The Oncosearch | Oncotarget

Mutational analysis of genes coding for cell surface proteins in colorectal cancer cell lines reveal novel altered pathways, druggable mutations and mutated epitopes for targeted therapy. Research Paper

Elisa Donnard, Paula F. Asprino, Bruna R. Correa, Fabiana Bettoni, Fernanda Koyama, Fabio C. Navarro, Rodrigo O. Perez, John Mariadason, Oliver M. Sieber, Robert L. Straussberg, Andrew J.G. Simpson, Denis L.F. Jardim, Luiz Fernando L. Reis, Raphael B. Parmigiani, Pedro A.F. Galante, Anamaria A. Camargo

Published Aug 25, 2014 · Vol. 5, No. 19 · pp. 9199-9213

Keywords: colorectal cancer, targeted therapy, cell surface proteins, somatic mutations.

FAK Inhibition with Small Molecule Inhibitor Y15 Decreases Viability, Clonogenicity, and Cell Attachment in Thyroid Cancer Cell Lines and Synergizes with Targeted Therapeutics Research Paper

Shalana Oâ€™Brien, Vita M. Golubovskaya, Jeffrey Conroy, Song Liu, Dan Wang, Biao Liu, William G. Cance

Published Aug 25, 2014 · Vol. 5, No. 17 · pp. 7945-7959

Crizotinib exhibits antitumor activity by targeting ALK signaling not c-MET in pancreatic cancer Research Paper

Hong Hua Yan, Kyung Hee Jung, Mi Kwon Son, Zhenghuan Fang, Soo Jung Kim, Ye-Lim Ryu, Juyoung Kim, Mi-Hyun Kim, Soon-Sun Hong

Published Aug 23, 2014 · Vol. 5, No. 19 · pp. 9150-9168

Keywords: Crizotinib, Pancreatic cancer, c-MET, ALK, Apoptosis

Cancer-derived immunoglobulin G promotes LPS-induced proinflammatory cytokine production via binding to TLR4 in cervical cancer cells Research Paper

Juping Wang, Danyi Lin, Hui Peng, Jimin Shao, Jiang Gu

Published Aug 23, 2014 · Vol. 5, No. 20 · pp. 9727-9743

Keywords: IgG, cancer, promote, TLR4, proinflammatory cytokine

p70 S6 kinase drives ovarian cancer metastasis through multicellular spheroid-peritoneum interaction and P-cadherin/β1 integrin signaling activation Research Paper

Carman Ka Man Ip, Susan Yung, Tak-Mao Chan, Sai-Wah Tsao, Alice Sze Tsai Wong

Published Aug 21, 2014 · Vol. 5, No. 19 · pp. 9133-9149

Keywords: p70S6K, P-cadherin, &beta, 1 integrin, adhesion, metastasis

A novel calcium-dependent mechanism of acquired resistance to IGF-1 receptor inhibition in prostate cancer cells Research Paper

Cale D. Fahrenholtz, Ann M. Greene, Pedro J. Beltran, Kerry L. Burnstein

Published Aug 19, 2014 · Vol. 5, No. 19 · pp. 9007-9021

Multiple blocks in the engagement of oxidative phosphorylation in putative ovarian cancer stem cells: implication for maintenance therapy with glycolysis inhibitors Research Paper

Ayesha B. Alvero, Michele K. Montagna, Natalia J. Sumi, Won Duk Joo, Emma Graham, Gil Mor

Published Aug 19, 2014 · Vol. 5, No. 18 · pp. 8703-8715

Using heterogeneity of the patient-derived xenograft model to identify the chemoresistant population in ovarian cancer Research Paper

Zachary C. Dobbin, Ashwini A. Katre, Adam D. Steg, Britt K. Erickson, Monjri M. Shah, Ronald D. Alvarez, Michael G. Conner, David Schneider, Dongquan Chen, Charles N. Landen

Published Aug 19, 2014 · Vol. 5, No. 18 · pp. 8750-8764

Induced cancer stem-like cells as a model for biological screening and discovery of agents targeting phenotypic traits of cancer stem cell Research Paper

