The Oncosearch | Oncotarget

Genomic clustering analysis identifies molecular subtypes of thymic epithelial tumors independent of World Health Organization histologic type Research Paper

Sukhmani K. Padda, Yesim Gökmen-Polar, Jessica A. Hellyer, Sunil S. Badve, Neeraj K. Singh, Sumanth M. Vasista, Kabya Basu, Ansu Kumar, Heather A. Wakelee

Published May 21, 2021 · Vol. 12, No. 12 · pp. 1178-1186

Keywords: thymic epithelial tumor, thymoma, genomics, clustering, computational analysis

Epigallocatechin-3-gallate modulates Tau Post-translational modifications and cytoskeletal network Research Paper

Shweta Kishor Sonawane, Subashchandrabose Chinnathambi

Published May 7, 2021 · Vol. 12, No. 11 · pp. 1083-1099

Keywords: Alzheimer’s disease, Tau protein, Tau PTMs, Tau glycation, Tau glycation inhibition

A high-content AlphaScreen™ identifies E6-specific small molecule inhibitors as potential therapeutics for HPV⁺ head and neck squamous cell carcinomas Research Paper

Lennox Chitsike, Chung-Hsiang Yuan, Anuradha Roy, Kristopher Boyle, Penelope J. Duerksen-Hughes

Published Feb 22, 2021 · Vol. 12, No. 6 · pp. 549-561

Keywords: HNSCC, HPV, E6, AlphaScreen™, 30-hydroxygambogic acid

Intratumoral immunotherapy with STING agonist, ADU-S100, induces CD8+ T-cell mediated anti-tumor immunity in an esophageal adenocarcinoma model Research Paper

Ali H. Zaidi, Ronan J. Kelly, Anastasia Gorbunova, Ashten N. Omstead, Madison S. Salvitti, Ping Zheng, Juliann E. Kosovec, Soyoung Lee, Shahin Ayazi, Laila Babar, Gene G. Finley, Ajay Goel, Blair A. Jobe

Published Feb 1, 2021 · Vol. 12, No. 4 · pp. 292-303

Keywords: esophageal adenocarcinoma, STING, PD-L1, CD8+ T-cells, IFNβ

Improved therapeutic efficacy of unmodified anti-tumor antibodies by immune checkpoint blockade and kinase targeted therapy in mouse models of melanoma Research Paper

Rolando Pérez-Lorenzo, Stephanie O. Erjavec, Angela M. Christiano, Raphael Clynes

Published Jan 6, 2021 · Vol. 12, No. 2 · pp. 66-80

Keywords: anti-tumor antibodies, targeted therapy, immunotherapy, combination therapies, melanoma

The significance of ovarian fibrosis Research Perspective

David A. Landry, Het T. Vaishnav, Barbara C. Vanderhyden

Published Nov 16, 2020 · Vol. 11, No. 47 · pp. 4366-4370

Keywords: ovarian fibrosis, ovarian cancer, female reproduction, fertility, metformin

Evidence for context-dependent functions of KDM5B in prostate development and prostate cancer Research Paper

Bigang Liu, Rahul Kumar, Hseuh-Ping Chao, Rashid Mehmood, Yibing Ji, Amanda Tracz, Dean G. Tang

Published Nov 10, 2020 · Vol. 11, No. 46 · pp. 4243-4252

Keywords: KDM5B, prostate cancer, prostate development, hyperplasia, epigenetics

Identification of Mubritinib (TAK 165) as an inhibitor of KSHV driven primary effusion lymphoma via disruption of mitochondrial OXPHOS metabolism Research Paper

Abram Calderon, Samantha S. Soldan, Alessandra De Leo, Zhong Deng, Drew M. Frase, Emma M. Anderson, Yue Zhang, Olga Vladimirova, Fang Lu, Jessica C. Leung, Maureen E. Murphy, Paul M. Lieberman

Published Nov 7, 2020 · Vol. 11, No. 46 · pp. 4224-4242

Keywords: KSHV, LANA, high-throughput screen (HTS), primary effusion lymphoma, Mubritinib

MEK inhibitors reduce cellular expression of ACE2, pERK, pRb while stimulating NK-mediated cytotoxicity and attenuating inflammatory cytokines relevant to SARS-CoV-2 infection Priority Research Paper

