Oncotarget

Clinical Research Papers:

Positive intratumoral chemokine (C-C motif) receptor 8 expression predicts high recurrence risk of post-operation clear-cell renal cell carcinoma patients

Qiang Fu, Yuan Chang, Lin Zhou, Huimin An, Yu Zhu, Le Xu, Weijuan Zhang and Jiejie Xu _

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Oncotarget. 2016; 7:8413-8421. https://doi.org/10.18632/oncotarget.6761

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Abstract

Qiang Fu1,*, Yuan Chang2,*, Lin Zhou2, Huimin An3, Yu Zhu3, Le Xu4, Weijuan Zhang5 and Jiejie Xu1

1 Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Fudan University, Shanghai, China

2 Department of Urology, Zhongshan Hospital, Fudan University, Shanghai, China

3 Department of Urology, Shanghai Cancer Center, Fudan University, Shanghai, China

4 Department of Urology, Ruijin Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China

5 Department of Immunology, School of Basic Medical Sciences, Fudan University, Shanghai, China

* These authors have contributed equally to this work

Correspondence to:

Weijuan Zhang, email:

Jiejie Xu, email:

Keywords: chemokine (C-C motif) receptor 8, clear-cell renal cell carcinoma, prognostic factor, recurrence-free survival

Received: September 08, 2015 Accepted: December 07, 2015 Published: December 24, 2015

Abstract

Chemokine (C-C motif) receptor 8 (CCR8) could drive cancer progress through recruiting certain immune cells. Recent evidences revealed the chemotaxis of CCR8+ human malignant tumor cells towards lymph node, and a significantly increased CCR8 expression in renal carcinomas patients. To assess the clinical association between CCR8 expression and the risk of post-surgery recurrence in patients with clear-cell renal cell carcinoma (ccRCC), we detected intratumoral CCR8 expression in 472 post-nephrectomy ccRCC patients retrospectively enrolled. Positive CCR8 staining tumor cell occurred in 26.1% (123 of 472) non-metastatic ccRCC cases, and the positive expression was associated with increased risks of recurrence (Log-Rank P < 0.001). In multivariate analyses, CCR8 expression was identified as an independent prognostic factor (P = 0.008) and entered into a newly-built nomogram together with T stage, Fuhrman grade, tumor size, necrosis and lymphovascular invasion. Calibration curves showed optimal agreement between predictions and observations, while its C-index was higher than that of Leibovich score for predicting recurrence-free survival (RFS) of localised RCC patients (0.854 vs 0.836, respectively; P = 0.044). The practical prognostic nomogram model may help clinicians in decision making and design of clinical studies.


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