The Oncosearch | Oncotarget

NOTCH1 PEST domain variants are responsive to standard of care treatments despite distinct transformative properties in a breast cancer model Research Paper

Karen Cravero, Morgan V. Pantone, Dong Ho Shin, Riley Bergman, Rory Cochran, David Chu, Daniel J. Zabransky, Swathi Karthikeyan, Ian G. Waters, Natasha Hunter, D. Marc Rosen, Kelly Kyker-Snowman, W. Brian Dalton, Berry Button, Dan Shinn, Hong Yuen Wong, Joshua Donaldson, Paula J. Hurley, Sarah Croessmann, Ben Ho Park

Published Feb 11, 2022 · Vol. 13, No. 1 · pp. 373-386

Keywords: NOTCH1, TNBC, breast cancer, PEST

Etoposide-induced DNA damage is increased in p53 mutants: identification of ATR and other genes that influence effects of p53 mutations on Top2-induced cytotoxicity Research Paper

Daniel Menendez, Jay R. Anand, Carri C. Murphy, Whitney J. Bell, Jiaqi Fu, Nadia Slepushkina, Eugen Buehler, Scott E. Martin, Madhu Lal-Nag, John L. Nitiss, Michael A. Resnick

Published Feb 4, 2022 · Vol. 13, No. 1 · pp. 332-346

Keywords: tumor suppressor, siRNA screen, synthetic lethality, ICE assay, Top2 covalent complexes

Impact of the glutathione synthesis pathway on sulfasalazine-treated endometrial cancer Research Paper

Kanako Sendo, Manabu Seino, Tsuyoshi Ohta, Satoru Nagase

Published Jan 24, 2022 · Vol. 13, No. 1 · pp. 224-236

Keywords: endometrial cancer, glutathione, sulfasalazine, xCT, cystathionine gamma-lyase

Correction: Dishevelled1-3 contribute to multidrug resistance in colorectal cancer via activating Wnt/β-catenin signaling Correction

Kun Zhang, Minhui Li, Houyi Huang, Linpeng Li, Jie Yang, Li Feng, Junjie Gou, Mengju Jiang, Liaotian Peng, Linyi Chen, Ting Li, Ping Yang, Yuhan Yang, Yuanyuan Wang, Quekun Peng, Xiaozhen Dai, Tao Zhang

Published Nov 23, 2021 · Vol. 12, No. 24 · pp. 2434-2434

Correction: YAP promotes tumorigenesis and cisplatin resistance in neuroblastoma Correction

Chao Yang, Juan Tan, Jun Zhu, Shan Wang, Guanghui Wei

Published Nov 17, 2021 · Vol. 13, No. 1 · pp. 784-784

Circulating low density neutrophils of breast cancer patients are associated with their worse prognosis due to the impairment of T cell responses Research Paper

Diana P. Saraiva, Bruna F. Correia, Rute Salvador, Nídia de Sousa, António Jacinto, Sofia Braga, M. Guadalupe Cabral

Published Nov 15, 2021 · Vol. 12, No. 24 · pp. 2388-2403

Keywords: breast cancer, chemotherapy response, tumor-associated neutrophils, low density neutrophils, biomarker

Correction: Lysosomal sequestration of hydrophobic weak base chemotherapeutics triggers lysosomal biogenesis and lysosome-dependent cancer multidrug resistance Correction

Benny Zhitomirsky, Yehuda G. Assaraf

Published Oct 28, 2021 · Vol. 13, No. 1 · pp. 585-586

Correction: Cdc6 contributes to cisplatin-resistance by activation of ATR-Chk1 pathway in bladder cancer cells Correction

Sansan Chen, Xinglu Chen, Gui’e Xie, Yue He, Daoyu Yan, Dianpeng Zheng, Shi Li, Xinyang Fu, Yeping Li, Xiang Pang, Zhiming Hu, Hongwei Li, Wanlong Tan, Jinlong Li

Published Oct 26, 2021

Comparison of MET gene amplification analysis by next-generation sequencing and fluorescence in situ hybridization Research Paper