Lanlan Zhou, Kelsey Huntington, Shengliang Zhang, Lindsey Carlsen, Eui-Young So, Cassandra Parker, Ilyas Sahin, Howard Safran, Suchitra Kamle, Chang-Min Lee, Chun Geun Lee, Jack A. Elias, Kerry S. Campbell, Mandar T. Naik, Walter J. Atwood, Emile Youssef, Jonathan A. Pachter, Arunasalam Navaraj, Attila A. Seyhan, Olin Liang, Wafik S. El-Deiry

Published Oct 28, 2020 · Vol. 11, No. 46 · pp. 4201-4223

Keywords: ACE2, TMPRSS2, SARS-CoV-2, COVID-19, pseudovirus

MEK inhibitors reduce cellular expression of ACE2, pERK, pRb while stimulating NK-mediated cytotoxicity and attenuating inflammatory cytokines relevant to SARS-CoV-2 infection Priority Research Paper

Lanlan Zhou, Kelsey Huntington, Shengliang Zhang, Lindsey Carlsen, Eui-Young So, Cassandra Parker, Ilyas Sahin, Howard Safran, Suchitra Kamle, Chang-Min Lee, Chun Geun Lee, Jack A. Elias, Kerry S. Campbell, Mandar T. Naik, Walter J. Atwood, Emile Youssef, Jonathan A. Pachter, Arunasalam Navaraj, Attila A. Seyhan, Olin Liang, Wafik S. El-Deiry

Published Oct 28, 2020

Keywords: ACE2, TMPRSS2, SARS-CoV-2, COVID-19, pseudovirus

Liquid biopsy and multi-analyte testing guided treatment of HER2 positive periampullary adenocarcinoma with durable complete response after trastuzumab based therapy Case Report

Rajnish Nagarkar, Darshana Patil, Sewanti Limaye, Pradip Devhare, Ashwini Ghaisas, Navin Srivastava, Sachin Apurwa, Sanket Patil, Jinumary John, Zarrine Raazi, Aditya Shreenivas, Janani Sambath, Ajay Srinivasan, Prashant Kumar, Dadasaheb Akolkar, Rajan Datar

Published Oct 24, 2020 · Vol. 11, No. 45 · pp. 4195-4200

Keywords: periampullary adenocarcinoma, ETA, HER2, trastuzumab

HER2 splice variants in breast cancer: investigating their impact on diagnosis and treatment outcomes Review

Vic Hart, Hannah Gautrey, John Kirby, Alison Tyson-Capper

Published Oct 22, 2020 · Vol. 11, No. 46 · pp. 4338-4357

Keywords: HER2, Δ16-HER2, splice variant, breast cancer, trastuzumab

Biomarkers and novel therapeutic approaches for diffuse large B-cell lymphoma in the era of precision medicine Review

Niraj Lodhi, Moe Tun, Poonam Nagpal, Arati A. Inamdar, Nehad M. Ayoub, Noor Siyam, Lucia Oton-Gonzalez, Angela Gerona, Dainelle Morris, Rana Sandhu, Kwangsun Stephen Suh

Published Oct 20, 2020 · Vol. 11, No. 44 · pp. 4045-4073

Keywords: DLBCL, diagnosis, R-CHOP, precision medicine, prognosis

Effect of eflornithine on mutation frequency in temozolomide-treated U87MG cells Research Paper

Noymi Yam, Jason Levin, Zhengzheng Bao, Wubin Qian, Victor A. Levin

Published Oct 9, 2020 · Vol. 11, No. 44 · pp. 3933-3942

Keywords: glioma, eflornithine, temozolomide, chemotherapy, secondary mutations

TRAIL receptor agonists convert the response of breast cancer cells to ONC201 from anti-proliferative to apoptotic Priority Research Paper

Marie D. Ralff, Aakash Jhaveri, Jocelyn E. Ray, Lanlan Zhou, Avital Lev, Kerry S. Campbell, David T. Dicker, Eric A. Ross, Wafik S. El-Deiry

Published Oct 6, 2020 · Vol. 11, No. 42 · pp. 3753-3769

Keywords: ONC201, TRAIL, breast cancer, death receptors, apoptosis

Ferroptosis of epithelial ovarian cancer: genetic determinants and therapeutic potential Research Perspective

