The Oncosearch | Oncotarget

Constitutively-active androgen receptor variants function independently of the HSP90 chaperone but do not confer resistance to HSP90 inhibitors Research Paper

Joanna L Gillis, Luke A Selth, Margaret M Centenera, Scott L Townley, Shihua Sun, Stephen R Plymate, Wayne D Tilley, Lisa M Butler

Published Apr 25, 2013 · Vol. 4, No. 5 · pp. 691-704

Keywords: androgen receptor, variant, HSP90, HSP90 inhibitor, prostate cancer

Nuclear DNA Methylation and Chromatin Condensation Phenotypes Are Distinct Between Normally Proliferating/Aging, Rapidly Growing/Immortal, and Senescent Cells Research Paper

Jin Ho Oh, Arkadiusz Gertych, Jian Tajbakhsh

Published Mar 26, 2013 · Vol. 4, No. 3 · pp. 474-493

Keywords: DNA methylation, chromatin condensation, cell proliferation, aging, senescence, cancer, 3D imaging, cell-by-cell analysis

Actin-binding protein alpha-actinin 4 (ACTN4) is a transcriptional co-activator of RelA/p65 sub-unit of NF-kB. Research Paper

Vasilisa Aksenova, Lidia Turoverova, Mikhail Khotin, Karl-Eric Magnusson, Eugene Tulchinsky, Gerry Melino, George P Pinaev, Nikolai Barlev, Dmitri Tentler

Published Feb 28, 2013 · Vol. 4, No. 2 · pp. 362-373

Keywords: ACTN4, RelA/p65, transcription regulation, MMP

Calcein-effluxing human colon cancer cells are enriched for self-renewal capacity and depend on Î²-catenin Research Paper

Joshua E. Allen, Wafik S. El-Deiry

Published Feb 18, 2013 · Vol. 4, No. 2 · pp. 184-191

Spliceosome mutations in myelodysplastic syndromes and chronic myelomonocytic leukemia Review

Virginie Chesnais, Olivier Kosmider, Frederik Damm, Raphael Itzykson, Olivier A Bernard, Eric Solary, Michaela Fontenay

Published Nov 30, 2012 · Vol. 3, No. 11 · pp. 1284-1293

Keywords: splicing, alternative splicing, mutations, myeloid malignancies

NRF2 and p53: Januses in cancer? Review

Barak Rotblat, Gerry Melino, Richard A. Knight

Published Nov 19, 2012 · Vol. 3, No. 11 · pp. 1272-1283

Identification of acetylation-dependent regulatory mechanisms that govern the oncogenic functions of Skp2 Research Perspective

Zhiwei Wang, Hiroyuki Inuzuka, Jiateng Zhong, Pengda Liu, Fakul H Sarkar, Yi Sun, Wenyi Wei

Published Nov 16, 2012 · Vol. 3, No. 11 · pp. 1294-1300

Keywords: acetylation, cancer, deacetylation, SIRT3, oncoprotein, ubiquitination, phosphorylation, F-box protein, Skp2, therapy

Up-regulation of c-MYC and SIRT1 expression correlates with malignant transformation in the serrated route to colorectal cancer Research Paper

Lydia Kriegl, Michael Vieth, Thomas Kirchner, Antje Menssen

Published Oct 3, 2012 · Vol. 3, No. 10 · pp. 1182-1193

Keywords: Serrated route, colorectal cancer, SIRT1, c-MYC, BRAF and KRAS mutation, wnt signalling

DNA damage-induced activation of ATM promotes Î²-TRCP-mediated Mdm2 ubiquitination and destruction Research Paper

Zhiwei Wang, Hiroyuki Inuzuka, Jiateng Zhong, Hidefumi Fukushima, Lixin Wan, Pengda Liu, Wenyi Wei

Published Sep 11, 2012 · Vol. 3, No. 9 · pp. 1026-1035

Keywords: Mdm2, ATM, CKI, phosphorylation, beta-TRCP, ubiquitination, DNA damage

Regulation of DNA Damage Following Termination of Hedgehog (HH) Survival Signaling at the level of the GLI Genes in Human Colon Cancer Research Paper

AKWASI AGYEMAN, Tapati Mazumdar, Janet A Houghton

Published Aug 20, 2012 · Vol. 3, No. 8 · pp. 854-868

Keywords: Hedgehog, GLI1/2 inhibition, GANT61, DNA damage, colon cancer

Novel targeted therapies for mantle cell lymphoma Research Perspective

Lapo Alinari, Beth Christian, Robert Baiocchi

Published Feb 22, 2012 · Vol. 3, No. 2 · pp. 203-211

Pooled shRNA screen for sensitizers to inhibition of the mitotic regulator polo-like kinase (PLK1) Research Paper

Nancy Liu-Sullivan, Jianping Zhang, Amy Bakleh, John Marchica, Jinyu Li, Despina Siolas, Sylvie Laquerre, Yan Y. Degenhardt, Richard Wooster, Kenneth Chang, Gregory J. Hannon, Scott Powers

Published Dec 30, 2011 · Vol. 2, No. 12 · pp. 1254-1264

Keywords: Polo-like kinase 1, shRNA library screening, retinoids, combination therapy strategies

A Novel Dual Signaling Axis for NSP 5a3a induced apoptosis in Head and Neck Carcinoma Research Paper

Luca D'Agostino, Antonio Giordano

Published Dec 14, 2011 · Vol. 2, No. 12 · pp. 1055-1074

Keywords: NSP 5a3a, p73, TRAF2, DAXX, TRADD, Apoptosis, Cancer

The GLI genes as the molecular switch in disrupting Hedgehog signaling in colon cancer Research Perspective

