The Oncosearch | Oncotarget

The anti-HER3 antibody patritumab abrogates cetuximab resistance mediated by heregulin in colorectal cancer cells Research Paper

Hisato Kawakami, Isamu Okamoto, Kimio Yonesaka, Kunio Okamoto, Kiyoko Shibata, Yume Shinkai, Haruka Sakamoto, Michiko Kitano, Takao Tamura, Kazuto Nishio, Kazuhiko Nakagawa

Published Dec 19, 2014 · Vol. 5, No. 23 · pp. 11847-11856

Keywords: colorectal cancer, heregulin, resistance, cetuximab, patritumab

Targeting miR-381-NEFL axis sensitizes glioblastoma cells to temozolomide by regulating stemness factors and multidrug resistance factors Research Paper

Zeyou Wang, Jing Yang, Gang Xu, Wei Wang, Changhong Liu, Honghui Yang, Zhibin Yu, Qianqian Lei, Lan Xiao, Jing Xiong, Liang Zeng, Juanjuan Xiang, Jian Ma, Guiyuan Li, Minghua Wu

Published Dec 18, 2014 · Vol. 6, No. 5 · pp. 3147-3164

MiR-125b regulates epithelial-mesenchymal transition via targeting Sema4C in paclitaxel-resistant breast cancer cells Research Paper

Qingling Yang, Yangyang Wang, Xiaohui Lu, Zunlan Zhao, Lihua Zhu, Sulian Chen, Qiong Wu, Changjie Chen, Zhiwei Wang

Published Dec 18, 2014 · Vol. 6, No. 5 · pp. 3268-3279

A microRNA-1280/JAG2 network comprises a novel biological target in high-risk medulloblastoma Research Paper

Fengfei Wang, Marc Remke, Kruttika Bhat, Eric T. Wong, Shuang Zhou, Vijay Ramaswamy, Adrian Dubuc, Ekokobe Fonkem, Saeed Salem, Hongbing Zhang, Tze-chen Hsieh, Stephen T. O'Rourke, Lizi Wu, David W. Li, Cynthia Hawkins, Isaac S. Kohane, Joseph M. Wu, Min Wu, Michael D. Taylor, Erxi Wu

Published Dec 17, 2014 · Vol. 6, No. 5 · pp. 2709-2724

A role for BMP-induced homeobox gene MIXL1 in acute myelogenous leukemia and identification of type I BMP receptor as a potential target for therapy Research Paper

Aaron Raymond, Bin Liu, Hong Liang, Ciamaio Wei, Michele Guindani, Yue Lu, Shoudan Liang, Lisa S. St. John, Jeff Molldrem, Lalitha Nagarajan

Published Dec 17, 2014 · Vol. 5, No. 24 · pp. 12675-12693

Targeting VEGFR1- and VEGFR2-expressing non-tumor cells is essential for esophageal cancer therapy Research Paper

Wen Wen Xu, Bin Li, Alfred KY Lam, Sai Wah Tsao, Simon YK Law, Kwok Wah Chan, Qiu Ju Yuan, Annie LM Cheung

Published Dec 17, 2014 · Vol. 6, No. 3 · pp. 1790-1805

Keywords: Tumor angiogenesis, Bone marrow-derived cells, Tumor microenvironment, VEGF receptors, Antibody therapy

The T-box transcription factor, TBX3, is a key substrate of AKT3 in melanomagenesis Research Paper

Jade Peres, Shaheen Mowla, Sharon Prince

Published Dec 16, 2014 · Vol. 6, No. 3 · pp. 1821-1833

Keywords: TBX3, AKT3, melanoma, E-cadherin, T-box factors.

