Oncotarget

Research Papers:

Genetic variation of long non-coding RNA TINCR contribute to the susceptibility and progression of colorectal cancer

Yongbin Zheng _, Chao Yang, Shilun Tong, Yu Ding, Wenhong Deng, Dan Song and Kuang Xiao

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Oncotarget. 2017; 8:33536-33543. https://doi.org/10.18632/oncotarget.16538

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Abstract

Yongbin Zheng1, Chao Yang1, Shilun Tong1, Yu Ding1, Wenhong Deng1, Dan Song1, Kuang Xiao1

1Department of Gastrointestinal Surgery, Renmin Hospital of Wuhan University, Wuhan, Hubei, PR China

Correspondence to:

Yongbin Zheng, email: zhengyongbinhb@163.com

Keywords: colorectal cancer, variation, genetic, TINCR, lncRNA

Received: January 05, 2017    Accepted: February 13, 2017    Published: March 24, 2017

ABSTRACT

Colorectal cancer (CRC) accounts for the leading causes of cancer-related morbidity and mortality. However, a large part of heritable factors are warranted to be explored. Long non-coding RNAs (lncRNAs) serve critical roles in cancer development and progression. Herein, we explored effect of genetic variants of Tissue differentiation-inducing non-protein coding RNA (TINCR), a key lncRNA required for somatic tissue differentiation and tumor progression, on risk and progression of CRC. Three tagSNPs, including rs2288947, rs8105637, and rs12610531, were evaluated in in a two-stage, case-control study. Two SNPs, rs2288947 and rs8105637, were significantly associated with susceptibility of CRC in both stages. When pooled together, the allele G was significantly associated with 23% decreased risk of CRC (OR=0.77; 95% CI=0.67-0.88; P value = 1.2×10-4)for SNP rs2288947. While for SNP rs8105637, the allele A was significantly associated with 22% increased risk of CRC (OR=1.22; 95% CI=1.09-1.37; P value = 6.2×10-4). The two SNPs were also statistically associated with occurrence of lymph node metastasis of CRC. The carriers of allele G are less likely to get lymph node metastasis (OR=0.77; 95% CI=0.63-0.94; P value = 0.011) for rs2288947, and the carriers of allele A are more likely to get lymph node metastasis (OR=1.22; 95% CI=1.03-1.43; P value = 0.019) for rs8105637. These results suggest that lncRNA TINCR polymorphisms may be implicated in the development and progression of CRC.


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