Chao-Chieh Lin, Jen-Tsan Chi

Published Sep 9, 2020 · Vol. 11, No. 39 · pp. 3562-3570

Keywords: ferroptosis, cystine, ovarian cancer, GPX4, NADPH oxidase

Advances in epidermal growth factor receptor specific immunotherapy: lessons to be learned from armed antibodies Review

Fleury Augustin Nsole Biteghe, Neelakshi Mungra, Nyangone Ekome Toung Chalomie, Jean De La Croix Ndong, Jean Engohang-Ndong, Guillaume Vignaux, Eden Padayachee, Krupa Naran, Stefan Barth

Published Aug 26, 2020 · Vol. 11, No. 38 · pp. 3531-3557

Keywords: epidermal growth factor receptor (EGFR), recombinant immunotoxins (ITs), targeted human cytolytic fusion proteins (hCFPs), recombinant antibody-drug conjugates (rADCs), recombinant antibody photoimmunoconjugates (rAPCs)

ATM inhibition overcomes resistance to histone deacetylase inhibitor due to p21 induction and cell cycle arrest Research Paper

Luigi Scotto, Xavier J. Serrano, Kelly Zullo, Cristina Kinahan, Changchun Deng, Ahmed Sawas, Susan Bates, Owen A. O’Connor

Published Aug 18, 2020 · Vol. 11, No. 37 · pp. 3432-3442

Keywords: lymphoma, HDAC inhibitor, ATM inhibitor, p21, cell cycle

The bromodomain inhibitor IBET-151 attenuates vismodegib-resistant esophageal adenocarcinoma growth through reduction of GLI signaling Research Paper

Annamil Alvarez-Trotta, Zhiqiang Wang, Elena Shersher, Bin Li, Jun Long, Ines Lohse, Claes Wahlestedt, Wael El-Rifai, David J. Robbins, Anthony J. Capobianco

Published Jul 28, 2020 · Vol. 11, No. 33 · pp. 3174-3187

Keywords: IBET-151, esophageal adenocarcinoma, GDC-0449 resistance, patient-derived xenografts, Hedgehog/GLI signaling pathway

Differentially expressed full-length, fusion and novel isoforms transcripts-based signature of well-differentiated keratinized oral squamous cell carcinoma Research Paper

Neetu Singh, Dinesh Kumar Sahu, Ratnesh Kumar Tripathi, Archana Mishra, Hari Shyam, Pratap Shankar, Mayank Jain, Nawazish Alam, Anil Kumar, Abhishek Mishra, Rebecca Chowdhry, Anjana Singh, Sameer Gupta, Divya Mehrotra, Preeti Agarwal, Madhu Mati Goel, Arun Chaturvedi, Satya Prakash Agarwal, Manish Bajpai, Devendra Kumar Gupta, Madan Lal Brahma Bhatt, Ravi Kant

Published Jul 22, 2020 · Vol. 11, No. 34 · pp. 3227-3243

Keywords: oral tongue squamous cell carcinoma, microarray, transcriptomics, integrative bioinformatics, differentially expressed gene

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Genomic clustering analysis identifies molecular subtypes of thymic epithelial tumors independent of World Health Organization histologic type Research Paper

Epigallocatechin-3-gallate modulates Tau Post-translational modifications and cytoskeletal network Research Paper

A high-content AlphaScreen™ identifies E6-specific small molecule inhibitors as potential therapeutics for HPV⁺ head and neck squamous cell carcinomas Research Paper

Intratumoral immunotherapy with STING agonist, ADU-S100, induces CD8+ T-cell mediated anti-tumor immunity in an esophageal adenocarcinoma model Research Paper

Improved therapeutic efficacy of unmodified anti-tumor antibodies by immune checkpoint blockade and kinase targeted therapy in mouse models of melanoma Research Paper

The significance of ovarian fibrosis Research Perspective

Evidence for context-dependent functions of KDM5B in prostate development and prostate cancer Research Paper

Identification of Mubritinib (TAK 165) as an inhibitor of KSHV driven primary effusion lymphoma via disruption of mitochondrial OXPHOS metabolism Research Paper

MEK inhibitors reduce cellular expression of ACE2, pERK, pRb while stimulating NK-mediated cytotoxicity and attenuating inflammatory cytokines relevant to SARS-CoV-2 infection Priority Research Paper

