The Oncosearch | Oncotarget

Evidence for functional and regulatory cross-talk between Wnt/β-catenin signalling and Mre11–Rad50–Nbs1 complex in the repair of cisplatin-induced DNA cross-links Research Paper

Sanjeev Pasadi, Kalappa Muniyappa

Published Oct 7, 2020 · Vol. 11, No. 44 · pp. 4028-4044

Keywords: cancer, cisplatin resistance, cisplatin-induced DNA crosslinks, Wnt/β-catenin signalling, Mre11–Rad50–Nbs1 complex

Evaluation of cancer-derived myocardial impairments using a mouse model Research Paper

Yoshihiro Miyagawa, Shota Nukaga, Takuya Mori, Rina Fujiwara-Tani, Kiyomu Fujii, Shiori Mori, Kei Goto, Shingo Kishi, Takamitsu Sasaki, Chie Nakashima, Hitoshi Ohmori, Isao Kawahara, Yi Luo, Hiroki Kuniyasu

Published Sep 20, 2020 · Vol. 11, No. 41 · pp. 3712-3722

Keywords: cachexia, myocardium, atrophy, mitochondria, oxidative stress

Novel combination therapy for melanoma induces apoptosis via a gap junction positive feedback mechanism Research Paper

Archis Bagati, Timothy C. Hutcherson, Zethan Koch, Joseph Pechette, Hossein Dianat, Cory Higley, Lisa Chiu, Yesul Song, Jay Shah, Elana Chazen, Andrew Nicolais, Peter Casey, Kyle Thompson, Kevin Burke, Mikhail A. Nikiforov, Jennifer Zirnheld, Shoshanna N. Zucker

Published Aug 27, 2020 · Vol. 11, No. 37 · pp. 3443-3458

Keywords: non-thermal plasma, gap junction, tirapazamine, melanoma, intercellular communication

Efavirenz induces DNA damage response pathway in lung cancer Research Paper

Rahaba Marima, Rodney Hull, Zodwa Dlamini, Clement Penny

Published Aug 22, 2020 · Vol. 11, No. 41 · pp. 3737-3748

Keywords: efavirenz, cell cycle, differential gene expression, DNA damage response pathway, lung cancer

Targeted CRM1-inhibition perturbs leukemogenic NUP214 fusion proteins and exerts anti-cancer effects in leukemia cell lines with NUP214 rearrangements Research Paper

Adélia Mendes, Ramona Jühlen, Valérie Martinelli, Birthe Fahrenkrog

Published Aug 11, 2020 · Vol. 11, No. 36 · pp. 3371-3386

Keywords: CRM1, NUP214, leukemia, nuclear export, nucleoporin

The temporal effects of topical NF-κB inhibition, in the in vivo prevention of bile-related oncogenic mRNA and miRNA phenotypes in murine hypopharyngeal mucosa: a preclinical model Research Paper

Dimitra P. Vageli, David Kasle, Sotirios G. Doukas, Panagiotis G. Doukas, Clarence T. Sasaki

Published Aug 3, 2020 · Vol. 11, No. 35 · pp. 3303-3314

Keywords: NF-κB inhibition, BAY 11-7082, bile, laryngopharyngeal reflux, hypopharyngeal cancer

A case report of metastatic giant sarcomatoid melanoma with BRAF V600E mutation: a complete response to targeted therapy Case Report

Matteo Torresetti, Donatella Brancorsini, Francesca Morgese, Valeria Cognigni, Alessandro Scalise, Rossana Berardi, Giovanni Di Benedetto

Published Jul 30, 2020 · Vol. 11, No. 34 · pp. 3256-3262

Keywords: sarcomatoid melanoma, giant melanoma, BRAF mutation, targeted therapy, next-generation sequencing

The bromodomain inhibitor IBET-151 attenuates vismodegib-resistant esophageal adenocarcinoma growth through reduction of GLI signaling Research Paper

Annamil Alvarez-Trotta, Zhiqiang Wang, Elena Shersher, Bin Li, Jun Long, Ines Lohse, Claes Wahlestedt, Wael El-Rifai, David J. Robbins, Anthony J. Capobianco

Published Jul 28, 2020 · Vol. 11, No. 33 · pp. 3174-3187

Keywords: IBET-151, esophageal adenocarcinoma, GDC-0449 resistance, patient-derived xenografts, Hedgehog/GLI signaling pathway

