The Oncosearch | Oncotarget

p53 regulates the transcription of the anti-inflammatory molecule developmental endothelial locus-1 (Del-1) Research Paper

Hyesoon Kim, Seung-Hwan Lee, Mi-Ni Lee, Goo Taeg Oh, Kyung-Chul Choi, Eun Young Choi

Published Oct 3, 2013 · Vol. 4, No. 11 · pp. 1976-1985

Keywords: p53, inflammation, endothelial cell, Del-1

MYCN is a novel oncogenic target in pediatric T-cell Acute Lymphoblastic Leukemia Research Paper

Annalisa Astolfi, Francesca Vendemini, Milena Urbini, Fraia Melchionda, Riccardo Masetti, Monica Franzoni, Virginia Libri, Salvatore Serravalle, Marco Togni, Giuseppina Paone, Luca Montemurro, Daniela Bressanin, Francesca Chiarini, Alberto M Martelli, Roberto Tonelli, Andrea Pession

Published Sep 29, 2013 · Vol. 5, No. 1 · pp. 120-130

Keywords: pediatric T-ALL, MYCN, peptide nucleic acid, TAL1

Crucial Role for Early Growth Response-1 in the Transcriptional Regulation of miR-20b in Breast Cancer Research Paper

Dongping Li, Yaroslav Ilnytskyy, Anna Kovalchuk, Levon M. Khachigian, Roderick T. Bronson, Bo Wang, Olga Kovalchuk

Published Jul 28, 2013 · Vol. 4, No. 9 · pp. 1373-1387

Keywords: EGR1, miR-20b, transcription, PTEN, BRCA1, breast cancer, proliferation, migration, cell cycle arrest

Small Molecule-Induced Mitochondrial Disruption Directs Prostate Cancer Inhibition via Unfolded Protein Response Signaling Research Paper

Elizabeth Rico-Bautista, Wenhong Zhu, Shinichi Kitada, Suthakar Ganapathy, Eric Lau, Stan Krajewski, Joel Ramirez, Jason A. Bush, Zhimin Yuan, Dieter A. Wolf

Published Jul 14, 2013 · Vol. 4, No. 8 · pp. 1212-1229

Keywords: Prostate cancer, cell cycle arrest, apoptosis, oxidative stress, small molecule inhibitor, mitochondrial function

The tumor suppressor TERE1 (UBIAD1) prenyltransferase regulates the elevated cholesterol phenotype in castration resistant prostate cancer by controlling a program of ligand dependent SXR target genes. Research Paper

William J. Fredericks, Jorge Sepulveda, Priti Lal, John E. Tomaszewski, Ming-Fong Lin, Terry McGarvey, Frank J. Rauscher III, S. Bruce Malkowicz

Published Jul 7, 2013 · Vol. 4, No. 7 · pp. 1075-1092

Keywords: TERE1, UBIAD1, prostate cancer, castrate resistant prostate cancer, CRPC, LnCaP, cholesterol, SXR, androgen catabolism, Vitamin K-2

Gli1 Transcriptional Activity is Negatively Regulated by AKT2 in Neuroblastoma Research Paper

Pritha Paul, Natasha S. Volny, Sora Lee, Jingbo Qiao, Dai H. Chung

Published Jun 29, 2013 · Vol. 4, No. 8 · pp. 1149-1157

Keywords: Gli1, AKT2, Neuroblastoma, SUFU

CK2-NCoR signaling cascade promotes prostate tumorigenesis Research Paper

Jung-Yoon Yoo, Beom Jin Lim, Hyo-Kyoung Choi, Soon Won Hong, Ho Sung Jang, Changsoo Kim, Kyung-Hee Chun, Kyung-Chul Choi, HoGeun Yoon

Published May 11, 2013 · Vol. 4, No. 7 · pp. 972-983

Keywords: CK2, NCoR, Prostate cancer, IP-10, transcriptional regulation

Targeting HSF1 sensitizes cancer cells to HSP90 inhibition Research Paper

Yaoyu Chen, Jinyun Chen, Alice Loo, Savina Jaeger, Linda Bagdasarian, Jianjun Yu, Franklin Chung, Joshua Korn, David Ruddy, Ribo Guo, Margaret Mclaughlin, Fei Feng, Ping Zhu, Frank Stegmeier, Raymond Pagliarini, Dale Porter, Wenlai Zhou