MEK inhibitors reduce cellular expression of ACE2, pERK, pRb while stimulating NK-mediated cytotoxicity and attenuating inflammatory cytokines relevant to SARS-CoV-2 infection Priority Research Paper

Liquid biopsy and multi-analyte testing guided treatment of HER2 positive periampullary adenocarcinoma with durable complete response after trastuzumab based therapy Case Report

HER2 splice variants in breast cancer: investigating their impact on diagnosis and treatment outcomes Review

Biomarkers and novel therapeutic approaches for diffuse large B-cell lymphoma in the era of precision medicine Review

Effect of eflornithine on mutation frequency in temozolomide-treated U87MG cells Research Paper

TRAIL receptor agonists convert the response of breast cancer cells to ONC201 from anti-proliferative to apoptotic Priority Research Paper

Ferroptosis of epithelial ovarian cancer: genetic determinants and therapeutic potential Research Perspective

Advances in epidermal growth factor receptor specific immunotherapy: lessons to be learned from armed antibodies Review

ATM inhibition overcomes resistance to histone deacetylase inhibitor due to p21 induction and cell cycle arrest Research Paper

The bromodomain inhibitor IBET-151 attenuates vismodegib-resistant esophageal adenocarcinoma growth through reduction of GLI signaling Research Paper

Differentially expressed full-length, fusion and novel isoforms transcripts-based signature of well-differentiated keratinized oral squamous cell carcinoma Research Paper

Publication Alerts

European Cancer and Oncology Congress

Oncoscience

Post-Publication Promotion

Search Oncotarget

Genomic clustering analysis identifies molecular subtypes of thymic epithelial tumors independent of World Health Organization histologic type Research Paper

Epigallocatechin-3-gallate modulates Tau Post-translational modifications and cytoskeletal network Research Paper

A high-content AlphaScreen™ identifies E6-specific small molecule inhibitors as potential therapeutics for HPV+ head and neck squamous cell carcinomas Research Paper

Intratumoral immunotherapy with STING agonist, ADU-S100, induces CD8+ T-cell mediated anti-tumor immunity in an esophageal adenocarcinoma model Research Paper

Improved therapeutic efficacy of unmodified anti-tumor antibodies by immune checkpoint blockade and kinase targeted therapy in mouse models of melanoma Research Paper

The significance of ovarian fibrosis Research Perspective

Evidence for context-dependent functions of KDM5B in prostate development and prostate cancer Research Paper

Identification of Mubritinib (TAK 165) as an inhibitor of KSHV driven primary effusion lymphoma via disruption of mitochondrial OXPHOS metabolism Research Paper

MEK inhibitors reduce cellular expression of ACE2, pERK, pRb while stimulating NK-mediated cytotoxicity and attenuating inflammatory cytokines relevant to SARS-CoV-2 infection Priority Research Paper

MEK inhibitors reduce cellular expression of ACE2, pERK, pRb while stimulating NK-mediated cytotoxicity and attenuating inflammatory cytokines relevant to SARS-CoV-2 infection Priority Research Paper

Liquid biopsy and multi-analyte testing guided treatment of HER2 positive periampullary adenocarcinoma with durable complete response after trastuzumab based therapy Case Report

HER2 splice variants in breast cancer: investigating their impact on diagnosis and treatment outcomes Review

Biomarkers and novel therapeutic approaches for diffuse large B-cell lymphoma in the era of precision medicine Review

Effect of eflornithine on mutation frequency in temozolomide-treated U87MG cells Research Paper

TRAIL receptor agonists convert the response of breast cancer cells to ONC201 from anti-proliferative to apoptotic Priority Research Paper

Ferroptosis of epithelial ovarian cancer: genetic determinants and therapeutic potential Research Perspective

Advances in epidermal growth factor receptor specific immunotherapy: lessons to be learned from armed antibodies Review

ATM inhibition overcomes resistance to histone deacetylase inhibitor due to p21 induction and cell cycle arrest Research Paper

The bromodomain inhibitor IBET-151 attenuates vismodegib-resistant esophageal adenocarcinoma growth through reduction of GLI signaling Research Paper

Differentially expressed full-length, fusion and novel isoforms transcripts-based signature of well-differentiated keratinized oral squamous cell carcinoma Research Paper

A high-content AlphaScreen™ identifies E6-specific small molecule inhibitors as potential therapeutics for HPV⁺ head and neck squamous cell carcinomas Research Paper