TH9 cell differentiation, transcriptional control and function in inflammation, autoimmune diseases and cancer

Yan Li, Qing Yu, Zhengguo Zhang, Jian Wang, Simin Li, Jiangyuan Zhang _ and Guangwei Liu

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Oncotarget. 2016; 7:71001-71012. https://doi.org/10.18632/oncotarget.11681

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Yan Li1,2, Qing Yu1, Zhengguo Zhang1,2, Jian Wang1,2, Simin Li1, Jiangyuan Zhang1 and Guangwei Liu1,2

1 Key Laboratory of Cell Proliferation and Regulation Biology of Ministry of Education, Institute of Cell Biology, College of Life Sciences, Beijing Normal University, Beijing, China

2 Department of Immunology, School of Basic Medical Sciences, Fudan University, Shanghai, China

Correspondence to:

Guangwei Liu , email:

Keywords: T cell differentiation; TH9; allergic airway inflammation; tumor; autoimmune diseases

Received: June 16, 2016 Accepted: August 26, 2016 Published: August 29, 2016


Naïve CD4+T cells differentiate into various T cell subsets depending on the specific cytokine environment. TH9 cells are less well-characterized than other T cell subsets, and factors that control their development and function have only recently been identified. It is now clear that TH9 cells play critical roles in immune-mediated diseases, including allergic airway, autoimmune and inflammatory bowel diseases, and cancer. Thus, the promotion or suppression of TH9 cell differentiation, transcriptional control and function may provide novel treatments for clinical inflammation, autoimmune diseases and tumors.

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