Mitochondrial translocation and interaction of cofilin and Drp1 are required for erucin-induced mitochondrial fission and apoptosis Research Paper

Guobing Li, Jing Zhou, Amit Budhraja, Xiaoye Hu, Yibiao Chen, Qi Cheng, Lei Liu, Ting Zhou, Ping Li, Ehu Liu, Ning Gao

Published Dec 16, 2014 · Vol. 6, No. 3 · pp. 1834-1849

Keywords: Cofilin, Drp1, mitochondrial fission, erucin, apoptosis

Active secretion of CXCL10 and CCL5 from colorectal cancer microenvironments associates with GranzymeB+ CD8+ T-cell infiltration Research Paper

Timothy J. Zumwalt, Mildred Arnold, Ajay Goel, C. Richard Boland

Published Dec 11, 2014 · Vol. 6, No. 5 · pp. 2981-2991

Identification of DEK as a potential therapeutic target for neuroendocrine prostate cancer Research Paper

Dong Lin, Xin Dong, Kendric Wang, Alexander W. Wyatt, Francesco Crea, Hui Xue, Yuwei Wang, Rebecca Wu, Robert H. Bell, Anne Haegert, Sonal Brahmbhatt, Antonio Hurtado-Coll, Peter W. Gout, Ladan Fazli, Martin E. Gleave, Colin C. Collins, Yuzhuo Wang

Published Dec 11, 2014 · Vol. 6, No. 3 · pp. 1806-1820

MicroRNA-135b, a HSF1 target, promotes tumor invasion and metastasis by regulating RECK and EVI5 in hepatocellular carcinoma Research Paper

Yan Li, Dan Xu, Chunyang Bao, Yuannv Zhang, Di Chen, Fangyu Zhao, Jie Ding, Linhui Liang, Qifeng Wang, Li Liu, Jinjun Li, Ming Yao, Shenglin Huang, Xianghuo He

Published Dec 11, 2014 · Vol. 6, No. 4 · pp. 2421-2433

DCLK1 is a broadly dysregulated target against epithelial-mesenchymal transition, focal adhesion, and stemness in clear cell renal carcinoma Research Paper

Nathaniel Weygant, Dongfeng Qu, Randal May, Ryan M. Tierney, William L. Berry, Lichao Zhao, Shweta Agarwal, Parthasarathy Chandrakesan, Harisha R. Chinthalapally, Nicholas T. Murphy, James D. Li, Sripathi M. Sureban, Michael J. Schlosser, James J. Tomasek, Courtney W. Houchen

Published Dec 11, 2014 · Vol. 6, No. 4 · pp. 2193-2205

Stabilization of LKB1 and Akt by neddylation regulates energy metabolism in liver cancer Research Paper

LucÃa Barbier-Torres, Teresa C. Delgado, Juan L. GarcÃa-RodrÃguez, Imanol Zubiete-Franco, David FernÃ¡ndez-Ramos, Xabier BuquÃ©, Ainara Cano, Virginia GutiÃ©rrez-de Juan, Itziar FernÃ¡ndez-DomÃnguez, Fernando Lopitz-Otsoa, Pablo FernÃ¡ndez-Tussy, Loreto Boix, Jordi Bruix, Erica Villa, Azucena Castro, Shelly C. Lu, Patricia Aspichueta, Dimitris Xirodimas, Marta Varela-Rey, JosÃ© M. Mato, Naiara Beraza, MarÃa L. MartÃnez-Chantar

Published Dec 11, 2014 · Vol. 6, No. 4 · pp. 2509-2523

Novel receptor tyrosine kinase targeted combination therapies for imatinib-resistant gastrointestinal stromal tumors (GIST) Research Paper

Daruka Mahadevan, Noah Theiss, Carla Morales, Amy E. Stejskal, Laurence S. Cooke, Min Zhu, Drew Kurtzman, Rachel Swart, Evan Ong, Wenqing Qi

Published Dec 10, 2014 · Vol. 6, No. 4 · pp. 1954-1966

Î²III-Tubulin: A novel mediator of chemoresistance and metastases in pancreatic cancer Research Paper

Joshua A. McCarroll, George Sharbeen, Jie Liu, Janet Youkhana, David Goldstein, Nigel McCarthy, Lydia F. Limbri, Dominic Dischl, GÃ¼ralp O. Ceyhan, Mert Erkan, Amber L. Johns, Andrew V. Biankin, Maria Kavallaris, Phoebe A. Phillips

Published Dec 10, 2014 · Vol. 6, No. 4 · pp. 2235-2249

Mutation profiling of tumor DNA from plasma and tumor tissue of colorectal cancer patients with a novel, high-sensitivity multiplexed mutation detection platform Clinical Research Papers