Published Apr 23, 2013 · Vol. 4, No. 6 · pp. 816-829

Keywords: HSF1, cancer cells, HSP90 inhibitor, Melanoma, HCC, DEDD2

Epidermal Growth Factor Receptor Tyrosine Kinase Inhibition Up-regulates Interleukin-6 in Cancer Cells and Induces Subsequent Development of Interstitial Pneumonia Research Paper

Yukari Ishiguro, Hitoshi Ishiguro, Hiroshi Miyamoto

Published Mar 31, 2013 · Vol. 4, No. 4 · pp. 550-559

Keywords: fibrosis, EGFR-TKI, IL-6, cytokine, side-effect

The Paradox of E-Cadherin: Role in response to hypoxia in the tumor microenvironment and regulation of energy metabolism Research Paper

Khoi Chu, Kimberkey M. Boley, Ricardo Moraes, Sanford H. Barsky, Fredika M. Robertson

Published Mar 21, 2013 · Vol. 4, No. 3 · pp. 446-462

Keywords: E-Cadherin, Inflammatory Breast Cander, Mesenchymal-Epithelial transition (MET), HIF-1Î±, Metabolism, Glycolysis

Actin-binding protein alpha-actinin 4 (ACTN4) is a transcriptional co-activator of RelA/p65 sub-unit of NF-kB. Research Paper

Vasilisa Aksenova, Lidia Turoverova, Mikhail Khotin, Karl-Eric Magnusson, Eugene Tulchinsky, Gerry Melino, George P Pinaev, Nikolai Barlev, Dmitri Tentler

Published Feb 28, 2013 · Vol. 4, No. 2 · pp. 362-373

Keywords: ACTN4, RelA/p65, transcription regulation, MMP

DNA-intercalators Causing Rapid Re-expression of Methylated and Silenced Genes in Cancer Cells Research Paper

M. Zulfiquer Hossain, Megan A. Healey, Calvin Lee, Weijie Poh, Sashidhar R. Yerram, Kalpesh Patel, Nilofer S. Azad, James G. Herman, Scott E. Kern

Published Feb 26, 2013 · Vol. 4, No. 2 · pp. 298-309

Keywords: cancer, gene methylation, demethylation, DNA-intercalator, quinacrine, DNMT inhibitor, epigenetics, silencing and re-activation of gene expression, small molecule-DNA interactions

TIMP-2 modulates cancer cell transcriptional profile and enhances E-cadherin/beta-catenin complex expression in A549 lung cancer cells Research Paper

Dimitra Bourboulia, HuiYing Han, Sandra Jensen-Taubman, Noah Gavil, Biju Isaac, Beiyang Wei, Len Neckers, William Stetler-Stevenson

Published Jan 27, 2013 · Vol. 4, No. 1 · pp. 163-173

Keywords: TIMP-2, microarray analysis, E-cadherin, cell adhesion, tumor growth inhibition

Autophagy-related gene 12 (ATG12) is a novel determinant of primary resistance to HER2-targeted therapies: Utility of transcriptome analysis of the autophagy interactome to guide breast cancer treatment Research Paper

SÃlvia CufÃ, Alejandro Vazquez-Martin, Ceistina Oliveras-Ferraros, Bruna Corominas-Faja, Ander Urruticoechea, BegoÃ±a Martin-Castillo, Javier A Menendez

Published Nov 17, 2012 · Vol. 3, No. 12 · pp. 1600-1614

Keywords: Autophagy, ATG genes, HER2, trastuzumab, lapatinib

Epigenetic Regulation of miRNA-211 by MMP-9 Governs Glioma Cell Apoptosis, Chemosensitivity and Radiosensitivity Research Paper

Swapna Asuthkar, Kiran Kumar Velpula, Chandramu Chetty, Bharathi Gorantla, Jasti S. Rao

