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A phase 1b, open-label study of trebananib plus bevacizumab or motesanib in patients with solid tumours Clinical Research Papers

David S. Hong, Razelle Kurzrock, Marilyn Mulay, Erik Rasmussen, Benjamin M. Wu, Michael B. Bass, Zhandong D. Zhong, Greg Friberg, Lee S. Rosen

Published Oct 23, 2014 · Vol. 5, No. 22 · pp. 11154-11167

Neuroblastoma in dialog with its stroma: NTRK1 is a regulator of cellular cross-talk with Schwann cells Research Paper

Kristian W. Pajtler, Ellen Mahlow, Andrea Odersky, Sven Lindner, Harald Stephan, Ivo Bendix, Angelika Eggert, Alexander Schramm, Johannes H. Schulte

Published Oct 21, 2014 · Vol. 5, No. 22 · pp. 11180-11192

Overexpression of platelet-derived growth factor receptor alpha promotes tumor progression and indicates poor prognosis in hepatocellular carcinoma Clinical Research Papers

Tao Wei, Li-Na Zhang, Yi Lv, Xiao-Ya Ma, Lei Zhi, Chang Liu, Feng Ma, Xu-Feng Zhang

Published Oct 17, 2014 · Vol. 5, No. 21 · pp. 10307-10317

Keywords: Platelet-derived growth factor receptor alpha, Hepatocellular carcinoma, survival, metastasis, CD31

AXL kinase as a novel target for cancer therapy Review

Xiaoliang Wu, Xuewen Liu, Sanjay Koul, Chang Youl Lee, Zhenfeng Zhang, Balazs Halmos

Published Oct 16, 2014 · Vol. 5, No. 20 · pp. 9546-9563

Keywords: AXL, receptor tyrosine kinase, lung cancer, targeted therapy

Hypoxia-inducible factors enhance glutamate signaling in cancer cells Priority Research Paper

Hongxia Hu, Naoharu Takano, Lisha Xiang, Daniele M. Gilkes, Weibo Luo, Gregg L. Semenza

Published Oct 15, 2014 · Vol. 5, No. 19 · pp. 8853-8868

The tyrosine phosphatase PTPRO sensitizes colon cancer cells to anti-EGFR therapy through activation of SRC-mediated EGFR signaling Research Paper

Layka Abbasi Asbagh, Iria Vazquez, Loredana Vecchione, Eva Budinska, Veerle De Vriendt, Maria Francesca Baietti, Mikhail Steklov, Bart Jacobs, Nicholas Hoe, Sharat Singh, Naga-Sailaja Imjeti, Pascale Zimmermann, Anna Sablina, Sabine Tejpar

Published Oct 11, 2014 · Vol. 5, No. 20 · pp. 10070-10083

Peritumoral Neuropilin-1 and VEGF receptor-2 expression increases time to recurrence in hepatocellular carcinoma patients undergoing curative hepatectomy Clinical Research Papers

Peng-Yuan Zhuang, Jian-Dong Wang, Zhao-Hui Tang, Xue-Ping Zhou, Yong Yang, Zhi-Wei Quan, Ying-Bin Liu, Jun Shen

Published Oct 11, 2014 · Vol. 5, No. 22 · pp. 11121-11132

Increased serum levels of circulating exosomal microRNA-373 in receptor-negative breast cancer patients Clinical Research Papers

Corinna Eichelser, Isabel StÃ¼ckrath, Volkmar MÃ¼ller, Karin Milde-Langosch, Harriet Wikman, Klaus Pantel, Heidi Schwarzenbach

Published Oct 7, 2014 · Vol. 5, No. 20 · pp. 9650-9663

Activation of EGFR, HER2 and HER3 by neurotensin/neurotensin receptor 1 renders breast tumors aggressive yet highly responsive to lapatinib and metformin in mice Research Paper

Sandra Dupouy, Van Kien Doan, Zherui Wu, Najat Mourra, Olivier De Wever, FrÃ©dÃ©rique Penault Llorca, Anne Cayre, Amal Kouchkar, Anne Gompel, Patricia Forgez

Published Oct 3, 2014 · Vol. 5, No. 18 · pp. 8235-8251

Keywords: ancer growth and metastasis, neurotensin, EGFR, HER2, HER3, EGF like ligands.

