Oncotarget

Clinical Research Papers:

Preoperative platelet to lymphocyte and neutrophil to lymphocyte ratios are independent prognostic factors for patients undergoing lung cancer radical surgery: A single institutional cohort study

Haidan Lan, Leng Zhou, Dongmei Chi, Qinghua Zhou, XiaoJun Tang, Daxing Zhu, Jianmin Yue and Bin Liu _

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Oncotarget. 2017; 8:35301-35310. https://doi.org/10.18632/oncotarget.13312

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Abstract

Haidan Lan1,*, Leng Zhou1,*, Dongmei Chi1, Qinghua Zhou2, XiaoJun Tang2, Daxing Zhu2, Jianmin Yue1 and Bin Liu1

1 Department of Anesthesiology, West China Hospital of Sichuan University, Chengdu, Sichuan, China

2 The lung cancer center, West China Hospital of Sichuan University, Chengdu, Sichuan, China

* These authors have contributed equally to this work

Correspondence to:

Bin Liu, email:

Keywords: non small cell lung cancer; platelet to lymphocyte ratio; neutrophil to lymphocyte ratio; postoperative pulmonary complications; overall survival

Received: September 02, 2016 Accepted: October 28, 2016 Published: November 11, 2016

Abstract

Background: The aim of this study was to assess the prognostic value for NSCLC patients who were scheduled to receive lung cancer radical resection.

Methods: In this cohort study (Dec.2014-Feb.2016), patients with non-small cell lung cancer (NSCLC) who underwent radical lung cancer thoracotomy were enrolled and accessed at postoperative complications, one-year overall survival (OS) and relapse-free survival (RFS). The preoperative PLR and NLR of all patients were calculated based on preoperative complete blood counts. Univariate and multivariate Cox regression analyses were performed to determine the associations of PLR and NLR with OS and RFS.

Results. A total of 174 NSCLC patients were studied. The results indicated that both high PLR (>148.6) and NLR (>2.9) were related to a high rate of postoperative pulmonary complications significantly (49.3%vs.29.1%, P = 0.007; 50.7% vs. 28.6%, P = 0.003). Moreover, NSCLC patients with a high PLR level (> 148.6) was significantly associated with a lower one-year OS (90.3% vs. 77.5%, P = 0.034).

Conclusions. Preoperative PLR and NLR were good prognostic factors for postoperative pulmonary complications and OS in NSCLC patients undergoing radical lung cancer surgery. Thus, blood PLR and NLR would be helpful as a prognostic tool before radical lung cancer surgery.


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