CD4+T cell specific B7-H1 selectively inhibits proliferation of naïve T cells and Th17 differentiation in experimental autoimmune encephalomyelitis
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Sheng-Jia Shi1,2,3,*, Mei-Ling Ding4,*, Li-Juan Wang5,*, Jie-Heng Wu1,*, Dong-Hui Han2, Guo-Xu Zheng1, Zhang-Yan Guo1, Wen-Jin Xi1, Wei-Jun Qin2, An-Gang Yang1 and Wei-Hong Wen1
1State Key Laboratory of Cancer Biology, Department of Immunology, Fourth Military Medical University, Xi’an, 710069, Shaanxi Province, P.R. China
2Department of Urology, Xijing Hospital, Fourth Military Medical University, Xi’an, 710032, Shaanxi Province, P.R. China
3Reproduction Medicine Center, No. 202 Hospital of PLA, Shenyang, 11000, Liaoning Province, P.R. China
4State Key Laboratory of Cancer Biology, National Clinical Research Center for Digestive Disease, Xijing Hospital of Digestive Diseases, Fourth Military Medical University, Xi’an, 710032, Shaanxi Province, P.R. China
5Department of Dermatology, First Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710061, Shaanxi Province, P.R. China
*These authors have contributed equally to this work
Wei-Hong Wen, email: firstname.lastname@example.org
Keywords: B7-H1, EAE, Th17 cells, multiple sclerosis
Received: March 09, 2017 Accepted: September 01, 2017 Published: September 28, 2017
It is widely acknowledged that interleukin 17-producing T helper (Th17) cells are critically participant in the pathogenesis of multiple sclerosis. In the current study, we identified that the expression of CD4+T cells specific co-inhibitory molecule B7-homologue 1(B7-H1) in spleenocytes and mononuclear cells isolated from brains and spinal cord were positive correlated with Th1 and Th17 cells generation and disease severity in experimental autoimmune encephalomyelitis (EAE). Furthermore, B7-H1 transgenic mice developed milder EAE symptoms and fewer Th17 cells than B7-H1 wild type mice. We also found the proliferation of naïve CD4+CD62+T cells isolated from B7-H1 transgenic mice was inhibited. And naïve T cells isolated from B7-H1 transgenic mice produced fewer Th17 cells than WT mice in Th17-polarizing conditions, but the Th1, Th2, and inducible Treg differentiation were the similar in naïve T cells isolated from B7-H1 transgenic mice and WT mice. In conclusion, our study show CD4+T cells specific B7-H1 is a slective inhibitor in proliferation of naïve T cells, Th17 differentiation and pathogenesis of multiple sclerosis.
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