Evelyn Kidess, Kyra Heirich, Matthew Wiggin, Valentina Vysotskaia, Brendan C. Visser, Andre Marziali, Bertram Wiedenmann, Jeffrey A. Norton, Mark Lee, Stefanie S. Jeffrey, George A. Poultsides

Published Dec 10, 2014 · Vol. 6, No. 4 · pp. 2549-2561

Targeting a ribonucleoprotein complex containing the caprin-1 protein and the c-Myc mRNA suppresses tumor growth in mice: an identification of a novel oncotarget Research Paper

Ya-Qi Qiu, Cheng-Wei Yang, Yue-Zhi Lee, Ruey-Bing Yang, Chih-Hao Lee, Hsing-Yu Hsu, Chien-Chung Chang, Shiow-Ju Lee

Published Dec 10, 2014 · Vol. 6, No. 4 · pp. 2148-2163

Multiple receptor tyrosine kinase activation attenuates therapeutic efficacy of the fibroblast growth factor receptor 2 inhibitor AZD4547 in FGFR2 amplified gastric cancer Research Paper

Jinjia Chang, Shanshan Wang, Zhe Zhang, Xinyang Liu, Zheng Wu, Ruixuan Geng, Xiaoxiao Ge, Congqi Dai, Rujiao Liu, Qunling Zhang, Wenhua Li, Jin Li

Published Dec 10, 2014 · Vol. 6, No. 4 · pp. 2009-2022

PRK1/PKN1 controls migration and metastasis of androgen-independent prostate cancer cells Research Paper

Cordula A. Jilg, Anett Ketscher, Eric Metzger, Barbara Hummel, Dominica Willmann, Vanessa RÃ¼sseler, Vanessa Drendel, Axel Imhof, Manfred Jung, Henriette Franz, Stefanie HÃ¶lz, Malte KrÃ¶nig, Judith M. MÃ¼ller, Roland SchÃ¼le

Published Dec 10, 2014 · Vol. 5, No. 24 · pp. 12646-12664

Î³-H2AX promotes hepatocellular carcinoma angiogenesis via EGFR/HIF-1Î±/VEGF pathways under hypoxic condition Research Paper

Heng Xiao, Rongliang Tong, Chaofeng Ding, Zhen Lv, Chengli Du, Chuanhui Peng, Shaobing Cheng, Haiyang Xie, Lin Zhou, Jian Wu, Shusen Zheng

Published Dec 10, 2014 · Vol. 6, No. 4 · pp. 2180-2192

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The anti-HER3 antibody patritumab abrogates cetuximab resistance mediated by heregulin in colorectal cancer cells Research Paper

Targeting miR-381-NEFL axis sensitizes glioblastoma cells to temozolomide by regulating stemness factors and multidrug resistance factors Research Paper

MiR-125b regulates epithelial-mesenchymal transition via targeting Sema4C in paclitaxel-resistant breast cancer cells Research Paper

A microRNA-1280/JAG2 network comprises a novel biological target in high-risk medulloblastoma Research Paper

A role for BMP-induced homeobox gene MIXL1 in acute myelogenous leukemia and identification of type I BMP receptor as a potential target for therapy Research Paper

Targeting VEGFR1- and VEGFR2-expressing non-tumor cells is essential for esophageal cancer therapy Research Paper

The T-box transcription factor, TBX3, is a key substrate of AKT3 in melanomagenesis Research Paper

Mitochondrial translocation and interaction of cofilin and Drp1 are required for erucin-induced mitochondrial fission and apoptosis Research Paper

Active secretion of CXCL10 and CCL5 from colorectal cancer microenvironments associates with GranzymeB+ CD8+ T-cell infiltration Research Paper

Identification of DEK as a potential therapeutic target for neuroendocrine prostate cancer Research Paper

MicroRNA-135b, a HSF1 target, promotes tumor invasion and metastasis by regulating RECK and EVI5 in hepatocellular carcinoma Research Paper