Mayuko Nishi, Hidenori Akutsu, Ayumi Kudoh, Hirokazu Kimura, Naoki Yamamoto, Akihiro Umezawa, Sam W. Lee, Akihide Ryo

Published Aug 17, 2014 · Vol. 5, No. 18 · pp. 8665-8680

ATF3 functions as a novel tumor suppressor with prognostic significance in esophageal squamous cell carcinoma Research Paper

Jian-Jun Xie, Yang-Min Xie, Bo Chen, Feng Pan, Jin-Cheng Guo, Qing Zhao, Jin-Hui Shen, Zhi-Yong Wu, Jian-Yi Wu, Li-Yan Xu, En-Min Li

Published Aug 10, 2014 · Vol. 5, No. 18 · pp. 8569-8582

Inhibition of lung tumor growth by targeting EGFR/VEGFR-Akt/NF-ÎºB pathways with novel theanine derivatives Research Paper

Guoying Zhang, Xinshan Ye, Dexin Ji, Huarong Zhang, Fujia Sun, Chunqing Shang, Ying Zhang, Erxi Wu, Fengfei Wang, Fei Wu, Huihui Tian, Xin Liu, Linlin Chen, Kun Liu, Hanchen Liu, Yishan Wang, Wenhua Zhang, Yukun Guan, Qinwen Wang, Xiaohang Zhao, Xiaochun Wan

Published Aug 10, 2014 · Vol. 5, No. 18 · pp. 8528-8543

Outcomes of patients with advanced cancer and KRAS mutations in phase I clinical trials Clinical Research Papers

Rabih Said, Yang Ye, Gerald Steven Falchook, Filip Janku, Aung Naing, Ralph Zinner, George R. Blumenschein Jr, Siqing Fu, David S. Hong, Sarina Anne Piha-Paul, Jennifer J. Wheler, Razelle Kurzrock, Gary A. Palmer, Kenneth Aldape, Kenneth . R Hess, Apostolia Maria Tsimberidou

Published Aug 10, 2014 · Vol. 5, No. 19 · pp. 8937-8946

ÂIntegrated analysis of epigenomic and genomic changes by DNA methylation dependent mechanisms provides potential novel biomarkers for prostate cancer Research Paper

Nicole M. A. White-Al Habeeb, Linh T. Ho, Ekaterina Olkhov-Mitsel, Ken Kron, Vaijayanti Pethe, Melanie Lehman, Lidija Jovanovic, Neil Fleshner, Theodorus van der Kwast, Colleen C. Nelson, Bharati Bapat

Published Aug 6, 2014 · Vol. 5, No. 17 · pp. 7858-7869

Assessment of the effect of sphingosine kinase inhibitors on apoptosis,unfolded protein response and autophagy of T-cell acute lymphoblastic leukemia cells; indications for novel therapeutics Research Paper

Cecilia Evangelisti, Camilla Evangelisti, Gabriella Teti, Francesca Chiarini, Mirella Falconi, Fraia Melchionda, Andrea Pession, Alice Bertaina, Franco Locatelli, James A. McCubrey, Dong Jae Beak, Robert Bittman, Susan Pyne, Nigel J. Pyne, Alberto M. Martelli

Published Aug 6, 2014 · Vol. 5, No. 17 · pp. 7886-7901

Fucoidan inhibition of lung cancer in vivo and in vitro : role of the Smurf2-dependent ubiquitin proteasome pathway in TGFÎ² receptor degradation Research Paper

Hsien-Yeh Hsu, Tung-Yi Lin, Yu-Chung Wu, Shu-Ming Tsao, Pai-An Hwang, Yu-Wei Shih, Jason Hsu

Published Aug 6, 2014 · Vol. 5, No. 17 · pp. 7870-7885

The novel Aryl hydrocarbon receptor inhibitor biseugenol inhibits gastric tumor growth and peritoneal dissemination Research Paper