Published Nov 16, 2012 · Vol. 3, No. 11 · pp. 1439-1454

Keywords: Matrix metalloproteinase-9 (MMP-9), microRNA-211 (miR-211), Cancer Stem Cells (CSC), Ionizing radiation (IR) and Temozolomide (Tem)

Down-regulation of Sox7 is associated with aberrant activation of Wnt/Î²-catenin signaling in endometrial cancer Research Paper

David W Chan, Celia SL Mak, Thomas HY Leung, Karen KL Chan, Hextan YS Ngan

Published Nov 7, 2012 · Vol. 3, No. 12 · pp. 1546-1556

Keywords: Sox7, Wnt/ï¢-catenin, endometrial cancer, TCF/LEF-1, CyclinD1, FGF9

Whole-exome sequencing identifies ATRX mutation as a key molecular determinant in lower-grade glioma Research Paper

Kasthuri Kannan, Akiko Inagaki, Joachim Silber, Daniel Gorovets, Jianan Zhang, Edward R. Kastenhuber, Adriana Heguy, John H. Petrini, Timothy A. Chan, Jason T. Huse

Published Oct 11, 2012 · Vol. 3, No. 10 · pp. 1194-1203

Keywords: glioma, astrocytoma, IDH, ATRX, whole-exome sequencing

Up-regulation of c-MYC and SIRT1 expression correlates with malignant transformation in the serrated route to colorectal cancer Research Paper

Lydia Kriegl, Michael Vieth, Thomas Kirchner, Antje Menssen

Published Oct 3, 2012 · Vol. 3, No. 10 · pp. 1182-1193

Keywords: Serrated route, colorectal cancer, SIRT1, c-MYC, BRAF and KRAS mutation, wnt signalling

FOXP3, a novel glioblastoma oncosuppressor, affects proliferation and migration Research Paper

VÃ©ronique Frattini, Federica Pisati, Maria Carmela Speranza, Pietro Luigi Poliani, Gianmaria FrigÃ©, Gabriele Cantini, Dimos Kapetis, Manuela Cominelli, Alessandra Rossi, Gaetano Finocchiaro, Serena Pellegatta

Published Sep 22, 2012 · Vol. 3, No. 10 · pp. 1146-1157

Keywords: FOXP3, glioblastoma, neurospheres, proliferation, migration

Regulation of DNA Damage Following Termination of Hedgehog (HH) Survival Signaling at the level of the GLI Genes in Human Colon Cancer Research Paper

AKWASI AGYEMAN, Tapati Mazumdar, Janet A Houghton

Published Aug 20, 2012 · Vol. 3, No. 8 · pp. 854-868

Keywords: Hedgehog, GLI1/2 inhibition, GANT61, DNA damage, colon cancer

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p53 regulates the transcription of the anti-inflammatory molecule developmental endothelial locus-1 (Del-1) Research Paper

MYCN is a novel oncogenic target in pediatric T-cell Acute Lymphoblastic Leukemia Research Paper

Crucial Role for Early Growth Response-1 in the Transcriptional Regulation of miR-20b in Breast Cancer Research Paper

Small Molecule-Induced Mitochondrial Disruption Directs Prostate Cancer Inhibition via Unfolded Protein Response Signaling Research Paper

The tumor suppressor TERE1 (UBIAD1) prenyltransferase regulates the elevated cholesterol phenotype in castration resistant prostate cancer by controlling a program of ligand dependent SXR target genes. Research Paper

Gli1 Transcriptional Activity is Negatively Regulated by AKT2 in Neuroblastoma Research Paper

CK2-NCoR signaling cascade promotes prostate tumorigenesis Research Paper

Targeting HSF1 sensitizes cancer cells to HSP90 inhibition Research Paper

Epidermal Growth Factor Receptor Tyrosine Kinase Inhibition Up-regulates Interleukin-6 in Cancer Cells and Induces Subsequent Development of Interstitial Pneumonia Research Paper

The Paradox of E-Cadherin: Role in response to hypoxia in the tumor microenvironment and regulation of energy metabolism Research Paper

Actin-binding protein alpha-actinin 4 (ACTN4) is a transcriptional co-activator of RelA/p65 sub-unit of NF-kB. Research Paper

