Vol 5, No 19

In vivo quantification and perturbation of Myc-Max interactions and the impact on oncogenic potential

Small molecule restoration of wildtype structure and function of mutant p53 using a novel zinc-metallochaperone based mechanism

MUC1-C confers EMT and KRAS independence in mutant KRAS lung cancer cells

The head and neck cancer cell oncogenome: A platform for the development of precision molecular therapies

Selected drugs that inhibit DNA methylation can preferentially kill p53 deficient cells

Plerixafor as a chemosensitizing agent in pediatric acute lymphoblastic leukemia: efficacy and potential mechanisms of resistance to CXCR4 inhibition

A novel tumor suppressor function of Kindlin-3 in solid cancer

Glycogen synthase kinase-3β inhibition depletes the population of prostate cancer stem/progenitor-like cells and attenuates metastatic growth

The class-specific BCR tonic signal modulates lymphomagenesis in a c-myc deregulation transgenic model

A novel calcium-dependent mechanism of acquired resistance to IGF-1 receptor inhibition in prostate cancer cells

Novel robust biomarkers for human bladder cancer based on activation of intracellular signaling pathways

The BCL2 inhibitor ABT-199 significantly enhances imatinib-induced cell death in chronic myeloid leukemia progenitors

Chemosensitization of solid tumors by inhibition of Bcl-xL expression using DNAzyme

Targeting tyrosine-kinases and estrogen receptor abrogates resistance to endocrine therapy in breast cancer

Gankyrin is a predictive and oncogenic factor in well-differentiated and dedifferentiated liposarcoma

Prolactin induces up-regulation of its cognate receptor in breast cancer cells via transcriptional activation of its generic promoter by cross-talk between ERα and STAT5

LGR5 promotes the proliferation and tumor formation of cervical cancer cells through the Wnt/β-catenin signaling pathway

MicroRNA-339-5p inhibits colorectal tumorigenesis through regulation of the MDM2/p53 signaling

Anti-rheumatic agent auranofin induced apoptosis in chronic myeloid leukemia cells resistant to imatinib through both Bcr/Abl-dependent and -independent mechanisms

p70 S6 kinase drives ovarian cancer metastasis through multicellular spheroid-peritoneum interaction and P-cadherin/β1 integrin signaling activation

Crizotinib exhibits antitumor activity by targeting ALK signaling not c-MET in pancreatic cancer

Biphasic regulation of autophagy by miR-96 in prostate cancer cells under hypoxia

Binding of a Smad4/Ets-1 complex to a novel intragenic regulatory element in exon12 of FPGS underlies decreased gene expression and antifolate resistance in leukemia

Mutational analysis of genes coding for cell surface proteins in colorectal cancer cell lines reveal novel altered pathways, druggable mutations and mutated epitopes for targeted therapy.

Vav1 promotes lung cancer growth by instigating tumor-microenvironment cross-talk via growth factor secretion

Piperlongumine selectively kills cancer cells and increases cisplatin antitumor activity in head and neck cancer

Efficacy of aerosol therapy of lung cancer correlates with EGFR paralysis induced by AvidinOX-anchored biotinylated Cetuximab

Rpb3 promotes hepatocellular carcinoma through its N-terminus

DCLK1 facilitates intestinal tumor growth via enhancing pluripotency and epithelial mesenchymal transition

Loss of Trop2 causes ErbB3 activation through a neuregulin-1-dependent mechanism in the mesenchymal subtype of HNSCC

Combining targeted drugs to overcome and prevent resistance of solid cancers with some stem-like cell features

Multidrug resistance protein 4/ ATP binding cassette transporter 4: a new potential therapeutic target for acute myeloid leukemia

P2Y₂R activation by nucleotides released from the highly metastatic breast cancer cell contributes to pre-metastatic niche formation by mediating lysyl oxidase secretion, collagen crosslinking, and monocyte recruitment

Androgen deprivation therapy sensitizes prostate cancer cells to T-cell killing through androgen receptor dependent modulation of the apoptotic pathway

Transcriptional coactivator CBP upregulates hTERT expression and tumor growth and predicts poor prognosis in human lung cancers

The fatty acid synthase inhibitor triclosan: repurposing an anti-microbial agent for targeting prostate cancer

Transcriptional profiling of GBM invasion genes identifies effective inhibitors of the LIM kinase-Cofilin pathway

The DNA2 nuclease/helicase is an estrogen-dependent gene mutated in breast and ovarian cancers

Overexpression of Collagen Triple Helix Repeat Containing 1 (CTHRC1) is associated with tumour aggressiveness and poor prognosis in human non-small cell lung cancer

Epigenetic signatures of alcohol abuse and hepatitis infection during human hepatocarcinogenesis

miR-524-5p suppresses the growth of oncogenic BRAF melanoma by targeting BRAF and ERK2

GUCY2C lysosomotropic endocytosis delivers immunotoxin therapy to metastatic colorectal cancer

miR-382 inhibits tumor growth and enhance chemosensitivity in osteosarcoma

What makes a blood cell based miRNA expression pattern disease specific? - A miRNome analysis of blood cell subsets in lung cancer patients and healthy controls

TOP2A^high is the phenotype of recurrence and metastasis whereas TOP2A^neg cells represent cancer stem cells in prostate cancer

FOXF1 mediates mesenchymal stem cell fusion-induced reprogramming of lung cancer cells