Christina Schmitt, Anna-Alice Schulz, Ria Winkelmann, Kevin Smith, Peter J. Wild, Melanie Demes

Published Oct 5, 2021 · Vol. 12, No. 22 · pp. 2273-2282

Keywords: next-generation sequencing (NGS), non-small cell lung cancer (NSCLC), fluorescence in situ hybridization (FISH), MET amplification, routine diagnostics

ATR inhibition reverses the resistance of homologous recombination deficient MGMT^low/MMR^proficient cancer cells to temozolomide Priority Research Paper

Lara H. El Touny, Curtis Hose, John Connelly, Erik Harris, Anne Monks, Angie B. Dull, Deborah F. Wilsker, Melinda G. Hollingshead, Michelle Gottholm-Ahalt, Sergio Y. Alcoser, Michael E. Mullendore, Ralph E. Parchment, James H. Doroshow, Beverly A. Teicher, Annamaria Rapisarda

Published Sep 28, 2021 · Vol. 12, No. 21 · pp. 2114-2130

Keywords: TMZ, MMR, ATR, HR, REV3L

Hyperprogression of a mismatch repair-deficient colon cancer in a humanized mouse model following administration of immune checkpoint inhibitor pembrolizumab Research Paper

Ilyas Sahin, Andrew George, Shengliang Zhang, Kelsey E. Huntington, Zehra Ordulu, Lanlan Zhou, Wafik S. El-Deiry

Published Sep 24, 2021 · Vol. 12, No. 21 · pp. 2131-2146

Keywords: cancer immunotherapy, immune checkpoint inhibitors, hyperprogressive disease (HPD), hyperprogression (HP), humanized mouse

Switching Hedgehog inhibitors and other strategies to address resistance when treating advanced basal cell carcinoma Review

Hung Q. Doan, Leon Chen, Zeena Nawas, Heng-Huan Lee, Sirunya Silapunt, Michael Migden

Published Sep 13, 2021 · Vol. 12, No. 20 · pp. 2089-2100

Keywords: basal cell carcinoma, Hedgehog pathway inhibitor, resistance, switching, combination therapy

TAK1-inhibitors are cytotoxic for multiple myeloma cells alone and in combination with melphalan Research Paper

Erling Håland, Ingrid Nyhus Moen, Elias Veidal, Hanne Hella, Kristine Misund, Tobias S. Slørdahl, Kristian K. Starheim

Published Sep 4, 2021 · Vol. 12, No. 21 · pp. 2158-2168

Keywords: multiple myeloma, TAK1, apoptosis, NF-κB, cancer treatment

Multipeptide stimulated PBMCs generate T_EM/T_CM for adoptive cell therapy in multiple myeloma Research Paper

Trupti Vardam-Kaur, Latha B. Pathangey, Daniel J. McCormick, P. Leif Bergsagel, Peter A. Cohen, Sandra J. Gendler

Published Aug 27, 2021 · Vol. 12, No. 20 · pp. 2051-2067

Keywords: multiple myeloma, cellular therapy, CD4/CD8 T cells, peptides, immunotherapy

Polyclonal on- and off-target resistance mutations in an EML4-ALK positive non-small cell lung cancer patient under ALK inhibition Case Report

Marcel Kemper, Georg Evers, Arik Bernard Schulze, Jan Sperveslage, Christoph Schülke, Georg Lenz, Thomas Herold, Wolfgang Hartmann, Hans-Ulrich Schildhaus, Annalen Bleckmann

Published Aug 23, 2021 · Vol. 12, No. 19 · pp. 1946-1952

Keywords: NSCLC, resistance mutations, ALK, KRAS, ALK inhibitors

Altered glucuronidation deregulates androgen dependent response profiles and signifies castration resistance in prostate cancer Research Paper

Brenna M. Zimmer, Michelle E. Howell, Linlin Ma, Jeffrey R. Enders, Danielle Lehman, Eva Corey, Joseph J. Barycki, Melanie A. Simpson