An integrative microenvironment approach for follicular lymphoma: roles of inflammatory cell subsets and immune-response polymorphisms on disease clinical course Research Paper

Guilherme Rossi Assis-Mendonça, André Fattori, Rafael Malagoli Rocha, Gustavo Jacob Lourenço, Márcia Torresan Delamain, Suely Nonogaki, Vladmir Cláudio Cordeiro de Lima, Gisele Wally Braga Colleoni, Cármino Antonio de Souza, Fernando Augusto Soares, Carmen Silvia Passos Lima, José Vassallo

Published Jul 25, 2020 · Vol. 11, No. 33 · pp. 3153-3173

Keywords: follicular lymphoma, tumor microenvironment, immunohistochemistry, single nucleotide polymorphisms, prognosis

Important players in carcinogenesis as potential targets in cancer therapy: an update Review

Justyna Magdalena Hermanowicz, Iwona Kwiatkowska, Dariusz Pawlak

Published Jul 21, 2020 · Vol. 11, No. 32 · pp. 3078-3101

Keywords: modulators of carcinogenesis, acetylcholine, peroxisome proliferator-activated receptors, aquaporins

cGAS-STING pathway in oncogenesis and cancer therapeutics Review

Brandon Yi Da Hoong, Yunn Hwen Gan, Haiyan Liu, Ee Sin Chen

Published Jun 30, 2020 · Vol. 11, No. 30 · pp. 2930-2955

Keywords: cyclic GMP-AMP synthase, stimulator of interferon, cGAS, STING, interferon

Australian experience of peptide receptor radionuclide therapy in lung neuroendocrine tumours Research Paper

Lisi Elizabeth Lim, David L. Chan, David Thomas, Yang Du, Gary Tincknell, Anna Kuchel, Alexander Davis, Dale L. Bailey, Nick Pavlakis, Gabrielle Cehic, William Macdonald, David Wyld, Eva Segelov

Published Jun 20, 2020 · Vol. 11, No. 27 · pp. 2636-2646

Keywords: lung, carcinoid, atypical, neuroendocrine, peptide receptor radionuclide therapy

IGF-1 and hyperglycaemia-induced FOXA1 and IGFBP-2 affect epithelial to mesenchymal transition in prostate epithelial cells Research Paper

Rehanna Mansor, Jeff Holly, Rachel Barker, Kalina Biernacka, Hanna Zielinska, Anthony Koupparis, Edward Rowe, Jon Oxley, Alex Sewell, Richard M. Martin, Athene Lane, Lucy Hackshaw-McGeagh, Claire Perks

Published Jun 11, 2020 · Vol. 11, No. 26 · pp. 2543-2559

Keywords: hyperglycaemia, prostate cancer, FOXA1, IGFBP-2, EMT

Development and comprehensive characterization of porcine hepatocellular carcinoma for translational liver cancer investigation Research Paper

Ron C. Gaba, Lobna Elkhadragy, F. Edward Boas, Sulalita Chaki, Hanna H. Chen, Mohammed El-Kebir, Kelly D. Garcia, Eileena F. Giurini, Grace Guzman, Francesca V. LoBianco, Mario F. Neto, Jordan L. Newson, Aisha Qazi, Maureen Regan, Lauretta A. Rund, Regina M. Schwind, Matthew C. Stewart, Faith M. Thomas, Herbert E. Whiteley, Jiaqi Wu, Lawrence B. Schook, Kyle M. Schachtschneider

Published Jun 10, 2020 · Vol. 11, No. 28 · pp. 2686-2701

Keywords: liver cancer, transgenic pigs, large animal model, interventional radiology, personalized medicine

Tumor suppressor p53 regulates insulin receptor (INSR) gene expression via direct binding to the INSR promoter Research Paper

Rive Sarfstein, Haim Werner

Published Jun 9, 2020 · Vol. 11, No. 25 · pp. 2424-2437

Keywords: insulin, insulin-like growth factor-1 (IGF1), insulin receptor, IGF1 receptor, p53

Inhibition of the RUNX1-CBFβ transcription factor complex compromises mammary epithelial cell identity: a phenotype potentially stabilized by mitotic gene bookmarking Research Paper

