Oncotarget

Research Papers:

High expression of long non-coding RNA NEAT1 indicates poor prognosis of human cancer

Jian Fang, Fuhao Qiao, Jingjing Tu, Jinfeng Xu, Fangfang Ding, Yun Liu, Bufugdi Andreas Akuo, Jianpeng Hu and Shihe Shao _

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Oncotarget. 2017; 8:45918-45927. https://doi.org/10.18632/oncotarget.17439

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Abstract

Jian Fang1, Fuhao Qiao1, Jingjing Tu1, Jinfeng Xu1, Fangfang Ding1, Yun Liu1, Bufugdi Andreas Akuo1, Jianpeng Hu2 and Shihe Shao1

1Department of Pathogenic Biology, School of Medicine, Jiangsu University, Zhenjiang, Jiangsu 212013, China

2Department of Urinary Surgery, Zhenjiang First People’s Hospital, Zhenjiang, Jiangsu 212013, China

Correspondence to:

Shihe Shao, email: [email protected]

Keywords: NEAT1, cancer, OS, meta-analysis, poor prognosis

Received: September 07, 2016     Accepted: April 11, 2017     Published: April 26, 2017

ABSTRACT

The nuclear paraspeckle assembly transcript 1 (NEAT1) is a long non-coding RNA. Many studies have reported that NEAT1 plays critical oncogenic roles and facilitates tumorigenesis of various human cancers. High NEAT1 expression is associated with a poor prognosis in cancer patients. This meta-analysis was conducted to assess the association between NEAT1 levels and survival times of cancer patients. Overall survival (OS) was the primary endpoint. Thirteen publications with 1,496 cancer patients from 5 databases (PubMed, EMBASE, Cochrane Library, Wiley Online Library, and Medline) met the criteria for this meta-analysis. Results of the analysis showed that NEAT1 expression in human cancer was significantly associated with OS (hazard ratio [HR]=1.53, 95% confidence interval [CI]: 1.39–1.68), including digestive system tumor (HR=1.54, 95% CI: 1.37–1.73) and respiratory carcinomas (HR=1.44, 95% CI: 1.11–1.85). The results also indicated that NEAT1 expression was highly associated with tumor size (>3 cm vs. ≤3 cm; odds ratio [OR]=2.51, 95% CI: 1.27–4.99; p=0.009), TNM stage (III+IV vs. I+II; OR=4.17, 95% CI: 2.42–7.18; p=0.00001), and distant metastasis (OR=2.73, 95% CI: 1.28–5.79; p=0.01). However, there was no significant association with differentiation (poor vs. well + moderate, OR=1.45, 95% CI: 0.72–2.91) and lymph node metastasis (OR=1.39, 95% CI: 0.54–3.60). This meta-analysis showed that NEAT1 expression may be a useful biomarker for predicting a poor prognosis in patients with cancer.


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