The Oncosearch | Oncotarget

Targeting metabolic flexibility by simultaneously inhibiting respiratory complex I and lactate generation retards melanoma progression Research Paper

Balkrishna Chaube, Parmanand Malvi, Shivendra Vikram Singh, Naoshad Mohammad, Avtar Singh Meena, Manoj Kumar Bhat

Published Oct 15, 2015 · Vol. 6, No. 35 · pp. 37281-37299

Common cancer-associated imbalances in the DNA damage response confer sensitivity to single agent ATR inhibition Priority Research Paper

Fiona K. Middleton, Miranda J. Patterson, Claire J. Elstob, Sarah Fordham, Ashleigh Herriott, Mark A. Wade, Aiste McCormick, Richard Edmondson, Felicity E.B. May, James M. Allan, John R. Pollard, Nicola J. Curtin

Published Oct 15, 2015 · Vol. 6, No. 32 · pp. 32396-32409

Specific inhibition by synthetic analogs of pyruvate reveals that the pyruvate dehydrogenase reaction is essential for metabolism and viability of glioblastoma cells Research Paper

Victoria I. Bunik, Artem Artiukhov, Alexey Kazantsev, Renata Goncalves, Danilo Daloso, Henry Oppermann, Elena Kulakovskaya, Nikolay Lukashev, Alisdair Fernie, Martin Brand, Frank Gaunitz

Published Oct 15, 2015 · Vol. 6, No. 37 · pp. 40036-40052

Tetracycline-inducible shRNA targeting long non-coding RNA PVT1 inhibits cell growth and induces apoptosis in bladder cancer cells Research Paper

Chengle Zhuang, Jianfa Li, Yuchen Liu, Mingwei Chen, Jiancheng Yuan, Xing Fu, Yonghao Zhan, Li Liu, Junhao Lin, Qing Zhou, Wen Xu, Guoping Zhao, Zhiming Cai, Weiren Huang

Published Oct 15, 2015 · Vol. 6, No. 38 · pp. 41194-41203

Arenobufagin intercalates with DNA leading to G₂ cell cycle arrest via ATM/ATR pathway Research Paper

Li-Juan Deng, Qun-Long Peng, Long-Hai Wang, Jun Xu, Jun-Shan Liu, Ying-Jie Li, Zhen-Jian Zhuo, Liang-Liang Bai, Li-Ping Hu, Wei-Min Chen, Wen-Cai Ye, Dong-Mei Zhang

Published Oct 13, 2015 · Vol. 6, No. 33 · pp. 34258-34275

Potential involvement of miR-375 in the premalignant progression of oral squamous cell carcinoma mediated via transcription factor KLF5 Research Paper

Wen Shi, Jing Yang, Siyuan Li, Xiaofeng Shan, Xiaosong Liu, Hong Hua, Chuanke Zhao, Zhendong Feng, Zhigang Cai, Lihe Zhang, Demin Zhou

Published Oct 12, 2015 · Vol. 6, No. 37 · pp. 40172-40185

Chemogenetic profiling identifies RAD17 as synthetically lethal with checkpoint kinase inhibition Research Paper

John Paul Shen, Rohith Srivas, Andrew Gross, Jianfeng Li, Eric J. Jaehnig, Su Ming Sun, Ana Bojorquez-Gomez, Katherine Licon, Vignesh Sivaganesh, Jia L. Xu, Kristin Klepper, Huwate Yeerna, Daniel Pekin, Chu Ping Qiu, Haico van Attikum, Robert W. Sobol, Trey Ideker

Published Sep 30, 2015 · Vol. 6, No. 34 · pp. 35755-35769

Effectiveness and safety of poly (ADP-ribose) polymerase inhibitors in cancer therapy: A systematic review and meta-analysis Clinical Review

Zhengqiang Bao, Chao Cao, Xinwei Geng, Baoping Tian, Yanping Wu, Chao Zhang, Zhihua Chen, Wen Li, Huahao Shen, Songmin Ying

Published Sep 22, 2015 · Vol. 7, No. 7 · pp. 7629-7639

Activation of human mast cells by retrocyclin and protegrin highlight their immunomodulatory and antimicrobial properties Research Paper