Joshua T. Rose, Eliana Moskovitz, Joseph R. Boyd, Jonathan A. Gordon, Nicole A. Bouffard, Andrew J. Fritz, Anuradha Illendula, John H. Bushweller, Jane B. Lian, Janet L. Stein, Sayyed K. Zaidi, Gary S. Stein

Published May 30, 2020 · Vol. 11, No. 26 · pp. 2512-2530

Keywords: mammary epithelial phenotype, epithelial phenotype, RUNX1, CBFβ, mitotic gene bookmarking

Increased CHST15 follows decline in arylsulfatase B (ARSB) and disinhibition of non-canonical WNT signaling: potential impact on epithelial and mesenchymal identity Research Paper

Sumit Bhattacharyya, Leo Feferman, Xiaorui Han, Ke Xia, Fuming Zhang, Robert J. Linhardt, Joanne K. Tobacman

Published May 28, 2020 · Vol. 11, No. 24 · pp. 2327-2344

Keywords: sulfotransferase, sulfatase, chondroitin sulfate, Wnt, EMT

IQGAP1 control of centrosome function defines distinct variants of triple negative breast cancer Research Paper

Mahasin A. Osman, William James Antonisamy, Evgeny Yakirevich

Published May 24, 2020 · Vol. 11, No. 26 · pp. 2493-2511

Keywords: IQGAP1, BRCA1, β-catenin, MNK1, triple negative breast cancer

Neuroendocrine carcinoma of uterine cervix findings shown by MRI for staging and survival analysis – Japan multicenter study Research Paper

Kazuhiro Kitajima, Takako Kihara, Yusuke Kawanaka, Aki Kido, Kotaro Yoshida, Yasunari Mizumoto, Akiko Tomiyama, Shigeo Okuda, Masahiro Jinzaki, Fumi Kato, Junko Takahama, Akiko Takahata, Yoshihiko Fukukura, Atsushi Nakamoto, Tetsuya Tsujikawa, Jiro Munechika, Yoshimitstu Ohgiya, Nobuyuki Kawai, Satoshi Goshima, Ayumi Ohya, Yasunari Fujinaga, Takeru Fukunaga, Shinya Fujii, Masahiro Tanabe, Katsuyoshi Ito, Takahiro Tsuboyama, Yuichiro Kanie, Shigeaki Umeoka, Shintaro Ichikawa, Utaroh Motosugi, Sayaka Daido, Ayumu Kido, Tsutomu Tamada, Mitsuru Matsuki, Tsuneo Yamashiro, Koichiro Yamakado

Published May 21, 2020 · Vol. 11, No. 40 · pp. 3675-3686

Keywords: cervical cancer, neuroendocrine carcinoma, small cell carcinoma, large cell carcinoma, MRI

Adoptive cell therapy in combination with checkpoint inhibitors in ovarian cancer Research Paper

Anders Handrup Kverneland, Magnus Pedersen, Marie Christine Wulff Westergaard, Morten Nielsen, Troels Holz Borch, Lars Rønn Olsen, Gitte Aasbjerg, Saskia J. Santegoets, Sjoerd H. van der Burg, Katy Milne, Brad H. Nelson, Özcan Met, Marco Donia, Inge Marie Svane

Published May 6, 2020 · Vol. 11, No. 22 · pp. 2092-2105

Keywords: adoptive cell therapy, tumor-infiltrating lymphocytes, ovarian cancer, combinational immune therapy, checkpoint inihibors

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Evidence for functional and regulatory cross-talk between Wnt/β-catenin signalling and Mre11–Rad50–Nbs1 complex in the repair of cisplatin-induced DNA cross-links Research Paper

Evaluation of cancer-derived myocardial impairments using a mouse model Research Paper

Novel combination therapy for melanoma induces apoptosis via a gap junction positive feedback mechanism Research Paper

Efavirenz induces DNA damage response pathway in lung cancer Research Paper

Targeted CRM1-inhibition perturbs leukemogenic NUP214 fusion proteins and exerts anti-cancer effects in leukemia cell lines with NUP214 rearrangements Research Paper

The temporal effects of topical NF-κB inhibition, in the in vivo prevention of bile-related oncogenic mRNA and miRNA phenotypes in murine hypopharyngeal mucosa: a preclinical model Research Paper

A case report of metastatic giant sarcomatoid melanoma with BRAF V600E mutation: a complete response to targeted therapy Case Report

