Meta-analysis of association between rs1447295 polymorphism and prostate cancer susceptibility
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Juan Zhou1,*, Yang Yu2,*, Anyou Zhu3,*, Fengchao Wang3, Shuxia Kang3, Yunfeng Pei1, Chunping Cao1, Chen Ding1, Duping Wang1, Li Sun1 and Guoping Niu1
1Department of Clinical Laboratory, Affiliated to Medical College of Southeast University and Xuzhou Central Hospital, Xuzhou, People’s Republic of China
2Department of Medical Oncology, Affiliated to Medical College of Southeast University and Xuzhou Central Hospital, Xuzhou, People’s Republic of China
3Department of Clinical Laboratory Science, The First Affiliated Hospital of Bengbu Medical College, Anhui, People’s Republic of China
*These authors have contributed equally to this work
Anyou Zhu, email: [email protected]
Keywords: meta-analysis, rs1447295, prostate cancer, susceptibility
Received: June 30, 2016 Accepted: March 04, 2017 Published: May 05, 2017
Aims: A number of studies have found that the single nucleotide polymorphisms (SNPs) within the 8q24 region of genome were associated with the susceptibility of prostate cancer. Association between 8q24 SNP variant rs1447295 and higher risk of prostate cancer had been investigated, but those studies were incomplete and the conclusions were obscure.
Methods: To better elucidate the relationship between rs1447295 polymorphism and the susceptibility of prostate cancer, we performed a more comprehensive meta-analysis about the association between rs1447295 polymorphism and prostate cancer susceptibility by collecting relevant articles published up to November, 2016 and excluding many replicated cohort data existing in previous reports, which made the conclusion more reliant and objective.
Results: The results showed that there was a significant prostate cancer risk associated with rs1447295 polymorphism not only in the total groups, but also in American, European and Asian descent subgroups. Meanwhile, a comprehensive analysis about the association between rs1447295 polymorphism and prostate cancer risk were conducted by using different clinical characteristic stratifications including Gleason score, tumor stage and PSA level. The result showed that rs1447295 polymorphism was correlated with different stages of prostate cancer
Conclusions: There are strong association between rs1447295 polymorphism and prostate cancer susceptibility in different ethnic groups and different prostate cancer stage, suggesting that rs1447295 might serve as a reliable biomarker for prostate cancer diagnosis.
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