Kshitij Gupta, Akhil Kotian, Hariharan Subramanian, Henry Daniell, Hydar Ali

Published Sep 10, 2015 · Vol. 6, No. 30 · pp. 28573-28587

Ibrutinib selectively and irreversibly targets EGFR (L858R, Del19) mutant but is moderately resistant to EGFR (T790M) mutant NSCLC Cells Research Paper

Hong Wu, Aoli Wang, Wei Zhang, Beilei Wang, Cheng Chen, Wenchao Wang, Chen Hu, Zi Ye, Zheng Zhao, Li Wang, Xixiang Li, Kailin Yu, Juan Liu, Jiaxin Wu, Xiao-E Yan, Peng Zhao, Jinhua Wang, Chu Wang, Ellen L. Weisberg, Nathanael S. Gray, Cai-Hong Yun, Jing Liu, Liang Chen, Qingsong Liu

Published Sep 5, 2015 · Vol. 6, No. 31 · pp. 31313-31322

B5, a thioredoxin reductase inhibitor, induces apoptosis in human cervical cancer cells by suppressing the thioredoxin system, disrupting mitochondrion-dependent pathways and triggering autophagy Research Paper

Fang-Yuan Shao, Zhi-Yun Du, Dong-Lei Ma, Wen-Bo Chen, Wu-Yu Fu, Bi-Bo Ruan, Wen Rui, Jia-Xuan Zhang, Sheng Wang, Nai Sum Wong, Hao Xiao, Man-Mei Li, Xiao Liu, Qiu-Ying Liu, Xiao-dong Zhou, Hai-Zhao Yan, Yi-Fei Wang, Chang-Yan Chen, Zhong Liu, Hong-Yuan Chen

Published Sep 4, 2015 · Vol. 6, No. 31 · pp. 30939-30956

A cytoplasmic C-terminal fragment of syndecan-1 is generated by sequential proteolysis and antagonizes syndecan-1 dependent lung tumor cell migration Research Paper

Tobias Pasqualon, Jessica Pruessmeyer, Vera Jankowski, Aaron Babendreyer, Esther Groth, Julian Schumacher, Andrea Koenen, Sarah Weidenfeld, Nicole Schwarz, Bernd Denecke, Holger Jahr, Daniela Dreymueller, Joachim Jankowski, Andreas Ludwig

Published Sep 3, 2015 · Vol. 6, No. 31 · pp. 31295-31312

Small molecule inhibition of the CHFR-PARP1 interaction as novel approach to overcome intrinsic taxane resistance in cancer Research Paper

Seth A. Brodie, Ge Li, Donald Harvey, Fadlo R. Khuri, Paula M. Vertino, Johann C. Brandes

Published Sep 1, 2015 · Vol. 6, No. 31 · pp. 30773-30786

A phase 1/2 study combining gemcitabine, Pegintron and p53 SLP vaccine in patients with platinum-resistant ovarian cancer Clinical Research Papers

Eveline M. Dijkgraaf, Saskia J.A.M. Santegoets, An K.L. Reyners, Renske Goedemans, Hans W. Nijman, MariÃ«tte I.E. van Poelgeest, Arien R. van Erkel, Vincent T.H.B.M. Smit, Toos A.H.H. Daemen, Jacobus J.M. van der Hoeven, Cornelis J.M. Melief, Marij J.P. Welters, Judith R. Kroep, Sjoerd H. van der Burg

Published Aug 14, 2015 · Vol. 6, No. 31 · pp. 32228-32243

Cenp-E inhibitor GSK923295: Novel synthetic route and use as a tool to generate aneuploidy Research Paper

Ailsa Bennett, Beatrice Bechi, Anthony Tighe, Sarah Thompson, David J Procter, Stephen S Taylor

Published Aug 6, 2015 · Vol. 6, No. 25 · pp. 20921-20932

Targeting SOD1 induces synthetic lethal killing in BLM- and CHEK2-deficient colorectal cancer cells Research Paper