The bromodomain inhibitor IBET-151 attenuates vismodegib-resistant esophageal adenocarcinoma growth through reduction of GLI signaling Research Paper

An integrative microenvironment approach for follicular lymphoma: roles of inflammatory cell subsets and immune-response polymorphisms on disease clinical course Research Paper

Important players in carcinogenesis as potential targets in cancer therapy: an update Review

cGAS-STING pathway in oncogenesis and cancer therapeutics Review

Australian experience of peptide receptor radionuclide therapy in lung neuroendocrine tumours Research Paper

IGF-1 and hyperglycaemia-induced FOXA1 and IGFBP-2 affect epithelial to mesenchymal transition in prostate epithelial cells Research Paper

Development and comprehensive characterization of porcine hepatocellular carcinoma for translational liver cancer investigation Research Paper

Tumor suppressor p53 regulates insulin receptor (INSR) gene expression via direct binding to the INSR promoter Research Paper

Inhibition of the RUNX1-CBFβ transcription factor complex compromises mammary epithelial cell identity: a phenotype potentially stabilized by mitotic gene bookmarking Research Paper

Increased CHST15 follows decline in arylsulfatase B (ARSB) and disinhibition of non-canonical WNT signaling: potential impact on epithelial and mesenchymal identity Research Paper

IQGAP1 control of centrosome function defines distinct variants of triple negative breast cancer Research Paper

Neuroendocrine carcinoma of uterine cervix findings shown by MRI for staging and survival analysis – Japan multicenter study Research Paper

Adoptive cell therapy in combination with checkpoint inhibitors in ovarian cancer Research Paper

Publication Alerts

European Cancer and Oncology Congress

Oncoscience

Post-Publication Promotion

Search Oncotarget

Evidence for functional and regulatory cross-talk between Wnt/β-catenin signalling and Mre11–Rad50–Nbs1 complex in the repair of cisplatin-induced DNA cross-links Research Paper

Evaluation of cancer-derived myocardial impairments using a mouse model Research Paper

Novel combination therapy for melanoma induces apoptosis via a gap junction positive feedback mechanism Research Paper

Efavirenz induces DNA damage response pathway in lung cancer Research Paper

Targeted CRM1-inhibition perturbs leukemogenic NUP214 fusion proteins and exerts anti-cancer effects in leukemia cell lines with NUP214 rearrangements Research Paper

The temporal effects of topical NF-κB inhibition, in the in vivo prevention of bile-related oncogenic mRNA and miRNA phenotypes in murine hypopharyngeal mucosa: a preclinical model Research Paper

A case report of metastatic giant sarcomatoid melanoma with BRAF V600E mutation: a complete response to targeted therapy Case Report

The bromodomain inhibitor IBET-151 attenuates vismodegib-resistant esophageal adenocarcinoma growth through reduction of GLI signaling Research Paper

An integrative microenvironment approach for follicular lymphoma: roles of inflammatory cell subsets and immune-response polymorphisms on disease clinical course Research Paper

Important players in carcinogenesis as potential targets in cancer therapy: an update Review

cGAS-STING pathway in oncogenesis and cancer therapeutics Review

Australian experience of peptide receptor radionuclide therapy in lung neuroendocrine tumours Research Paper

IGF-1 and hyperglycaemia-induced FOXA1 and IGFBP-2 affect epithelial to mesenchymal transition in prostate epithelial cells Research Paper

Development and comprehensive characterization of porcine hepatocellular carcinoma for translational liver cancer investigation Research Paper

Tumor suppressor p53 regulates insulin receptor (INSR) gene expression via direct binding to the INSR promoter Research Paper

Inhibition of the RUNX1-CBFβ transcription factor complex compromises mammary epithelial cell identity: a phenotype potentially stabilized by mitotic gene bookmarking Research Paper

Increased CHST15 follows decline in arylsulfatase B (ARSB) and disinhibition of non-canonical WNT signaling: potential impact on epithelial and mesenchymal identity Research Paper

IQGAP1 control of centrosome function defines distinct variants of triple negative breast cancer Research Paper

Neuroendocrine carcinoma of uterine cervix findings shown by MRI for staging and survival analysis – Japan multicenter study Research Paper

Adoptive cell therapy in combination with checkpoint inhibitors in ovarian cancer Research Paper