Tapati Mazumdar, Jennifer DeVecchio, Akwasi Agyeman, Ting Shi, Janet A. Houghton

Published Aug 21, 2011 · Vol. 2, No. 8 · pp. 638-645

Keywords: Hedgehog signaling, Colon carcinoma, DNA damage

Targeting tumor angiogenesis with TSP-1-based compounds: rational design of antiangiogenic mimetics of endogenous inhibitors Research Perspective

Giulia Taraboletti, Marco Rusnati, Laura Ragona, Giorgio Colombo

Published Nov 25, 2010 · Vol. 1, No. 7 · pp. 662-673

Sumoylation of Vimentin354 Is Associated with PIAS3 Inhibition of Glioma Cell Migration Research Paper

Liming Wang, Jian Zhang, Sipra Banerjee, Laura Barnes, Venkateswara Sajja, Yiding Liu, Baochuan Guo, Yuping Du, Mukesh K. Agarwal, David N. Wald, Qin Wang, Jinbo Yang

Published Nov 11, 2010 · Vol. 1, No. 7 · pp. 620-627

Evaluation of an Actinomycin D/VX-680 aurora kinase inhibitor combination in p53-based cyclotherapy Research Paper

Bhavya Rao, Ingeborg M.M. van Leeuwen, Maureen Higgins, Johanna Campbell, Alastair M. Thompson, David P. Lane, Sonia Lain

Published Oct 30, 2010 · Vol. 1, No. 7 · pp. 639-650

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Constitutively-active androgen receptor variants function independently of the HSP90 chaperone but do not confer resistance to HSP90 inhibitors Research Paper

Nuclear DNA Methylation and Chromatin Condensation Phenotypes Are Distinct Between Normally Proliferating/Aging, Rapidly Growing/Immortal, and Senescent Cells Research Paper

Actin-binding protein alpha-actinin 4 (ACTN4) is a transcriptional co-activator of RelA/p65 sub-unit of NF-kB. Research Paper

Calcein-effluxing human colon cancer cells are enriched for self-renewal capacity and depend on Î²-catenin Research Paper

Spliceosome mutations in myelodysplastic syndromes and chronic myelomonocytic leukemia Review

NRF2 and p53: Januses in cancer? Review

Identification of acetylation-dependent regulatory mechanisms that govern the oncogenic functions of Skp2 Research Perspective

Up-regulation of c-MYC and SIRT1 expression correlates with malignant transformation in the serrated route to colorectal cancer Research Paper

DNA damage-induced activation of ATM promotes Î²-TRCP-mediated Mdm2 ubiquitination and destruction Research Paper

Regulation of DNA Damage Following Termination of Hedgehog (HH) Survival Signaling at the level of the GLI Genes in Human Colon Cancer Research Paper

Novel targeted therapies for mantle cell lymphoma Research Perspective

Pooled shRNA screen for sensitizers to inhibition of the mitotic regulator polo-like kinase (PLK1) Research Paper

A Novel Dual Signaling Axis for NSP 5a3a induced apoptosis in Head and Neck Carcinoma Research Paper

The GLI genes as the molecular switch in disrupting Hedgehog signaling in colon cancer Research Perspective

Targeting tumor angiogenesis with TSP-1-based compounds: rational design of antiangiogenic mimetics of endogenous inhibitors Research Perspective

Sumoylation of Vimentin354 Is Associated with PIAS3 Inhibition of Glioma Cell Migration Research Paper

Evaluation of an Actinomycin D/VX-680 aurora kinase inhibitor combination in p53-based cyclotherapy Research Paper

Publication Alerts

European Cancer and Oncology Congress

Oncoscience

Post-Publication Promotion

Search Oncotarget

Constitutively-active androgen receptor variants function independently of the HSP90 chaperone but do not confer resistance to HSP90 inhibitors Research Paper

Nuclear DNA Methylation and Chromatin Condensation Phenotypes Are Distinct Between Normally Proliferating/Aging, Rapidly Growing/Immortal, and Senescent Cells Research Paper

Actin-binding protein alpha-actinin 4 (ACTN4) is a transcriptional co-activator of RelA/p65 sub-unit of NF-kB. Research Paper

Calcein-effluxing human colon cancer cells are enriched for self-renewal capacity and depend on Î²-catenin Research Paper

Spliceosome mutations in myelodysplastic syndromes and chronic myelomonocytic leukemia Review

NRF2 and p53: Januses in cancer? Review

Identification of acetylation-dependent regulatory mechanisms that govern the oncogenic functions of Skp2 Research Perspective

Up-regulation of c-MYC and SIRT1 expression correlates with malignant transformation in the serrated route to colorectal cancer Research Paper

DNA damage-induced activation of ATM promotes Î²-TRCP-mediated Mdm2 ubiquitination and destruction Research Paper

Regulation of DNA Damage Following Termination of Hedgehog (HH) Survival Signaling at the level of the GLI Genes in Human Colon Cancer Research Paper

Novel targeted therapies for mantle cell lymphoma Research Perspective

Pooled shRNA screen for sensitizers to inhibition of the mitotic regulator polo-like kinase (PLK1) Research Paper

A Novel Dual Signaling Axis for NSP 5a3a induced apoptosis in Head and Neck Carcinoma Research Paper

The GLI genes as the molecular switch in disrupting Hedgehog signaling in colon cancer Research Perspective

Targeting tumor angiogenesis with TSP-1-based compounds: rational design of antiangiogenic mimetics of endogenous inhibitors Research Perspective

Sumoylation of Vimentin354 Is Associated with PIAS3 Inhibition of Glioma Cell Migration Research Paper

Evaluation of an Actinomycin D/VX-680 aurora kinase inhibitor combination in p53-based cyclotherapy Research Paper