The Oncosearch | Oncotarget

Syringaresinol protects against hypoxia/reoxygenation-induced cardiomyocytes injury and death by destabilization of HIF-1Î± in a FOXO3-dependent mechanism Priority Research Paper

Siyoung Cho, Miook Cho, Juewon Kim, Matt Kaeberlein, Sang Jun Lee, Yousin Suh

Published Nov 6, 2014 · Vol. 6, No. 1 · pp. 43-55

Resistin promotes tumor metastasis by down-regulation of miR-519d through the AMPK/p38 signaling pathway in human chondrosarcoma cells Research Paper

Chun-Hao Tsai, Hsiao-Chi Tsai, Ho-Ning Huang, Chih-Hung Hung, Chin-Jung Hsu, Yi-Chin Fong, Horng-Chaung Hsu, Yuan-Li Huang, Chih-Hsin Tang

Published Nov 6, 2014 · Vol. 6, No. 1 · pp. 258-270

Therapeutic potential of ERK5 targeting in triple negative breast cancer Research Paper

MarÃa JesÃºs Ortiz-Ruiz, Stela Ãlvarez-FernÃ¡ndez, Tracy Parrott, Sara Zaknoen, Francis J. Burrows, Alberto OcaÃ±a, Atanasio Pandiella, Azucena EsparÃs-Ogando

Published Nov 4, 2014 · Vol. 5, No. 22 · pp. 11308-11318

The head and neck cancer cell oncogenome: A platform for the development of precision molecular therapies Priority Research Paper

Daniel Martin, Martin C. Abba, Alfredo A. Molinolo, Lynn Vitale-Cross, Zhiyong Wang, Moraima Zaida, Naomi C. Delic, Yardena Samuels, Guy J. Lyons, J. Silvio Gutkind

Published Nov 4, 2014 · Vol. 5, No. 19 · pp. 8906-8923

MicroRNA expression patterns in the malignant progression of gliomas and a 5-microRNA signature for prognosis Research Paper

Wei Yan, Rui Li, Yanwei Liu, Pei Yang, Zheng Wang, Chuanbao Zhang, Zhaoshi Bao, Wei Zhang, Yongping You, Tao Jiang

Published Nov 4, 2014 · Vol. 5, No. 24 · pp. 12908-12915

Divergent behaviors and underlying mechanisms of cell migration and invasion in non-metastatic T24 and its metastatic derivative T24T bladder cancer cell lines Research Paper

Honglei Jin, Yonghui Yu, Young Hu, Chris Lu, Jingxia Li, Jiayan Gu, Liping Zhang, Haishan Huang, Dongyun Zhang, Xue-Ru Wu, Jimin Gao, Chuanshu Huang

Published Nov 4, 2014 · Vol. 6, No. 1 · pp. 522-536

The cylindromatosis gene product, CYLD, interacts with MIB2 to regulate notch signalling Research Paper

Neil Rajan, Richard J.R. Elliott, Alice Smith, Naomi Sinclair, Sally Swift, Christopher J. Lord, Alan Ashworth

Published Nov 3, 2014 · Vol. 5, No. 23 · pp. 12126-12140

VER-246608, a novel pan-isoform ATP competitive inhibitor of pyruvate dehydrogenase kinase, disrupts Warburg metabolism and induces context-dependent cytostasis in cancer cells Research Paper

Jonathan D. Moore, Anna Staniszewska, Terence Shaw, Jalanie Dâ€™Alessandro, Ben Davis, Alan Surgenor, Lisa Baker, Natalia Matassova, James Murray, Alba Macias, Paul Brough, Mike Wood, Patrick C. Mahon

Published Nov 2, 2014 · Vol. 5, No. 24 · pp. 12862-12876

The DNA2 nuclease/helicase is an estrogen-dependent gene mutated in breast and ovarian cancers Research Paper

Carmit Strauss, Maya Kornowski, Avraham Benvenisty, Amit Shahar, Hadas Masury, Ittai Ben-Porath, Tommer Ravid, Ayelet Arbel-Eden, Michal Goldberg

Published Nov 1, 2014 · Vol. 5, No. 19 · pp. 9396-9409

MicroRNA-9 promotes tumor metastasis via repressing E-cadherin in esophageal squamous cell carcinoma Research Paper

Ye Song, Jiangchao Li, Yinghui Zhu, Yongdong Dai, Tingting Zeng, Lulu Liu, Jianbiao Li, Hongbo Wang, Yanru Qin, Musheng Zeng, Xin-Yuan Guan, Yan Li

Published Oct 31, 2014 · Vol. 5, No. 22 · pp. 11669-11680

Suppressor of fused (Sufu) represses Gli1 transcription and nuclear accumulation, inhibits glioma cell proliferation, invasion and vasculogenic mimicry, improving glioma chemo-sensitivity and prognosis Research Paper

Xing Liu, Xiaofeng Wang, Wenzhong Du, Lingchao Chen, Guangzhi Wang, Yuqiong Cui, Yang Liu, Zhijin Dou, Hongjun Wang, Ping Zhang, Liang Chang, Liye Yi, Jinquan Cai, Chuanlu Jiang