DNA-intercalators Causing Rapid Re-expression of Methylated and Silenced Genes in Cancer Cells Research Paper

TIMP-2 modulates cancer cell transcriptional profile and enhances E-cadherin/beta-catenin complex expression in A549 lung cancer cells Research Paper

Autophagy-related gene 12 (ATG12) is a novel determinant of primary resistance to HER2-targeted therapies: Utility of transcriptome analysis of the autophagy interactome to guide breast cancer treatment Research Paper

Epigenetic Regulation of miRNA-211 by MMP-9 Governs Glioma Cell Apoptosis, Chemosensitivity and Radiosensitivity Research Paper

Down-regulation of Sox7 is associated with aberrant activation of Wnt/Î²-catenin signaling in endometrial cancer Research Paper

Whole-exome sequencing identifies ATRX mutation as a key molecular determinant in lower-grade glioma Research Paper

Up-regulation of c-MYC and SIRT1 expression correlates with malignant transformation in the serrated route to colorectal cancer Research Paper

FOXP3, a novel glioblastoma oncosuppressor, affects proliferation and migration Research Paper

Regulation of DNA Damage Following Termination of Hedgehog (HH) Survival Signaling at the level of the GLI Genes in Human Colon Cancer Research Paper

Publication Alerts

European Cancer and Oncology Congress

Oncoscience

Post-Publication Promotion

Search Oncotarget

p53 regulates the transcription of the anti-inflammatory molecule developmental endothelial locus-1 (Del-1) Research Paper

MYCN is a novel oncogenic target in pediatric T-cell Acute Lymphoblastic Leukemia Research Paper

Crucial Role for Early Growth Response-1 in the Transcriptional Regulation of miR-20b in Breast Cancer Research Paper

Small Molecule-Induced Mitochondrial Disruption Directs Prostate Cancer Inhibition via Unfolded Protein Response Signaling Research Paper

The tumor suppressor TERE1 (UBIAD1) prenyltransferase regulates the elevated cholesterol phenotype in castration resistant prostate cancer by controlling a program of ligand dependent SXR target genes. Research Paper

Gli1 Transcriptional Activity is Negatively Regulated by AKT2 in Neuroblastoma Research Paper

CK2-NCoR signaling cascade promotes prostate tumorigenesis Research Paper

Targeting HSF1 sensitizes cancer cells to HSP90 inhibition Research Paper

Epidermal Growth Factor Receptor Tyrosine Kinase Inhibition Up-regulates Interleukin-6 in Cancer Cells and Induces Subsequent Development of Interstitial Pneumonia Research Paper

The Paradox of E-Cadherin: Role in response to hypoxia in the tumor microenvironment and regulation of energy metabolism Research Paper

Actin-binding protein alpha-actinin 4 (ACTN4) is a transcriptional co-activator of RelA/p65 sub-unit of NF-kB. Research Paper

DNA-intercalators Causing Rapid Re-expression of Methylated and Silenced Genes in Cancer Cells Research Paper

TIMP-2 modulates cancer cell transcriptional profile and enhances E-cadherin/beta-catenin complex expression in A549 lung cancer cells Research Paper

Autophagy-related gene 12 (ATG12) is a novel determinant of primary resistance to HER2-targeted therapies: Utility of transcriptome analysis of the autophagy interactome to guide breast cancer treatment Research Paper

Epigenetic Regulation of miRNA-211 by MMP-9 Governs Glioma Cell Apoptosis, Chemosensitivity and Radiosensitivity Research Paper

Down-regulation of Sox7 is associated with aberrant activation of Wnt/Î²-catenin signaling in endometrial cancer Research Paper

Whole-exome sequencing identifies ATRX mutation as a key molecular determinant in lower-grade glioma Research Paper

Up-regulation of c-MYC and SIRT1 expression correlates with malignant transformation in the serrated route to colorectal cancer Research Paper

FOXP3, a novel glioblastoma oncosuppressor, affects proliferation and migration Research Paper

Regulation of DNA Damage Following Termination of Hedgehog (HH) Survival Signaling at the level of the GLI Genes in Human Colon Cancer Research Paper