The Oncosearch | Oncotarget

Minor grove binding ligands disrupt PARP-1 activation pathways Research Paper

Kirill Kirsanov, Elena Kotova, Petr Makhov, Konstantin Golovine, Ekaterina A. Lesovaya, Vladimir M. Kolenko, Marianna G. Yakubovskaya, Alexei V. Tulin

Published Jan 3, 2014 · Vol. 5, No. 2 · pp. 428-437

Keywords: PARP-1, PARP-1 inhibitors, DNA-binding small molecules, poly(ADP-ribose)

Poly (ADP-ribose) polymerase 1 transcriptional regulation: A novel crosstalk between histone modification H3K9ac and ETS1 motif hypomethylation in BRCA1-mutated ovarian cancer Research Paper

Da Li, Fang-Fang Bi, Ji-Min Cao, Chen Cao, Chun-Yan Li, Bo Liu, Qing Yang

Published Dec 29, 2013 · Vol. 5, No. 1 · pp. 291-297

Keywords: PARP1, H3K9ac, ETS1, BRCA1, Ovarian cancer

CITED1 confers stemness to Wilms tumor and enhances tumorigenic responses when enriched in the nucleus Research Paper

Andrew J. Murphy, Janene Pierce, Christian de Caestecker, Gregory D. Ayers, Alex Zhao, Jonathan R. Krebs, Vincente Kenyi Saito-Diaz, Ethan Lee, Alan O. Perantoni, Mark P. de Caestecker, Harold N. Lovvorn, III

Published Dec 28, 2013 · Vol. 5, No. 2 · pp. 386-402

Keywords: CITED1, Wilms tumor, WNT, WiT49, cancer stem cell

Alternative splicing of FBP-interacting repressor coordinates c-Myc, P27Kip1/cyclinE and Ku86/XRCC5 expression as a molecular sensor for bleomycin-induced DNA damage pathway Research Paper

Bahityar Rahmutulla, Kazuyuki Matsushita, Mamoru Satoh, Masanori Seimiya, Sachio Tsuchida, Shuji Kubo, Hideaki Shimada, Masayuki Ohtsuka, Masaru Miyazaki, Fumio Nomura

Published Dec 21, 2013 · Vol. 5, No. 9 · pp. 2404-2417

Keywords: FBP interacting repressor (FIR), bleomycin, DNA damage, Ku86, c-Myc, P27Kip1

A novel Cdk9 inhibitor preferentially targets tumor cells and synergizes with fludarabine Research Paper

Elisabeth Walsby, Guy Pratt, Hao Shao, Abdullah Y. Abbas, Peter M. Fischer, Tracey D. Bradshaw, Paul Brennan, Chris Fegan, Shudong Wang, Chris Pepper

Published Dec 18, 2013 · Vol. 5, No. 2 · pp. 375-385

Keywords: CLL, cdk9, synergy, MCL1

Anti-oxidative stress response genes: bioinformatic analysis of their expression and relevance in multiple cancers Research Perspective

Barak Rotblat, Thomas G. P. Grunewald, Gabriel Leprivier, Gerry Melino, Richard A. Knight

Published Dec 15, 2013 · Vol. 4, No. 12 · pp. 2577-2590

Keywords: anti-oxidant genes, glutathione, thioredoxin, breast cancer, lung cancer, NRF2, G6PD

A loss-of-function mutation in PTCH1 suggests a role for autocrine hedgehog signaling in colorectal tumorigenesis Brief Reports

Jon H. Chung, Fred Bunz

Published Dec 11, 2013 · Vol. 4, No. 12 · pp. 2208-2211

Keywords: Hedgehog, colorectal cancer, Patched, vismodegib, autocrine

The polycomb group protein EZH2 is a novel therapeutic target in tongue cancer Research Paper

Zhongwu li, Yanling Wang, Jing Qiu, Qiang Li, Chunping Yuan, Wei Zhang, Dongmiao Wang, Jinhai Ye, Hongbin Jiang, Jianrong Yang, Jie Cheng

Published Dec 7, 2013 · Vol. 4, No. 12 · pp. 2532-2549

Keywords: tongue squamous cell carcinoma, polycomb complex, EZH2, DZNep

ERG induces a mesenchymal-like state associated with chemoresistance in leukemia cells Research Paper

Liliana H. Mochmann, Martin Neumann, Eva K. von Der Heide, Verena Nowak, Anja A. KÃ¼hl, Jutta Ortiz-Tanchez, Juliane Bock, Wolf K Hofmann, Claudia D Baldus

Published Dec 4, 2013 · Vol. 5, No. 2 · pp. 351-362

Keywords: ERG, ERK, EMT, Chemoresistance

A TRAF2 binding independent region of TNFR2 is responsible for TRAF2 depletion and enhancement of cytotoxicity driven by TNFR1 Research Paper

LucÃa Cabal-Hierro, Noelia Artime, JuliÃ¡n Iglesias, Miguel A. Prado, Lorea Ugarte-Gil, Pedro Casado, BelÃ©n FernÃ¡ndez-GarcÃa, Bryant G. Darnay, Pedro S. Lazo