Neurotensin (NTS) and its receptor (NTSR1) causes EGFR, HER2 and HER3 over-expression and their autocrine/paracrine activation in lung tumors, confirming responsiveness to erlotinib Research Paper

Mohamad Younes, Zherui Wu, Sandra Dupouy, Audrey Mansuet Lupo, Najat Mourra, Takashi Takahashi, Jean-Francois Flejou, Jean TrÃ©daniel, Jean FranÃ§ois RÃ©gnard, Diane Damotte, Marco Alifano, Patricia Forgez

Published Sep 26, 2014 · Vol. 5, No. 18 · pp. 8252-8269

Keywords: Cancer growth and metastasis, neurotensin, EGFR, HER2, HER3, EGF like ligands.

Androgen receptor promotes gastric cancer cell migration and invasion via AKT-phosphorylation dependent upregulation of matrix metalloproteinase 9 Research Paper

Bao-gui Zhang, Tao Du, Ming-de Zang, Qing Chang, Zhi-yuan Fan, Jian-fang Li, Bei-qin Yu, Li-ping Su, Chen Li, Chao Yan, Qin-long Gu, Zheng-gang Zhu, Min Yan, Bingya Liu

Published Sep 25, 2014 · Vol. 5, No. 21 · pp. 10584-10595

CAMK2N1 inhibits prostate cancer progression through androgen receptor-dependent signaling Clinical Research Papers

Tao Wang, Shuiming Guo, Zhuo Liu, Licheng Wu, Mingchao Li, Jun Yang, Ruibao Chen, Xiaming Liu, Hua Xu, Shaoxin Cai, Hui Chen, Weiyong Li, Shaohua Xu, Liang Wang, Zhiquan Hu, Qianyuan Zhuang, Liping Wang, Kongming Wu, Jihong Liu, Zhangqun Ye, Jun-Yuan Ji, Chenguang Wang, Ke Chen

Published Sep 25, 2014 · Vol. 5, No. 21 · pp. 10293-10306

CCR9/CCL25 expression in non-small cell lung cancer correlates with aggressive disease and mediates key steps of metastasis Research Paper

Pranav Gupta, Praveen K. Sharma, Hina Mir, Rajesh Singh, Nalinaksha Singh, Goetz H. Kloecker, James W. Lillard, Jr., Shailesh Singh

Published Sep 25, 2014 · Vol. 5, No. 20 · pp. 10170-10179

Suppression of p53 by Notch3 is mediated by Cyclin G1 and sustained by MDM2 and miR-221 axis in hepatocellular carcinoma Research Paper

Catia Giovannini, Manuela Minguzzi, Michele Baglioni, Francesca Fornari, Ferdinando Giannone, Matteo Ravaioli, Matteo Cescon, Pasquale Chieco, Luigi Bolondi, Laura Gramantieri

Published Sep 25, 2014 · Vol. 5, No. 21 · pp. 10607-10620

Systematic dissection of the mechanisms underlying progesterone receptor downregulation in endometrial cancer Research Paper

Shujie Yang, Yichen Jia, Xiaoyue Liu, Christopher Winters, Xinjun Wang, Yuping Zhang, Eric J. Devor, Adriann M. Hovey, Henry D. Reyes, Xue Xiao, Yang Xu, Donghai Dai, Xiangbing Meng, Kristina W. Thiel, Frederick E. Domann, Kimberly K. Leslie

Published Sep 22, 2014 · Vol. 5, No. 20 · pp. 9783-9797

Intratumoral administration of mRNA encoding a fusokine consisting of IFN-Î² and the ectodomain of the TGF-Î² receptor II potentiates antitumor immunity Research Paper

