Oncotarget

Research Papers:

Genetic variants in the acylphosphatase 2 gene and the risk of breast cancer in a Han Chinese population

Fuli Zhang, Yan Zhang, Zhiping Deng, Pengcheng Xu, Xiyang Zhang, Tianbo Jin and Qiufang Liu _

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Oncotarget. 2016; 7:86704-86712. https://doi.org/10.18632/oncotarget.13495

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Abstract

Fuli Zhang1,*, Yan Zhang1,*, Zhiping Deng2, Pengcheng Xu3, Xiyang Zhang4, Tianbo Jin4,5, Qiufang Liu6

1Department of Oncology Surgery, Traditional Chinese Medicine Hospital of Xi’an, Xi’an, Shaanxi 710021, China

2Department of Breast Surgery, Tumor Hospital of Shaanxi Province, Xi’an 710061, China

3Inner Mongolia Medical University, Hohhot 010010, Inner Mongolia, China

4School of Life Sciences, Northwest University, Xi’an, Shaanxi 710069, China

5Key Laboratory of Resource Biology and Biotechnology, Ministry of Education, Northwest University, Xi’an, Shaanxi 710069, China

6Department of Radiotherapy, Tumor Hospital of Shaanxi Province, Xi’an 710061, China

*These authors contributed equally to this work

Correspondence to:

Qiufang Liu, email: [email protected]

Keywords: breast cancer, ACYP2, single nucleotide polymorphism, association study

Received: July 28, 2016     Accepted: October 19, 2016     Published: November 22, 2016

ABSTRACT

We performed a case-control study to investigate the associations between seven single nucleotide polymorphisms (SNPs) in the acylphosphatase 2 (ACYP2) gene and breast cancer (BC) risk in a Han Chinese population. There were 183 BC cases and 195 healthy controls included in the study. The SNPs were genotyped using the Sequenom MassARRAY platform. Logistic regression (adjusted for age group, body mass index [BMI], and menopause status), was used to evaluate the associations between the various genotypes and BC risk. Statistical analysis revealed that rs12621038 was associated with a decreased risk of BC in the allele (T vs. C: odds ratio [OR] = 0.71, 95% confidence interval [95% CI] = 0.52–0.94; p = 0.016), homozygous (TT vs. CC: OR = 0.47, 95% CI = 0.24–0.85; p = 0.014), dominant (OR = 0.62; 95% CI = 0.40−0.96; p = 0.032), and additive (OR = 0.68; 95% CI = 0.50–0.92; p = 0.012) models. In addition, we found that rs1682111 and rs17045754 were associated with the risk of BC and correlated with recurrence, and that rs6713088 correlated with tumor size. In sum, our findings reveal significant associations between SNPs in the ACYP2 gene and BC risk in a Han Chinese population.


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