Published Aug 19, 2021 · Vol. 12, No. 19 · pp. 1886-1902

Keywords: prostate cancer, castration resistance, detoxification, UDP-glucose dehydrogenase, patient-derived xenografts

The value of comprehensive genomic sequencing to maximize the identification of clinically actionable alterations in advanced cancer patients: a case series Case Report

Kevin Drenner, Gargi D. Basu, Laurie J. Goodman, Audrey A. Ozols, Janine R. LoBello, Thomas Royce, Michael S. Gordon, Erkut H. Borazanci, Margaux A. Steinbach, Jeffrey Trent, Sunil Sharma

Published Aug 6, 2021 · Vol. 12, No. 18 · pp. 1836-1847

Keywords: whole exome sequencing, RNA sequencing, precision medicine, rare mutations, genomic alteration

Correlation between PD-L1 expression and MET gene amplification in patients with advanced non-small cell lung cancer and no other actionable oncogenic driver Research Paper

Marta Domènech, Ana M. Muñoz Marmol, Jose Luis Mate, Anna Estival, Teresa Moran, Marc Cucurull, Maria Saigi, Ainhoa Hernandez, Carolina Sanz, Alba Hernandez-Gallego, Aintzane Urbizu, Anna Martinez-Cardus, Adrià Bernat, Enric Carcereny

Published Aug 5, 2021 · Vol. 12, No. 18 · pp. 1802-1810

Keywords: non-small cell lung cancer, oncogenic driver, PD-L1, MET amplification, smoking habit

Multifaceted effect of chlorpromazine in cancer: implications for cancer treatment Review

Pareesa Kamgar-Dayhoff, Tinatin I. Brelidze

Published Jun 19, 2021 · Vol. 12, No. 14 · pp. 1406-1426

Keywords: chlorpromazine, repurposing

Esomeprazole enhances the effect of ionizing radiation to improve tumor control Research Paper

Kassidy A. Hebert, Sergio Jaramillo, Wangjie Yu, Min Wang, Ratna Veeramachaneni, Vlad C. Sandulache, Andrew G. Sikora, Mark D. Bonnen, Ananth V. Annapragada, David Corry, Farrah Kheradmand, Raj K. Pandita, Michelle S. Ludwig, Tej K. Pandita, Shixia Huang, Cristian Coarfa, Sandra L. Grimm, Dimuthu Perera, George Miles, Yohannes T. Ghebre

Published Jun 19, 2021 · Vol. 12, No. 14 · pp. 1339-1353

Keywords: esomeprazole, proton pump inhibitors, ionizing radiation, radiosensitization, tumor control

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NOTCH1 PEST domain variants are responsive to standard of care treatments despite distinct transformative properties in a breast cancer model Research Paper

Etoposide-induced DNA damage is increased in p53 mutants: identification of ATR and other genes that influence effects of p53 mutations on Top2-induced cytotoxicity Research Paper

Impact of the glutathione synthesis pathway on sulfasalazine-treated endometrial cancer Research Paper

Correction: Dishevelled1-3 contribute to multidrug resistance in colorectal cancer via activating Wnt/β-catenin signaling Correction

Correction: YAP promotes tumorigenesis and cisplatin resistance in neuroblastoma Correction

Circulating low density neutrophils of breast cancer patients are associated with their worse prognosis due to the impairment of T cell responses Research Paper

Correction: Lysosomal sequestration of hydrophobic weak base chemotherapeutics triggers lysosomal biogenesis and lysosome-dependent cancer multidrug resistance Correction

Correction: Cdc6 contributes to cisplatin-resistance by activation of ATR-Chk1 pathway in bladder cancer cells Correction

Comparison of MET gene amplification analysis by next-generation sequencing and fluorescence in situ hybridization Research Paper

ATR inhibition reverses the resistance of homologous recombination deficient MGMT^low/MMR^proficient cancer cells to temozolomide Priority Research Paper