Kevin Van der Jeught, Patrick Tjok Joe, Lukasz Bialkowski, Carlo Heirman, Lidia Daszkiewicz, Therese Liechtenstein, David Escors, Kris Thielemans, Karine Breckpot

Published Sep 19, 2014 · Vol. 5, No. 20 · pp. 10100-10113

Src-dependent phosphorylation at Y406 on the thyroid hormone receptor Î² confers the tumor suppressor activity Research Paper

Jeong Won Park, Li Zhao, Paul Webb, Sheue-yann Cheng

Published Sep 16, 2014 · Vol. 5, No. 20 · pp. 10002-10016

RNA sequencing identifies specific PIWI-interacting small non-coding RNA expression patterns in breast cancer Research Paper

Adnan Hashim, Francesca Rizzo, Giovanna Marchese, Maria Ravo, Roberta Tarallo, Giovanni Nassa, Giorgio Giurato, Gianluca Santamaria, Angela Cordella, Concita Cantarella, Alessandro Weisz

Published Sep 16, 2014 · Vol. 5, No. 20 · pp. 9901-9910

Glipizide, an antidiabetic drug, suppresses tumor growth and metastasis by inhibiting angiogenesis Research Paper

Cuiling Qi, Qin Zhou, Bin Li, Yang Yang, Liu Cao, Yuxiang Ye, Jiangchao Li, Yi Ding, Huiping Wang, Jintao Wang, Xiaodong He, Qianqian Zhang, Tian Lan, Kenneth Ka Ho Lee, Weidong Li, Xiaoyu Song, Jia Zhou, Xuesong Yang, Lijing Wang

Published Sep 16, 2014 · Vol. 5, No. 20 · pp. 9966-9979

The Hippo transducer TAZ as a biomarker of pathological complete response in HER2-positive breast cancer patients treated with trastuzumab-based neoadjuvant therapy Clinical Research Papers

Patrizia Vici, Marcella Mottolese, Laura Pizzuti, Maddalena Barba, Francesca Sperati, Irene Terrenato, Anna Di Benedetto, Clara Natoli, Teresa Gamucci, Domenico Angelucci, Maria Teresa Ramieri, Luigi Di Lauro, Domenico Sergi, Monica Bartucci, Rosanna Dattilo, Alfredo Pagliuca, Ruggero De Maria, Marcello Maugeri-SaccÃ

Published Sep 8, 2014 · Vol. 5, No. 20 · pp. 9619-9625

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A phase 1b, open-label study of trebananib plus bevacizumab or motesanib in patients with solid tumours Clinical Research Papers

Neuroblastoma in dialog with its stroma: NTRK1 is a regulator of cellular cross-talk with Schwann cells Research Paper

Overexpression of platelet-derived growth factor receptor alpha promotes tumor progression and indicates poor prognosis in hepatocellular carcinoma Clinical Research Papers

AXL kinase as a novel target for cancer therapy Review

Hypoxia-inducible factors enhance glutamate signaling in cancer cells Priority Research Paper

The tyrosine phosphatase PTPRO sensitizes colon cancer cells to anti-EGFR therapy through activation of SRC-mediated EGFR signaling Research Paper

Peritumoral Neuropilin-1 and VEGF receptor-2 expression increases time to recurrence in hepatocellular carcinoma patients undergoing curative hepatectomy Clinical Research Papers

Increased serum levels of circulating exosomal microRNA-373 in receptor-negative breast cancer patients Clinical Research Papers

Activation of EGFR, HER2 and HER3 by neurotensin/neurotensin receptor 1 renders breast tumors aggressive yet highly responsive to lapatinib and metformin in mice Research Paper

Neurotensin (NTS) and its receptor (NTSR1) causes EGFR, HER2 and HER3 over-expression and their autocrine/paracrine activation in lung tumors, confirming responsiveness to erlotinib Research Paper

Androgen receptor promotes gastric cancer cell migration and invasion via AKT-phosphorylation dependent upregulation of matrix metalloproteinase 9 Research Paper

CAMK2N1 inhibits prostate cancer progression through androgen receptor-dependent signaling Clinical Research Papers