Published Nov 29, 2013 · Vol. 5, No. 1 · pp. 224-236

Keywords: TNF receptors, Death Receptors, TRAF2, Apoptosis, NF-kappaB

Inhibition of BET bromodomain proteins as a therapeutic approach in prostate cancer. Research Paper

Anastasia Wyce, Yan Degenhardt, Yuchen Bai, BaoChau Le, Susan Korenchuk, Ming-Chih Crouthamel, Charles McHugh, Robert Vessella, Caretha Creasy, Peter Tummino, Olena Barbash

Published Nov 23, 2013 · Vol. 4, No. 12 · pp. 2419-2429

Keywords: BET inhibitor, prostate cancer, c-Myc

Deficiency in p53 is required for doxorubicin induced transcriptional activation of NF-ÐºB target genes in human breast cancer Research Paper

Alba Dalmases, Irene Gonzalez-Navarrete, Silvia Menendez, Oriol ArpÃ, Josep Maria Coromines, Sonia Servitja, Ignasi Tusquets, Cristina Chamizo, RaÃºl RincÃ³n, LluÃs Espinosa, Anna Bigas, Pilar Eroles, Jessica Furriol, Anna Lluch, Ana Rovira, Joan Albanell, Federico Rojo

Published Nov 23, 2013 · Vol. 5, No. 1 · pp. 196-210

Keywords: breast cancer, chemoresistance, NF-ÐºB, p53, prognosis

High Mdm4 levels suppress p53 activity and enhance its half-life in acute myeloid leukaemia Research Paper

Ban Xiong Tan, Kian Hoe Khoo, Tit Meng Lim, David Philip Lane

Published Nov 22, 2013 · Vol. 5, No. 4 · pp. 933-943

Keywords: p53, AML, Mdm4

EI24 regulates epithelial-to-mesenchymal transition and tumor progression by suppressing TRAF2-mediated NF-ÎºB activity Research Paper

Jung-Min Choi, Sushil Devkota, Young Hoon Sung, Han-Woong Lee

Published Nov 17, 2013 · Vol. 4, No. 12 · pp. 2383-2396

Keywords: EI24, EMT, NF-ÎºB, tumor progression

FOXD3 is a novel tumor suppressor that affects growth, invasion, metastasis and angiogenesis of neuroblastoma Research Paper

Dan Li, Hong Mei, Meng Qi, Dehua Yang, Xiang Zhao, Xuan Xiang, Jiarui Pu, Kai Huang, Liduan Zheng, Qiangsong Tong

Published Nov 5, 2013 · Vol. 4, No. 11 · pp. 2021-2044

Enrichment of human osteosarcoma stem cells based on hTERT transcriptional activity Research Paper

Ling Yu, Shiqing Liu, Chun Zhang, Bo Zhang, Bruno M. Simoes, Rachel Eyre, Yi Liang, Huichao Yan, Zheng Wu, Weichun Guo, Robert B. Clarke

Published Nov 5, 2013 · Vol. 4, No. 12 · pp. 2326-2338

Keywords: osteosarcoma, stem cells, sarcospheres, telomerase

Aberrantly hypermethylated Homeobox A2 derepresses metalloproteinase-9 through TBP and promotes invasion in Nasopharyngeal carcinoma Research Paper

Hsin-Pai Li, Chen-Ching Peng, I-Che Chung, Mei-Yuan Huang, Shao-Tung Huang, Chia-Chun Chen, Kai-Ping Chang, Cheng-Lung Hsu, Yu-Sun Chang

Published Nov 4, 2013 · Vol. 4, No. 11 · pp. 2154-2165

Keywords: HOXA2, DNA methylation, NPC, MMP9

COX-2 overexpression increases malignant potential of human glioma cells through Id1 Research Paper

Kaiming Xu, Lanfang Wang, Hui-Kuo G. Shu

Published Oct 31, 2013 · Vol. 5, No. 5 · pp. 1241-1252

Keywords: glioblastoma, brain tumor, tumorigenesis, cyclooxygenase-2, Id1

BET bromodomain protein inhibition is a therapeutic option for medulloblastoma Research Paper

Anton George Henssen, Theresa Thor, Andrea Odersky, Lukas Heukamp, Nicolai El-Hindy, Anneleen Beckers, Frank Slpeleman, Kristina Althoff, Simon SchÃ¤fers, Alexander Schramm, Ulrich Sure, Gudrun Fleischhack, Angelika Eggert, Johannes Hubertus Schulte

Published Oct 27, 2013 · Vol. 4, No. 11 · pp. 2080-2095

Keywords: BET bromodomains, BRD4, MYC, JQ1, pediatric brain tumors, targeted therapy

NFkB disrupts tissue polarity in 3D by preventing integration of microenvironmental signals Research Paper

Sabine Becker-Weimann, Gaofeng Xiong, Saori Furuta, Ju Han, Irene Kuhn, Uri-David Akavia, Dana Pe'er, Mina J. Bissell, Ren Xu

Published Oct 14, 2013 · Vol. 4, No. 11 · pp. 2010-2020

Keywords: disorganization gene signature, p65, RelB, three-dimensional tissue structure, tissue polarity