De-Wei Lai, Shing-Hwa Liu, Anna Isabella Karlsson, Wen-Jane Lee, Keh-Bin Wang, Yi-Ching Chen, Chin-Chang Shen, Sheng-Mao Wu, Chia-Yu Liu, Hsing-Ru Tien, Yen-Chun Peng, Yee-Jee Jan, Te-Hsin Chao, Keng-Hsin Lan, Jack L. Arbiser, Meei-Ling Sheu

Published Aug 4, 2014 · Vol. 5, No. 17 · pp. 7788-7804

A highly efficient tumor-infiltrating MDSC differentiation system for discovery of anti-neoplastic targets, which circumvents the need for tumor establishment in mice Research Paper

Therese Liechtenstein, Noemi Perez-Janices, Maria Gato, Fabio Caliendo, Grazyna Kochan, Idoia Blanco-Luquin, Frederick Arce, David Guerrero-Setas, Joaquin Fernandez-Irigoyen, Enrique Santamaria, Karine Breckpot, David Escors

Published Aug 4, 2014 · Vol. 5, No. 17 · pp. 7843-7857

Overexpression of secretagogin inhibits cell apoptosis and induces chemoresistance in small cell lung cancer under the regulation of miR-494 Research Paper

Yifeng Bai, Yanqin Sun, Juan Peng, Hongzhan Liao, Hongyi Gao, Ying Guo, Linlang Guo

Published Aug 4, 2014 · Vol. 5, No. 17 · pp. 7760-7775

MicroRNA-mediated down-regulation of NKG2D ligands contributes to glioma immune escape Research Paper

Paula Codo, Michael Weller, Gunter Meister, Emese Szabo, Alexander Steinle, Marietta Wolter, Guido Reifenberger, Patrick Roth

Published Jul 31, 2014 · Vol. 5, No. 17 · pp. 7651-7662

HDAC inhibitors and immunotherapy; a double edged sword? Review

Michiel Kroesen, Paul R. Gielen, Ingrid C. Brok, Inna Armandari, Peter M. Hoogerbrugge, Gosse J. Adema

Published Jul 31, 2014 · Vol. 5, No. 16 · pp. 6558-6572

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Mutational analysis of genes coding for cell surface proteins in colorectal cancer cell lines reveal novel altered pathways, druggable mutations and mutated epitopes for targeted therapy. Research Paper

FAK Inhibition with Small Molecule Inhibitor Y15 Decreases Viability, Clonogenicity, and Cell Attachment in Thyroid Cancer Cell Lines and Synergizes with Targeted Therapeutics Research Paper

Crizotinib exhibits antitumor activity by targeting ALK signaling not c-MET in pancreatic cancer Research Paper

Cancer-derived immunoglobulin G promotes LPS-induced proinflammatory cytokine production via binding to TLR4 in cervical cancer cells Research Paper

p70 S6 kinase drives ovarian cancer metastasis through multicellular spheroid-peritoneum interaction and P-cadherin/β1 integrin signaling activation Research Paper

A novel calcium-dependent mechanism of acquired resistance to IGF-1 receptor inhibition in prostate cancer cells Research Paper

Multiple blocks in the engagement of oxidative phosphorylation in putative ovarian cancer stem cells: implication for maintenance therapy with glycolysis inhibitors Research Paper

Using heterogeneity of the patient-derived xenograft model to identify the chemoresistant population in ovarian cancer Research Paper

Induced cancer stem-like cells as a model for biological screening and discovery of agents targeting phenotypic traits of cancer stem cell Research Paper

ATF3 functions as a novel tumor suppressor with prognostic significance in esophageal squamous cell carcinoma Research Paper

Inhibition of lung tumor growth by targeting EGFR/VEGFR-Akt/NF-ÎºB pathways with novel theanine derivatives Research Paper

Outcomes of patients with advanced cancer and KRAS mutations in phase I clinical trials Clinical Research Papers

ÂIntegrated analysis of epigenomic and genomic changes by DNA methylation dependent mechanisms provides potential novel biomarkers for prostate cancer Research Paper