Hyperprogression of a mismatch repair-deficient colon cancer in a humanized mouse model following administration of immune checkpoint inhibitor pembrolizumab Research Paper

Switching Hedgehog inhibitors and other strategies to address resistance when treating advanced basal cell carcinoma Review

TAK1-inhibitors are cytotoxic for multiple myeloma cells alone and in combination with melphalan Research Paper

Multipeptide stimulated PBMCs generate T_EM/T_CM for adoptive cell therapy in multiple myeloma Research Paper

Polyclonal on- and off-target resistance mutations in an EML4-ALK positive non-small cell lung cancer patient under ALK inhibition Case Report

Altered glucuronidation deregulates androgen dependent response profiles and signifies castration resistance in prostate cancer Research Paper

The value of comprehensive genomic sequencing to maximize the identification of clinically actionable alterations in advanced cancer patients: a case series Case Report

Correlation between PD-L1 expression and MET gene amplification in patients with advanced non-small cell lung cancer and no other actionable oncogenic driver Research Paper

Multifaceted effect of chlorpromazine in cancer: implications for cancer treatment Review

Esomeprazole enhances the effect of ionizing radiation to improve tumor control Research Paper

Publication Alerts

European Cancer and Oncology Congress

Oncoscience

Post-Publication Promotion

Search Oncotarget

NOTCH1 PEST domain variants are responsive to standard of care treatments despite distinct transformative properties in a breast cancer model Research Paper

Etoposide-induced DNA damage is increased in p53 mutants: identification of ATR and other genes that influence effects of p53 mutations on Top2-induced cytotoxicity Research Paper

Impact of the glutathione synthesis pathway on sulfasalazine-treated endometrial cancer Research Paper

Correction: Dishevelled1-3 contribute to multidrug resistance in colorectal cancer via activating Wnt/β-catenin signaling Correction

Correction: YAP promotes tumorigenesis and cisplatin resistance in neuroblastoma Correction

Circulating low density neutrophils of breast cancer patients are associated with their worse prognosis due to the impairment of T cell responses Research Paper

Correction: Lysosomal sequestration of hydrophobic weak base chemotherapeutics triggers lysosomal biogenesis and lysosome-dependent cancer multidrug resistance Correction

Correction: Cdc6 contributes to cisplatin-resistance by activation of ATR-Chk1 pathway in bladder cancer cells Correction

Comparison of MET gene amplification analysis by next-generation sequencing and fluorescence in situ hybridization Research Paper

ATR inhibition reverses the resistance of homologous recombination deficient MGMTlow/MMRproficient cancer cells to temozolomide Priority Research Paper

Hyperprogression of a mismatch repair-deficient colon cancer in a humanized mouse model following administration of immune checkpoint inhibitor pembrolizumab Research Paper

Switching Hedgehog inhibitors and other strategies to address resistance when treating advanced basal cell carcinoma Review

TAK1-inhibitors are cytotoxic for multiple myeloma cells alone and in combination with melphalan Research Paper

Multipeptide stimulated PBMCs generate TEM/TCM for adoptive cell therapy in multiple myeloma Research Paper

Polyclonal on- and off-target resistance mutations in an EML4-ALK positive non-small cell lung cancer patient under ALK inhibition Case Report

Altered glucuronidation deregulates androgen dependent response profiles and signifies castration resistance in prostate cancer Research Paper

The value of comprehensive genomic sequencing to maximize the identification of clinically actionable alterations in advanced cancer patients: a case series Case Report

Correlation between PD-L1 expression and MET gene amplification in patients with advanced non-small cell lung cancer and no other actionable oncogenic driver Research Paper

Multifaceted effect of chlorpromazine in cancer: implications for cancer treatment Review

Esomeprazole enhances the effect of ionizing radiation to improve tumor control Research Paper

ATR inhibition reverses the resistance of homologous recombination deficient MGMT^low/MMR^proficient cancer cells to temozolomide Priority Research Paper

Multipeptide stimulated PBMCs generate T_EM/T_CM for adoptive cell therapy in multiple myeloma Research Paper