos early breast cancer.

Here, the Oncotarget authors show that the small molecule Akt antagonist MK-2206, when combined with the Th1 cytokines IFN-gamma and TNF-alpha, maximize indicators of apoptotic cell death in a... continue reading >>

Oncotarget: Inhibition of HAS2 and hyaluronic acid production by 1,25-Dihydroxyvitamin D3 in breast cancer

Oncotarget Volume 11, Issue 30 reported that genomic profiling of murine mammary tumor cells with differential VDR expression identified 35 transcripts that were altered by the 1,25D3-VDR complex including Hyaluronan Synthase-2.

Here the Oncotarget authors confirmed that 1,25D3 reduces both HAS2 gene expression and hyaluronic acid synthesis in multiple models of breast cancer.

HAS2 expression and HA production are elevated in immortalized human mammary epithelial cells induced to undergo... continue reading >>

Oncotarget: The Golgi protein TMEM165 controls migration/invasion for carcinoma

The cover for issue 28 of Oncotarget features Figure 5, "TMEM165 expression levels alters N-linked glycosylation," by Murali, et al., and reported that the TMEM165 protein was not detected in non-malignant matched breast tissues and was detected in invasive ductal breast carcinoma tissues by mass spectrometry.

The hypothesis is that the TMEM165 protein confers a growth advantage to breast cancer.

The authors created a CRISPR/Cas9 knockout of TMEM165 in the human invasive breast cancer cell... continue reading >>

Oncotarget: Determination of HER oncogene co-amplifications in breast cancer

Oncotarget recently published "Working together for the family: determination of HER oncogene co-amplifications in breast cancer" which reported that despite specific treatment, unfortunately, 20% of primary and 70% of metastatic HER2 tumors develop resistance.

In addition, the authors developed a protocol based on the combination of MLPA with ddPCR to detect the tumor proportion of co-amplified HERs.

On 111 IDC, the HER2 MLPA results were validated by FISH, CISH, and IHC.

The percentage of... continue reading >>

Oncotarget: Stemness genes and the capacity of breast tumors for metastasis

Volume 11, Issue 21 of @Oncotarget reported that using primary cultures from the breast tumor of patient St23784/17 with stemness gene amplification and patient Ti41749/17 without stemness gene amplification in the tumor, the research team studied the expression of stemness genes, proliferative tumor stem-cell activity, mammosphere formation, and expression of the CD44 tumor stem cell marker.

Primary cultures of Ep Cam+ tumor cells from patients with stemness gene amplifications revealed high... continue reading >>

NFk B drives stemness and resistance to therapy in ER+HER2- breast cancer

Volume 11, Number 19 of @Oncotarget reported that RANK pathway affects the expression of cell cycle regulators and decreases sensitivity to fulvestrant of estrogen receptor-positive /HER2- breast cancer cells, MCF-7 and T47D.

These results suggest that ER+HER2- RANK-positive cells may constitute an important reservoir of slow cycling, therapy-resistance cancer cells; and that RANK pathway activation is deleterious in all ER+HER2- breast cancer cells, independently of RANK levels.

Dr. Sandra... continue reading >>

A distinct pattern of one-carbon metabolism in invasive breast cancer

Volume 11, Issue 18 of @Oncotarget reported that activation of one-carbon metabolism in tumor cells can sustain oncogenesis while contributing to epigenetic changes and metabolic adaptation during tumor progression.

The authors assessed whether increased one-carbon metabolism activity is a metabolic feature of invasive ductal carcinoma.

Their targeted metabolomics analysis showed distinct metabolomics profiles between IDC and adjacent tissue, where IDC displayed a comparative enrichment of... continue reading >>

Proteomic analysis identifies signatures associated w/ survival in breast cancer patients

The cover for issue 17 of @Oncotarget features Figure 8, "Survival probability according to the expression of IGF1R mRNA and an additional gene," by Sinai-Livne, et al.

READ MORE: While this paradigm is based on well-established biological facts, including the potent anti-apoptotic and cell survival capabilities of the receptor, most Phase III clinical trials designed to target the IGF1R led to disappointing results.

Of clinical relevance, these analyses indicate that high IGF1R baseline... continue reading >>

Oncotarget | Risk factors for breast cancer brain metastases: a systematic review

Oncotarget Volume 11, Issue 6 reported that A systematic literature search of EMBASE and MEDLINE was conducted to elucidate the current state of knowledge on known and novel prognostic factors associated with 1) the risk for BCBM and 2) the time to brain metastases (TTBM).

Of these, 69 studies reported risk factors of BCBM, 46 factors associated with the TTBM and twenty studies examined variables for both outcomes.

Young age, estrogen receptor negativity, overexpression of human epidermal... continue reading >>

Therapeutic inhibition of Mcl-1 blocks cell survival in estrogen receptor-positive breast cancers

While estrogen receptor - + breast cancers express high levels of three anti-apoptotic Bcl-2 family members, pharmacological inhibition of Bcl-2 and/or Bcl-xL fails to induce cell death in ER + breast cancer cell lines, due to rapid and robust Mcl-1 upregulation.

Cells treated with a pharmacological inhibitor of cap-dependent translation, or with the mTORC1 inhibitor RAD001/everolimus, displayed reduced protein levels of Mcl-1 under basal conditions, and failed to upregulate Mcl-1 protein... continue reading >>



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