Published Oct 29, 2014 · Vol. 5, No. 22 · pp. 11681-11694

The novel IÎºB kinase Î² inhibitor IMD-0560 prevents bone invasion by oral squamous cell carcinoma Research Paper

Yukiyo Tada, Shoichiro Kokabu, Goro Sugiyama, Chihiro Nakatomi, Kazuhiro Aoki, Hidefumi Fukushima, Kenji Osawa, Yasutaka Sugamori, Keiichi Ohya, Masato Okamoto, Tomoyuki Fujikawa, Akiko Itai, Kou Matsuo, Seiji Watanabe, Eijiro Jimi

Published Oct 28, 2014 · Vol. 5, No. 23 · pp. 12317-12330

The small molecule tyrosine kinase inhibitor NVP-BHG712 antagonizes ABCC10-mediated paclitaxel resistance: a preclinical and pharmacokinetic study Research Paper

Rishil J. Kathawala, Liuya Wei, Nagaraju Anreddy, Kang Chen, Atish Patel, Saeed Alqahtani, Yun-Kai Zhang, Yi-Jun Wang, Kamlesh Sodani, Amal Kaddoumi, Charles R. Ashby Jr., Zhe-Sheng Chen

Published Oct 28, 2014 · Vol. 6, No. 1 · pp. 510-521

Preclinical efficacy of maternal embryonic leucine-zipper kinase (MELK) inhibition in acute myeloid leukemia Research Paper

Houda Alachkar, Martin B.G. Mutonga, Klaus H. Metzeler, Noreen Fulton, Gregory Malnassy, Tobias Herold, Karsten Spiekermann, Stefan K. Bohlander, Wolfgang Hiddemann, Yo Matsuo, Wendy Stock, Yusuke Nakamura

Published Oct 28, 2014 · Vol. 5, No. 23 · pp. 12371-12382

A novel DAG-dependent mechanism links PKCɑ and Cyclin B1 regulating cell cycle progression Research Paper

Alessandro Poli, Giulia Ramazzotti, Alessandro Matteucci, Lucia Manzoli, Annalisa Lonetti, Pann-Ghill Suh, James A. McCubrey, Lucio Cocco

Published Oct 24, 2014 · Vol. 5, No. 22 · pp. 11526-11540

Keywords: PKC, Cyclin, Cell Cycle, PLC, DAG, nuclei

ZNF282 (Zinc finger protein 282), a novel E2F1 co-activator, promotes esophageal squamous cell carcinoma Research Paper

So-Young Yeo, Sang Yun Ha, Eun Ji Yu, Keun-Woo Lee, Jeong Hoon Kim, Seok-Hyung Kim

Published Oct 24, 2014 · Vol. 5, No. 23 · pp. 12260-12272

microRNA-29b prevents liver fibrosis by attenuating hepatic stellate cell activation and inducing apoptosis through targeting PI3K/AKT pathway Research Paper

Jia Wang, Eagle S.H . Chu, Hai-Yong Chen, Kwan Man, Minnie Y.Y. Go, Xiao Ru Huang, Hui Yao Lan, Joseph J.Y. Sung, Jun Yu

Published Oct 22, 2014 · Vol. 6, No. 9 · pp. 7325-7338

CDKL2 promotes epithelial-mesenchymal transition and breast cancer progression Research Paper

Linna Li, Chunping Liu, Robert J. Amato, Jeffrey T. Chang, Wenliang Li, Wenliang Li

Published Oct 21, 2014 · Vol. 5, No. 21 · pp. 10840-10853

Keywords: cyclin-dependent kinase-like 2 (CDKL2), epithelialâ€“mesenchymal transition (EMT), breast cancer, kinases, CD44

Proscillaridin A is cytotoxic for glioblastoma cell lines and controls tumor xenograft growth in vivo Research Paper

Emilie DenicolaÃ¯, Nathalie Baeza-Kallee, AurÃ©lie Tchoghandjian, Manon CarrÃ©, Carole Colin, Carine Jiguet Jiglaire, Sandy Mercurio, Christophe Beclin, Dominique Figarella-Branger

Published Oct 21, 2014 · Vol. 5, No. 21 · pp. 10934-10948

Keywords: Proscillaridin A, glioblastoma, cytotoxicity, tumor growth control, Na+/K+ ATPase Î±1 subunit

BRAF vs RAS oncogenes: Are mutations of the same pathway equal? Differential signalling and therapeutic implications Review

Eftychia Oikonomou, Evangelos Koustas, Maria Goulielmaki, Alexander Pintzas

Published Oct 21, 2014 · Vol. 5, No. 23 · pp. 11752-11777

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Syringaresinol protects against hypoxia/reoxygenation-induced cardiomyocytes injury and death by destabilization of HIF-1Î± in a FOXO3-dependent mechanism Priority Research Paper

Resistin promotes tumor metastasis by down-regulation of miR-519d through the AMPK/p38 signaling pathway in human chondrosarcoma cells Research Paper

Therapeutic potential of ERK5 targeting in triple negative breast cancer Research Paper

The head and neck cancer cell oncogenome: A platform for the development of precision molecular therapies Priority Research Paper