Babu V. Sajesh, Kirk J. McManus

Published Jul 31, 2015 · Vol. 6, No. 29 · pp. 27907-27922

Coupling the modules of EMT and stemness: A tunable â€˜stemness windowâ€™ model Research Paper

Mohit Kumar Jolly, Dongya Jia, Marcelo Boareto, Sendurai A. Mani, Kenneth J. Pienta, Eshel Ben-Jacob, Herbert Levine

Published Jul 23, 2015 · Vol. 6, No. 28 · pp. 25161-25174

GL-V9, a new synthetic flavonoid derivative, ameliorates DSS-induced colitis against oxidative stress by up-regulating Trx-1 expression via activation of AMPK/FOXO3a pathway Research Paper

Yue Zhao, Yang Sun, Youxiang Ding, Xiaoping Wang, Yuxin Zhou, Wenjun Li, Shaoliang Huang, Zhiyu Li, Lingyi Kong, Qinglong Guo, Na Lu

Published Jul 16, 2015 · Vol. 6, No. 28 · pp. 26291-26307

A synthetic peptide targeting the BH4 domain of Bcl-2 induces apoptosis in multiple myeloma and follicular lymphoma cells alone or in combination with agents targeting the BH3-binding pocket of Bcl-2 Research Paper

Andrew R. Lavik, Fei Zhong, Ming-Jin Chang, Edward Greenberg, Yuvraj Choudhary, Mitchell R. Smith, Karen S. McColl, John Pink, Frederic J. Reu, Shigemi Matsuyama, Clark W. Distelhorst

Published Jul 11, 2015 · Vol. 6, No. 29 · pp. 27388-27402

PERK/CHOP contributes to the CGK733-induced vesicular calcium sequestration which is accompanied by non-apoptotic cell death Research Paper

Yufeng Wang, Yasuhiro Kuramitsu, Byron Baron, Takao Kitagawa, Junko Akada, Kazuhiro Tokuda, Dan Cui, Kazuyuki Nakamura

Published Jul 10, 2015 · Vol. 6, No. 28 · pp. 25252-25265

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Targeting metabolic flexibility by simultaneously inhibiting respiratory complex I and lactate generation retards melanoma progression Research Paper

Common cancer-associated imbalances in the DNA damage response confer sensitivity to single agent ATR inhibition Priority Research Paper

Specific inhibition by synthetic analogs of pyruvate reveals that the pyruvate dehydrogenase reaction is essential for metabolism and viability of glioblastoma cells Research Paper

Tetracycline-inducible shRNA targeting long non-coding RNA PVT1 inhibits cell growth and induces apoptosis in bladder cancer cells Research Paper

Arenobufagin intercalates with DNA leading to G₂ cell cycle arrest via ATM/ATR pathway Research Paper

Potential involvement of miR-375 in the premalignant progression of oral squamous cell carcinoma mediated via transcription factor KLF5 Research Paper

Chemogenetic profiling identifies RAD17 as synthetically lethal with checkpoint kinase inhibition Research Paper

Effectiveness and safety of poly (ADP-ribose) polymerase inhibitors in cancer therapy: A systematic review and meta-analysis Clinical Review

Activation of human mast cells by retrocyclin and protegrin highlight their immunomodulatory and antimicrobial properties Research Paper

Ibrutinib selectively and irreversibly targets EGFR (L858R, Del19) mutant but is moderately resistant to EGFR (T790M) mutant NSCLC Cells Research Paper

B5, a thioredoxin reductase inhibitor, induces apoptosis in human cervical cancer cells by suppressing the thioredoxin system, disrupting mitochondrion-dependent pathways and triggering autophagy Research Paper

A cytoplasmic C-terminal fragment of syndecan-1 is generated by sequential proteolysis and antagonizes syndecan-1 dependent lung tumor cell migration Research Paper

Small molecule inhibition of the CHFR-PARP1 interaction as novel approach to overcome intrinsic taxane resistance in cancer Research Paper

A phase 1/2 study combining gemcitabine, Pegintron and p53 SLP vaccine in patients with platinum-resistant ovarian cancer Clinical Research Papers