DCLK1 is a broadly dysregulated target against epithelial-mesenchymal transition, focal adhesion, and stemness in clear cell renal carcinoma Research Paper

Stabilization of LKB1 and Akt by neddylation regulates energy metabolism in liver cancer Research Paper

Novel receptor tyrosine kinase targeted combination therapies for imatinib-resistant gastrointestinal stromal tumors (GIST) Research Paper

Î²III-Tubulin: A novel mediator of chemoresistance and metastases in pancreatic cancer Research Paper

Mutation profiling of tumor DNA from plasma and tumor tissue of colorectal cancer patients with a novel, high-sensitivity multiplexed mutation detection platform Clinical Research Papers

Targeting a ribonucleoprotein complex containing the caprin-1 protein and the c-Myc mRNA suppresses tumor growth in mice: an identification of a novel oncotarget Research Paper

Multiple receptor tyrosine kinase activation attenuates therapeutic efficacy of the fibroblast growth factor receptor 2 inhibitor AZD4547 in FGFR2 amplified gastric cancer Research Paper

PRK1/PKN1 controls migration and metastasis of androgen-independent prostate cancer cells Research Paper

Î³-H2AX promotes hepatocellular carcinoma angiogenesis via EGFR/HIF-1Î±/VEGF pathways under hypoxic condition Research Paper

Publication Alerts

European Cancer and Oncology Congress

Oncoscience

Post-Publication Promotion

Search Oncotarget

The anti-HER3 antibody patritumab abrogates cetuximab resistance mediated by heregulin in colorectal cancer cells Research Paper

Targeting miR-381-NEFL axis sensitizes glioblastoma cells to temozolomide by regulating stemness factors and multidrug resistance factors Research Paper

MiR-125b regulates epithelial-mesenchymal transition via targeting Sema4C in paclitaxel-resistant breast cancer cells Research Paper

A microRNA-1280/JAG2 network comprises a novel biological target in high-risk medulloblastoma Research Paper

A role for BMP-induced homeobox gene MIXL1 in acute myelogenous leukemia and identification of type I BMP receptor as a potential target for therapy Research Paper

Targeting VEGFR1- and VEGFR2-expressing non-tumor cells is essential for esophageal cancer therapy Research Paper

The T-box transcription factor, TBX3, is a key substrate of AKT3 in melanomagenesis Research Paper

Mitochondrial translocation and interaction of cofilin and Drp1 are required for erucin-induced mitochondrial fission and apoptosis Research Paper

Active secretion of CXCL10 and CCL5 from colorectal cancer microenvironments associates with GranzymeB+ CD8+ T-cell infiltration Research Paper

Identification of DEK as a potential therapeutic target for neuroendocrine prostate cancer Research Paper

MicroRNA-135b, a HSF1 target, promotes tumor invasion and metastasis by regulating RECK and EVI5 in hepatocellular carcinoma Research Paper

DCLK1 is a broadly dysregulated target against epithelial-mesenchymal transition, focal adhesion, and stemness in clear cell renal carcinoma Research Paper

Stabilization of LKB1 and Akt by neddylation regulates energy metabolism in liver cancer Research Paper

Novel receptor tyrosine kinase targeted combination therapies for imatinib-resistant gastrointestinal stromal tumors (GIST) Research Paper

Î²III-Tubulin: A novel mediator of chemoresistance and metastases in pancreatic cancer Research Paper

Mutation profiling of tumor DNA from plasma and tumor tissue of colorectal cancer patients with a novel, high-sensitivity multiplexed mutation detection platform Clinical Research Papers

Targeting a ribonucleoprotein complex containing the caprin-1 protein and the c-Myc mRNA suppresses tumor growth in mice: an identification of a novel oncotarget Research Paper

Multiple receptor tyrosine kinase activation attenuates therapeutic efficacy of the fibroblast growth factor receptor 2 inhibitor AZD4547 in FGFR2 amplified gastric cancer Research Paper

PRK1/PKN1 controls migration and metastasis of androgen-independent prostate cancer cells Research Paper

Î³-H2AX promotes hepatocellular carcinoma angiogenesis via EGFR/HIF-1Î±/VEGF pathways under hypoxic condition Research Paper