Assessment of the effect of sphingosine kinase inhibitors on apoptosis,unfolded protein response and autophagy of T-cell acute lymphoblastic leukemia cells; indications for novel therapeutics Research Paper

Fucoidan inhibition of lung cancer in vivo and in vitro : role of the Smurf2-dependent ubiquitin proteasome pathway in TGFÎ² receptor degradation Research Paper

The novel Aryl hydrocarbon receptor inhibitor biseugenol inhibits gastric tumor growth and peritoneal dissemination Research Paper

A highly efficient tumor-infiltrating MDSC differentiation system for discovery of anti-neoplastic targets, which circumvents the need for tumor establishment in mice Research Paper

Overexpression of secretagogin inhibits cell apoptosis and induces chemoresistance in small cell lung cancer under the regulation of miR-494 Research Paper

MicroRNA-mediated down-regulation of NKG2D ligands contributes to glioma immune escape Research Paper

HDAC inhibitors and immunotherapy; a double edged sword? Review

Publication Alerts

European Cancer and Oncology Congress

Oncoscience

Post-Publication Promotion

Search Oncotarget

Mutational analysis of genes coding for cell surface proteins in colorectal cancer cell lines reveal novel altered pathways, druggable mutations and mutated epitopes for targeted therapy. Research Paper

FAK Inhibition with Small Molecule Inhibitor Y15 Decreases Viability, Clonogenicity, and Cell Attachment in Thyroid Cancer Cell Lines and Synergizes with Targeted Therapeutics Research Paper

Crizotinib exhibits antitumor activity by targeting ALK signaling not c-MET in pancreatic cancer Research Paper

Cancer-derived immunoglobulin G promotes LPS-induced proinflammatory cytokine production via binding to TLR4 in cervical cancer cells Research Paper

p70 S6 kinase drives ovarian cancer metastasis through multicellular spheroid-peritoneum interaction and P-cadherin/β1 integrin signaling activation Research Paper

A novel calcium-dependent mechanism of acquired resistance to IGF-1 receptor inhibition in prostate cancer cells Research Paper

Multiple blocks in the engagement of oxidative phosphorylation in putative ovarian cancer stem cells: implication for maintenance therapy with glycolysis inhibitors Research Paper

Using heterogeneity of the patient-derived xenograft model to identify the chemoresistant population in ovarian cancer Research Paper

Induced cancer stem-like cells as a model for biological screening and discovery of agents targeting phenotypic traits of cancer stem cell Research Paper

ATF3 functions as a novel tumor suppressor with prognostic significance in esophageal squamous cell carcinoma Research Paper

Inhibition of lung tumor growth by targeting EGFR/VEGFR-Akt/NF-ÎºB pathways with novel theanine derivatives Research Paper

Outcomes of patients with advanced cancer and KRAS mutations in phase I clinical trials Clinical Research Papers

Â­Integrated analysis of epigenomic and genomic changes by DNA methylation dependent mechanisms provides potential novel biomarkers for prostate cancer Research Paper

Assessment of the effect of sphingosine kinase inhibitors on apoptosis,unfolded protein response and autophagy of T-cell acute lymphoblastic leukemia cells; indications for novel therapeutics Research Paper

Fucoidan inhibition of lung cancer in vivo and in vitro : role of the Smurf2-dependent ubiquitin proteasome pathway in TGFÎ² receptor degradation Research Paper

The novel Aryl hydrocarbon receptor inhibitor biseugenol inhibits gastric tumor growth and peritoneal dissemination Research Paper

A highly efficient tumor-infiltrating MDSC differentiation system for discovery of anti-neoplastic targets, which circumvents the need for tumor establishment in mice Research Paper

Overexpression of secretagogin inhibits cell apoptosis and induces chemoresistance in small cell lung cancer under the regulation of miR-494 Research Paper

MicroRNA-mediated down-regulation of NKG2D ligands contributes to glioma immune escape Research Paper

HDAC inhibitors and immunotherapy; a double edged sword? Review

ÂIntegrated analysis of epigenomic and genomic changes by DNA methylation dependent mechanisms provides potential novel biomarkers for prostate cancer Research Paper