Hypoxia inducible factors in hepatocellular carcinoma

Chu Chen and Tao Lou _

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Oncotarget. 2017; 8:46691-46703. https://doi.org/10.18632/oncotarget.17358

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Chu Chen1, Tao Lou1

1Department of Internal Medicine, Fourth Affiliated Hospital of Zhejiang University, School of Medicine, Yiwu, 322000, Zhejiang, China

Correspondence to:

Tao Lou, email: [email protected]

Keywords: liver cancer, hepatoma, HIF, hypoxia, therapy

Received: February 13, 2017     Accepted: April 04, 2017     Published: April 21, 2017


Hepatocellular carcinoma is one of the most prevalent and lethal cancers with limited therapeutic options. Pathogenesis of this disease involves tumor hypoxia and the activation of hypoxia inducible factors. In this review, we describe the current understanding of hypoxia signaling pathway and summarize the expression, function and target genes of hypoxia inducible factors in hepatocellular carcinoma. We also highlight the recent progress in hypoxia-targeted therapeutic strategies in hepatocellular carcinoma and discuss further the future efforts for the study of hypoxia and/or hypoxia inducible factors in this deadly disease.

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