Cenp-E inhibitor GSK923295: Novel synthetic route and use as a tool to generate aneuploidy Research Paper

Targeting SOD1 induces synthetic lethal killing in BLM- and CHEK2-deficient colorectal cancer cells Research Paper

Coupling the modules of EMT and stemness: A tunable â€˜stemness windowâ€™ model Research Paper

GL-V9, a new synthetic flavonoid derivative, ameliorates DSS-induced colitis against oxidative stress by up-regulating Trx-1 expression via activation of AMPK/FOXO3a pathway Research Paper

A synthetic peptide targeting the BH4 domain of Bcl-2 induces apoptosis in multiple myeloma and follicular lymphoma cells alone or in combination with agents targeting the BH3-binding pocket of Bcl-2 Research Paper

PERK/CHOP contributes to the CGK733-induced vesicular calcium sequestration which is accompanied by non-apoptotic cell death Research Paper

Publication Alerts

European Cancer and Oncology Congress

Oncoscience

Post-Publication Promotion

Search Oncotarget

Targeting metabolic flexibility by simultaneously inhibiting respiratory complex I and lactate generation retards melanoma progression Research Paper

Common cancer-associated imbalances in the DNA damage response confer sensitivity to single agent ATR inhibition Priority Research Paper

Specific inhibition by synthetic analogs of pyruvate reveals that the pyruvate dehydrogenase reaction is essential for metabolism and viability of glioblastoma cells Research Paper

Tetracycline-inducible shRNA targeting long non-coding RNA PVT1 inhibits cell growth and induces apoptosis in bladder cancer cells Research Paper

Arenobufagin intercalates with DNA leading to G2 cell cycle arrest via ATM/ATR pathway Research Paper

Potential involvement of miR-375 in the premalignant progression of oral squamous cell carcinoma mediated via transcription factor KLF5 Research Paper

Chemogenetic profiling identifies RAD17 as synthetically lethal with checkpoint kinase inhibition Research Paper

Effectiveness and safety of poly (ADP-ribose) polymerase inhibitors in cancer therapy: A systematic review and meta-analysis Clinical Review

Activation of human mast cells by retrocyclin and protegrin highlight their immunomodulatory and antimicrobial properties Research Paper

Ibrutinib selectively and irreversibly targets EGFR (L858R, Del19) mutant but is moderately resistant to EGFR (T790M) mutant NSCLC Cells Research Paper

B5, a thioredoxin reductase inhibitor, induces apoptosis in human cervical cancer cells by suppressing the thioredoxin system, disrupting mitochondrion-dependent pathways and triggering autophagy Research Paper

A cytoplasmic C-terminal fragment of syndecan-1 is generated by sequential proteolysis and antagonizes syndecan-1 dependent lung tumor cell migration Research Paper

Small molecule inhibition of the CHFR-PARP1 interaction as novel approach to overcome intrinsic taxane resistance in cancer Research Paper

A phase 1/2 study combining gemcitabine, Pegintron and p53 SLP vaccine in patients with platinum-resistant ovarian cancer Clinical Research Papers

Cenp-E inhibitor GSK923295: Novel synthetic route and use as a tool to generate aneuploidy Research Paper

Targeting SOD1 induces synthetic lethal killing in BLM- and CHEK2-deficient colorectal cancer cells Research Paper

Coupling the modules of EMT and stemness: A tunable â€˜stemness windowâ€™ model Research Paper

GL-V9, a new synthetic flavonoid derivative, ameliorates DSS-induced colitis against oxidative stress by up-regulating Trx-1 expression via activation of AMPK/FOXO3a pathway Research Paper

A synthetic peptide targeting the BH4 domain of Bcl-2 induces apoptosis in multiple myeloma and follicular lymphoma cells alone or in combination with agents targeting the BH3-binding pocket of Bcl-2 Research Paper

PERK/CHOP contributes to the CGK733-induced vesicular calcium sequestration which is accompanied by non-apoptotic cell death Research Paper

Arenobufagin intercalates with DNA leading to G₂ cell cycle arrest via ATM/ATR pathway Research Paper