Vol 5, No 14

Targeting lemurs against cancer metastasis

Ras in epidermal proliferation

Knowledge-based computational models

An epigenetic marker panel for recurrence risk prediction of low grade papillary urothelial cell carcinoma (LGPUCC) and its potential use for surveillance after transurethral resection using urine

Low PKCα expression within the MRD-HR stratum defines a new subgroup of childhood T-ALL with very poor outcome

High circulating hepatocyte growth factor levels associate with epithelial to mesenchymal transition and poor outcome in small cell lung cancer patients

CD271 is an imperfect marker for melanoma initiating cells

Circulating miR-148b and miR-133a as biomarkers for breast cancer detection

Loss of ARID1A expression sensitizes cancer cells to PI3K- and AKT-inhibition

A FcγRIII-engaging bispecific antibody expands the range of HER2-expressing breast tumors eligible to antibody therapy

Functional genomics identifies novel genes essential for clear cell renal cell carcinoma tumor cell proliferation and migration

Galectin-4 expression is associated with reduced lymph node metastasis and modulation of Wnt/β-catenin signalling in pancreatic adenocarcinoma

Macrophages are recruited to hypoxic tumor areas and acquire a Pro-Angiogenic M2-Polarized phenotype via hypoxic cancer cell derived cytokines Oncostatin M and Eotaxin

GRP78 enhances the glutamine metabolism to support cell survival from glucose deficiency by modulating the β-catenin signaling

Combined therapy with RAD001 e BEZ235 overcomes resistance of PET immortalized cell lines to mTOR inhibition

FOXO1 downregulation contributes to the oncogenic program of primary mediastinal B-cell lymphoma

Tumor suppressor XAF1 induces apoptosis, inhibits angiogenesis and inhibits tumor growth in hepatocellular carcinoma

MiR-143 acts as a tumor suppressor by targeting N-RAS and enhances temozolomide-induced apoptosis in glioma

The response of head and neck squamous cell carcinoma to cetuximab treatment depends on Aurora kinase A polymorphism

Tumor-derived exosomes promote tumor progression and T-cell dysfunction through the regulation of enriched exosomal microRNAs in human nasopharyngeal carcinoma

Clinically used antirheumatic agent auranofin is a proteasomal deubiquitinase inhibitor and inhibits tumor growth

Triple negative tumors accumulate significantly less methylglyoxal specific adducts than other human breast cancer subtypes

Hedgehog signaling sensitizes Glioma stem cells to endogenous nano-irradiation

A nucleolin-DNMT1 regulatory axis in acute myeloid leukemogenesis

Sustained conditional knockdown reveals intracellular bone sialoprotein as essential for breast cancer skeletal metastasis

Sensitization of radio-resistant prostate cancer cells with a unique cytolethal distending toxin

Tumor suppressor p53 negatively regulates glycolysis stimulated by hypoxia through its target RRAD

Hepatocyte growth factor-like protein is required for prostate tumor growth in the TRAMP mouse model

Usp5 links suppression of p53 and FAS levels in melanoma to the BRAF pathway

Small interfering RNA (siRNA)-mediated knockdown of macrophage migration inhibitory factor (MIF) suppressed cyclin D1 expression and hepatocellular carcinoma cell proliferation

Specific delivery of microRNA93 into HBV-replicating hepatocytes downregulates protein expression of liver cancer susceptible gene MICA

E3-ligase Skp2 predicts poor prognosis and maintains cancer stem cell pool in nasopharyngeal carcinoma

The tumor suppressive role of NUMB isoform 1 in esophageal squamous cell carcinoma

Development of replication-competent adenovirus for bladder cancer by controlling adenovirus E1a and E4 gene expression with the survivin promoter

Upregulation of microRNA135a-3p and death receptor 5 plays a critical role in Tanshinone I sensitized prostate cancer cells to TRAIL induced apoptosis

Histone deacetylase inhibitor treatment induces ‘BRCAness’ and synergistic lethality with PARP inhibitor and cisplatin against human triple negative breast cancer cells

A novel class I HDAC inhibitor, MPT0G030, induces cell apoptosis and differentiation in human colorectal cancer cells via HDAC1/PKCδ and E-cadherin

TFF1 activates p53 through down-regulation of miR-504 in gastric cancer

Potentiation of tumor responses to DNA damaging therapy by the selective ATR inhibitor VX-970

Multiple myeloma cell-derived microvesicles are enriched in CD147 expression and enhance tumor cell proliferation

Loss of PPM1A expression enhances invasion and the epithelial-to-mesenchymal transition in bladder cancer by activating the TGF-β/Smad signaling pathway

FAS/FASL are dysregulated in chordoma and their loss-of-function impairs zebrafish notochord formation

Regulatory role of miR-142-3p on the functional hepatic cancer stem cell marker CD133

H-Prune through GSK-3β interaction sustains canonical WNT/β-catenin signaling enhancing cancer progression in NSCLC

The ALK inhibitor ASP3026 eradicates NPM-ALK⁺ T-cell anaplastic large-cell lymphoma in vitro and in a systemic xenograft lymphoma model

Dissecting DNA repair in adult high grade gliomas for patient stratification in the post-genomic era

Thrombospondin 1 promotes an aggressive phenotype through epithelial-to-mesenchymal transition in human melanoma

Histone demethylase RBP2 induced by Helicobactor Pylori CagA participates in the malignant transformation of gastric epithelial cells

Oncogene-mediated regulation of p53 ISGylation and functions

Novel celastrol derivatives inhibit the growth of hepatocellular carcinoma patient-derived xenografts

HERG1 functions as an oncogene in pancreatic cancer and is downregulated by miR-96