CCR9/CCL25 expression in non-small cell lung cancer correlates with aggressive disease and mediates key steps of metastasis Research Paper

Suppression of p53 by Notch3 is mediated by Cyclin G1 and sustained by MDM2 and miR-221 axis in hepatocellular carcinoma Research Paper

Systematic dissection of the mechanisms underlying progesterone receptor downregulation in endometrial cancer Research Paper

Intratumoral administration of mRNA encoding a fusokine consisting of IFN-Î² and the ectodomain of the TGF-Î² receptor II potentiates antitumor immunity Research Paper

Src-dependent phosphorylation at Y406 on the thyroid hormone receptor Î² confers the tumor suppressor activity Research Paper

RNA sequencing identifies specific PIWI-interacting small non-coding RNA expression patterns in breast cancer Research Paper

Glipizide, an antidiabetic drug, suppresses tumor growth and metastasis by inhibiting angiogenesis Research Paper

The Hippo transducer TAZ as a biomarker of pathological complete response in HER2-positive breast cancer patients treated with trastuzumab-based neoadjuvant therapy Clinical Research Papers

Publication Alerts

European Cancer and Oncology Congress

Oncoscience

Post-Publication Promotion

Search Oncotarget

A phase 1b, open-label study of trebananib plus bevacizumab or motesanib in patients with solid tumours Clinical Research Papers

Neuroblastoma in dialog with its stroma: NTRK1 is a regulator of cellular cross-talk with Schwann cells Research Paper

Overexpression of platelet-derived growth factor receptor alpha promotes tumor progression and indicates poor prognosis in hepatocellular carcinoma Clinical Research Papers

AXL kinase as a novel target for cancer therapy Review

Hypoxia-inducible factors enhance glutamate signaling in cancer cells Priority Research Paper

The tyrosine phosphatase PTPRO sensitizes colon cancer cells to anti-EGFR therapy through activation of SRC-mediated EGFR signaling Research Paper

Peritumoral Neuropilin-1 and VEGF receptor-2 expression increases time to recurrence in hepatocellular carcinoma patients undergoing curative hepatectomy Clinical Research Papers

Increased serum levels of circulating exosomal microRNA-373 in receptor-negative breast cancer patients Clinical Research Papers

Activation of EGFR, HER2 and HER3 by neurotensin/neurotensin receptor 1 renders breast tumors aggressive yet highly responsive to lapatinib and metformin in mice Research Paper

Neurotensin (NTS) and its receptor (NTSR1) causes EGFR, HER2 and HER3 over-expression and their autocrine/paracrine activation in lung tumors, confirming responsiveness to erlotinib Research Paper

Androgen receptor promotes gastric cancer cell migration and invasion via AKT-phosphorylation dependent upregulation of matrix metalloproteinase 9 Research Paper

CAMK2N1 inhibits prostate cancer progression through androgen receptor-dependent signaling Clinical Research Papers

CCR9/CCL25 expression in non-small cell lung cancer correlates with aggressive disease and mediates key steps of metastasis Research Paper

Suppression of p53 by Notch3 is mediated by Cyclin G1 and sustained by MDM2 and miR-221 axis in hepatocellular carcinoma Research Paper

Systematic dissection of the mechanisms underlying progesterone receptor downregulation in endometrial cancer Research Paper

Intratumoral administration of mRNA encoding a fusokine consisting of IFN-Î² and the ectodomain of the TGF-Î² receptor II potentiates antitumor immunity Research Paper

Src-dependent phosphorylation at Y406 on the thyroid hormone receptor Î² confers the tumor suppressor activity Research Paper

RNA sequencing identifies specific PIWI-interacting small non-coding RNA expression patterns in breast cancer Research Paper

Glipizide, an antidiabetic drug, suppresses tumor growth and metastasis by inhibiting angiogenesis Research Paper

The Hippo transducer TAZ as a biomarker of pathological complete response in HER2-positive breast cancer patients treated with trastuzumab-based neoadjuvant therapy Clinical Research Papers