Publication Alerts

European Cancer and Oncology Congress

Post-Publication Promotion

Search Oncotarget

Minor grove binding ligands disrupt PARP-1 activation pathways Research Paper

Poly (ADP-ribose) polymerase 1 transcriptional regulation: A novel crosstalk between histone modification H3K9ac and ETS1 motif hypomethylation in BRCA1-mutated ovarian cancer Research Paper

CITED1 confers stemness to Wilms tumor and enhances tumorigenic responses when enriched in the nucleus Research Paper

Alternative splicing of FBP-interacting repressor coordinates c-Myc, P27Kip1/cyclinE and Ku86/XRCC5 expression as a molecular sensor for bleomycin-induced DNA damage pathway Research Paper

A novel Cdk9 inhibitor preferentially targets tumor cells and synergizes with fludarabine Research Paper

Anti-oxidative stress response genes: bioinformatic analysis of their expression and relevance in multiple cancers Research Perspective

A loss-of-function mutation in PTCH1 suggests a role for autocrine hedgehog signaling in colorectal tumorigenesis Brief Reports

The polycomb group protein EZH2 is a novel therapeutic target in tongue cancer Research Paper

ERG induces a mesenchymal-like state associated with chemoresistance in leukemia cells Research Paper

A TRAF2 binding independent region of TNFR2 is responsible for TRAF2 depletion and enhancement of cytotoxicity driven by TNFR1 Research Paper

Inhibition of BET bromodomain proteins as a therapeutic approach in prostate cancer. Research Paper

Deficiency in p53 is required for doxorubicin induced transcriptional activation of NF-ÐºB target genes in human breast cancer Research Paper

High Mdm4 levels suppress p53 activity and enhance its half-life in acute myeloid leukaemia Research Paper

EI24 regulates epithelial-to-mesenchymal transition and tumor progression by suppressing TRAF2-mediated NF-ÎºB activity Research Paper

FOXD3 is a novel tumor suppressor that affects growth, invasion, metastasis and angiogenesis of neuroblastoma Research Paper

Enrichment of human osteosarcoma stem cells based on hTERT transcriptional activity Research Paper

Aberrantly hypermethylated Homeobox A2 derepresses metalloproteinase-9 through TBP and promotes invasion in Nasopharyngeal carcinoma Research Paper

COX-2 overexpression increases malignant potential of human glioma cells through Id1 Research Paper

BET bromodomain protein inhibition is a therapeutic option for medulloblastoma Research Paper

NFkB disrupts tissue polarity in 3D by preventing integration of microenvironmental signals Research Paper

Publication Alerts

European Cancer and Oncology Congress

Oncoscience

Post-Publication Promotion

Search Oncotarget

Minor grove binding ligands disrupt PARP-1 activation pathways Research Paper

Poly (ADP-ribose) polymerase 1 transcriptional regulation: A novel crosstalk between histone modification H3K9ac and ETS1 motif hypomethylation in BRCA1-mutated ovarian cancer Research Paper

CITED1 confers stemness to Wilms tumor and enhances tumorigenic responses when enriched in the nucleus Research Paper

Alternative splicing of FBP-interacting repressor coordinates c-Myc, P27Kip1/cyclinE and Ku86/XRCC5 expression as a molecular sensor for bleomycin-induced DNA damage pathway Research Paper

A novel Cdk9 inhibitor preferentially targets tumor cells and synergizes with fludarabine Research Paper

Anti-oxidative stress response genes: bioinformatic analysis of their expression and relevance in multiple cancers Research Perspective

A loss-of-function mutation in PTCH1 suggests a role for autocrine hedgehog signaling in colorectal tumorigenesis Brief Reports

The polycomb group protein EZH2 is a novel therapeutic target in tongue cancer Research Paper

ERG induces a mesenchymal-like state associated with chemoresistance in leukemia cells Research Paper

A TRAF2 binding independent region of TNFR2 is responsible for TRAF2 depletion and enhancement of cytotoxicity driven by TNFR1 Research Paper

Inhibition of BET bromodomain proteins as a therapeutic approach in prostate cancer. Research Paper

Deficiency in p53 is required for doxorubicin induced transcriptional activation of NF-ÐºB target genes in human breast cancer Research Paper

High Mdm4 levels suppress p53 activity and enhance its half-life in acute myeloid leukaemia Research Paper

EI24 regulates epithelial-to-mesenchymal transition and tumor progression by suppressing TRAF2-mediated NF-ÎºB activity Research Paper

FOXD3 is a novel tumor suppressor that affects growth, invasion, metastasis and angiogenesis of neuroblastoma Research Paper

Enrichment of human osteosarcoma stem cells based on hTERT transcriptional activity Research Paper

Aberrantly hypermethylated Homeobox A2 derepresses metalloproteinase-9 through TBP and promotes invasion in Nasopharyngeal carcinoma Research Paper

COX-2 overexpression increases malignant potential of human glioma cells through Id1 Research Paper

BET bromodomain protein inhibition is a therapeutic option for medulloblastoma Research Paper

NFkB disrupts tissue polarity in 3D by preventing integration of microenvironmental signals Research Paper