A common CD55 rs2564978 variant is associated with the susceptibility of non-small cell lung cancer
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Yanyan Zhang1,2, Zhi Zhang3, Lei Cao1, Jia Lin1, Zhenbang Yang1, Xuemei Zhang1
1Institute of Molecular Genetics, College of Life Science, North China University of Science and Technology, Tangshan, China
2Institute of Epidemiology, School of Public Health, North China University of Science and Technology, Tangshan, China
3Affiliated Tangshan Gongren Hospital, North China University of Science and Technology, Tangshan, China
Xuemei Zhang, email: firstname.lastname@example.org
Keywords: CD55, single nucleotide polymorphism, complement, lung cancer, susceptibility
Received: June 29, 2016 Accepted: December 12, 2016 Published: December 20, 2016
CD55, as one of key membrane-bound complement-regulatory proteins (mCRPs), is crucial for the progression of various cancers. This study aims to investigate the role of CD55 variants in the development of non-small cell lung cancer (NSCLC). A case-control study, including 706 lung cancer cases and 706 health controls, was conducted in a Chinese population. The odds ratio (OR) and 95% confidence interval (95% CI) were estimated by unconditional logistic regression. We found that significantly higher lung cancer risk was linked with CD55 rs2564978 CC genotype (OR = 1.52, 95% CI = 1.11−2.07) or CT genotypes (OR = 1.34, 95% CI = 1.05−1.71), compared to the TT genotype. Stratified analysis showed that rs2564978 CC was associated with NSCLC risk among males (OR = 1.69, 95% CI = 1.14−2.49) and older subjects (OR = 1.75, 95% CI = 1.08−2.82). When stratified by smoking status, the risk effect of rs2564978 CC was more evident among smokers (OR = 2.01, 95% CI = 1.18−3.43) than non-smokers (OR = 1.30, 95% CI = 0.88−1.90). We also conducted the stratified analysis by NSCLC histological types and found that CD55 rs2564978 CC increased the risk of adenocarcinoma with OR (95% CI) of 1.35 (1.01−1.80). The reporter gene expression driven by rs2564978T-containing CD55 promoter was respectively 1.48-fold, 1.96-fold and 1.93-fold higher than those driven by the rs2564978C-containing CD55 promoter in A549, NCI-H2030 and NCI-H23 cells (P = 0.045, 0.010 and < 0.001). These findings indicate that CD55 rs2564978 polymorphism may contribute to an increased risk of NSCLC in Chinese population.
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