MicroRNA expression patterns in the malignant progression of gliomas and a 5-microRNA signature for prognosis Research Paper

Divergent behaviors and underlying mechanisms of cell migration and invasion in non-metastatic T24 and its metastatic derivative T24T bladder cancer cell lines Research Paper

The cylindromatosis gene product, CYLD, interacts with MIB2 to regulate notch signalling Research Paper

VER-246608, a novel pan-isoform ATP competitive inhibitor of pyruvate dehydrogenase kinase, disrupts Warburg metabolism and induces context-dependent cytostasis in cancer cells Research Paper

The DNA2 nuclease/helicase is an estrogen-dependent gene mutated in breast and ovarian cancers Research Paper

MicroRNA-9 promotes tumor metastasis via repressing E-cadherin in esophageal squamous cell carcinoma Research Paper

Suppressor of fused (Sufu) represses Gli1 transcription and nuclear accumulation, inhibits glioma cell proliferation, invasion and vasculogenic mimicry, improving glioma chemo-sensitivity and prognosis Research Paper

The novel IÎºB kinase Î² inhibitor IMD-0560 prevents bone invasion by oral squamous cell carcinoma Research Paper

The small molecule tyrosine kinase inhibitor NVP-BHG712 antagonizes ABCC10-mediated paclitaxel resistance: a preclinical and pharmacokinetic study Research Paper

Preclinical efficacy of maternal embryonic leucine-zipper kinase (MELK) inhibition in acute myeloid leukemia Research Paper

A novel DAG-dependent mechanism links PKCɑ and Cyclin B1 regulating cell cycle progression Research Paper

ZNF282 (Zinc finger protein 282), a novel E2F1 co-activator, promotes esophageal squamous cell carcinoma Research Paper

microRNA-29b prevents liver fibrosis by attenuating hepatic stellate cell activation and inducing apoptosis through targeting PI3K/AKT pathway Research Paper

CDKL2 promotes epithelial-mesenchymal transition and breast cancer progression Research Paper

Proscillaridin A is cytotoxic for glioblastoma cell lines and controls tumor xenograft growth in vivo Research Paper

BRAF vs RAS oncogenes: Are mutations of the same pathway equal? Differential signalling and therapeutic implications Review

Publication Alerts

European Cancer and Oncology Congress

Oncoscience

Post-Publication Promotion

Search Oncotarget

Syringaresinol protects against hypoxia/reoxygenation-induced cardiomyocytes injury and death by destabilization of HIF-1Î± in a FOXO3-dependent mechanism Priority Research Paper

Resistin promotes tumor metastasis by down-regulation of miR-519d through the AMPK/p38 signaling pathway in human chondrosarcoma cells Research Paper

Therapeutic potential of ERK5 targeting in triple negative breast cancer Research Paper

The head and neck cancer cell oncogenome: A platform for the development of precision molecular therapies Priority Research Paper

MicroRNA expression patterns in the malignant progression of gliomas and a 5-microRNA signature for prognosis Research Paper

Divergent behaviors and underlying mechanisms of cell migration and invasion in non-metastatic T24 and its metastatic derivative T24T bladder cancer cell lines Research Paper

The cylindromatosis gene product, CYLD, interacts with MIB2 to regulate notch signalling Research Paper

VER-246608, a novel pan-isoform ATP competitive inhibitor of pyruvate dehydrogenase kinase, disrupts Warburg metabolism and induces context-dependent cytostasis in cancer cells Research Paper

The DNA2 nuclease/helicase is an estrogen-dependent gene mutated in breast and ovarian cancers Research Paper

MicroRNA-9 promotes tumor metastasis via repressing E-cadherin in esophageal squamous cell carcinoma Research Paper

Suppressor of fused (Sufu) represses Gli1 transcription and nuclear accumulation, inhibits glioma cell proliferation, invasion and vasculogenic mimicry, improving glioma chemo-sensitivity and prognosis Research Paper

The novel IÎºB kinase Î² inhibitor IMD-0560 prevents bone invasion by oral squamous cell carcinoma Research Paper

The small molecule tyrosine kinase inhibitor NVP-BHG712 antagonizes ABCC10-mediated paclitaxel resistance: a preclinical and pharmacokinetic study Research Paper

Preclinical efficacy of maternal embryonic leucine-zipper kinase (MELK) inhibition in acute myeloid leukemia Research Paper

A novel DAG-dependent mechanism links PKCɑ and Cyclin B1 regulating cell cycle progression Research Paper

ZNF282 (Zinc finger protein 282), a novel E2F1 co-activator, promotes esophageal squamous cell carcinoma Research Paper

microRNA-29b prevents liver fibrosis by attenuating hepatic stellate cell activation and inducing apoptosis through targeting PI3K/AKT pathway Research Paper

CDKL2 promotes epithelial-mesenchymal transition and breast cancer progression Research Paper

Proscillaridin A is cytotoxic for glioblastoma cell lines and controls tumor xenograft growth in vivo Research Paper

BRAF vs RAS oncogenes: Are mutations of the same pathway equal? Differential signalling and therapeutic implications Review